 Nucleic Acid Denaturation
"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
| Descriptor ID |
D009691
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| MeSH Number(s) |
E05.393.640 G02.111.603 G05.627
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| Concept/Terms |
Nucleic Acid Denaturation- Nucleic Acid Denaturation
- Acid Denaturation, Nucleic
- Denaturation, Nucleic Acid
- Nucleic Acid Denaturations
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Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".
This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in this website by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 3 | 3 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 2 | 2 | | 2014 | 0 | 2 | 2 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles.
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Amorim LM, Santos THS, Hollenbach JA, Norman PJ, Marin WM, Dandekar R, Ribeiro EMSF, Petzl-Erler ML, Augusto DG. Cost-effective and fast KIR gene-content genotyping by multiplex melting curve analysis. HLA. 2018 12; 92(6):384-391.
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Vejlegaard K, Paul S, Kosbar T, Wengel J, Caruthers MH. Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers. Bioorg Med Chem Lett. 2017 07 15; 27(14):3173-3176.
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Jastrzebska K, Maciaszek A, Dolot R, Bujacz G, Guga P. Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices. Org Biomol Chem. 2015 Oct 21; 13(39):10032-40.
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Elder RM, Pfaendtner J, Jayaraman A. Effect of Hydrophobic and Hydrophilic Surfaces on the Stability of Double-Stranded DNA. Biomacromolecules. 2015 Jun 08; 16(6):1862-9.
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Holmstrom ED, Nesbitt DJ. Single-molecule fluorescence resonance energy transfer studies of the human telomerase RNA pseudoknot: temperature-/urea-dependent folding kinetics and thermodynamics. J Phys Chem B. 2014 Apr 10; 118(14):3853-63.
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Holmstrom ED, Dupuis NF, Nesbitt DJ. Pulsed IR heating studies of single-molecule DNA duplex dissociation kinetics and thermodynamics. Biophys J. 2014 Jan 07; 106(1):220-31.
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Keel AY, Jha BK, Kieft JS. Structural architecture of an RNA that competitively inhibits RNase L. RNA. 2012 Jan; 18(1):88-99.
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Evans JD, Peddigari S, Chaurasiya KR, Williams MC, Martin SL. Paired mutations abolish and restore the balanced annealing and melting activities of ORF1p that are required for LINE-1 retrotransposition. Nucleic Acids Res. 2011 Jul; 39(13):5611-21.
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Ariefdjohan MW, Savaiano DA, Nakatsu CH. Comparison of DNA extraction kits for PCR-DGGE analysis of human intestinal microbial communities from fecal specimens. Nutr J. 2010 May 22; 9:23.
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Jacobs AC, Resendiz MJ, Greenberg MM. Direct strand scission from a nucleobase radical in RNA. J Am Chem Soc. 2010 Mar 24; 132(11):3668-9.
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