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Thomas R Cech

TitleDistinguished Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/492-8606
    Other Positions
    TitleDistinguished Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentBiology-MCD Instruction


    Collapse Research 
    Collapse research activities and funding
    R01GM099705     (CECH, THOMAS ROBERT)May 1, 2012 - Jan 31, 2020
    NIH
    TERT Promoter Mutations and Telomerase Reactivation in Cancer Cells
    Role: Principal Investigator
    C06RR030428     (CECH, THOMAS ROBERT)Mar 18, 2010 - Dec 17, 2012
    NIH
    University of Colorado Systems Biotechnology Building
    Role: Principal Investigator
    R01GM028039     (CECH, THOMAS ROBERT)Aug 1, 1980 - May 31, 2011
    NIH
    Telomerase and Telomeres: Structure, Function and Regulation
    Role: Principal Investigator
    R37GM028039     (CECH, THOMAS R)Aug 1, 1980 - Jul 31, 1998
    NIH
    NUCLEIC ACID STRUCTURE AND REACTIVITY
    Role: Principal Investigator
    R01GM025273     (CECH, THOMAS R)Apr 1, 1978 - Mar 31, 1989
    NIH
    CHROMATIN STRUCTURE OF A TRANSCRIPTION UNIT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Forino NM, Woo JZ, Zaug AJ, Jimenez AG, Cech TR, Rouskin S, Stone MD. Dissecting telomerase RNA structural heterogeneity in living human cells with DMS-MaPseq. bioRxiv. 2023 Oct 05. PMID: 37873413.
      View in: PubMed
    2. Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337. PMID: 37733873.
      View in: PubMed
    3. Long Y, Hwang T, Gooding AR, Goodrich KJ, Vallery TK, Rinn JL, Cech TR. Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells. bioRxiv. 2023 Aug 18. PMID: 37645830.
      View in: PubMed
    4. Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR. Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. Proc Natl Acad Sci U S A. 2023 06 27; 120(26):e2220537120. PMID: 37339225.
      View in: PubMed
    5. Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220528120. PMID: 37252986.
      View in: PubMed
    6. Tubby K, Adamcikova K, Adamson K, Akiba M, Barnes I, Boron P, Bragan?a H, Bulgakov T, Burgdorf N, Capretti P, Cech T, Cleary M, Davydenko K, Drenkhan R, Elvira-Recuenco M, Enderle R, Gardner J, Georgieva M, Ghelardini L, Husson C, Iturritxa E, Markovskaja S, Mesanza N, Ogris N, Oskay F, Pi?kur B, Queloz V, Raitelaityte K, Raposo R, Soukainen M, Strasser L, Vahal?k P, Vester M, Mullett M. The increasing threat to European forests from the invasive foliar pine pathogen, Lecanosticta acicola. For Ecol Manage. 2023 May 15; 536:120847. PMID: 37193248.
      View in: PubMed
    7. Song J, Gooding AR, Hemphill WO, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. bioRxiv. 2023 Feb 06. PMID: 36798278.
      View in: PubMed
    8. Strader LC, Staller MV, Willis AE, Faulkner GJ, Beggs JD, Cech TR. The complexity of transferring genetic information. Mol Cell. 2023 Feb 02; 83(3):320-323. PMID: 36736305.
      View in: PubMed
    9. Jansson-Fritzberg LI, Sousa CI, Smallegan MJ, Song JJ, Gooding AR, Kasinath V, Rinn JL, Cech TR. DNMT1 inhibition by pUG-fold quadruplex RNA. RNA. 2023 03; 29(3):346-360. PMID: 36574982.
      View in: PubMed
    10. Laas M, Adamson K, Barnes I, Janou?ek J, Mullett MS, Adamc?kov? K, Akiba M, Beenken L, Braganca H, Bulgakov TS, Capretti P, Cech T, Cleary M, Enderle R, Ghelardini L, Jankovsk? L, Markovskaja S, Matsiakh I, Meyer JB, Oskay F, Pi?kur B, Raitelaityte K, Sadikovic D, Drenkhan R. Diversity, migration routes, and worldwide population genetic structure of Lecanosticta acicola, the causal agent of brown spot needle blight. Mol Plant Pathol. 2022 11; 23(11):1620-1639. PMID: 35957598.
      View in: PubMed
    11. Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 2022 08; 608(7924):819-825. PMID: 35831508.
      View in: PubMed
    12. Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119. PMID: 35617427.
      View in: PubMed
    13. Cech TR. RNA in biological condensates. RNA. 2022 01; 28(1):1-2. PMID: 34903621.
      View in: PubMed
    14. Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665. PMID: 34718732.
      View in: PubMed
    15. Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 Oct 21; 12(1):6189. PMID: 34675241.
      View in: PubMed
    16. Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38). PMID: 34518220.
      View in: PubMed
    17. Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308. PMID: 34083519.
      View in: PubMed
    18. Lim CJ, Cech TR. Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 Apr; 22(4):299. PMID: 33608692.
      View in: PubMed
    19. Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298. PMID: 33564154.
      View in: PubMed
    20. Long Y, Cech TR. Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools. Methods. 2021 07; 191:44-58. PMID: 33444739.
      View in: PubMed
    21. Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9. PMID: 33338397.
      View in: PubMed
    22. Cornejo C, Hauser A, Beenken L, Cech T, Rigling D. Cryphonectria carpinicola sp. nov. Associated with hornbeam decline in Europe. Fungal Biol. 2021 05; 125(5):347-356. PMID: 33910676.
      View in: PubMed
    23. Rowland TJ, Bonham AJ, Cech TR. Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers. Mol Oncol. 2020 10; 14(10):2358-2374. PMID: 33245585.
      View in: PubMed
    24. Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet. 2020 09; 52(9):931-938. PMID: 32632336.
      View in: PubMed
    25. Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science. 2020 06 05; 368(6495):1081-1085. PMID: 32499435.
      View in: PubMed
    26. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2020 May 26; 31(8):107718. PMID: 32460014.
      View in: PubMed
    27. Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062. PMID: 32276990.
      View in: PubMed
    28. Heenan PR, Wang X, Gooding AR, Cech TR, Perkins TT. Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid. Nucleic Acids Res. 2020 04 06; 48(6):2969-2981. PMID: 32043141.
      View in: PubMed
    29. Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR. Regulation of histone methylation by automethylation of PRC2. Genes Dev. 2019 10 01; 33(19-20):1416-1427. PMID: 31488576.
      View in: PubMed
    30. Rowland TJ, Dumbovic G, Hass EP, Rinn JL, Cech TR. Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18488-18497. PMID: 31451652.
      View in: PubMed
    31. Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR. C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms. RNA. 2019 08; 25(8):935-947. PMID: 31048495.
      View in: PubMed
    32. Greenwood J, Patel H, Cech TR, Cooper JP. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Nucleic Acids Res. 2018 09 28; 46(17):8865-8875. PMID: 29992245.
      View in: PubMed
    33. Cech TR. A Lifelong Passion for All Things Ribonucleic. Cell. 2018 09 20; 175(1):14-17. PMID: 30217358.
      View in: PubMed
    34. Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New?RNA?Crystal?Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3. PMID: 29910185.
      View in: PubMed
    35. Youmans DT, Schmidt JC, Cech TR. Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits. Genes Dev. 2018 06 01; 32(11-12):794-805. PMID: 29891558.
      View in: PubMed
    36. Schmidt JC, Zaug AJ, Kufer R, Cech TR. Dynamics of human telomerase recruitment depend on template-telomere base pairing. Mol Biol Cell. 2018 Apr 01; 29(7):869-880. PMID: 29386295.
      View in: PubMed
    37. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR. Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes. Cell Rep. 2017 12 26; 21(13):3700-3707. PMID: 29281820.
      View in: PubMed
    38. Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X. Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2. Elife. 2017 11 29; 6. PMID: 29185984.
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    39. Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 Dec; 24(12):1028-1038. PMID: 29058709.
      View in: PubMed
    40. Lim CJ, Zaug AJ, Kim HJ, Cech TR. Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity. Nat Commun. 2017 10 20; 8(1):1075. PMID: 29057866.
      View in: PubMed
    41. Jung T, Jung MH, Cacciola SO, Cech T, Bakonyi J, Seress D, Mosca S, Schena L, Seddaiu S, Pane A, di San Lio GM, Maia C, Cravador A, Franceschini A, Scanu B. Multiple new cryptic pathogenic Phytophthora species from Fagaceae forests in Austria, Italy and Portugal. IMA Fungus. 2017 Dec; 8(2):219-244. PMID: 29242773.
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    42. Long Y, Wang X, Youmans DT, Cech TR. How do lncRNAs regulate transcription? Sci Adv. 2017 09; 3(9):eaao2110. PMID: 28959731.
      View in: PubMed
    43. Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C. Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell. 2017 Mar 16; 65(6):1056-1067.e5. PMID: 28306504.
      View in: PubMed
    44. Goldfarb KC, Cech TR. Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing. Genes Dev. 2017 01 01; 31(1):59-71. PMID: 28115465.
      View in: PubMed
    45. Dickinson DL, Cazier J, Cech T. A practical validation study of a commercial accelerometer using good and poor sleepers. Health Psychol Open. 2016 Jul; 3(2):2055102916679012. PMID: 28815052.
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    46. Schmidt JC, Zaug AJ, Cech TR. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016 Aug 25; 166(5):1188-1197.e9. PMID: 27523609.
      View in: PubMed
    47. Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. PMID: 27180905.
      View in: PubMed
    48. Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016 Apr; 23(4):286-92. PMID: 26950371.
      View in: PubMed
    49. Davidovich C, Cech TR. The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2. RNA. 2015 Dec; 21(12):2007-22. PMID: 26574518.
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    50. Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10; 16:231. PMID: 26553065.
      View in: PubMed
    51. Xi L, Cech TR. Protein-RNA interaction restricts telomerase from running through the stop sign. Nat Struct Mol Biol. 2015 Nov; 22(11):835-6. PMID: 26581514.
      View in: PubMed
    52. Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 2015 Nov 01; 29(21):2219-24. PMID: 26515115.
      View in: PubMed
    53. Wang X, Schwartz JC, Cech TR. Nucleic acid-binding specificity of human FUS protein. Nucleic Acids Res. 2015 Sep 03; 43(15):7535-43. PMID: 26150427.
      View in: PubMed
    54. Schmidt JC, Cech TR. Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes Dev. 2015 Jun 01; 29(11):1095-105. PMID: 26063571.
      View in: PubMed
    55. Cech TR. RNA World research-still evolving. RNA. 2015 Apr; 21(4):474-5. PMID: 25780099.
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    56. Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR. Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer. Science. 2015 Feb 27; 347(6225):1006-10. PMID: 25722414.
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    57. Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1291-1303. PMID: 25623306.
      View in: PubMed
    58. Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015 Feb 05; 57(3):552-8. PMID: 25601759.
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    59. Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annu Rev Biochem. 2015; 84:355-79. PMID: 25494299.
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    60. Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015 Jan 15; 128(2):331-41. PMID: 25416818.
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    61. Watson-Capps JJ, Cech TR. Academia and industry: Companies on campus. Nature. 2014 Oct 16; 514(7522):297-8. PMID: 25318508.
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    62. Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3. PMID: 25271372.
      View in: PubMed
    63. Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Mol Biol Cell. 2014 Sep 01; 25(17):2571-8. PMID: 25009283.
      View in: PubMed
    64. Davidovich C, Goodrich KJ, Gooding AR, Cech TR. A dimeric state for PRC2. Nucleic Acids Res. 2014 Aug; 42(14):9236-48. PMID: 24992961.
      View in: PubMed
    65. Xi L, Cech TR. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res. 2014 Jul; 42(13):8565-77. PMID: 24990373.
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    66. Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 2014 Mar 27; 157(1):77-94. PMID: 24679528.
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    67. McKay DB, Xi L, Barthel KKB, Cech TR. Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA. J Mol Biol. 2014 Apr 17; 426(8):1766-1785. PMID: 24486609.
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    68. Schwartz JC, Wang X, Podell ER, Cech TR. RNA seeds higher-order assembly of FUS protein. Cell Rep. 2013 Nov 27; 5(4):918-25. PMID: 24268778.
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    69. Theodorescu D, Cech TR. Telomerase in bladder cancer: back to a better future? Eur Urol. 2014 Feb; 65(2):370-1. PMID: 24184027.
      View in: PubMed
    70. Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. J Biol Chem. 2013 Nov 15; 288(46):33171-80. PMID: 24097987.
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    71. Davidovich C, Zheng L, Goodrich KJ, Cech TR. Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol. 2013 Nov; 20(11):1250-7. PMID: 24077223.
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    72. Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. BMC Mol Biol. 2013 Sep 21; 14:23. PMID: 24053768.
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    73. Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013 Oct; 41(19):8969-78. PMID: 23901009.
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    74. Dalby AB, Goodrich KJ, Pfingsten JS, Cech TR. RNA recognition by the DNA end-binding Ku heterodimer. RNA. 2013 Jun; 19(6):841-51. PMID: 23610127.
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    75. Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol. 2013 Feb; 14(2):69-82. PMID: 23299958.
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    76. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR. FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev. 2012 Dec 15; 26(24):2690-5. PMID: 23249733.
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    77. Cech TR. How a chemist looks at RNA. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):75-8. PMID: 23203538.
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    78. Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 2012 Nov 21; 151(5):1138-1138.e1. PMID: 23178129.
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    79. Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9. PMID: 23103865.
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    80. Santini A, Ghelardini L, De Pace C, Desprez-Loustau ML, Capretti P, Chandelier A, Cech T, Chira D, Diamandis S, Gaitniekis T, Hantula J, Holdenrieder O, Jankovsky L, Jung T, Jurc D, Kirisits T, Kunca A, Lygis V, Malecka M, Marcais B, Schmitz S, Schumacher J, Solheim H, Solla A, Szab? I, Tsopelas P, Vannini A, Vettraino AM, Webber J, Woodward S, Stenlid J. Biogeographical patterns and determinants of invasion by forest pathogens in Europe. New Phytol. 2013 Jan; 197(1):238-250. PMID: 23057437.
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    81. Cech TR. The RNA worlds in context. Cold Spring Harb Perspect Biol. 2012 Jul 01; 4(7):a006742. PMID: 21441585.
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    82. Goldfarb KC, Borah S, Cech TR. RNase P branches out from RNP to protein: organelle-triggered diversification? Genes Dev. 2012 May 15; 26(10):1005-9. PMID: 22588715.
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    83. Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 2012 Mar 02; 148(5):922-32. PMID: 22365814.
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    84. Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1371-5. PMID: 22101935.
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    85. Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res. 2012 Jan; 40(1):235-44. PMID: 21911358.
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    86. Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 2011 May 22; 474(7351):399-402. PMID: 21602826.
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    87. Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7. PMID: 21596049.
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    88. Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR. Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA. 2011 Feb; 17(2):298-311. PMID: 21177376.
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    89. Berman AJ, Gooding AR, Cech TR. Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol. 2010 Oct; 30(20):4965-76. PMID: 20713447.
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    90. Talg? V, Chastagner G, Thomsen IM, Cech T, Riley K, Lange K, Klemsdal SS, Stensvand A. Sydowia polyspora associated with current season needle necrosis (CSNN) on true fir (Abies spp.). Fungal Biol. 2010 Jul; 114(7):545-54. PMID: 20943166.
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    91. Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes Dev. 2010 Mar 15; 24(6):613-22. PMID: 20231318.
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    92. Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8. PMID: 20194781.
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    93. Latrick CM, Cech TR. POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J. 2010 Mar 03; 29(5):924-33. PMID: 20094033.
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    94. Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):651-6. PMID: 20080730.
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    95. Cech TR. Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harb Symp Quant Biol. 2009; 74:11-6. PMID: 19850851.
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    96. Andrews N, Burris JE, Cech TR, Coller BS, Crowley WF, Gallin EK, Kelner KL, Kirch DG, Leshner AI, Morris CD, Nguyen FT, Oates J, Sung NS. Translational careers. Science. 2009 May 15; 324(5929):855. PMID: 19443750.
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    97. Cech TR. Crawling out of the RNA world. Cell. 2009 Feb 20; 136(4):599-602. PMID: 19239881.
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    117. Zaug AJ, Podell ER, Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10864-9. PMID: 16043710.
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    120. Mandell JG, B?hler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005; 6(1):R1. PMID: 15642092.
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    122. Cech TR, Rubin GM. Nurturing interdisciplinary research. Nat Struct Mol Biol. 2004 Dec; 11(12):1166-9. PMID: 15578058.
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    126. Aigner S, Cech TR. The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA. 2004 Jul; 10(7):1108-18. PMID: 15208446.
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    131. Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 2003 Nov 13; 426(6963):198-203. PMID: 14614509.
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    132. Seto AG, Umansky K, Tzfati Y, Zaug AJ, Blackburn EH, Cech TR. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 2003 Nov; 9(11):1323-32. PMID: 14561882.
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    133. Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Mol Biol Cell. 2003 Dec; 14(12):4794-804. PMID: 13679509.
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    134. Classen S, Lyons D, Cech TR, Schultz SC. Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry. 2003 Aug 12; 42(31):9269-77. PMID: 12899613.
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    135. Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Curr Biol. 2003 May 27; 13(11):942-6. PMID: 12781132.
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    136. Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47. PMID: 12741831.
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    137. Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC. Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol. 2003 May; 132(1):19-24. PMID: 12746507.
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    138. F?rstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55. PMID: 12626706.
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    139. Cech TR. Rebalancing teaching and research. Science. 2003 Jan 10; 299(5604):165. PMID: 12522218.
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    140. Friedman KL, Heit JJ, Long DM, Cech TR. N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Mol Biol Cell. 2003 Jan; 14(1):1-13. PMID: 12529422.
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    141. Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8. PMID: 12110898.
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    142. Guo F, Cech TR. In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002 May; 8(5):647-58. PMID: 12022231.
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    143. Livengood AJ, Zaug AJ, Cech TR. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol. 2002 Apr; 22(7):2366-74. PMID: 11884619.
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    144. Jarstfer MB, Cech TR. Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry. 2002 Jan 08; 41(1):151-61. PMID: 11772012.
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    145. Cech TR. HHMI's attention to Wiley's lab staff. Science. 2002 Jan 04; 295(5552):43. PMID: 11780644.
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    147. Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 2001 May 11; 292(5519):1171-5. PMID: 11349150.
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    148. Cohen SB, Cech TR. Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry. Curr Protoc Nucleic Acid Chem. 2001 May; Chapter 5:Unit 5.1. PMID: 18428857.
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    149. Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure. 2001 Mar 07; 9(3):221-31. PMID: 11286889.
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    150. Cech TR, Leonard JS. Science and business. Conflicts of interest--moving beyond disclosure. Science. 2001 Feb 09; 291(5506):989. PMID: 11232584.
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    151. Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. RNA. 2001 Feb; 7(2):161-6. PMID: 11233973.
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    152. Aigner S, Lingner J, Goodrich KJ, Grosshans CA, Shevchenko A, Mann M, Cech TR. Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting. EMBO J. 2000 Nov 15; 19(22):6230-9. PMID: 11080168.
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    153. Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 2000 Oct 10; 39(40):12465-75. PMID: 11015228.
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    154. Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 2000 Oct; 11(10):3265-75. PMID: 11029034.
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    155. Cech TR. Structural biology. The ribosome is a ribozyme. Science. 2000 Aug 11; 289(5481):878-9. PMID: 10960319.
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    156. Bryan TM, Goodrich KJ, Cech TR. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J Biol Chem. 2000 Aug 04; 275(31):24199-207. PMID: 10807925.
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    157. Bryan TM, Goodrich KJ, Cech TR. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol Cell. 2000 Aug; 6(2):493-9. PMID: 10983995.
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    158. Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6367-72. PMID: 10829083.
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    159. Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA. 1999 Dec; 5(12):1665-74. PMID: 10606276.
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    160. Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. EMBO J. 1999 Nov 15; 18(22):6491-500. PMID: 10562561.
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    161. Friedman KL, Cech TR. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 1999 Nov 01; 13(21):2863-74. PMID: 10557213.
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    162. Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 1999 Oct 26; 38(43):14224-37. PMID: 10571996.
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    163. Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 1999 Sep 09; 401(6749):177-80. PMID: 10490028.
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    164. Juneau K, Cech TR. In vitro selection of RNAs with increased tertiary structure stability. RNA. 1999 Aug; 5(8):1119-29. PMID: 10445885.
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    166. Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol. 1999 Jun; 11(3):318-24. PMID: 10395557.
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    167. Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998 Dec; 4(12):1481-92. PMID: 9848647.
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    168. Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science. 1998 Oct 16; 282(5388):493-6. PMID: 9774280.
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    169. Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science. 1998 Oct 09; 282(5387):259-64. PMID: 9841391.
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    170. Cohen SB, Cech TR. A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps. RNA. 1998 Oct; 4(10):1179-85. PMID: 9769093.
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    171. Zhang B, Cech TR. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chem Biol. 1998 Oct; 5(10):539-53. PMID: 9818147.
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    172. Szewczak AA, Podell ER, Bevilacqua PC, Cech TR. Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry. 1998 Aug 11; 37(32):11162-70. PMID: 9698362.
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    173. Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8479-84. PMID: 9671703.
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    174. Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998 May 15; 12(10):1504-14. PMID: 9585510.
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    175. Bevilacqua PC, George CX, Samuel CE, Cech TR. Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry. 1998 May 05; 37(18):6303-16. PMID: 9572845.
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    176. Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 1998 Apr 14; 37(15):5162-72. PMID: 9548747.
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    177. Lingner J, Cech TR. Telomerase and chromosome end maintenance. Curr Opin Genet Dev. 1998 Apr; 8(2):226-32. PMID: 9610414.
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    178. Nakamura TM, Cech TR. Reversing time: origin of telomerase. Cell. 1998 Mar 06; 92(5):587-90. PMID: 9506510.
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    179. Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54. PMID: 9405070.
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    180. Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 1997 Nov 06; 390(6655):96-100. PMID: 9363898.
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    181. Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry (Mosc). 1997 Nov; 62(11):1202-5. PMID: 9467843.
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    182. Chapon C, Cech TR, Zaug AJ. Polyadenylation of telomerase RNA in budding yeast. RNA. 1997 Nov; 3(11):1337-51. PMID: 9409624.
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    183. Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11190-5. PMID: 9326584.
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    184. Hammond PW, Cech TR. dGTP-dependent processivity and possible template switching of euplotes telomerase. Nucleic Acids Res. 1997 Sep 15; 25(18):3698-704. PMID: 9278493.
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    185. Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51. PMID: 9292502.
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    186. Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 1997 Aug 21; 388(6644):805-8. PMID: 9285596.
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    187. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9. PMID: 9252327.
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    188. Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. J Mol Biol. 1997 Aug 01; 270(5):711-23. PMID: 9245599.
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    189. Szewczak AA, Cech TR. An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 1997 Aug; 3(8):838-49. PMID: 9257643.
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    190. McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 1997 Jul 08; 36(27):8293-303. PMID: 9204875.
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    191. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997 Apr 25; 276(5312):561-7. PMID: 9110970.
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    192. Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 1997 Feb 20; 385(6618):744-7. PMID: 9034194.
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    193. Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science. 1997 Feb 07; 275(5301):847-9. PMID: 9012355.
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    194. Hammond PW, Lively TN, Cech TR. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Mol Cell Biol. 1997 Jan; 17(1):296-308. PMID: 8972210.
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    195. Cech TR, Lingner J. Telomerase and the chromosome end replication problem. Ciba Found Symp. 1997; 211:20-8; discussion 28-34. PMID: 9524749.
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    196. Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. RNA. 1996 Dec; 2(12):1295-305. PMID: 8972777.
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    197. Rusconi CP, Cech TR. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes Dev. 1996 Nov 15; 10(22):2870-80. PMID: 8918888.
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    198. Lingner J, Cech TR. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10712-7. PMID: 8855245.
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    199. Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Res. 1996 Oct 01; 24(19):3722-7. PMID: 8871550.
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    200. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85. PMID: 8781224.
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    201. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science. 1996 Sep 20; 273(5282):1696-9. PMID: 8781229.
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    202. Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 1996 Sep 03; 35(35):11493-502. PMID: 8784205.
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    203. Bevilacqua PC, Cech TR. Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR. Biochemistry. 1996 Aug 06; 35(31):9983-94. PMID: 8756460.
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    204. Cech TR, Szewczak AA. Selecting apt RNAs for NMR. RNA. 1996 Jul; 2(7):625-7. PMID: 8756405.
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    205. Rusconi CP, Cech TR. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. EMBO J. 1996 Jul 01; 15(13):3286-95. PMID: 8670829.
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    206. Downs WD, Cech TR. Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA. 1996 Jul; 2(7):718-32. PMID: 8756414.
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    207. Golden BL, Cech TR. Conformational switches involved in orchestrating the successive steps of group I RNA splicing. Biochemistry. 1996 Mar 26; 35(12):3754-63. PMID: 8619996.
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    208. Zaug AJ, Linger J, Cech TR. Method for determining RNA 3' ends and application to human telomerase RNA. Nucleic Acids Res. 1996 Feb 01; 24(3):532-3. PMID: 8602368.
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    209. Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 1996 Jan 30; 35(4):1201-11. PMID: 8573575.
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    210. Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science. 1996 Jan 19; 271(5247):345-8. PMID: 8553068.
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    211. Tanner M, Cech T. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus. RNA. 1996 Jan; 2(1):74-83. PMID: 8846298.
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    212. Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. EMBO J. 1995 Oct 02; 14(19):4849-59. PMID: 7588614.
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    213. Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science. 1995 Sep 15; 269(5230):1533-4. PMID: 7545310.
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    214. Campbell TB, Cech TR. Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. RNA. 1995 Aug; 1(6):598-609. PMID: 7489519.
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    215. Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30. PMID: 7628013.
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    216. Fang G, Cech TR. Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates. J Cell Biol. 1995 Jul; 130(2):243-53. PMID: 7615628.
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    217. Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 1995 Jun 13; 34(23):7728-38. PMID: 7540041.
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    218. Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Res. 1995 Jun 11; 23(11):1887-93. PMID: 7596814.
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    219. Tanner MA, Cech TR. An important RNA tertiary interaction of group I and group II introns is implicated in gram-positive RNase P RNAs. RNA. 1995 Jun; 1(4):349-50. PMID: 7493313.
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    225. Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science. 1995 Feb 03; 267(5198):675-9. PMID: 7839142.
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    227. Strobel SA, Cech TR, Usman N, Beigelman L. The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA. Biochemistry. 1994 Nov 22; 33(46):13824-35. PMID: 7524665.
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    229. Cech TR, Uhlenbeck OC. Ribozymes. Hammerhead nailed down. Nature. 1994 Nov 03; 372(6501):39-40. PMID: 7969416.
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    233. Lingner J, Hendrick LL, Cech TR. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 1994 Aug 15; 8(16):1984-98. PMID: 7958872.
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    234. Laggerbauer B, Murphy FL, Cech TR. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. EMBO J. 1994 Jun 01; 13(11):2669-76. PMID: 8013466.
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    237. Hicke BJ, Willis MC, Koch TH, Cech TR. Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine. Biochemistry. 1994 Mar 22; 33(11):3364-73. PMID: 8136374.
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    238. Murphy FL, Cech TR. GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. J Mol Biol. 1994 Feb 11; 236(1):49-63. PMID: 8107125.
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    243. Sullenger BA, Cech TR. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science. 1993 Dec 03; 262(5139):1566-9. PMID: 8248806.
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    245. Fang G, Cech TR. Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein. Biochemistry. 1993 Nov 02; 32(43):11646-57. PMID: 8218232.
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    249. Herschlag D, Eckstein F, Cech TR. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry. 1993 Aug 17; 32(32):8312-21. PMID: 7688573.
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    250. Herschlag D, Eckstein F, Cech TR. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry. 1993 Aug 17; 32(32):8299-311. PMID: 7688572.
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    252. Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 1993 Jul; 13(7):4301-10. PMID: 8321232.
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    253. Fang G, Cech TR. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6056-60. PMID: 8327484.
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    258. Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8. PMID: 8421499.
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    259. Legault P, Herschlag D, Celander DW, Cech TR. Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis. Nucleic Acids Res. 1992 Dec 25; 20(24):6613-9. PMID: 1480482.
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    265. Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR. Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11105-9. PMID: 1763026.
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    266. Young B, Herschlag D, Cech TR. Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell. 1991 Nov 29; 67(5):1007-19. PMID: 1959129.
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    267. Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 1991 Nov 15; 67(4):807-14. PMID: 1840510.
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    268. Fang GW, Cech TR. Molecular cloning of telomere-binding protein genes from Stylonychia mytilis. Nucleic Acids Res. 1991 Oct 25; 19(20):5515-8. PMID: 1945829.
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    269. Gampel A, Cech TR. Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev. 1991 Oct; 5(10):1870-80. PMID: 1916266.
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    270. D?vila-Aponte JA, Huss VA, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic Acids Res. 1991 Aug 25; 19(16):4429-36. PMID: 1886767.
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    271. Grosshans CA, Cech TR. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification. Nucleic Acids Res. 1991 Jul 25; 19(14):3875-80. PMID: 1650453.
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    273. Zahler AM, Williamson JR, Cech TR, Prescott DM. Inhibition of telomerase by G-quartet DNA structures. Nature. 1991 Apr 25; 350(6320):718-20. PMID: 2023635.
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    274. Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 1991 Apr 18; 350(6319):628-31. PMID: 1708111.
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    279. Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry. 1990 Nov 06; 29(44):10172-80. PMID: 2271646.
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    281. Raghuraman MK, Cech TR. Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein. Nucleic Acids Res. 1990 Aug 11; 18(15):4543-52. PMID: 2388834.
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    282. Downs WD, Cech TR. An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry. 1990 Jun 12; 29(23):5605-13. PMID: 2201409.
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    285. Celander DW, Cech TR. Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms. Biochemistry. 1990 Feb 13; 29(6):1355-61. PMID: 2110477.
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    286. Hicke BJ, Celander DW, MacDonald GH, Price CM, Cech TR. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1481-5. PMID: 1689486.
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    293. Raghuraman MK, Cech TR. Assembly and self-association of oxytricha telomeric nucleoprotein complexes. Cell. 1989 Nov 17; 59(4):719-28. PMID: 2582492.
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    294. Flor PJ, Flanegan JB, Cech TR. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. EMBO J. 1989 Nov; 8(11):3391-9. PMID: 2684642.
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    295. Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic Acids Res. 1989 Sep 12; 17(17):6969-81. PMID: 2674904.
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    297. Grosshans CA, Cech TR. Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry. 1989 Aug 22; 28(17):6888-94. PMID: 2684268.
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    340. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic Acids Res. 1985 Nov 11; 13(21):7759-79. PMID: 2415924.
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    341. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic Acids Res. 1985 Nov 11; 13(21):7741-58. PMID: 2415923.
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    342. Zaug AJ, Kent JR, Cech TR. Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry. 1985 Oct 22; 24(22):6211-8. PMID: 4084515.
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    343. Zaug AJ, Cech TR. Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science. 1985 Sep 13; 229(4718):1060-4. PMID: 2412290.
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    344. Sullivan FX, Cech TR. Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell. 1985 Sep; 42(2):639-48. PMID: 3849344.
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    345. Price JV, Cech TR. Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli. Science. 1985 May 10; 228(4700):719-22. PMID: 2986286.
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    346. Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic Acids Res. 1985 Mar 25; 13(6):1871-89. PMID: 4000946.
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    347. Inoue T, Cech TR. Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):648-52. PMID: 2579378.
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    348. Cech TR. Self-splicing RNA: implications for evolution. Int Rev Cytol. 1985; 93:3-22. PMID: 3891660.
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    349. Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 1984 Sep; 38(2):501-10. PMID: 6432344.
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    350. Zaug AJ, Kent JR, Cech TR. A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science. 1984 May 11; 224(4649):574-8. PMID: 6200938.
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    351. Palen TE, Cech TR. Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena. Cell. 1984 Apr; 36(4):933-42. PMID: 6323028.
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    352. Bass BL, Cech TR. Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA. Nature. 1984 Apr 26-May 2; 308(5962):820-6. PMID: 6562377.
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    353. Pardue ML, Fostel JM, Cech TR. DNA-protein interactions in the Drosophila virilis mitochondrial chromosome. Nucleic Acids Res. 1984 Feb 24; 12(4):1991-9. PMID: 6322130.
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    354. Cech TR. RNA splicing: three themes with variations. Cell. 1983 Oct; 34(3):713-6. PMID: 6354470.
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    355. Cech TR, Tanner NK, Tinoco I, Weir BR, Zuker M, Perlman PS. Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3903-7. PMID: 6306649.
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    356. Brehm SL, Cech TR. Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry. 1983 May 10; 22(10):2390-7. PMID: 6860634.
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    357. Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Res. 1983 Apr 11; 11(7):2093-109. PMID: 6835846.
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    358. Palen TE, Cech TR. Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic Acids Res. 1983 Apr 11; 11(7):2077-91. PMID: 6300792.
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    359. Zaug AJ, Grabowski PJ, Cech TR. Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction. Nature. 1983 Feb 17-23; 301(5901):578-83. PMID: 6186917.
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    360. Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 1982 Nov; 31(1):147-57. PMID: 6297745.
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    361. Zaug AJ, Cech TR. The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic Acids Res. 1982 May 11; 10(9):2823-38. PMID: 7099968.
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    362. Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 1981 Dec; 27(3 Pt 2):487-96. PMID: 6101203.
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    363. Cech TR, Brehm SL. Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic Acids Res. 1981 Jul 24; 9(14):3531-43. PMID: 7279667.
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    364. Cech TR. Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-links. Biochemistry. 1981 Mar 17; 20(6):1431-7. PMID: 6261794.
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    365. Grabowski PJ, Zaug AJ, Cech TR. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 1981 Feb; 23(2):467-76. PMID: 6162571.
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    366. Potter DA, Fostel JM, Berninger M, Pardue ML, Cech TR. DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4118-22. PMID: 6776522.
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    367. Cech TR, Karrer KM. Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo. J Mol Biol. 1980 Feb 05; 136(4):395-416. PMID: 7365791.
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    368. Zaug AJ, Cech TR. In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell. 1980 Feb; 19(2):331-8. PMID: 7357611.
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    369. Cech TR, Rio DC. Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5051-5. PMID: 291921.
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    370. Cech T, Pathak MA, Biswas RK. An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives. Biochim Biophys Acta. 1979 Apr 26; 562(2):342-60. PMID: 444530.
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    371. Cech TR, Potter D, Pardue ML. Chromatin structure in living cells. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 1:191-8. PMID: 277339.
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    372. Cech T, Potter D, Pardue ML. Electron microscopy of DNA cross-linked with trimethylpsoralen: a probe for chromatin structure. Biochemistry. 1977 Nov 29; 16(24):5313-21. PMID: 921934.
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    373. Cech T, Pardue ML. Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure. Cell. 1977 Jul; 11(3):631-40. PMID: 560256.
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    374. Cech TR, Pardue ML. Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2644-8. PMID: 1066674.
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    375. Cech TR, Hearst JE. Organization of highly repeated sequences in mouse main-band DNA. J Mol Biol. 1976 Jan 25; 100(3):227-56. PMID: 768484.
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    376. Cech TR, Hearst JE. An electron microscopic study of mouse foldback DNA. Cell. 1975 Aug; 5(4):429-46. PMID: 1157097.
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    377. Hearst JE, Cech TR, Marx KA, Rosenfeld A, Allen JR. Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA. Cold Spring Harb Symp Quant Biol. 1974; 38:329-39. PMID: 4208786.
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    378. Cech TR, Rosenfeld A, Hearst JE. Characterization of the most rapidly renaturing sequences in mouse main-band DNA. J Mol Biol. 1973 Dec 15; 81(3):299-325. PMID: 4767458.
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