 Protein Aggregation, Pathological
"Protein Aggregation, Pathological" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Descriptor ID |
D066263
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| MeSH Number(s) |
C23.550.770 G02.111.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Aggregation, Pathological".
Below are MeSH descriptors whose meaning is more specific than "Protein Aggregation, Pathological".
This graph shows the total number of publications written about "Protein Aggregation, Pathological" by people in this website by year, and whether "Protein Aggregation, Pathological" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 1 | 3 | | 2017 | 3 | 0 | 3 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Aggregation, Pathological" by people in Profiles.
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Anderson EN, Morera AA, Kour S, Cherry JD, Ramesh N, Gleixner A, Schwartz JC, Ebmeier C, Old W, Donnelly CJ, Cheng JP, Kline AE, Kofler J, Stein TD, Pandey UB. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Elife. 2021 05 26; 10.
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Bubak AN, Beseler C, Como CN, Tyring SK, Haley C, Mescher T, Hassell JE, Cohrs RJ, Potter H, Nagel MA. Acute zoster plasma contains elevated amyloid, correlating with A?42 and amylin levels, and is amyloidogenic. J Neurovirol. 2020 06; 26(3):422-428.
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Hughes C, Choi ML, Yi JH, Kim SC, Drews A, George-Hyslop PS, Bryant C, Gandhi S, Cho K, Klenerman D. Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat?neuronal cell death. Commun Biol. 2020 02 18; 3(1):79.
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Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V. a-Sheet secondary structure in amyloid ?-peptide drives aggregation and toxicity in Alzheimer's disease. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8895-8900.
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Guerrero-G?mez D, Mora-Lorca JA, S?enz-Narciso B, Naranjo-Galindo FJ, Mu?oz-Lobato F, Parrado-Fern?ndez C, Goikolea J, Cedazo-Minguez ?, Link CD, Neri C, Sequedo MD, V?zquez-Manrique RP, Fern?ndez-Su?rez E, Goder V, Pan? R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A. Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation. Cell Death Differ. 2019 09; 26(9):1545-1565.
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Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA. Cofilin-actin rod formation in neuronal processes after brain ischemia. PLoS One. 2018; 13(10):e0198709.
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Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH. Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells. Chembiochem. 2018 10 04; 19(19):2033-2038.
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Shah DD, Zhang J, Maity H, Mallela KMG. Effect of photo-degradation on the structure, stability, aggregation, and function of an IgG1 monoclonal antibody. Int J Pharm. 2018 Aug 25; 547(1-2):438-449.
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Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11029-E11036.
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St?hr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 09; 9(9):874-881.
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