 Riboswitch
"Riboswitch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Part of a MESSENGER RNA molecule that undergoes a conformation change upon binding a specific metabolite or other small molecule thereby regulating the messenger RNA's transcription, post-transcriptional processing, transport, translation, or stability in response to varying levels of the metabolite or other small molecule.
| Descriptor ID |
D058928
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| MeSH Number(s) |
D13.444.735.544.427 D13.444.735.790.878.942.500 G02.111.570.080.689.687.124 G05.360.080.689.687.124
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Riboswitch".
Below are MeSH descriptors whose meaning is more specific than "Riboswitch".
This graph shows the total number of publications written about "Riboswitch" by people in this website by year, and whether "Riboswitch" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 5 | 0 | 5 | | 2012 | 5 | 1 | 6 | | 2013 | 3 | 0 | 3 | | 2014 | 5 | 0 | 5 | | 2015 | 6 | 2 | 8 | | 2016 | 1 | 0 | 1 | | 2017 | 3 | 0 | 3 | | 2018 | 3 | 0 | 3 | | 2019 | 3 | 0 | 3 | | 2020 | 5 | 2 | 7 | | 2021 | 1 | 0 | 1 | | 2022 | 3 | 0 | 3 | | 2023 | 3 | 0 | 3 |
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Below are the most recent publications written about "Riboswitch" by people in Profiles.
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Lennon SR, Wierzba AJ, Siwik SH, Gryko D, Palmer AE, Batey RT. Targeting Riboswitches with Beta-Axial-Substituted Cobalamins. ACS Chem Biol. 2023 05 19; 18(5):1136-1147.
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Hansen LN, Kletzien OA, Urquijo M, Schwanz LT, Batey RT. Context-dependence of T-loop Mediated Long-range RNA Tertiary Interactions. J Mol Biol. 2023 05 15; 435(10):168070.
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Marton Menendez A, Nesbitt DJ. Ionic Cooperativity between Lysine and Potassium in the Lysine Riboswitch: Single-Molecule Kinetic and Thermodynamic Studies. J Phys Chem B. 2023 03 23; 127(11):2430-2440.
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Sung HL, Nesbitt DJ. Ligand-Dependent Volumetric Characterization of Manganese Riboswitch Folding: A High-Pressure Single-Molecule Kinetic Study. J Phys Chem B. 2022 Dec 01; 126(47):9781-9789.
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Sung HL, Nesbitt DJ. Synergism in the Molecular Crowding of Ligand-Induced Riboswitch Folding: Kinetic/Thermodynamic Insights from Single-Molecule Spectroscopy. J Phys Chem B. 2022 09 01; 126(34):6419-6427.
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Lennon SR, Batey RT. Regulation of Gene Expression Through Effector-dependent Conformational Switching by Cobalamin Riboswitches. J Mol Biol. 2022 09 30; 434(18):167585.
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Sherlock ME, Higgs G, Yu D, Widner DL, White NA, Sudarsan N, Sadeeshkumar H, Perkins KR, Mirihana Arachchilage G, Malkowski SN, King CG, Harris KA, Gaffield G, Atilho RM, Breaker RR. Architectures and complex functions of tandem riboswitches. RNA Biol. 2022 01; 19(1):1059-1076.
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Marton Menendez A, Nesbitt DJ. Lysine-Dependent Entropy Effects in the B. subtilis Lysine Riboswitch: Insights from Single-Molecule Thermodynamic Studies. J Phys Chem B. 2022 01 13; 126(1):69-79.
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Drogalis LK, Batey RT. Requirements for efficient ligand-gated co-transcriptional switching in designed variants of the B. subtilis pbuE adenine-responsive riboswitch in E. coli. PLoS One. 2020; 15(12):e0243155.
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Iwasaki RS, Batey RT. SPRINT: a Cas13a-based platform for detection of small molecules. Nucleic Acids Res. 2020 09 25; 48(17):e101.
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