 Riboswitch
"Riboswitch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Part of a MESSENGER RNA molecule that undergoes a conformation change upon binding a specific metabolite or other small molecule thereby regulating the messenger RNA's transcription, post-transcriptional processing, transport, translation, or stability in response to varying levels of the metabolite or other small molecule.
| Descriptor ID |
D058928
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| MeSH Number(s) |
D13.444.735.544.427 D13.444.735.790.878.942.500 G02.111.570.080.689.687.124 G05.360.080.689.687.124
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Riboswitch".
Below are MeSH descriptors whose meaning is more specific than "Riboswitch".
This graph shows the total number of publications written about "Riboswitch" by people in this website by year, and whether "Riboswitch" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 5 | 0 | 5 | | 2012 | 5 | 1 | 6 | | 2013 | 3 | 0 | 3 | | 2014 | 5 | 0 | 5 | | 2015 | 6 | 2 | 8 | | 2016 | 1 | 0 | 1 | | 2017 | 3 | 0 | 3 | | 2018 | 3 | 0 | 3 | | 2019 | 3 | 0 | 3 | | 2020 | 5 | 2 | 7 | | 2021 | 1 | 0 | 1 | | 2022 | 3 | 0 | 3 | | 2023 | 3 | 0 | 3 | | 2024 | 2 | 0 | 2 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Riboswitch" by people in Profiles.
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Spradlin SF, Dickerson KA, Batey RT. Structural and functional clues challenge the hypothesis that the yjdF riboswitch is natively regulated through broad recognition of azaaromatic compounds. Nucleic Acids Res. 2025 Nov 13; 53(21).
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Li C, Yang X, Dickerson KA, Zanon PRA, Springer NA, Wang J, Jia Y, Munshi NC, Batey RT, Disney MD. Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch. J Am Chem Soc. 2025 Oct 22; 147(42):38684-38690.
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Sung HL, Nesbitt DJ. Two-dimensional (P/T) studies of secondary/tertiary conformational dynamics in nucleic acids: pressure induced melting and Maxwell relations at the single molecule level. Phys Chem Chem Phys. 2025 Mar 06; 27(10):5285-5295.
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Marton Menendez A, Nesbitt DJ. Thermodynamic compensation to temperature extremes in B. subtilis vs T. maritima lysine riboswitches. Biophys J. 2024 10 01; 123(19):3331-3345.
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Olenginski LT, Spradlin SF, Batey RT. Flipping the script: Understanding riboswitches from an alternative perspective. J Biol Chem. 2024 03; 300(3):105730.
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Lennon SR, Wierzba AJ, Siwik SH, Gryko D, Palmer AE, Batey RT. Targeting Riboswitches with Beta-Axial-Substituted Cobalamins. ACS Chem Biol. 2023 05 19; 18(5):1136-1147.
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Hansen LN, Kletzien OA, Urquijo M, Schwanz LT, Batey RT. Context-dependence of T-loop Mediated Long-range RNA Tertiary Interactions. J Mol Biol. 2023 05 15; 435(10):168070.
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Marton Menendez A, Nesbitt DJ. Ionic Cooperativity between Lysine and Potassium in the Lysine Riboswitch: Single-Molecule Kinetic and Thermodynamic Studies. J Phys Chem B. 2023 03 23; 127(11):2430-2440.
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Sung HL, Nesbitt DJ. Ligand-Dependent Volumetric Characterization of Manganese Riboswitch Folding: A High-Pressure Single-Molecule Kinetic Study. J Phys Chem B. 2022 12 01; 126(47):9781-9789.
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Sung HL, Nesbitt DJ. Synergism in the Molecular Crowding of Ligand-Induced Riboswitch Folding: Kinetic/Thermodynamic Insights from Single-Molecule Spectroscopy. J Phys Chem B. 2022 09 01; 126(34):6419-6427.
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