 Genomic Instability
"Genomic Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased tendency of the GENOME to acquire MUTATIONS when various processes involved in maintaining and replicating the genome are dysfunctional.
| Descriptor ID |
D042822
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| MeSH Number(s) |
C23.550.362 G05.365.590.335 G05.370
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| Concept/Terms |
Genomic Instability- Genomic Instability
- Genomic Instabilities
- Instabilities, Genomic
- Instability, Genomic
- Genome Instability
- Genome Instabilities
- Instabilities, Genome
- Instability, Genome
Genomic Stability- Genomic Stability
- Genomic Stabilities
- Stabilities, Genomic
- Stability, Genomic
- Genome Stability
- Genome Stabilities
- Stabilities, Genome
- Stability, Genome
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Below are MeSH descriptors whose meaning is more general than "Genomic Instability".
Below are MeSH descriptors whose meaning is more specific than "Genomic Instability".
This graph shows the total number of publications written about "Genomic Instability" by people in this website by year, and whether "Genomic Instability" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2008 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 3 | 4 | | 2015 | 2 | 0 | 2 | | 2016 | 2 | 1 | 3 | | 2017 | 2 | 1 | 3 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2020 | 4 | 3 | 7 | | 2022 | 1 | 0 | 1 | | 2024 | 2 | 1 | 3 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Genomic Instability" by people in Profiles.
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Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, Doymaz A, Wu J, Anderson KS, Gazzo A, Pareja F, Yamaguchi TN, Vougiouklakis T, Ahmed-Seghir S, Steinberg P, Neiman-Golden A, Azeroglu B, Gomez-Aguilar J, da Silva EM, Hussain S, Higginson D, Boutros PC, Riaz N, Reis-Filho JS, Powell SN, Sfeir A. RNA transcripts serve as a template for double-strand break repair in human cells. Nat Commun. 2025 May 10; 16(1):4349.
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Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb PG, Nephew KP, Neville M, Woodruff ER, Bitler BG. Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Cancer Res Commun. 2025 01 01; 5(1):39-53.
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Haase MAB, Lazar-Stefanita L, ?lafsson G, Wudzinska A, Shen MJ, Truong DM, Boeke JD. macroH2A1 drives nucleosome dephasing and genome instability in histone humanized yeast. Cell Rep. 2024 07 23; 43(7):114472.
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Villagomez FR, Lang J, Rosario FJ, Nunez-Avellaneda D, Webb P, Neville M, Woodruff ER, Bitler BG. Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei. Cancer Res Commun. 2024 07 01; 4(7):1625-1642.
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Olson CL, Wuttke DS. Guardians of the Genome: How the Single-Stranded DNA-Binding Proteins RPA and CST Facilitate Telomere Replication. Biomolecules. 2024 Feb 22; 14(3).
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Morris BB, Smith JP, Zhang Q, Jiang Z, Hampton OA, Churchman ML, Arnold SM, Owen DH, Gray JE, Dillon PM, Soliman HH, Stover DG, Colman H, Chakravarti A, Shain KH, Silva AS, Villano JL, Vogelbaum MA, Borges VF, Akerley WL, Gentzler RD, Hall RD, Matsen CB, Ulrich CM, Post AR, Nix DA, Singer EA, Larner JM, Stukenberg PT, Jones DR, Mayo MW. Replicative Instability Drives Cancer Progression. Biomolecules. 2022 10 26; 12(11).
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Heasley LR, Sampaio NMV, Argueso JL. Systemic and rapid restructuring of the genome: a new perspective on punctuated equilibrium. Curr Genet. 2021 Feb; 67(1):57-63.
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Sampaio NMV, Ajith VP, Watson RA, Heasley LR, Chakraborty P, Rodrigues-Prause A, Malc EP, Mieczkowski PA, Nishant KT, Argueso JL. Characterization of systemic genomic instability in budding yeast. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28221-28231.
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Heasley LR, Watson RA, Argueso JL. Punctuated Aneuploidization of the Budding Yeast Genome. Genetics. 2020 09; 216(1):43-50.
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Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, Murphy G, Rabinovitch M, Rader DJ, Steinberg MH, Topol E, Yang W, Knowles JW, Jaquish CE, Ruczinski I, Mathias RA. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Res. 2020 07; 46:101803.
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