 I-kappa B Kinase
"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
| Descriptor ID |
D051550
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| MeSH Number(s) |
D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
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| Concept/Terms |
I-kappa B Kinase- I-kappa B Kinase
- B Kinase, I-kappa
- Kinase, I-kappa B
- NK-kappa B-Activating Kinase NAK
- NK kappa B Activating Kinase NAK
- IkappaB Kinase
- Kinase, IkappaB
- I kappa B Kinase
IkappaB Kinase gamma- IkappaB Kinase gamma
- IKK gamma
- NF-kappaB Essential Modifier
- Essential Modifier, NF-kappaB
- NF kappaB Essential Modifier
IkappaB Kinase alpha- IkappaB Kinase alpha
- Kinase alpha, IkappaB
- IKK 1 Kinase
- IKK alpha
- Conserved Helix-Loop-Helix Ubiquitous Kinase
- Conserved Helix Loop Helix Ubiquitous Kinase
- CHUK Kinase
- I Kappa B alpha-Associated Protein Kinase
- I Kappa B alpha Associated Protein Kinase
- IkappaBalpha Kinase
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Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".
Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".
This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 5 | 5 | | 2005 | 0 | 4 | 4 | | 2006 | 2 | 1 | 3 | | 2007 | 1 | 2 | 3 | | 2008 | 5 | 2 | 7 | | 2009 | 2 | 3 | 5 | | 2011 | 0 | 3 | 3 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.
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Abbott J, Ehler AC, Jayaraman D, Reynolds PR, Otsu K, Manka L, Gelfand EW. Heterozygous IKKß activation loop mutation results in a complex immunodeficiency syndrome. J Allergy Clin Immunol. 2021 02; 147(2):737-740.e6.
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Kirkley KS, Popichak KA, Hammond SL, Davies C, Hunt L, Tjalkens RB. Genetic suppression of IKK2/NF-?B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease. Neurobiol Dis. 2019 07; 127:193-209.
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Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.
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Miot C, Imai K, Imai C, Mancini AJ, Kucuk ZY, Kawai T, Nishikomori R, Ito E, Pellier I, Dupuis Girod S, Rosain J, Sasaki S, Chandrakasan S, Pachlopnik Schmid J, Okano T, Colin E, Olaya-Vargas A, Yamazaki-Nakashimada M, Qasim W, Espinosa Padilla S, Jones A, Krol A, Cole N, Jolles S, Bleesing J, Vraetz T, Gennery AR, Abinun M, Güngör T, Costa-Carvalho B, Condino-Neto A, Veys P, Holland SM, Uzel G, Moshous D, Neven B, Blanche S, Ehl S, Döffinger R, Patel SY, Puel A, Bustamante J, Gelfand EW, Casanova JL, Orange JS, Picard C. Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations. Blood. 2017 09 21; 130(12):1456-1467.
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Altonsy MO, Mostafa MM, Gerber AN, Newton R. Long-acting ß2-agonists promote glucocorticoid-mediated repression of NF-?B by enhancing expression of the feedback regulator TNFAIP3. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 01; 312(3):L358-L370.
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Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P. I?B Kinase e Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016 07 12; 16(2):405-418.
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Kan M, Auer PL, Wang GT, Bucasas KL, Hooker S, Rodriguez A, Li B, Ellis J, Adrienne Cupples L, Ida Chen YD, Dupuis J, Fox CS, Gross MD, Smith JD, Heard-Costa N, Meigs JB, Pankow JS, Rotter JI, Siscovick D, Wilson JG, Shendure J, Jackson R, Peters U, Zhong H, Lin D, Hsu L, Franceschini N, Carlson C, Abecasis G, Gabriel S, Bamshad MJ, Altshuler D, Nickerson DA, North KE, Lange LA, Reiner AP, Leal SM. Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project. Eur J Hum Genet. 2016 08; 24(8):1181-7.
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Prekeris R. Analyzing the functions of Rab11-effector proteins during cell division. Methods Cell Biol. 2015; 130:19-34.
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Kim SW, Schifano M, Oleksyn D, Jordan CT, Ryan D, Insel R, Zhao J, Chen L. Protein kinase C-associated kinase regulates NF-?B activation through inducing IKK activation. Int J Oncol. 2014 Oct; 45(4):1707-14.
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Thein S, Pham A, Bayer KU, Tao-Cheng JH, Dosemeci A. IKK regulates the deubiquitinase CYLD at the postsynaptic density. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):550-4.
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