 Protein Binding
"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
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| MeSH Number(s) |
G02.111.679 G03.808
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 16 | 16 | | 1997 | 1 | 15 | 16 | | 1998 | 0 | 21 | 21 | | 1999 | 0 | 13 | 13 | | 2000 | 0 | 29 | 29 | | 2001 | 0 | 38 | 38 | | 2002 | 0 | 49 | 49 | | 2003 | 0 | 38 | 38 | | 2004 | 1 | 45 | 46 | | 2005 | 0 | 67 | 67 | | 2006 | 0 | 64 | 64 | | 2007 | 0 | 53 | 53 | | 2008 | 1 | 61 | 62 | | 2009 | 0 | 64 | 64 | | 2010 | 0 | 67 | 67 | | 2011 | 1 | 91 | 92 | | 2012 | 0 | 92 | 92 | | 2013 | 2 | 86 | 88 | | 2014 | 0 | 69 | 69 | | 2015 | 2 | 64 | 66 | | 2016 | 0 | 93 | 93 | | 2017 | 0 | 77 | 77 | | 2018 | 2 | 81 | 83 | | 2019 | 0 | 66 | 66 | | 2020 | 0 | 73 | 73 | | 2021 | 2 | 42 | 44 | | 2022 | 0 | 21 | 21 | | 2023 | 0 | 17 | 17 | | 2024 | 10 | 40 | 50 | | 2025 | 0 | 51 | 51 | | 2026 | 0 | 26 | 26 |
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Below are the most recent publications written about "Protein Binding" by people in Profiles.
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Wilhelm FM, Pluhackova K, Janetzko J, Masureel M, Marsh E, Hudspeth J, Gaßner W, Schertler GFX, Kobilka BK, Müller DJ. Factors modulating the assembly of human ß2-adrenergic receptor-ß-arrestin complexes. Nat Struct Mol Biol. 2026 Aug; 33(8):1158-1170.
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Lee E, Redzic JS, Sarkar S, Rivkin D, Gordon B, Saviola AJ, Maroney SP, Thorstenson JC, Hansen KC, Horswill AR, Hamelberg D, Eisenmesser E. N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases. Sci Adv. 2026 07 24; 12(30):eaeh5197.
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Kuang Z, Kosmyna B, Li X, Tang Z, Shi S, Lambert K, Zhang W, Giovinazzo J, Effenberger KA, Sierra J, Ying L, Barraza SJ, Li W, Wang J, Trotta CR, Zhao R. The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function. Nat Commun. 2026 Jul 16; 17(1).
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Gaurav N, Ebert LK, Lachance C, Selvam K, Chen RW, Qin W, Pozharskaia V, Chi C, Côté V, Cox KL, Fuchs HA, Musselman CA, Leonhardt H, Morral N, Song K, Poirier MG, Côté J, Schermer B, Kutateladze TG. Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex. Nat Commun. 2026 Jul 11; 17(1).
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Kotz J, Martz EJ, Nelson M, Savoie N, Schmitt L, States J, Holton N, Guillen D, Kasinath V, Hansen K, Johnson AM. Physical interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression. Cell Rep. 2026 Jul 28; 45(7):117564.
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McAllister RA, Stiegler AL, Chari K, Chari M, Bhattacharyya M, Gupta K. Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation. Proc Natl Acad Sci U S A. 2026 Jul 07; 123(27):e2528109123.
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Van Gundy T, Schneider C, Ebmeier CC, Chambers GZ, Cramer NA, Chambers KM, Drecktrah D, Hyde JA, Skare JT, Marconi RT, Samuels DS, Lybecker MC. Identification of proteins exhibiting in vitro RNA chaperone activity through gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi. RNA Biol. 2026 Dec; 23(1):1-23.
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Lee YH, Rinn JL, Hwang T. Protocol for massively parallel RNA assay combined with immunoprecipitation for high-throughput analysis of RNA-protein interactions in cells. STAR Protoc. 2026 Jun 19; 7(2):104624.
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Li X, Li J, Shi S, Kuang Z, Srivastava P, Issaian A, Bevers S, Wagley ME, D'Alessandro A, Zhao R. U1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast. Nucleic Acids Res. 2026 Jun 08; 54(11).
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Yang D, Wang X, Liu J, Gong Y, Nair P, Sun J, Qian X, Cui J, Zeng H, Dong A, Harding RJ, Burgess-Brown N, Beyett TS, Song D, Krause HM, Diamond ML, Bolhuis DL, Brown NG, Arrowsmith CH, Edwards AM, Halabelian L, Peng H. High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds. Proc Natl Acad Sci U S A. 2026 Jun 23; 123(25):e2515940123.
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