 Trophoblasts
"Trophoblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
| Descriptor ID |
D014327
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| MeSH Number(s) |
A11.382.992 A16.254.500.766 A16.710.802
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trophoblasts".
Below are MeSH descriptors whose meaning is more specific than "Trophoblasts".
This graph shows the total number of publications written about "Trophoblasts" by people in this website by year, and whether "Trophoblasts" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 3 | 2 | 5 | | 1999 | 2 | 1 | 3 | | 2000 | 3 | 1 | 4 | | 2001 | 0 | 1 | 1 | | 2002 | 4 | 2 | 6 | | 2003 | 3 | 1 | 4 | | 2004 | 3 | 0 | 3 | | 2006 | 2 | 1 | 3 | | 2007 | 1 | 1 | 2 | | 2008 | 2 | 0 | 2 | | 2009 | 4 | 1 | 5 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 2 | 3 | | 2012 | 3 | 2 | 5 | | 2013 | 1 | 2 | 3 | | 2014 | 4 | 4 | 8 | | 2015 | 5 | 1 | 6 | | 2016 | 3 | 1 | 4 | | 2017 | 4 | 0 | 4 | | 2018 | 1 | 4 | 5 | | 2019 | 5 | 3 | 8 | | 2020 | 3 | 4 | 7 | | 2021 | 2 | 1 | 3 | | 2022 | 4 | 1 | 5 | | 2023 | 3 | 2 | 5 | | 2024 | 1 | 5 | 6 | | 2025 | 6 | 2 | 8 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Trophoblasts" by people in Profiles.
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Rosario FJ, Shimada H, Fredrick SBJ, Barentsen K, Powell TL, Urschitz J, Brown TL, Brown L, Jansson T. Trophoblast-specific overexpression of Slc7a5 increases fetal amino acid availability and hepatic mTOR signalling and causes increased fetal growth. J Physiol. 2026 Mar; 604(5):2276-2301.
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Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T. Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2026 Jan 01; 330(1):H124-H136.
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Shimada H, Sakuragi T, Barentsen K, Erickson K, Urschitz J, Powell TL, Jansson T, Rosario FJ. Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression. Free Radic Biol Med. 2026 Feb 01; 243:276-290.
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Shimada H, Urschitz J, Powell TL, Jansson T, Rosario FJ. Inducible trophoblast-specific knockdown of mechanistic target of rapamycin impairs placental folate transport in mice. J Nutr Biochem. 2026 Mar; 149:110189.
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Yoon EJ, Beltcheva M, Ali SS, Fu S, Yang A, Dong C, Zemke JE, Karvas RM, Chang CT, Fischer LA, Gontarz P, Zhang B, Dietmann S, Theunissen TW, Solnica-Krezel L. Manifold roles of the chemokine G-protein-coupled receptor CCR7 in differentiation of human trophoblast into extravillous and syncytiotrophoblast lineages. Development. 2025 Sep 01; 152(17).
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Rosario FJ, Urschitz J, Razavy H, Elston M, Powell TL, Jansson T. PiggyBac transposase-mediated inducible trophoblast-specific knockdown of Mtor decreases placental nutrient transport and fetal growth. Clin Sci (Lond). 2025 Jul 31; 139(14):825-845.
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Nunes LGA, Weingrill RB, Fredrick SBJ, Lorca R, Lee MJ, Atif SM, Chicco AJ, Rosario FJ, Urschitz J. Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice. Acta Physiol (Oxf). 2025 Apr; 241(4):e70012.
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Kramer A, Vaughan OR, Barentsen K, Urschitz J, Powell TL, Jansson T, Rosario FJ. Lentivirus-Mediated Trophoblast-Specific Deptor Knockdown Increases Transplacental System A and System L Amino Acid Transport and Fetal Growth in Mice. Function (Oxf). 2025 Mar 24; 6(2).
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Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ. Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Nano Lett. 2025 03 26; 25(12):4800-4808.
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Nunes LGA, Rosario FJ, Urschitz J. In vivo placental gene modulation via sonoporation. Placenta. 2025 Jun 13; 166:109-116.
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