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Min Han

TitleDistinguished Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Research 
    Collapse research activities and funding
    R35GM139631     (HAN, MIN)Jan 1, 2021 - Dec 31, 2025
    NIH
    Novel Nutrient Functions and Sensing Mechanisms
    Role: Principal Investigator
    R01AR074503     (HAN, MIN)Jul 15, 2019 - Jun 30, 2024
    NIH
    Mechanism?by?which?fatty?acid?metabolism?impacts?muscle?maintenance
    Role: Principal Investigator
    R01GM047869     (HAN, MIN)Aug 1, 1992 - Jan 31, 2021
    NIH
    Development Control in C. elegans
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sewell AK, Poss ZC, Ebmeier CC, Jacobsen JR, Old WM, Han M. The TORC1 phosphoproteome in C.?elegans reveals roles in transcription and autophagy. iScience. 2022 May 20; 25(5):104186. PMID: 35479415.
      View in: PubMed
    2. Tian D, Han M. Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists. Dev Cell. 2022 02 07; 57(3):361-372.e5. PMID: 35045336.
      View in: PubMed
    3. Tang H, Cui M, Han M. Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis. Cell Rep. 2021 08 17; 36(7):109539. PMID: 34407398.
      View in: PubMed
    4. Sewell AK, Han M. Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency. Genes Dev. 2021 02 01; 35(3-4):177-179. PMID: 33526584.
      View in: PubMed
    5. Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han M. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Dev Cell. 2020 05 04; 53(3):358-369.e6. PMID: 32302544.
      View in: PubMed
    6. Jia F, Chi C, Han M. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Cell Rep. 2020 02 11; 30(6):1848-1861.e5. PMID: 32049015.
      View in: PubMed
    7. Blackwell TK, Sewell AK, Wu Z, Han M. TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging. Genetics. 2019 10; 213(2):329-360. PMID: 31594908.
      View in: PubMed
    8. Sewell AK, Han M, Qi B. An unexpected benefit from E. coli: how enterobactin benefits host health. Microb Cell. 2018 Sep 27; 5(10):469-471. PMID: 30386791.
      View in: PubMed
    9. Qi B, Han M. Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase. Cell. 2018 10 04; 175(2):571-582.e11. PMID: 30146159.
      View in: PubMed
    10. Weaver BP, Han M. Tag team: Roles of miRNAs and Proteolytic Regulators in Ensuring Robust Gene Expression Dynamics. Trends Genet. 2018 01; 34(1):21-29. PMID: 29037438.
      View in: PubMed
    11. Zabinsky RA, Weum BM, Cui M, Han M. RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development. G3 (Bethesda). 2017 08 07; 7(8):2511-2518. PMID: 28576776.
      View in: PubMed
    12. Weaver BP, Weaver YM, Mitani S, Han M. Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development. Dev Cell. 2017 06 19; 41(6):665-673.e6. PMID: 28602583.
      View in: PubMed
    13. Qi B, Kniazeva M, Han M. A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal's food behavior and growth. Elife. 2017 06 01; 6. PMID: 28569665.
      View in: PubMed
    14. Tang H, Han M. Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. Cell. 2017 04 20; 169(3):457-469.e13. PMID: 28431246.
      View in: PubMed
    15. Cui M, Wang Y, Cavaleri J, Kelson T, Teng Y, Han M. Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans. Genetics. 2017 02; 205(2):775-785. PMID: 27974500.
      View in: PubMed
    16. Weaver BP, Sewell AK, Han M. Time to move the fat. Genes Dev. 2016 07 01; 30(13):1481-2. PMID: 27401550.
      View in: PubMed
    17. Chi C, Han M. Notch signaling protects animals from nucleotide deficiency. Cell Cycle. 2016 08 02; 15(15):1941-2. PMID: 27111808.
      View in: PubMed
    18. Chi C, Ronai D, Than MT, Walker CJ, Sewell AK, Han M. Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans. Genes Dev. 2016 Feb 01; 30(3):307-20. PMID: 26833730.
      View in: PubMed
    19. Jia F, Cui M, Than MT, Han M. Developmental Defects of Caenorhabditis elegans Lacking Branched-chain a-Ketoacid Dehydrogenase Are Mainly Caused by Monomethyl Branched-chain Fatty Acid Deficiency. J Biol Chem. 2016 Feb 05; 291(6):2967-73. PMID: 26683372.
      View in: PubMed
    20. Han M. Twists and turns--How we stepped into and had fun in the "boring" lipid field. Sci China Life Sci. 2015 Nov; 58(11):1073-83. PMID: 26511515.
      View in: PubMed
    21. Zhu H, Sewell AK, Han M. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Genes Dev. 2015 Jun 15; 29(12):1218-23. PMID: 26109047.
      View in: PubMed
    22. Kniazeva M, Zhu H, Sewell AK, Han M. A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C.?elegans. Dev Cell. 2015 May 04; 33(3):260-71. PMID: 25892013.
      View in: PubMed
    23. Cohen ML, Kim S, Morita K, Kim SH, Han M. The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet. 2015 Mar; 11(3):e1005099. PMID: 25816370.
      View in: PubMed
    24. Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife. 2014 Dec 30; 3:e04265. PMID: 25432023.
      View in: PubMed
    25. Zhu H, Han M. Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Annu Rev Genet. 2014; 48:119-48. PMID: 25195508.
      View in: PubMed
    26. Than M, Han M. Functional analysis of the miRNA-mRNA interaction network in C. elegans. Worm. 2013 Oct 01; 2(4):e26894. PMID: 24744982.
      View in: PubMed
    27. Wang R, Kniazeva M, Han M. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. PLoS One. 2013; 8(9):e76270. PMID: 24086720.
      View in: PubMed
    28. Than MT, Kudlow BA, Han M. Functional analysis of neuronal microRNAs in Caenorhabditis elegans dauer formation by combinational genetics and Neuronal miRISC immunoprecipitation. PLoS Genet. 2013 Jun; 9(6):e1003592. PMID: 23818874.
      View in: PubMed
    29. Zhu H, Shen H, Sewell AK, Kniazeva M, Han M. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Elife. 2013 May 21; 2:e00429. PMID: 23705068.
      View in: PubMed
    30. Cui M, Cohen ML, Teng C, Han M. The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans. Curr Biol. 2013 Jun 03; 23(11):975-80. PMID: 23664972.
      View in: PubMed
    31. Kniazeva M, Han M. Fat chance for longevity. Genes Dev. 2013 Feb 15; 27(4):351-4. PMID: 23431052.
      View in: PubMed
    32. Kudlow BA, Zhang L, Han M. Systematic analysis of tissue-restricted miRISCs reveals a broad role for microRNAs in suppressing basal activity of the C. elegans pathogen response. Mol Cell. 2012 May 25; 46(4):530-41. PMID: 22503424.
      View in: PubMed
    33. Kniazeva M, Shen H, Euler T, Wang C, Han M. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev. 2012 Mar 15; 26(6):554-66. PMID: 22426533.
      View in: PubMed
    34. Zhang X, Zabinsky R, Teng Y, Cui M, Han M. microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):17997-8002. PMID: 22011579.
      View in: PubMed
    35. Zhang X, Han M. Nuclear migration: rock and roll facilitated by dynein and kinesin. Curr Biol. 2010 Dec 07; 20(23):R1027-9. PMID: 21145020.
      View in: PubMed
    36. Kim S, Johnson W, Chen C, Sewell AK, Bystr?m AS, Han M. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Genetics. 2010 Aug; 185(4):1235-47. PMID: 20479142.
      View in: PubMed
    37. Han M. Advancing biology with a growing worm field. Dev Dyn. 2010 May; 239(5):1263-4. PMID: 20419781.
      View in: PubMed
    38. Green RM, Gally F, Keeney JG, Alper S, Gao B, Han M, Martin RJ, Weinberger AR, Case SR, Minor MN, Chu HW. Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. PLoS One. 2009 Aug 31; 4(8):e6860. PMID: 19718433.
      View in: PubMed
    39. Zhang L, Hammell M, Kudlow BA, Ambros V, Han M. Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development. 2009 Sep; 136(18):3043-55. PMID: 19675127.
      View in: PubMed
    40. Seamen E, Blanchette JM, Han M. P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans. PLoS Genet. 2009 Aug; 5(8):e1000589. PMID: 19662161.
      View in: PubMed
    41. Cui M, Allen MA, Larsen A, Macmorris M, Han M, Blumenthal T. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16665-70. PMID: 18946043.
      View in: PubMed
    42. Kniazeva M, Euler T, Han M. A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans. Genes Dev. 2008 Aug 01; 22(15):2102-10. PMID: 18676815.
      View in: PubMed
    43. Tucker M, Han M. Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1. Dev Biol. 2008 Jun 15; 318(2):215-23. PMID: 18452914.
      View in: PubMed
    44. Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR, Han M. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell. 2007 Nov 30; 28(4):598-613. PMID: 18042455.
      View in: PubMed
    45. Ding L, Han M. GW182 family proteins are crucial for microRNA-mediated gene silencing. Trends Cell Biol. 2007 Aug; 17(8):411-6. PMID: 17766119.
      View in: PubMed
    46. Cui M, Han M. Roles of chromatin factors in C. elegans development. WormBook. 2007 May 03; 1-16. PMID: 18050494.
      View in: PubMed
    47. Morita K, Han M. Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J. 2006 Dec 13; 25(24):5794-804. PMID: 17139256.
      View in: PubMed
    48. Cui M, Kim EB, Han M. Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet. 2006 May; 2(5):e74. PMID: 16710447.
      View in: PubMed
    49. Cui M, Chen J, Myers TR, Hwang BJ, Sternberg PW, Greenwald I, Han M. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell. 2006 May; 10(5):667-72. PMID: 16678779.
      View in: PubMed
    50. Suzuki Y, Han M. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Genes Dev. 2006 Feb 15; 20(4):423-8. PMID: 16481471.
      View in: PubMed
    51. Morita K, Hirono K, Han M. The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells. EMBO Rep. 2005 Dec; 6(12):1163-8. PMID: 16170304.
      View in: PubMed
    52. Eastburn DJ, Han M. A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras. Mol Cell Biol. 2005 Nov; 25(21):9427-34. PMID: 16227593.
      View in: PubMed
    53. Ding L, Spencer A, Morita K, Han M. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell. 2005 Aug 19; 19(4):437-47. PMID: 16109369.
      View in: PubMed
    54. Chen Z, Eastburn DJ, Han M. The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development. Mol Cell Biol. 2004 Sep; 24(17):7345-58. PMID: 15314147.
      View in: PubMed
    55. Kniazeva M, Crawford QT, Seiber M, Wang CY, Han M. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol. 2004 Sep; 2(9):E257. PMID: 15340492.
      View in: PubMed
    56. Cui M, Fay DS, Han M. lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics. 2004 Jul; 167(3):1177-85. PMID: 15280233.
      View in: PubMed
    57. Eastburn D, Han M. When Ras signaling reaches the mediator. Dev Cell. 2004 Feb; 6(2):158-9. PMID: 14960267.
      View in: PubMed
    58. Yoder JH, Chong H, Guan KL, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004 Jan 14; 23(1):111-9. PMID: 14685271.
      View in: PubMed
    59. Cui M, Han M. Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17. Dev Biol. 2003 May 01; 257(1):104-16. PMID: 12710960.
      View in: PubMed
    60. Starr DA, Han M. ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci. 2003 Jan 15; 116(Pt 2):211-6. PMID: 12482907.
      View in: PubMed
    61. Kniazeva M, Sieber M, McCauley S, Zhang K, Watts JL, Han M. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Genetics. 2003 Jan; 163(1):159-69. PMID: 12586704.
      View in: PubMed
    62. Suzuki Y, Morris GA, Han M, Wood WB. A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape. Genetics. 2002 Dec; 162(4):1631-9. PMID: 12524338.
      View in: PubMed
    63. Starr DA, Han M. Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science. 2002 Oct 11; 298(5592):406-9. PMID: 12169658.
      View in: PubMed
    64. Antoshechkin I, Han M. The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Dev Cell. 2002 May; 2(5):579-91. PMID: 12015966.
      View in: PubMed
    65. Hanna-Rose W, Han M. The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis. Dev Biol. 2002 Jan 15; 241(2):247-58. PMID: 11784109.
      View in: PubMed
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