 DNA Repair
"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
| Descriptor ID |
D004260
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| MeSH Number(s) |
G02.111.222 G05.219
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| Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
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Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 2 | 3 | 5 | | 2001 | 2 | 1 | 3 | | 2002 | 0 | 2 | 2 | | 2003 | 3 | 0 | 3 | | 2004 | 5 | 2 | 7 | | 2005 | 2 | 1 | 3 | | 2006 | 2 | 6 | 8 | | 2007 | 3 | 5 | 8 | | 2008 | 4 | 2 | 6 | | 2009 | 3 | 3 | 6 | | 2010 | 3 | 3 | 6 | | 2011 | 4 | 2 | 6 | | 2012 | 2 | 3 | 5 | | 2013 | 2 | 4 | 6 | | 2014 | 3 | 6 | 9 | | 2015 | 6 | 5 | 11 | | 2016 | 4 | 6 | 10 | | 2017 | 2 | 7 | 9 | | 2018 | 4 | 7 | 11 | | 2019 | 4 | 6 | 10 | | 2020 | 4 | 3 | 7 | | 2021 | 3 | 2 | 5 | | 2022 | 2 | 9 | 11 | | 2023 | 3 | 4 | 7 | | 2024 | 1 | 4 | 5 | | 2025 | 7 | 1 | 8 | | 2026 | 4 | 2 | 6 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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Jewett CE, Holland AJ, Pearson CG. The DNA damage response pathway is required for multiciliated cell differentiation. Curr Biol. 2026 Apr 20; 36(8):2156-2166.e3.
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Sottnik JL, Shackleford MT, Nesiba CS, Richer AL, Fleischmann Z, Swartz JM, Rowland CE, Musick M, Fu R, Myler LR, Opresko PL, Mehrotra S, Sokol ES, Hesselberth JR, Diamond JR, Sikora MJ. Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition. Cancer Res. 2026 Apr 02; 86(7):1605-1621.
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Morcom L, Xia W, Xu Z, Awasthi Y, Geywitz C, Ellis MO, Noli T, Zulji A, Yamamoto D, Girdler GC, Kai L, Zhu K, Wei M, Tang XY, Hoi KK, Gonzalez-Maya J, Duncan GJ, Vaquie AM, Gold Diaz D, Kawaguchi R, Liu E, Sun Y, Yang D, Jordan GD, Lu IL, Holmqvist S, Bartels T, Ridley K, Choi JJ, Franco SJ, Huang EJ, Emery B, Geschwind D, Schirmer L, Balmus G, Popko B, Fancy SPJ, Rowitch DH. DNA damage burden causes selective CUX2 neuron loss in neuroinflammation. Nature. 2026 May; 653(8115):809-818.
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Xia W, Morcom L, Xu Z, Lu IL, Wang Q, Hoi KK, Wei M, Zhu K, Jordan G, Tang XY, Gonzalez-Maya J, Mattera VS, Panigrahi SM, Kawaguchi R, Emery B, Franco SJ, Geschwind DH, Popko B, Rowitch DH, Fancy SPJ. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair. Nature. 2026 May; 653(8115):819-830.
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Clayfield L, Malik D, Whittle J, Xu J, Mevel R, Fadlullah MZH, Patel R, Szpakowska M, Maqbool MA, Jones M, Lie-A-Ling M, Chevigne A, Paggetti J, Moussay E, Baker SM, Iqbal M, Maire P, Somervaille TCP, Ford HL, Kouskoff V, Largeot A, Lacaud G. Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia. Cell Rep. 2026 Feb 24; 45(2):116875.
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Nebenfuehr B, Sanford L, Taylor ER, Ball K, Woods-Killam CE, Ghasemi HI, Proctor B, Ortega R, Sempeck C, Dowell RD, Arnoult N. Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation. Cell Rep. 2026 Jan 27; 45(1):116850.
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Jing ZB, Wang WL, Wu QY, Chen Z, Wu YP, Peng L, Yang ZC, Cai XH, Zhu P, Chen ZL, Linden KG. Far-UVC (222 nm) Suppresses Bacterial UV Resistance and Repair through Inhibition of DNA Repair Pathways. Environ Sci Technol. 2026 Jan 13; 60(1):1368-1377.
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RodrÃguez RA, Sangsanont J, Linden KG. Mechanistic Insights into Adenovirus Resistance to UV: Dose-Dependent Repair and Delayed Suppression of Host DNA Damage Response. Environ Sci Technol. 2025 Dec 16; 59(49):26830-26839.
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Rudolph J, Luger K. Histone PARylation factor 1: a review of its role in the DNA damage response. Nucleic Acids Res. 2025 Oct 28; 53(20).
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Lamolinara A, Di Lisio C, Hixon JA, Simeone P, De Cola A, Falco MD, Meyer TJ, Ferrone A, Genovesi D, Lanuti P, Li W, De Laurenzi V, Iezzi M, Aiello FB, Durum SK. IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells. Front Immunol. 2025; 16:1633892.
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