 Interleukins
"Interleukins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
| Descriptor ID |
D007378
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| MeSH Number(s) |
D12.644.276.374.465 D12.776.467.374.465 D23.529.374.465
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Interleukins".
Below are MeSH descriptors whose meaning is more specific than "Interleukins".
This graph shows the total number of publications written about "Interleukins" by people in this website by year, and whether "Interleukins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 2 | 4 | | 1996 | 2 | 3 | 5 | | 1997 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 3 | 2 | 5 | | 2006 | 7 | 1 | 8 | | 2007 | 1 | 2 | 3 | | 2008 | 9 | 2 | 11 | | 2009 | 3 | 0 | 3 | | 2010 | 5 | 2 | 7 | | 2011 | 10 | 3 | 13 | | 2012 | 3 | 3 | 6 | | 2013 | 9 | 5 | 14 | | 2014 | 4 | 6 | 10 | | 2015 | 7 | 3 | 10 | | 2016 | 2 | 3 | 5 | | 2017 | 5 | 1 | 6 | | 2018 | 4 | 5 | 9 | | 2019 | 7 | 0 | 7 | | 2020 | 3 | 5 | 8 | | 2021 | 4 | 2 | 6 | | 2022 | 1 | 7 | 8 | | 2023 | 1 | 4 | 5 | | 2024 | 1 | 1 | 2 | | 2025 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukins" by people in Profiles.
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Niehaus C, Geanon D, Lietzau A, Jankovic M, Maucourant C, Maasoumy B, Sparrelid E, Wedemeyer H, Kahlhöfer J, Falk CS, Andrade IM, Ponzetta A, Björkström NK, Kraft ARM, Cornberg M, Strunz B. Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites. Eur J Immunol. 2025 Jun; 55(6):e51311.
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Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 May 22; 10(10).
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Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells. Nat Immunol. 2025 Jan; 26(1):92-104.
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Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Rana N, Li P, Chen P, Vadász T, Spolski R, Heuser-Loy C, Slavkovic-Lukic D, Noronha P, Damiano G, Raccosta L, Maggioni D, Pullugula S, Lin JX, Oh J, Grandinetti P, Lecce M, Hesse L, Kocks E, Martín-Santos A, Gebhard C, Telford WG, Ji Y, Restifo NP, Russo V, Rehli M, Herr W, Leonard WJ, Gattinoni L. LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal Transduct Target Ther. 2024 08 09; 9(1):199.
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Okurut S, Boulware DR, Okafor E, Rhein J, Kajumbula H, Bagaya BS, Bwanga F, Olobo JO, Manabe YC, Meya DB, Janoff EN. Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis. Front Immunol. 2023; 14:1275443.
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Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1? secretion. Proc Natl Acad Sci U S A. 2023 11 07; 120(45):e2306476120.
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Adawy A, Li L, Hirao H, Irie T, Yoshii D, Yano H, Fujiwara Y, Esumi S, Honda M, Suzu S, Komohara Y, Hibi T. Potential involvement of IL-32 in cell-to-cell communication between macrophages and hepatoblastoma. Pediatr Surg Int. 2023 Sep 26; 39(1):275.
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Uzen R, Bayram F, Dursun H, Kardas F, Cakir M, Cucer N, Eken A, Donmez-Altuntas H. Characterization of peripheral blood T follicular helper (TFH) cells in patients with type 1 Gaucher disease and carriers. Blood Cells Mol Dis. 2023 05; 100:102728.
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Teufel LU, Netea MG, van de Veerdonk FL, Dinarello CA, Joosten LAB, Arts RJW. Opposing Effects of Interleukin-36? and Interleukin-38 on Trained Immunity. Int J Mol Sci. 2023 Jan 24; 24(3).
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de Graaf DM, Teufel LU, de Nooijer AH, van Gammeren AJ, Ermens AAM, Ga?l IO, Cri?an TO, van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LAB, Arts RJW. Exploratory analysis of interleukin-38 in hospitalized COVID-19 patients. Immun Inflamm Dis. 2022 11; 10(11):e712.
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