 Interleukins
"Interleukins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.
| Descriptor ID |
D007378
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| MeSH Number(s) |
D12.644.276.374.465 D12.776.467.374.465 D23.529.374.465
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Interleukins".
Below are MeSH descriptors whose meaning is more specific than "Interleukins".
This graph shows the total number of publications written about "Interleukins" by people in this website by year, and whether "Interleukins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 3 | 5 | | 1997 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 3 | 2 | 5 | | 2006 | 7 | 1 | 8 | | 2007 | 1 | 2 | 3 | | 2008 | 9 | 2 | 11 | | 2009 | 3 | 0 | 3 | | 2010 | 5 | 2 | 7 | | 2011 | 10 | 3 | 13 | | 2012 | 3 | 3 | 6 | | 2013 | 9 | 6 | 15 | | 2014 | 4 | 6 | 10 | | 2015 | 7 | 3 | 10 | | 2016 | 2 | 3 | 5 | | 2017 | 5 | 1 | 6 | | 2018 | 4 | 5 | 9 | | 2019 | 7 | 1 | 8 | | 2020 | 3 | 5 | 8 | | 2021 | 4 | 1 | 5 | | 2022 | 1 | 7 | 8 | | 2023 | 1 | 4 | 5 | | 2024 | 0 | 1 | 1 | | 2025 | 2 | 2 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukins" by people in Profiles.
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Aldridge DL, Lanzar Z, Phan AT, Christian DA, Pardy RD, Min B, Kedl R, Hunter CA. IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion. Elife. 2025 Dec 15; 14.
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Lanzar ZR, Aldridge DL, Cruz-Morales E, Howard CA, Conway IO, Zhong Z, Eberhard JN, Pereira JA, Phan AT, Ring AM, Parker M, Kanellopoulou C, Min B, Kedl RM, Christian DA, Hunter CA. IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis. Proc Natl Acad Sci U S A. 2025 Dec 16; 122(50):e2519141122.
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Niehaus C, Geanon D, Lietzau A, Jankovic M, Maucourant C, Maasoumy B, Sparrelid E, Wedemeyer H, Kahlhöfer J, Falk CS, Andrade IM, Ponzetta A, Björkström NK, Kraft ARM, Cornberg M, Strunz B. Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites. Eur J Immunol. 2025 Jun; 55(6):e51311.
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Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 May 22; 10(10).
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Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells. Nat Immunol. 2025 Jan; 26(1):92-104.
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Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Rana N, Li P, Chen P, Vadász T, Spolski R, Heuser-Loy C, Slavkovic-Lukic D, Noronha P, Damiano G, Raccosta L, Maggioni D, Pullugula S, Lin JX, Oh J, Grandinetti P, Lecce M, Hesse L, Kocks E, Martín-Santos A, Gebhard C, Telford WG, Ji Y, Restifo NP, Russo V, Rehli M, Herr W, Leonard WJ, Gattinoni L. LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling. Signal Transduct Target Ther. 2024 08 09; 9(1):199.
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Aldridge DL, Moodley D, Park J, Phan AT, Rausch M, White KF, Ren Y, Golin K, Radaelli E, Kedl R, Holland PM, Hill J, Hunter CA. Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells. mBio. 2024 Mar 13; 15(3):e0008324.
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Okurut S, Boulware DR, Okafor E, Rhein J, Kajumbula H, Bagaya BS, Bwanga F, Olobo JO, Manabe YC, Meya DB, Janoff EN. Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis. Front Immunol. 2023; 14:1275443.
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Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1ß secretion. Proc Natl Acad Sci U S A. 2023 11 07; 120(45):e2306476120.
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Adawy A, Li L, Hirao H, Irie T, Yoshii D, Yano H, Fujiwara Y, Esumi S, Honda M, Suzu S, Komohara Y, Hibi T. Potential involvement of IL-32 in cell-to-cell communication between macrophages and hepatoblastoma. Pediatr Surg Int. 2023 Sep 26; 39(1):275.
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