 Interleukin-12
"Interleukin-12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
| Descriptor ID |
D018664
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| MeSH Number(s) |
D12.644.276.374.465.512 D12.776.467.374.465.512 D23.529.374.465.512
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| Concept/Terms |
Interleukin-12- Interleukin-12
- Natural Killer Cell Stimulatory Factor
- IL-12
- Cytotoxic Lymphocyte Maturation Factor
- IL 12
- Edodekin Alfa
- IL-12 p70
- Interleukin-12 p70
- Interleukin 12 p70
- p70, Interleukin-12
- Interleukin 12
- IL12
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Below are MeSH descriptors whose meaning is more general than "Interleukin-12".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-12".
This graph shows the total number of publications written about "Interleukin-12" by people in this website by year, and whether "Interleukin-12" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 | | 1998 | 2 | 1 | 3 | | 1999 | 2 | 3 | 5 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 4 | 5 | | 2002 | 2 | 6 | 8 | | 2003 | 3 | 7 | 10 | | 2004 | 1 | 2 | 3 | | 2005 | 1 | 3 | 4 | | 2006 | 1 | 2 | 3 | | 2007 | 0 | 3 | 3 | | 2008 | 4 | 2 | 6 | | 2009 | 1 | 2 | 3 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 2 | 3 | | 2012 | 0 | 2 | 2 | | 2013 | 4 | 5 | 9 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2018 | 0 | 2 | 2 | | 2019 | 1 | 2 | 3 | | 2020 | 2 | 3 | 5 | | 2022 | 1 | 2 | 3 | | 2024 | 0 | 1 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interleukin-12" by people in Profiles.
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Lanzar ZR, Aldridge DL, Jayaraman B, Haskins B, Howard CA, Arana K, Bunkofske ME, Mulka K, Pardy RD, Byerly J, Striepen B, Lupardus P, Hunter CA. De-coupling immune parameters and toxicity associated with IL-12 agonism. Cell Rep. 2025 Jun 24; 44(6):115840.
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Aunins EA, Phan AT, Alameh MG, Dwivedi G, Cruz-Morales E, Christian DA, Tam Y, Bunkofske ME, Peñafiel AZ, O'Dea KM, Merolle M, Furey C, Scott P, Vonderheide RH, Hensley SE, Kedl RM, Weissman D, Hunter CA. An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses. Sci Immunol. 2025 06 06; 10(108):eads1328.
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Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA. Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium. J Exp Med. 2024 Jul 01; 221(7).
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Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022; 13:1072720.
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Hunter R, Imbach KJ, Zhou C, Dougan J, Hamilton JAG, Chen KZ, Do P, Townsel A, Gibson G, Dreaden EC, Waller EK, Haynes KA, Henry CJ, Porter CC. B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12. Sci Rep. 2022 07 13; 12(1):11870.
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Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A, Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S, Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother. 2022 Sep; 71(9):2127-2139.
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Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020; 11:610010.
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Prince N, Penatzer JA, Dietz MJ, Boyd JW. Localized cytokine responses to total knee arthroplasty and total knee revision complications. J Transl Med. 2020 08 31; 18(1):330.
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Do P, Perdue LA, Chyong A, Hunter R, Dougan J, Henry CJ, Porter CC, Dreaden EC. Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia. ACS Comb Sci. 2020 10 12; 22(10):533-541.
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Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Amin MA, Zomorrodi RK, Arami S, Gonzalez M, Rao V, Zanotti B, Fox DA, Sweiss N, Shahrara S. IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion. Cell Mol Immunol. 2021 09; 18(9):2199-2210.
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