 Charles A Dinarello
| Title | Distinguished Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-MED |
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| Phone | 303/724-4920 |
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 Research R21AI128443 (LI, SUZHAO)Aug 14, 2017 - Jul 31, 2020 NIH
Molecular Mechanisms of Cytokine Induced Insulin Resistance
Role: Co-Principal Investigator |
| P01HL068743 (DINARELLO, CHARLES ANTHONY)Aug 1, 2002 - Jun 30, 2008 NIH
Heterogeneous Neutrophil Responses in Acute Lung Injury
Role: Principal Investigator |
| R56AI015614 (DINARELLO, CHARLES ANTHONY)Dec 1, 1986 - Nov 2, 2017 NIH
Pathogenesis of Fever in Man
Role: Principal Investigator |
| R37AI015614 (DINARELLO, CHARLES ANTHONY)Dec 1, 1986 - Aug 31, 1998 NIH
PATHOGENESIS OF FEVER IN HUMANS
Role: Principal Investigator |
| R01AI015614 (DINARELLO, CHARLES ANTHONY)Dec 1, 1978 - Aug 31, 2026 NIH
Pathogenesis of Fever in Man
Role: Principal Investigator |
Bibliographic
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Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1? secretion. Proc Natl Acad Sci U S A. 2023 Nov 07; 120(45):e2306476120. PMID: 37906644.
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Tengesdal IW, Dinarello CA, Marchetti C. NLRP3 and cancer: Pathogenesis and therapeutic opportunities. Pharmacol Ther. 2023 Nov; 251:108545. PMID: 37866732.
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Amo-Aparicio J, Dominguez A, Atif SM, Dinarello A, Azam T, Alula KM, Piper M, Lieu CH, Lentz RW, Leal AD, Bagby SM, Messersmith WA, Karam SD, Dinarello CA, Pitts TM, Marchetti C. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment. Cancer Res Commun. 2023 09 20; 3(9):1899-1911. PMID: 37772994.
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The E, Zhai Y, Yao Q, Ao L, Li S, Fullerton DA, Dinarello CA, Meng X. Recombinant IL-37 Exerts an Anti-inflammatory Effect on Human Aortic Valve Interstitial Cells through Extracellular and Intracellular Actions. Int J Biol Sci. 2023; 19(12):3908-3919. PMID: 37564205.
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Amo-Aparicio J, Daly J, H?jen JF, Dinarello CA. Pharmacologic inhibition of NLRP3 reduces the levels of a-synuclein and protects dopaminergic neurons in a model of Parkinson's disease. J Neuroinflammation. 2023 Jun 22; 20(1):147. PMID: 37349821.
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Ghezzi P, Fantuzzi G, Dinarello CA. Perspective: Daniela Novick, cytokines and their receptors. Front Immunol. 2023; 14:1160651. PMID: 37251377.
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Teufel LU, Netea MG, van de Veerdonk FL, Dinarello CA, Joosten LAB, Arts RJW. Opposing Effects of Interleukin-36? and Interleukin-38 on Trained Immunity. Int J Mol Sci. 2023 Jan 24; 24(3). PMID: 36768634.
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Dinarello A, Mills TS, Tengesdal IW, Powers NE, Azam T, Dinarello CA. Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions. Cells. 2023 01 12; 12(2). PMID: 36672229.
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de Graaf DM, Teufel LU, de Nooijer AH, van Gammeren AJ, Ermens AAM, Ga?l IO, Cri?an TO, van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LAB, Arts RJW. Exploratory analysis of interleukin-38 in hospitalized COVID-19 patients. Immun Inflamm Dis. 2022 11; 10(11):e712. PMID: 36301025.
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Lonnemann N, Hosseini S, Ohm M, Geffers R, Hiller K, Dinarello CA, Korte M. IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer's disease mouse model. Elife. 2022 08 30; 11. PMID: 36040311.
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The E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2202577119. PMID: 36037361.
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Teufel LU, de Graaf DM, Netea MG, Dinarello CA, Joosten LAB, Arts RJW. Circulating interleukin-38 concentrations in healthy adults. Front Immunol. 2022; 13:964365. PMID: 36016926.
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Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14; 27(14). PMID: 35889366.
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Brunt VE, Ikoba AP, Ziemba BP, Ballak DB, Hoischen A, Dinarello CA, Ehringer MA, Seals DR. Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs. Geroscience. 2023 02; 45(1):65-84. PMID: 35622271.
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de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. IL-38 Gene Deletion Worsens Murine Colitis. Front Immunol. 2022; 13:840719. PMID: 35693797.
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Tengesdal IW, Li S, Powers NE, May M, Neff CP, Joosten LAB, Marchetti C, Dinarello CA. Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers. Pharmaceuticals (Basel). 2022 May 04; 15(5). PMID: 35631400.
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de Graaf DM, Teufel LU, Joosten LAB, Dinarello CA. Interleukin-38 in Health and Disease. Cytokine. 2022 04; 152:155824. PMID: 35220115.
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van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2022 01 18; 132(2). PMID: 34847078.
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Teufel LU, Arts RJW, Netea MG, Dinarello CA, Joosten LAB. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine. 2022 02; 150:155773. PMID: 34844039.
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Lunding LP, Skouras DB, Vock C, Dinarello CA, Wegmann M. The NLRP3 inflammasome inhibitor, OLT1177? , ameliorates experimental allergic asthma in mice. Allergy. 2022 03; 77(3):1035-1038. PMID: 34716997.
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Molteni R, Biavasco R, Stefanoni D, Nemkov T, Dom?nguez-Andr?s J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal IW, Maksud P, Piras F, Cesana D, Cassina L, Distefano G, Loffreda A, Gnani D, De Luca G, Tomelleri A, Campochiaro C, Joosten LAB, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Doglioni C, Ferrarini M, Ferrero E, Boletta A, D'Alessandro A, Montini E, Netea MG, Cavalli G. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood. 2021 10 28; 138(17):1554-1569. PMID: 34077954.
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Amo-Aparicio J, Garcia-Garcia J, Puigdomenech M, Francos-Quijorna I, Skouras DB, Dinarello CA, Lopez-Vales R. Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury. Exp Neurol. 2022 01; 347:113889. PMID: 34624330.
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Schr?der A, Lunding LP, Zissler UM, Vock C, Webering S, Ehlers JC, Orinska Z, Chaker A, Schmidt-Weber CB, Lang NJ, Schiller HB, Mall MA, Fehrenbach H, Dinarello CA, Wegmann M. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33. Allergy. 2022 03; 77(3):856-869. PMID: 34460953.
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Tengesdal IW, Dinarello A, Powers NE, Burchill MA, Joosten LAB, Marchetti C, Dinarello CA. Tumor NLRP3-Derived IL-1? Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression. Front Immunol. 2021; 12:661323. PMID: 34531850.
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Zhao P, Yao Q, Zhang PJ, The E, Zhai Y, Ao L, Jarrett MJ, Dinarello CA, Fullerton DA, Meng X. Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip. Sci Adv. 2021 08; 7(34). PMID: 34417174.
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Javan H, Li L, Schaaf CL, Lee YS, Salama ME, Dinarello CA, Selzman CH. Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure. Ann Thorac Surg. 2022 07; 114(1):98-107. PMID: 34419440.
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Badii M, Gaal OI, Cleophas MC, Kl?ck V, Davar R, Habibi E, Keating ST, Novakovic B, Helsen MM, Dalbeth N, Stamp LK, Macartney-Coxson D, Phipps-Green AJ, Stunnenberg HG, Dinarello CA, Merriman TR, Netea MG, Crisan TO, Joosten LAB. Urate-induced epigenetic modifications in myeloid cells. Arthritis Res Ther. 2021 07 28; 23(1):202. PMID: 34321071.
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Briukhovetska D, D?rr J, Endres S, Libby P, Dinarello CA, Kobold S. Interleukins in cancer: from biology to therapy. Nat Rev Cancer. 2021 08; 21(8):481-499. PMID: 34083781.
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van Deuren RC, Arts P, Cavalli G, Jaeger M, Steehouwer M, van de Vorst M, Gilissen C, Joosten LAB, Dinarello CA, Mhlanga MM, Kumar V, Netea MG, van de Veerdonk FL, Hoischen A. Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses. Genome Med. 2021 05 25; 13(1):94. PMID: 34034819.
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Kouwenberg M, Pulskens WPC, Diepeveen L, Bakker-van Bebber M, Dinarello CA, Netea MG, Hilbrands LB, van der Vlag J. Reduced CXCL1 production by endogenous IL-37 expressing dendritic cells does not affect T cell activation. PLoS One. 2021; 16(5):e0251809. PMID: 34029331.
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Pizarro TT, Dinarello CA, Cominelli F. Editorial: Cytokines and Intestinal Mucosal Immunity. Front Immunol. 2021; 12:698693. PMID: 34054881.
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van der Heijden WA, Van de Wijer L, Keramati F, Trypsteen W, Rutsaert S, Horst RT, Jaeger M, Koenen HJ, Stunnenberg HG, Joosten I, Verweij PE, van Lunzen J, Dinarello CA, Joosten LA, Vandekerckhove L, Netea MG, van der Ven AJ, de Mast Q. Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells. JCI Insight. 2021 04 08; 6(7). PMID: 33630761.
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Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Dom?nguez-Andr?s J, Molteni R, Stefanoni D, Cantoni E, Cassina L, Giugliano S, Schraa K, Mills TS, Pietras EM, Eisenmensser EZ, Dagna L, Boletta A, D'Alessandro A, Joosten LAB, Netea MG, Dinarello CA. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021 04 06; 35(1):108955. PMID: 33826894.
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Li S, Jiang L, Beckmann K, H?jen JF, Pessara U, Powers NE, de Graaf DM, Azam T, Lindenberger J, Eisenmesser EZ, Fischer S, Dinarello CA. A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling. J Biol Chem. 2021 Jan-Jun; 296:100630. PMID: 33823154.
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Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649199.
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Mountford S, Effenberger M, Noll-Puchta H, Griessmair L, Ringleb A, Haas S, Denk G, Reiter FP, Mayr D, Dinarello CA, Tilg H, Bufler P. Modulation of Liver Inflammation and Fibrosis by Interleukin-37. Front Immunol. 2021; 12:603649. PMID: 33746950.
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de Graaf DM, Teufel LU, van de Veerdonk FL, Joosten LAB, Netea MG, Dinarello CA, Arts RJW. IL-38 prevents induction of trained immunity by inhibition of mTOR signaling. J Leukoc Biol. 2021 11; 110(5):907-915. PMID: 33620105.
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Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. PMID: 33288963.
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Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds. Aging Cell. 2021 02; 20(2):e13309. PMID: 33480151.
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Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA. Interleukin 1a: a comprehensive review on the role of IL-1a in the pathogenesis and treatment of autoimmune and inflammatory diseases. Autoimmun Rev. 2021 Mar; 20(3):102763. PMID: 33482337.
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S?nchez-Fern?ndez A, Zandee S, Amo-Aparicio J, Charabati M, Prat A, Garlanda C, Eisenmesser EZ, Dinarello CA, L?pez-Vales R. IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. Theranostics. 2021; 11(1):1-13. PMID: 33391457.
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Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, D'Alessandro A, Dinarello CA, Korte M. The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32145-32154. PMID: 33257576.
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R?nholt K, Nielsen AL, Johansen C, Vestergaard C, Fauerbye A, L?pez-Vales R, Dinarello CA, Iversen L. IL-37 Expression Is Downregulated in Lesional Psoriasis Skin. Immunohorizons. 2020 11 25; 4(11):754-761. PMID: 33239358.
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de Graaf DM, Jaeger M, van den Munckhof ICL, Ter Horst R, Schraa K, Zwaag J, Kox M, Fujita M, Yamauchi T, Mercurio L, Madonna S, Rutten JHW, de Graaf J, Riksen NP, van de Veerdonk FL, Netea MG, Joosten LAB, Dinarello CA. Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects. Eur J Immunol. 2021 03; 51(3):662-671. PMID: 33125159.
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de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser E, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL. Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease. Cytokine. 2021 01; 137:155334. PMID: 33128926.
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Amo-Aparicio J, Sanchez-Fernandez A, Li S, Eisenmesser EZ, Garlanda C, Dinarello CA, Lopez-Vales R. Extracellular and nuclear roles of IL-37 after spinal cord injury. Brain Behav Immun. 2021 01; 91:194-201. PMID: 33002630.
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Zhai Z, Samson JM, Yamauchi T, Vaddi PK, Matsumoto Y, Dinarello CA, Ravindran Menon D, Fujita M. Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma. Cancers (Basel). 2020 Sep 04; 12(9). PMID: 32899791.
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Vecchi? A, Bonaventura A, Toldo S, Dagna L, Dinarello CA, Abbate A. IL-18 and infections: Is there a role for targeted therapies? J Cell Physiol. 2021 03; 236(3):1638-1657. PMID: 32794180.
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Kanni T, Argyropoulou M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ. MABp1 targeting interleukin-1a in hidradenitis suppurativa ineligible for adalimumab treatment: results of the open-label extension period. Clin Exp Dermatol. 2021 Jan; 46(1):162-163. PMID: 32516832.
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Grander C, Schaefer B, Schw?rzler J, Grabherr F, de Graaf DM, Enrich B, Oberhuber G, Mayr L, Sangineto M, Jaschke N, Adolph TE, Effenberger M, Moschen AR, Dinarello CA, Zoller H, Tilg H. Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans. Gut. 2021 03; 70(3):585-594. PMID: 32699098.
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Cauchois R, Koubi M, Delarbre D, Manet C, Carvelli J, Blasco VB, Jean R, Fouche L, Bornet C, Pauly V, Mazodier K, Pestre V, Jarrot PA, Dinarello CA, Kaplanski G. Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):18951-18953. PMID: 32699149.
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Abbate A, Toldo S, Marchetti C, Kron J, Van Tassell BW, Dinarello CA. Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease. Circ Res. 2020 04 24; 126(9):1260-1280. PMID: 32324502.
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Kl?ck V, Jansen TLTA, Janssen M, Comarniceanu A, Efd? M, Tengesdal IW, Schraa K, Cleophas MCP, Scribner CL, Skouras DB, Marchetti C, Dinarello CA, Joosten LAB. Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial. Lancet Rheumatol. 2020 May; 2(5):e270-e280. PMID: 33005902.
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Kl?ck V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Cri?an TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA. Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout. Ann Rheum Dis. 2020 04; 79(4):536-544. PMID: 32114511.
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Menghini P, Corridoni D, Butt? LF, Osme A, Shivaswamy S, Lam M, Bamias G, Pizarro TT, Rodriguez-Palacios A, Dinarello CA, Cominelli F. Neutralization of IL-1a ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26717-26726. PMID: 31843928.
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Powers NE, Swartzwelter B, Marchetti C, de Graaf DM, Lerchner A, Schlapschy M, Datar R, Binder U, Edwards CK, Skerra A, Dinarello CA. PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis. J Biol Chem. 2020 01 17; 295(3):868-882. PMID: 31819009.
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Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice. Aging Cell. 2020 01; 19(1):e13074. PMID: 31755162.
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Mountford S, Ringleb A, Schwaiger R, Mayr D, Kobold S, Dinarello CA, Bufler P. Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis. Front Immunol. 2019; 10:2632. PMID: 31781119.
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S?nchez-Fern?ndez A, Skouras DB, Dinarello CA, L?pez-Vales R. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Immunol. 2019; 10:2578. PMID: 31736980.
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Dinarello CA. The IL-1 family of cytokines and receptors in rheumatic diseases. Nat Rev Rheumatol. 2019 10; 15(10):612-632. PMID: 31515542.
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Donath MY, Dinarello CA, Mandrup-Poulsen T. Targeting innate immune mediators in type 1 and type 2 diabetes. Nat Rev Immunol. 2019 12; 19(12):734-746. PMID: 31501536.
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H?jen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA. IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. Nat Immunol. 2019 09; 20(9):1138-1149. PMID: 31427775.
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Madonna S, Girolomoni G, Dinarello CA, Albanesi C. The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis. Int J Mol Sci. 2019 Jul 05; 20(13). PMID: 31284527.
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Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597. PMID: 31101752.
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Osborne DG, Domenico J, Luo Y, Reid AL, Amato C, Zhai Z, Gao D, Ziman M, Dinarello CA, Robinson WA, Fujita M. Interleukin-37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome. Mol Carcinog. 2019 09; 58(9):1670-1679. PMID: 31099111.
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Mantovani A, Dinarello CA, Molgora M, Garlanda C. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity. 2019 04 16; 50(4):778-795. PMID: 30995499.
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Cavalli G, Dinarello CA. Corrigendum: Anakinra Therapy for Non-cancer Inflammatory Diseases. Front Pharmacol. 2019; 10:148. PMID: 30906259.
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Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522. PMID: 30819901.
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Cavalli G, Tomelleri A, De Luca G, Campochiaro C, Dinarello CA, Baldissera E, Dagna L. Correction to: Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease. Arthritis Res Ther. 2019 Feb 25; 21(1):69. PMID: 30803447.
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Li S, Amo-Aparicio J, Neff CP, Tengesdal IW, Azam T, Palmer BE, L?pez-Vales R, Bufler P, Dinarello CA. Role for nuclear interleukin-37 in the suppression of innate immunity. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4456-4461. PMID: 30792349.
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Cavalli G, Tomelleri A, De Luca G, Campochiaro C, Dinarello CA, Baldissera E, Dagna L. Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease. Arthritis Res Ther. 2019 02 13; 21(1):54. PMID: 30760322.
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Cleophas MCP, Crisan TO, Kl?ck V, Hoogerbrugge N, Netea-Maier RT, Dinarello CA, Netea MG, Joosten LAB. Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression. Arthritis Res Ther. 2019 02 06; 21(1):50. PMID: 30728075.
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Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN. Blocking IL-1? reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1361-1369. PMID: 30545915.
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Kurzrock R, Hickish T, Wyrwicz L, Saunders M, Wu Q, Stecher M, Mohanty P, Dinarello CA, Simard J. Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1a antibody, in a phase III randomized study of advanced colorectal cancer. Oncoimmunology. 2019; 8(3):1551651. PMID: 30723583.
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Tunjungputri RN, Li Y, de Groot PG, Dinarello CA, Smeekens SP, Jaeger M, Doppenberg-Oosting M, Cruijsen M, Lemmers H, Toenhake-Dijkstra H, Aguirre-Gamboa R, Kumar V, Wijmenga C, Joosten LAB, Netea MG, van der Ven A, de Mast Q. The Inter-Relationship of Platelets with Interleukin-1?-Mediated Inflammation in Humans. Thromb Haemost. 2018 Dec; 118(12):2112-2125. PMID: 30453346.
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Cavalli G, Dinarello CA. Anakinra Therapy for Non-cancer Inflammatory Diseases. Front Pharmacol. 2018; 9:1157. PMID: 30459597.
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Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis. 2018 10 30; 9(11):1104. PMID: 30377293.
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Voronov E, Dinarello CA, Apte RN. Interleukin-1a as an intracellular alarmin in cancer biology. Semin Immunol. 2018 08; 38:3-14. PMID: 30554608.
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Tengesdal IW, Kitzenberg D, Li S, Nyuydzefe MS, Chen W, Weiss JM, Zhang J, Waksal SD, Zanin-Zhorov A, Dinarello CA. The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6. Eur J Immunol. 2018 10; 48(10):1679-1686. PMID: 30098001.
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Dinarello CA. An Interleukin-1 Signature in Breast Cancer Treated with Interleukin-1 Receptor Blockade: Implications for Treating Cytokine Release Syndrome of Checkpoint Inhibitors. Cancer Res. 2018 09 15; 78(18):5200-5202. PMID: 30217872.
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Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 10 15; 201(8):2232-2243. PMID: 30185516.
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Marchetti C, Swartzwelter B, Koenders MI, Azam T, Tengesdal IW, Powers N, de Graaf DM, Dinarello CA, Joosten LAB. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther. 2018 08 03; 20(1):169. PMID: 30075804.
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Kuipers EN, van Dam AD, Ballak DB, de Wit EA, Dinarello CA, Stienstra R, van Diepen JA, Rensen PCN, Boon MR. IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake. Int J Mol Sci. 2018 Aug 02; 19(8). PMID: 30072596.
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De Luca G, Campochiaro C, Dinarello CA, Dagna L, Cavalli G. Treatment of Dilated Cardiomyopathy With Interleukin-1 Inhibition. Ann Intern Med. 2018 12 04; 169(11):819-820. PMID: 30073251.
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Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Kl?ck V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA. Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue. J Biol Chem. 2018 09 14; 293(37):14224-14236. PMID: 30006351.
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Dinarello CA, Kaplanski G. Indeed, IL-18 is more than an inducer of IFN-?. J Leukoc Biol. 2018 08; 104(2):237-238. PMID: 29733453.
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Gomes RS, Silva MVT, Dos Santos JC, van Linge C, Reis JM, Teixeira MM, Pinto SA, Dorta ML, Bai X, Chan ED, Dinarello CA, Oliveira MAP, Joosten LAB, Ribeiro-Dias F. Human Interleukin-32? Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice. Infect Immun. 2018 05; 86(5). PMID: 29483288.
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Dinarello CA. Treatment of Inflammatory Diseases with IL-1 Blockade. Curr Otorhinolaryngol Rep. 2018; 6(1):1-14. PMID: 33133777.
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Damen MSMA, Dos Santos JC, Hermsen R, Adam van der Vliet J, Netea MG, Riksen NP, Dinarello CA, Joosten LAB, Heinhuis B. Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes. Atherosclerosis. 2018 04; 271:193-202. PMID: 29524862.
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Kerstholt M, Vrijmoeth H, Lachmandas E, Oosting M, Lupse M, Flonta M, Dinarello CA, Netea MG, Joosten LAB. Role of glutathione metabolism in host defense against Borrelia burgdorferi infection. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2320-E2328. PMID: 29444855.
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Brinkmann CR, H?jen JF, Rasmussen TA, Kj?r AS, Olesen R, Denton PW, ?stergaard L, Ouyang Z, Lichterfeld M, Yu X, S?gaard OS, Dinarello C, Tolstrup M. Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses. mSphere. 2018 Jan-Feb; 3(1). PMID: 29468194.
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Jeong MY, Lin YH, Wennersten SA, Demos-Davies KM, Cavasin MA, Mahaffey JH, Monzani V, Saripalli C, Mascagni P, Reece TB, Ambardekar AV, Granzier HL, Dinarello CA, McKinsey TA. Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism. Sci Transl Med. 2018 02 07; 10(427). PMID: 29437146.
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Magenau JM, Goldstein SC, Peltier D, Soiffer RJ, Braun T, Pawarode A, Riwes MM, Kennel M, Antin JH, Cutler CS, Ho VT, Alyea EP, Parkin BL, Yanik GA, Choi SW, Lewis EC, Dinarello CA, Koreth J, Reddy P. a1-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease. Blood. 2018 03 22; 131(12):1372-1379. PMID: 29437593.
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Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1530-E1539. PMID: 29378952.
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Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018 01; 281(1):8-27. PMID: 29247995.
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van de Veerdonk FL, de Graaf DM, Joosten LA, Dinarello CA. Biology of IL-38 and its role in disease. Immunol Rev. 2018 01; 281(1):191-196. PMID: 29247986.
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Dinarello CA. Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity. Immunol Rev. 2018 01; 281(1):5-7. PMID: 29248001.
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Cavalli G, Dinarello CA. Suppression of inflammation and acquired immunity by IL-37. Immunol Rev. 2018 01; 281(1):179-190. PMID: 29247987.
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Grabherr F, Grander C, Adolph TE, Wieser V, Mayr L, Enrich B, Macheiner S, Sangineto M, Reiter A, Viveiros A, Zoller H, Bufler P, Moschen AR, Dinarello CA, Tilg H. Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease. Liver Int. 2018 06; 38(6):1095-1101. PMID: 29193575.
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Nold-Petry CA, Nold MF, Levy O, Kliger Y, Oren A, Borukhov I, Becker C, Wirtz S, Sandhu MK, Neurath M, Dinarello CA. Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation. Front Immunol. 2017; 8:1531. PMID: 29312281.
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Cavalli G, Koenders M, Kalabokis V, Kim J, Choon Tan A, Garlanda C, Mantovani A, Dagna L, Joosten LAB, Dinarello CA. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford). 2017 12 01; 56(12):2256. PMID: 28968825.
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Kanni T, Argyropoulou M, Spyridopoulos T, Pistiki A, Stecher M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ. MABp1 Targeting IL-1a for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study. J Invest Dermatol. 2018 04; 138(4):795-801. PMID: 29129600.
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Hoeke G, Khedoe PPSJ, van Diepen JA, Pike-Overzet K, van de Ven B, Vazirpanah N, Mol I, Hiemstra PS, Staal FJT, Stienstra R, Netea MG, Dinarello CA, Rensen PCN, Berb?e JFP. The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice. Int J Mol Sci. 2017 Aug 09; 18(8). PMID: 28792474.
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Choi SW, Braun T, Henig I, Gatza E, Magenau J, Parkin B, Pawarode A, Riwes M, Yanik G, Dinarello CA, Reddy P. Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT. Blood. 2017 10 12; 130(15):1760-1767. PMID: 28784598.
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Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
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Gomes RS, Silva MVT, Dos Santos JC, de Lima Silva LL, Batista AC, Machado JR, Teixeira MM, Dorta ML, de Oliveira MAP, Dinarello CA, Joosten LAB, Ribeiro-Dias F. IL-32? promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis. Parasit Vectors. 2017 Jul 14; 10(1):336. PMID: 28709468.
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Damen MSMA, Popa CD, Netea MG, Dinarello CA, Joosten LAB. Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases. Atherosclerosis. 2017 Sep; 264:83-91. PMID: 28716457.
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Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneewei? A, Stock M, M?ller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H. IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun. 2017; 9(4):403-418. PMID: 28601872.
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Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017 06 05; 214(6):1737-1752. PMID: 28487310.
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Crisan TO, Cleophas MCP, Novakovic B, Erler K, van de Veerdonk FL, Stunnenberg HG, Netea MG, Dinarello CA, Joosten LAB. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5485-5490. PMID: 28484006.
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Novick D, Dinarello CA. IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation. J Allergy Clin Immunol. 2017 07; 140(1):316. PMID: 28457594.
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Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X. IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells. Mol Med. 2017 05; 23:83-91. PMID: 28362018.
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Needell JC, Dinarello CA, Ir D, Robertson CE, Ryan SM, Kroehl ME, Frank DN, Zipris D. Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes. PLoS One. 2017; 12(3):e0173968. PMID: 28301545.
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Roerink ME, Bredie SJH, Heijnen M, Dinarello CA, Knoop H, Van der Meer JWM. Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial. Ann Intern Med. 2017 Apr 18; 166(8):557-564. PMID: 28265678.
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Zhai Z, Liu W, Kaur M, Luo Y, Domenico J, Samson JM, Shellman YG, Norris DA, Dinarello CA, Spritz RA, Fujita M. NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. Oncogene. 2017 07 06; 36(27):3820-3830. PMID: 28263976.
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Dos Santos JC, Heinhuis B, Gomes RS, Damen MS, Real F, Mortara RA, Keating ST, Dinarello CA, Joosten LA, Ribeiro-Dias F. Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species. PLoS Negl Trop Dis. 2017 02; 11(2):e0005413. PMID: 28241012.
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Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine. 2017 07; 95:55-63. PMID: 28237874.
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Maicas N, van der Vlag J, Bublitz J, Florquin S, Bakker-van Bebber M, Dinarello CA, Verweij V, Masereeuw R, Joosten LA, Hilbrands LB. Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. PLoS One. 2017; 12(2):e0168981. PMID: 28235038.
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Daveg?rdh C, Broholm C, Perfilyev A, Henriksen T, Garc?a-Calz?n S, Peijs L, Hansen NS, Volkov P, Kj?bsted R, Wojtaszewski JF, Pedersen M, Pedersen BK, Ballak DB, Dinarello CA, Heinhuis B, Joosten LA, Nilsson E, Vaag A, Scheele C, Ling C. Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects. BMC Med. 2017 02 22; 15(1):39. PMID: 28222718.
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Rider P, Voronov E, Dinarello CA, Apte RN, Cohen I. Alarmins: Feel the Stress. J Immunol. 2017 02 15; 198(4):1395-1402. PMID: 28167650.
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Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2313-2318. PMID: 28193888.
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Cavalli G, Foppoli M, Cabrini L, Dinarello CA, Tresoldi M, Dagna L. Interleukin-1 Receptor Blockade Rescues Myocarditis-Associated End-Stage Heart Failure. Front Immunol. 2017; 8:131. PMID: 28232838.
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Damen MS, Agca R, Holewijn S, de Graaf J, Dos Santos JC, van Riel PL, Fransen J, Coenen MJ, Nurmohamed MT, Netea MG, Dinarello CA, Joosten LA, Heinhuis B, Popa CD. IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis. Sci Rep. 2017 01 30; 7:41629. PMID: 28134327.
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Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1631-1636. PMID: 28137840.
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Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW. Interleukin-1 as a mediator of fatigue in disease: a narrative review. J Neuroinflammation. 2017 01 21; 14(1):16. PMID: 28109186.
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Davis CJ, Zielinski MR, Dunbrasky D, Taishi P, Dinarello CA, Krueger JM. Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection. Neurobiol Sleep Circadian Rhythms. 2017 Jun; 3:1-9. PMID: 28070566.
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Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gon?alves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG. Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell Metab. 2016 12 13; 24(6):807-819. PMID: 27866838.
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Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LAB, Netea MG. Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell. 2016 11 03; 167(4):1111-1124.e13. PMID: 27814508.
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Bekkering S, van den Munckhof I, Nielen T, Lamfers E, Dinarello C, Rutten J, de Graaf J, Joosten LA, Netea MG, Gomes ME, Riksen NP. Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in?vivo. Atherosclerosis. 2016 11; 254:228-236. PMID: 27764724.
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Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S. a-Linoleic acid enhances the capacity of a-1 antitrypsin to inhibit lipopolysaccharide induced IL-1? in human blood neutrophils. Mol Med. 2016 Dec; 22:680-693. PMID: 27452044.
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Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2017 Mar; 28(3):971-980. PMID: 27647856.
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Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford). 2016 Dec; 55(12):2220-2229. PMID: 27567100.
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Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W, Franzosa EA, Ng A, Graham D, Lassen K, Schraa K, Netea-Maier R, Smit J, de Mast Q, van de Veerdonk F, Kullberg BJ, Tack C, van de Munckhof I, Rutten J, van der Graaf J, Franke L, Hofker M, Jonkers I, Platteel M, Maatman A, Fu J, Zhernakova A, van der Meer JW, Dinarello CA, van der Ven A, Huttenhouwer C, Koenen H, Joosten I, Xavier RJ, Wijmenga C. Understanding human immune function using the resources from the Human Functional Genomics Project. Nat Med. 2016 08 04; 22(8):831-3. PMID: 27490433.
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Cavalli G, Pappalardo F, Mangieri A, Dinarello CA, Dagna L, Tresoldi M. Treating Life-Threatening Myocarditis by Blocking Interleukin-1. Crit Care Med. 2016 Aug; 44(8):e751-4. PMID: 27031379.
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Toldo S, Mauro AG, Marchetti C, Rose SW, Mezzaroma E, Van Tassell BW, Kim S, Dinarello CA, Abbate A. Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition. J Cardiovasc Pharmacol. 2016 Jul; 68(1):27-32. PMID: 26945157.
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Van Tassell BW, Abouzaki NA, Oddi Erdle C, Carbone S, Trankle CR, Melchior RD, Turlington JS, Thurber CJ, Christopher S, Dixon DL, Fronk DT, Thomas CS, Rose SW, Buckley LF, Dinarello CA, Biondi-Zoccai G, Abbate A. Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study. J Cardiovasc Pharmacol. 2016 Jun; 67(6):544-51. PMID: 26906034.
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Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA. Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. Mol Med. 2016 05 24; 22. PMID: 27261776.
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Marcondes AM, Hockenbery D, Lesnikova M, Dinarello CA, Woolfrey A, Gernsheimer T, Loghman-Adham M, Gelmont D, Storer B, Hansen JA, Deeg HJ. Response of Steroid-Refractory Acute GVHD to a1-Antitrypsin. Biol Blood Marrow Transplant. 2016 09; 22(9):1596-1601. PMID: 27223109.
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Joosten LA, Abdollahi-Roodsaz S, Dinarello CA, O'Neill L, Netea MG. Toll-like receptors and chronic inflammation in rheumatic diseases: new developments. Nat Rev Rheumatol. 2016 06; 12(6):344-57. PMID: 27170508.
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Dinarello CA, Nold-Petry C, Nold M, Fujita M, Li S, Kim S, Bufler P. Suppression of innate inflammation and immunity by interleukin-37. Eur J Immunol. 2016 05; 46(5):1067-81. PMID: 27060871.
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Lust JA, Lacy MQ, Zeldenrust SR, Witzig TE, Moon-Tasson LL, Dinarello CA, Donovan KA. Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma. Am J Hematol. 2016 06; 91(6):571-4. PMID: 26945843.
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Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, Colombo C, Fiscarelli E, Lass-Fl?rl C, Majo F, Cariani L, Russo M, Porcaro L, Ricciotti G, Ellemunter H, Ratclif L, De Benedictis FM, Talesa VN, Dinarello CA, van de Veerdonk FL, Romani L. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun. 2016 Mar 14; 7:10791. PMID: 26972847.
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Shakoory B, Carcillo JA, Chatham WW, Amdur RL, Zhao H, Dinarello CA, Cron RQ, Opal SM. Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial. Crit Care Med. 2016 Feb; 44(2):275-81. PMID: 26584195.
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Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN. Novel strategies for targeting innate immune responses to influenza. Mucosal Immunol. 2016 09; 9(5):1173-82. PMID: 26813341.
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Coll-Mir? M, Francos-Quijorna I, Santos-Nogueira E, Torres-Espin A, Bufler P, Dinarello CA, L?pez-Vales R. Beneficial effects of IL-37 after spinal cord injury in mice. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1411-6. PMID: 26787859.
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Hayashi M, Jin Y, Yorgov D, Santorico SA, Hagman J, Ferrara TM, Jones KL, Cavalli G, Dinarello CA, Spritz RA. Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1357-62. PMID: 26787886.
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Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1363-8. PMID: 26787888.
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Dinarello CA, Joosten LA. Inflammation in rheumatology in 2015: New tools to tackle inflammatory arthritis. Nat Rev Rheumatol. 2016 Feb; 12(2):78-80. PMID: 26763730.
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Cohen I, Rider P, Vornov E, Tomas M, Tudor C, Wegner M, Brondani L, Freudenberg M, Mittler G, Ferrando-May E, Dinarello CA, Apte RN, Schneider R. Corrigendum: IL-1a is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2016 Jan 11; 6:19100. PMID: 26750721.
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Tzanetakou V, Kanni T, Giatrakou S, Katoulis A, Papadavid E, Netea MG, Dinarello CA, van der Meer JWM, Rigopoulos D, Giamarellos-Bourboulis EJ. Safety and Efficacy of Anakinra in Severe Hidradenitis Suppurativa: A Randomized Clinical Trial. JAMA Dermatol. 2016 Jan; 152(1):52-59. PMID: 26579854.
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Heinhuis B, Plantinga TS, Semango G, K?sters B, Netea MG, Dinarello CA, Smit JWA, Netea-Maier RT, Joosten LAB. Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines. Carcinogenesis. 2016 Feb; 37(2):197-205. PMID: 26678222.
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Henry CJ, Cas?s-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682.
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Cohen I, Idan C, Rider P, Peleg R, Vornov E, Elena V, Tomas M, Martin T, Tudor C, Cicerone T, Wegner M, Mareike W, Brondani L, Lydia B, Freudenberg M, Marina F, Mittler G, Gerhard M, Ferrando-May E, Elisa FM, Dinarello CA, Apte RN, Ron AN, Schneider R, Robert S. IL-1a is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity. Sci Rep. 2015 Oct 06; 5:14756. PMID: 26439902.
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Roerink ME, Knoop H, Bredie SJ, Heijnen M, Joosten LA, Netea MG, Dinarello CA, van der Meer JW. Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial. Trials. 2015 Oct 05; 16:439. PMID: 26438161.
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Frenzel E, Wrenger S, Br?gger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S. a1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. J Immunol. 2015 Oct 15; 195(8):3605-16. PMID: 26363050.
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Borghi M, De Luca A, Puccetti M, Jaeger M, Mencacci A, Oikonomou V, Pariano M, Garlanda C, Moretti S, Bartoli A, Sobel J, van de Veerdonk FL, Dinarello CA, Netea MG, Romani L. Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra. Cell Host Microbe. 2015 Aug 12; 18(2):198-209. PMID: 26269955.
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Cavalli G, Dinarello CA. Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatology (Oxford). 2015 Dec; 54(12):2134-44. PMID: 26209330.
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Ballak DB, Stienstra R, Tack CJ, Dinarello CA, van Diepen JA. IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance. Cytokine. 2015 Oct; 75(2):280-90. PMID: 26194067.
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Joosten LA, Crisan TO, Azam T, Cleophas MC, Koenders MI, van de Veerdonk FL, Netea MG, Kim S, Dinarello CA. Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1? and by the induction of endogenous IL-1Ra. Ann Rheum Dis. 2016 06; 75(6):1219-27. PMID: 26174021.
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Rider P, Carmi Y, Yossef R, Guttman O, Eini H, Azam T, Dinarello CA, Lewis EC. IL-1 Receptor Antagonist Chimeric Protein: Context-Specific and Inflammation-Restricted Activation. J Immunol. 2015 Aug 15; 195(4):1705-12. PMID: 26157171.
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Bai X, Dinarello CA, Chan ED. The role of interleukin-32 against tuberculosis. Cytokine. 2015 Dec; 76(2):585-587. PMID: 26144292.
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H?gh K?lb?k Kj?r AS, Brinkmann CR, Dinarello CA, Olesen R, ?stergaard L, S?gaard OS, Tolstrup M, Rasmussen TA. The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients. AIDS. 2015 Jun 19; 29(10):1195-200. PMID: 25870990.
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Michels M, de Mast Q, Netea MG, Joosten LA, Dinarello CA, Rudiman PI, Sinarta S, Wisaksana R, Alisjahbana B, van der Ven AJ. Normal free interleukin-18 (IL-18) plasma levels in dengue virus infection and the need to measure both total IL-18 and IL-18 binding protein levels. Clin Vaccine Immunol. 2015 Jun; 22(6):650-5. PMID: 25878254.
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H?jen JF, Rasmussen TA, Andersen KL, Winckelmann AA, Laursen RR, Gunst JD, M?ller HJ, Fujita M, ?stergaard L, S?gaard OS, Dinarello CA, Tolstrup M. Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir. Mol Med. 2015 Apr 14; 21:337-45. PMID: 25879630.
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Dinarello CA. The history of fever, leukocytic pyrogen and interleukin-1. Temperature (Austin). 2015 Jan-Mar; 2(1):8-16. PMID: 27226996.
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Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405. PMID: 25792098.
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Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL, Takeda K, Chan MM, Dakhama A, Kinney WH, Trostel J, Bai A, Honda JR, Achcar R, Hartney J, Joosten LA, Kim SH, Orme I, Dinarello CA, Ordway DJ, Chan ED. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5111-6. PMID: 25820174.
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Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. IL-37 requires the receptors IL-18Ra and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 2015 Apr; 16(4):354-65. PMID: 25729923.
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Cavalli G, Fallanca F, Dinarello CA, Dagna L. Treating pulmonary silicosis by blocking interleukin 1. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):596-8. PMID: 25723826.
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Tunjungputri RN, van der Ven AJ, Riksen N, Rongen G, Tacke S, van den Berg TN, Fijnheer R, Gomes ME, Dinarello CA, van de Veerdonk FL, Gasem MH, Netea MG, Joosten LA, de Groot PG, de Mast Q. Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses. Thromb Haemost. 2015 May; 113(5):1035-45. PMID: 25716539.
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Bai X, Kinney WH, Su WL, Bai A, Ovrutsky AR, Honda JR, Netea MG, Henao-Tamayo M, Ordway DJ, Dinarello CA, Chan ED. Caspase-3-independent apoptotic pathways contribute to interleukin-32?-mediated control of Mycobacterium tuberculosis infection in THP-1 cells. BMC Microbiol. 2015 Feb 21; 15:39. PMID: 25887904.
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Carta S, Penco F, Lavieri R, Martini A, Dinarello CA, Gattorno M, Rubartelli A. Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2835-40. PMID: 25730877.
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Stoffels M, Zaal R, Kok N, van der Meer JW, Dinarello CA, Simon A. ATP-Induced IL-1? Specific Secretion: True Under Stringent Conditions. Front Immunol. 2015; 6:54. PMID: 25729382.
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Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, Kim S, Dinarello CA. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2497-502. PMID: 25654981.
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Cleophas MC, Crisan TO, Lemmers H, Toenhake-Dijkstra H, Fossati G, Jansen TL, Dinarello CA, Netea MG, Joosten LA. Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases. Ann Rheum Dis. 2016 Mar; 75(3):593-600. PMID: 25589513.
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Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ, Leenders F, Bufler P, Boekschoten MV, M?ller M, Kersten S, Li S, Kim S, Eini H, Lewis EC, Joosten LA, Tilg H, Netea MG, Tack CJ, Dinarello CA, Stienstra R. Corrigendum: IL-37 protects against obesity-induced inflammation and insulin resistance. Nat Commun. 2015 Jan 12; 6:6039. PMID: 25580956.
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van de Veerdonk FL, Gresnigt MS, Oosting M, van der Meer JW, Joosten LA, Netea MG, Dinarello CA. Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37. Front Microbiol. 2014; 5:762. PMID: 25620965.
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Dinarello CA. An expanding role for interleukin-1 blockade from gout to cancer. Mol Med. 2014 Dec 16; 20 Suppl 1:S43-58. PMID: 25549233.
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Netea MG, van de Veerdonk FL, van der Meer JW, Dinarello CA, Joosten LA. Inflammasome-independent regulation of IL-1-family cytokines. Annu Rev Immunol. 2015; 33:49-77. PMID: 25493334.
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Li S, Fossati G, Marchetti C, Modena D, Pozzi P, Reznikov LL, Moras ML, Azam T, Abbate A, Mascagni P, Dinarello CA. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23; 290(4):2368-78. PMID: 25451941.
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Choi SW, Gatza E, Hou G, Sun Y, Whitfield J, Song Y, Oravecz-Wilson K, Tawara I, Dinarello CA, Reddy P. Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans. Blood. 2015 Jan 29; 125(5):815-9. PMID: 25428224.
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Smeekens SP, Gresnigt MS, Becker KL, Cheng SC, Netea SA, Jacobs L, Jansen T, van de Veerdonk FL, Williams DL, Joosten LA, Dinarello CA, Netea MG. An anti-inflammatory property of Candida albicans ?-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. Cytokine. 2015 Feb; 71(2):215-22. PMID: 25461401.
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Sonnino C, Christopher S, Oddi C, Toldo S, Falcao RA, Melchior RD, Mueller GH, Abouzaki NA, Varma A, Gambill ML, Van Tassell BW, Dinarello CA, Abbate A. Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra. Mol Med. 2014 Nov 18; 20:486-9. PMID: 25121719.
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Bamias G, Dinarello CA, Rivera-Nieves J. Innate cytokines dictate the fate of acute intestinal inflammation. Gastroenterology. 2015 Jan; 148(1):248-50. PMID: 25451656.
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Abbate A, Kontos MC, Abouzaki NA, Melchior RD, Thomas C, Van Tassell BW, Oddi C, Carbone S, Trankle CR, Roberts CS, Mueller GH, Gambill ML, Christopher S, Markley R, Vetrovec GW, Dinarello CA, Biondi-Zoccai G. Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies). Am J Cardiol. 2015 Feb 01; 115(3):288-92. PMID: 25482680.
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Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Iannitti RG, Puccetti M, Garlanda C, Kim S, Li S, van de Veerdonk FL, Dinarello CA, Romani L. IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog. 2014 Nov; 10(11):e1004462. PMID: 25375146.
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Abbate A, Van Tassell BW, Christopher S, Abouzaki NA, Sonnino C, Oddi C, Carbone S, Melchior RD, Gambill ML, Roberts CS, Kontos MC, Peberdy MA, Toldo S, Vetrovec GW, Biondi-Zoccai G, Dinarello CA. Effects of Prolastin C (Plasma-Derived Alpha-1 Antitrypsin) on the acute inflammatory response in patients with ST-segment elevation myocardial infarction (from the VCU-alpha 1-RT pilot study). Am J Cardiol. 2015 Jan 01; 115(1):8-12. PMID: 25456867.
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Luo Y, Cai X, Liu S, Wang S, Nold-Petry CA, Nold MF, Bufler P, Norris D, Dinarello CA, Fujita M. Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15178-83. PMID: 25294929.
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Marcondes AM, Karoopongse E, Lesnikova M, Margineantu D, Welte T, Dinarello CA, Hockenbery D, Janciauskiene S, Deeg HJ. a-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics. Blood. 2014 Oct 30; 124(18):2881-91. PMID: 25224412.
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Rasmussen TA, Tolstrup M, Brinkmann CR, Olesen R, Erikstrup C, Solomon A, Winckelmann A, Palmer S, Dinarello C, Buzon M, Lichterfeld M, Lewin SR, ?stergaard L, S?gaard OS. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV. 2014 Oct; 1(1):e13-21. PMID: 26423811.
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Abbate A, Dinarello CA. Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution? Eur Heart J. 2015 Feb 07; 36(6):337-9. PMID: 25205529.
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Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ, Leenders F, Bufler P, Boekschoten MV, M?ller M, Kersten S, Li S, Kim S, Eini H, Lewis EC, Joosten LA, Tilg H, Netea MG, Tack CJ, Dinarello CA, Stienstra R. IL-37 protects against obesity-induced inflammation and insulin resistance. Nat Commun. 2014 Sep 03; 5:4711. PMID: 25182023.
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van de Veerdonk FL, Dinarello CA. Deficient autophagy unravels the ROS paradox in chronic granulomatous disease. Autophagy. 2014 Jun; 10(6):1141-2. PMID: 24879159.
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Frenzel E, Wrenger S, Immenschuh S, Koczulla R, Mahadeva R, Deeg HJ, Dinarello CA, Welte T, Marcondes AM, Janciauskiene S. Acute-phase protein a1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion. J Immunol. 2014 Jun 01; 192(11):5354-62. PMID: 24760148.
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Dinarello CA. Interleukin-1a neutralisation in patients with cancer. Lancet Oncol. 2014 May; 15(6):552-3. PMID: 24746840.
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Canada JM, Van Tassell BW, Christopher S, Oddi C, Abouzaki NA, Gambill ML, Mueller G, Melchior R, Shah KB, Dinarello CA, Abbate A, Arena R. Clinical predictors of response to anakinra in patients with heart failure. Int J Cardiol. 2014 May 15; 173(3):537-9. PMID: 24679681.
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Gresnigt MS, Bozza S, Becker KL, Joosten LA, Abdollahi-Roodsaz S, van der Berg WB, Dinarello CA, Netea MG, Fontaine T, De Luca A, Moretti S, Romani L, Latge JP, van de Veerdonk FL. A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog. 2014 Mar; 10(3):e1003936. PMID: 24603878.
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de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL. IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3526-31. PMID: 24550444.
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Toldo S, Mezzaroma E, O'Brien L, Marchetti C, Seropian IM, Voelkel NF, Van Tassell BW, Dinarello CA, Abbate A. Interleukin-18 mediates interleukin-1-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H1025-31. PMID: 24531812.
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Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1? responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1418-26. PMID: 24527714.
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Bulau AM, Nold MF, Li S, Nold-Petry CA, Fink M, Mansell A, Schwerd T, Hong J, Rubartelli A, Dinarello CA, Bufler P. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2650-5. PMID: 24481253.
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van der Meer JW, Simon A, Dinarello CA. Comment on "Power of rare diseases: found in translation". Sci Transl Med. 2014 Jan 15; 6(219):219le1. PMID: 24431110.
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Christensen DP, Gysemans C, Lundh M, Dahll?f MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T. Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and ?-cell protection. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1055-9. PMID: 24395784.
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Falcao RA, Christopher S, Oddi C, Reznikov L, Grizzard JD, Abouzaki NA, Varma A, Van Tassell BW, Dinarello CA, Abbate A. Interleukin-10 in patients with ST-segment elevation myocardial infarction. Int J Cardiol. 2014 Mar 01; 172(1):e6-8. PMID: 24467979.
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Abbate A, Canada JM, Van Tassell BW, Wise CM, Dinarello CA. Interleukin-1 blockade in rheumatoid arthritis and heart failure: a missed opportunity? Int J Cardiol. 2014 Feb 15; 171(3):e125-6. PMID: 24418290.
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Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013 Dec 12; 39(6):1003-18. PMID: 24332029.
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. IL-32 promotes angiogenesis. J Immunol. 2014 Jan 15; 192(2):589-602. PMID: 24337385.
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Cantarini L, Vitale A, Scalini P, Dinarello CA, Rigante D, Franceschini R, Simonini G, Borsari G, Caso F, Lucherini OM, Frediani B, Bertoldi I, Punzi L, Galeazzi M, Cimaz R. Anakinra treatment in drug-resistant Behcet's disease: a case series. Clin Rheumatol. 2015 Jul; 34(7):1293-301. PMID: 24305945.
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Choi SW, Braun T, Chang L, Ferrara JL, Pawarode A, Magenau JM, Hou G, Beumer JH, Levine JE, Goldstein S, Couriel DR, Stockerl-Goldstein K, Krijanovski OI, Kitko C, Yanik GA, Lehmann MH, Tawara I, Sun Y, Paczesny S, Mapara MY, Dinarello CA, DiPersio JF, Reddy P. Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol. 2014 Jan; 15(1):87-95. PMID: 24295572.
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Dinarello CA, van der Meer JW. Treating inflammation by blocking interleukin-1 in humans. Semin Immunol. 2013 Dec 15; 25(6):469-84. PMID: 24275598.
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Dinarello CA, Bufler P. Interleukin-37. Semin Immunol. 2013 Dec 15; 25(6):466-8. PMID: 24275599.
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Dinarello CA. Overview of the interleukin-1 family of ligands and receptors. Semin Immunol. 2013 Dec 15; 25(6):389-93. PMID: 24275600.
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Joosten LA, Netea MG, Dinarello CA. Interleukin-1? in innate inflammation, autophagy and immunity. Semin Immunol. 2013 Dec 15; 25(6):416-24. PMID: 24275601.
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Novick D, Kim S, Kaplanski G, Dinarello CA. Interleukin-18, more than a Th1 cytokine. Semin Immunol. 2013 Dec 15; 25(6):439-48. PMID: 24275602.
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Kim B, Lee Y, Kim E, Kwak A, Ryoo S, Bae SH, Azam T, Kim S, Dinarello CA. The Interleukin-1a Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines. Front Immunol. 2013; 4:391. PMID: 24312098.
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Dinarello CA. The C3a receptor, caspase-1, and release of IL-1?. Blood. 2013 Nov 14; 122(20):3394-5. PMID: 24235127.
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Dinarello CA, Novick D, Kim S, Kaplanski G. Interleukin-18 and IL-18 binding protein. Front Immunol. 2013 Oct 08; 4:289. PMID: 24115947.
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Van Tassell BW, Arena R, Biondi-Zoccai G, Canada JM, Oddi C, Abouzaki NA, Jahangiri A, Falcao RA, Kontos MC, Shah KB, Voelkel NF, Dinarello CA, Abbate A. Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study). Am J Cardiol. 2014 Jan 15; 113(2):321-327. PMID: 24262762.
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Hara N, Alkanani AK, Dinarello CA, Zipris D. Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade. Innate Immun. 2014 Aug; 20(6):574-84. PMID: 24062197.
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Hara N, Alkanani AK, Dinarello CA, Zipris D. Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes. J Mol Med (Berl). 2014 Jan; 92(1):93-102. PMID: 23982318.
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Jonigk D, Al-Omari M, Maegel L, M?ller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S. Anti-inflammatory and immunomodulatory properties of a1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15007-12. PMID: 23975926.
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Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442.
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Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, Rider P, Kaplanov I, Aychek T, Dinarello CA, Apte RN, Voronov E. Non-redundant properties of IL-1a and IL-1? during acute colon inflammation in mice. Gut. 2014 Apr; 63(4):598-609. PMID: 23793223.
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Kratzer A, Salys J, Nold-Petry C, Cool C, Zamora M, Bowler R, Koczulla AR, Janciauskiene S, Edwards MG, Dinarello CA, Taraseviciene-Stewart L. Role of IL-18 in second-hand smoke-induced emphysema. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):725-32. PMID: 23392573.
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Heinhuis B, Popa CD, van Tits BL, Kim SH, Zeeuwen PL, van den Berg WB, van der Meer JW, van der Vliet JA, Stalenhoef AF, Dinarello CA, Netea MG, Joosten LA. Towards a role of interleukin-32 in atherosclerosis. Cytokine. 2013 Oct; 64(1):433-40. PMID: 23727326.
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Lee S, Lee Y, Hong K, Hong J, Bae S, Choi J, Jhun H, Kwak A, Kim E, Jo S, Dinarello CA, Kim S. Effect of recombinant a1-antitrypsin Fc-fused (AAT-Fc)protein on the inhibition of inflammatory cytokine production and streptozotocin-induced diabetes. Mol Med. 2013 May 20; 19:65-71. PMID: 23552726.
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Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol. 2013 May; 14(5):480-8. PMID: 23525089.
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Plantinga TS, Costantini I, Heinhuis B, Huijbers A, Semango G, Kusters B, Netea MG, Hermus AR, Smit JW, Dinarello CA, Joosten LA, Netea-Maier RT. A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma. Carcinogenesis. 2013 Jul; 34(7):1529-35. PMID: 23486016.
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Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E. The role of IL-1? in the early tumor cell-induced angiogenic response. J Immunol. 2013 Apr 01; 190(7):3500-9. PMID: 23475218.
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Joosten LA, Heinhuis B, Netea MG, Dinarello CA. Novel insights into the biology of interleukin-32. Cell Mol Life Sci. 2013 Oct; 70(20):3883-92. PMID: 23463238.
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Abbate A, Van Tassell BW, Biondi-Zoccai G, Kontos MC, Grizzard JD, Spillman DW, Oddi C, Roberts CS, Melchior RD, Mueller GH, Abouzaki NA, Rengel LR, Varma A, Gambill ML, Falcao RA, Voelkel NF, Dinarello CA, Vetrovec GW. Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. Am J Cardiol. 2013 May 15; 111(10):1394-400. PMID: 23453459.
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Levandowski CB, Mailloux CM, Ferrara TM, Gowan K, Ben S, Jin Y, McFann KK, Holland PJ, Fain PR, Dinarello CA, Spritz RA. NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1? processing via the NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2952-6. PMID: 23382179.
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Rasmussen TA, Schmeltz S?gaard O, Brinkmann C, Wightman F, Lewin SR, Melchjorsen J, Dinarello C, ?stergaard L, Tolstrup M. Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation. Hum Vaccin Immunother. 2013 May; 9(5):993-1001. PMID: 23370291.
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Gresnigt MS, R?sler B, Jacobs CW, Becker KL, Joosten LA, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL. The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. Eur J Immunol. 2013 Feb; 43(2):416-26. PMID: 23147407.
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Edwards CK, Green JS, Volk HD, Schiff M, Kotzin BL, Mitsuya H, Kawaguchi T, Sakata KM, Cheronis J, Trollinger D, Bankaitis-Davis D, Dinarello CA, Norris DA, Bevilacqua MP, Fujita M, Burmester GR. Combined anti-tumor necrosis factor-a therapy and DMARD therapy in rheumatoid arthritis patients reduces inflammatory gene expression in whole blood compared to DMARD therapy alone. Front Immunol. 2012; 3:366. PMID: 23264777.
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Dahll?f MS, Christensen DP, Lundh M, Dinarello CA, Mascagni P, Grunnet LG, Mandrup-Poulsen T. The lysine deacetylase inhibitor Givinostat inhibits ?-cell IL-1? induced IL-1? transcription and processing. Islets. 2012 Nov-Dec; 4(6):417-22. PMID: 23486342.
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Gresnigt MS, Joosten LA, Verschueren I, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL. Neutrophil-mediated inhibition of proinflammatory cytokine responses. J Immunol. 2012 Nov 15; 189(10):4806-15. PMID: 23053514.
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Dinarello CA. Keep up the heat on IL-1. Blood. 2012 Sep 27; 120(13):2538-9. PMID: 23019200.
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Liu W, Luo Y, Dunn JH, Norris DA, Dinarello CA, Fujita M. Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma. J Invest Dermatol. 2013 Feb; 133(2):518-27. PMID: 22931929.
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Heinhuis B, Netea MG, van den Berg WB, Dinarello CA, Joosten LA. Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death. Cytokine. 2012 Nov; 60(2):321-7. PMID: 22878344.
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Chiossone L, Audonnet S, Chetaille B, Chasson L, Farnarier C, Berda-Haddad Y, Jordan S, Koszinowski UH, Dalod M, Mazodier K, Novick D, Dinarello CA, Vivier E, Kaplanski G. Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein. Front Immunol. 2012; 3:239. PMID: 22891066.
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Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov. 2012 Aug; 11(8):633-52. PMID: 22850787.
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Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahll?f MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, Grunnet LG, Morgan NG, Mandrup-Poulsen T. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia. 2012 Sep; 55(9):2421-31. PMID: 22772764.
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Cavelti-Weder C, Babians-Brunner A, Keller C, Stahel MA, Kurz-Levin M, Zayed H, Solinger AM, Mandrup-Poulsen T, Dinarello CA, Donath MY. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care. 2012 Aug; 35(8):1654-62. PMID: 22699287.
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Dinarello CA. Membrane interleukin-18 revisits membrane IL-1a in T-helper type 1 responses. Eur J Immunol. 2012 Jun; 42(6):1385-7. PMID: 22678894.
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Van Tassell BW, Arena RA, Toldo S, Mezzaroma E, Azam T, Seropian IM, Shah K, Canada J, Voelkel NF, Dinarello CA, Abbate A. Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure. PLoS One. 2012; 7(3):e33438. PMID: 22438931.
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Wang J, Nikrad MP, Travanty EA, Zhou B, Phang T, Gao B, Alford T, Ito Y, Nahreini P, Hartshorn K, Wentworth D, Dinarello CA, Mason RJ. Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 2012; 7(3):e29879. PMID: 22396727.
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Dinarello CA. Grand challenge in inflammation. Front Immunol. 2012; 3:12. PMID: 22566898.
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van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, Dinarello CA. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3001-5. PMID: 22315422.
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Heinhuis B, Koenders MI, van den Berg WB, Netea MG, Dinarello CA, Joosten LA. Interleukin 32 (IL-32) contains a typical a-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1. J Biol Chem. 2012 Feb 17; 287(8):5733-43. PMID: 22203669.
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Tawara I, Sun Y, Lewis EC, Toubai T, Evers R, Nieves E, Azam T, Dinarello CA, Reddy P. Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):564-9. PMID: 22203983.
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Berda-Haddad Y, Robert S, Salers P, Zekraoui L, Farnarier C, Dinarello CA, Dignat-George F, Kaplanski G. Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1a. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20684-9. PMID: 22143786.
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G?l A, Tugal-Tutkun I, Dinarello CA, Reznikov L, Esen BA, Mirza A, Scannon P, Solinger A. Interleukin-1?-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study. Ann Rheum Dis. 2012 Apr; 71(4):563-6. PMID: 22084392.
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Bai X, Ovrutsky AR, Kartalija M, Chmura K, Kamali A, Honda JR, Oberley-Deegan RE, Dinarello CA, Crapo JD, Chang LY, Chan ED. IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease. Int Immunol. 2011 Nov; 23(11):679-91. PMID: 22033195.
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Shainheit MG, Lasocki KW, Finger E, Larkin BM, Smith PM, Sharpe AH, Dinarello CA, Rutitzky LI, Stadecker MJ. The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1?. J Immunol. 2011 Nov 15; 187(10):5328-35. PMID: 22003203.
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Murray DR, Mummidi S, Valente AJ, Yoshida T, Somanna NK, Delafontaine P, Dinarello CA, Chandrasekar B. ?2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. J Mol Cell Cardiol. 2012 Jan; 52(1):206-18. PMID: 22004899.
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Rubartelli A, Gattorno M, Netea MG, Dinarello CA. Interplay between redox status and inflammasome activation. Trends Immunol. 2011 Dec; 32(12):559-66. PMID: 21962746.
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Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN. IL-1a and IL-1? recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol. 2011 Nov 01; 187(9):4835-43. PMID: 21930960.
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Keswani A, Chustz RT, Suh L, Carter R, Peters AT, Tan BK, Chandra R, Kim SH, Azam T, Dinarello CA, Kern RC, Schleimer RP, Kato A. Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps. Allergy. 2012 Jan; 67(1):25-32. PMID: 21899560.
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Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ. Inhibition of IL-32 activation by a-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model. Blood. 2011 Nov 03; 118(18):5031-9. PMID: 21900190.
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Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D, Oostingh GJ, Pfaller T, Pixner C, Posselt G, Italiani P, Nold MF, Nold-Petry CA, Bufler P, Dinarello CA. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw. 2011 Sep; 22(3):127-47. PMID: 22047735.
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McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, Nold MF, Nold-Petry C, Bufler P, Dinarello CA, Rivera-Nieves J. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16711-6. PMID: 21873195.
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Carta S, Tassi S, Pettinati I, Delfino L, Dinarello CA, Rubartelli A. The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering. J Biol Chem. 2011 Aug 05; 286(31):27069-80. PMID: 21628463.
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Moschen AR, Fritz T, Clouston AD, Rebhan I, Bauhofer O, Barrie HD, Powell EE, Kim SH, Dinarello CA, Bartenschlager R, Jonsson JR, Tilg H. Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis. Hepatology. 2011 Jun; 53(6):1819-29. PMID: 21381070.
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Toldo S, Seropian IM, Mezzaroma E, Van Tassell BW, Salloum FN, Lewis EC, Voelkel N, Dinarello CA, Abbate A. Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2011 Aug; 51(2):244-51. PMID: 21600901.
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Dinarello CA, Fossati G, Mascagni P. Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer. Mol Med. 2011 May-Jun; 17(5-6):333-52. PMID: 21556484.
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Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-?: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. J Immunol. 2011 May 01; 186(9):5024-33. PMID: 21505214.
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Dinarello CA. A clinical perspective of IL-1? as the gatekeeper of inflammation. Eur J Immunol. 2011 May; 41(5):1203-17. PMID: 21523780.
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Vojinovic J, Damjanov N, D'Urzo C, Furlan A, Susic G, Pasic S, Iagaru N, Stefan M, Dinarello CA. Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 2011 May; 63(5):1452-8. PMID: 21538322.
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Netea MG, Dinarello CA. More than inflammation: interleukin-1beta polymorphisms and the lipid metabolism. J Clin Endocrinol Metab. 2011 May; 96(5):1279-81. PMID: 21543437.
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Matalon S, Rasmussen TA, Dinarello CA. Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir. Mol Med. 2011 May-Jun; 17(5-6):466-72. PMID: 21424110.
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Arts RJ, Joosten LA, Dinarello CA, Kullberg BJ, van der Meer JW, Netea MG. TREM-1 interaction with the LPS/TLR4 receptor complex. Eur Cytokine Netw. 2011 Mar; 22(1):11-4. PMID: 21393102.
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Kamari Y, Shaish A, Vax E, Shemesh S, Kandel-Kfir M, Arbel Y, Olteanu S, Barshack I, Dotan S, Voronov E, Dinarello CA, Apte RN, Harats D. Lack of interleukin-1a or interleukin-1? inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. J Hepatol. 2011 Nov; 55(5):1086-94. PMID: 21354232.
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Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF. Protection from RNA and DNA viruses by IL-32. J Immunol. 2011 Apr 01; 186(7):4110-8. PMID: 21346229.
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Furlan A, Monzani V, Reznikov LL, Leoni F, Fossati G, Modena D, Mascagni P, Dinarello CA. Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol Med. 2011 May-Jun; 17(5-6):353-62. PMID: 21365126.
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van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA. Inflammasome activation and IL-1? and IL-18 processing during infection. Trends Immunol. 2011 Mar; 32(3):110-6. PMID: 21333600.
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Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011 Apr 07; 117(14):3720-32. PMID: 21304099.
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van de Veerdonk FL, Netea MG, Dinarello CA, van der Meer JW. Anakinra for the inflammatory complications of chronic granulomatous disease. Neth J Med. 2011 Feb; 69(2):95. PMID: 21411850.
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Kamari Y, Shaish A, Shemesh S, Vax E, Grosskopf I, Dotan S, White M, Voronov E, Dinarello CA, Apte RN, Harats D. Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1a. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):197-203. PMID: 21219852.
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Dinarello CA. Blocking interleukin-1? in acute and chronic autoinflammatory diseases. J Intern Med. 2011 Jan; 269(1):16-28. PMID: 21158974.
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Heinhuis B, Koenders MI, van Riel PL, van de Loo FA, Dinarello CA, Netea MG, van den Berg WB, Joosten LA. Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis. 2011 Apr; 70(4):660-7. PMID: 21187297.
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Lewis EC, Blaabjerg L, St?rling J, Ronn SG, Mascagni P, Dinarello CA, Mandrup-Poulsen T. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet ? cells in vivo and in vitro. Mol Med. 2011 May-Jun; 17(5-6):369-77. PMID: 21193899.
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Migliorini P, Anzilotti C, Pratesi F, Quattroni P, Bargagna M, Dinarello CA, Boraschi D. Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur Cytokine Netw. 2010 Dec; 21(4):264-71. PMID: 21126942.
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Elkabets M, Ribeiro VS, Dinarello CA, Ostrand-Rosenberg S, Di Santo JP, Apte RN, Vosshenrich CA. IL-1? regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function. Eur J Immunol. 2010 Dec; 40(12):3347-57. PMID: 21110318.
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Choi J, Bae S, Hong J, Ryoo S, Jhun H, Hong K, Yoon D, Lee S, Her E, Choi W, Kim J, Azam T, Dinarello CA, Kim S. Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21082-6. PMID: 21078994.
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Dinarello C, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A, Kelk P, Peyman K, van de Veerdonk F, Gabel C. IL-1 family nomenclature. Nat Immunol. 2010 Nov; 11(11):973. PMID: 20959797.
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Dinarello CA. How interleukin-1? induces gouty arthritis. Arthritis Rheum. 2010 Nov; 62(11):3140-4. PMID: 20662058.
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Raffeiner B, Botsios C, Dinarello C, Ometto F, Punzi L, Ramonda R. Adult-onset Still's disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra. Joint Bone Spine. 2011 Jan; 78(1):100-1. PMID: 21036649.
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Joosten LA, Van De Veerdonk FL, Vonk AG, Boerman OC, Keuter M, Fantuzzi G, Verschueren I, Van Der Poll T, Dinarello CA, Kullberg BJ, Van Der Meer JW, Netea MG. Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1a, IL-1? or IL-1 receptor type I. APMIS. 2010 Dec; 118(12):1000-7. PMID: 21091783.
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Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol. 2010 Nov; 11(11):1014-22. PMID: 20935647.
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Lundh M, Christensen DP, Rasmussen DN, Mascagni P, Dinarello CA, Billestrup N, Grunnet LG, Mandrup-Poulsen T. Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia. 2010 Dec; 53(12):2569-78. PMID: 20878317.
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Dinarello CA, Donath MY, Mandrup-Poulsen T. Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Aug; 17(4):314-21. PMID: 20588114.
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Dinarello CA. Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev. 2010 Jun; 29(2):317-29. PMID: 20422276.
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Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest. 2010 Jun; 120(6):2156-70. PMID: 20501948.
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Heinhuis B, Koenders MI, van de Loo FA, van Lent PL, Kim SH, Dinarello CA, Joosten LA, van den Berg WB. IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2. Ann Rheum Dis. 2010 Oct; 69(10):1866-72. PMID: 20472585.
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Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. J Acquir Immune Defic Syndr. 2010 May 01; 54(1):1-9. PMID: 20300007.
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Abbate A, Kontos MC, Grizzard JD, Biondi-Zoccai GG, Van Tassell BW, Robati R, Roach LM, Arena RA, Roberts CS, Varma A, Gelwix CC, Salloum FN, Hastillo A, Dinarello CA, Vetrovec GW. Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol. 2010 May 15; 105(10):1371-1377.e1. PMID: 20451681.
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Abbate A, Van Tassell BW, Seropian IM, Toldo S, Robati R, Varma A, Salloum FN, Smithson L, Dinarello CA. Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse. Eur J Heart Fail. 2010 Apr; 12(4):319-22. PMID: 20335350.
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Dinarello CA. Anti-inflammatory Agents: Present and Future. Cell. 2010 Mar 19; 140(6):935-50. PMID: 20303881.
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Dinarello CA. IL-1: discoveries, controversies and future directions. Eur J Immunol. 2010 Mar; 40(3):599-606. PMID: 20201008.
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Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol. 2010 Apr 01; 184(7):3830-40. PMID: 20190143.
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van de Veerdonk FL, Smeekens SP, Joosten LA, Kullberg BJ, Dinarello CA, van der Meer JW, Netea MG. Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3030-3. PMID: 20133696.
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Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, Apte RN. Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2574-9. PMID: 20133797.
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Chou RC, Dinarello CA, Ferry JA, Dal Cin P. A 36-year-old woman with recurrent high-grade fevers, hypotension, and hypertriglyceridemia. Arthritis Care Res (Hoboken). 2010 Jan 15; 62(1):128-36. PMID: 20191502.
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Okamoto M, Liu W, Luo Y, Tanaka A, Cai X, Norris DA, Dinarello CA, Fujita M. Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem. 2010 Feb 26; 285(9):6477-88. PMID: 20038581.
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Joosten LA, Netea MG, Fantuzzi G, Koenders MI, Helsen MM, Sparrer H, Pham CT, van der Meer JW, Dinarello CA, van den Berg WB. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum. 2009 Dec; 60(12):3651-62. PMID: 19950280.
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Silliman CC, Kelher MR, Gamboni-Robertson F, Hamiel C, England KM, Dinarello CA, Wyman TH, Khan SY, McLaughlin NJ, Bercovitz RS, Banerjee A. Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C714-24. PMID: 19907017.
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Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S. Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta. Cytokine. 2010 Feb; 49(2):171-6. PMID: 19880327.
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Wang M, Tan J, Wang Y, Meldrum KK, Dinarello CA, Meldrum DR. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17499-504. PMID: 19805173.
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Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M, Huszar M, White MR, Dinarello CA, Apte RN. The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis. J Immunol. 2009 Oct 01; 183(7):4705-14. PMID: 19752225.
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Shein NA, Grigoriadis N, Alexandrovich AG, Simeonidou C, Lourbopoulos A, Polyzoidou E, Trembovler V, Mascagni P, Dinarello CA, Shohami E. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J. 2009 Dec; 23(12):4266-75. PMID: 19723705.
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Lonnemann G, Bahlmann FH, Freise J, Hertel B, Dinarello CA. Low-flux hemodialysis suppresses interferon-gamma production: the possible role of beta2-microglobulin. Clin Nephrol. 2009 Sep; 72(3):170-6. PMID: 19761720.
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Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, Boraschi D, Migliorini P. IL-18 activity in systemic lupus erythematosus. Ann N Y Acad Sci. 2009 Sep; 1173:301-9. PMID: 19758166.
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Novick D, Elbirt D, Miller G, Dinarello CA, Rubinstein M, Sthoeger ZM. High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein. J Autoimmun. 2010 Mar; 34(2):121-6. PMID: 19699611.
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Kliger Y, Levy O, Oren A, Ashkenazy H, Tiran Z, Novik A, Rosenberg A, Amir A, Wool A, Toporik A, Schreiber E, Eshel D, Levine Z, Cohen Y, Nold-Petry C, Dinarello CA, Borukhov I. Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):13797-801. PMID: 19666568.
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Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, Hong JW, Kim SH, Dinarello CA. Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J Biol Chem. 2009 Sep 18; 284(38):25900-11. PMID: 19592492.
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Kleinnijenhuis J, Joosten LA, van de Veerdonk FL, Savage N, van Crevel R, Kullberg BJ, van der Ven A, Ottenhoff TH, Dinarello CA, van der Meer JW, Netea MG. Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis. Eur J Immunol. 2009 Jul; 39(7):1914-22. PMID: 19544485.
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Bani-Hani AH, Leslie JA, Asanuma H, Dinarello CA, Campbell MT, Meldrum DR, Zhang H, Hile K, Meldrum KK. IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis. Kidney Int. 2009 Sep; 76(5):500-11. PMID: 19536084.
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Dinarello CA. Interleukin-1beta and the autoinflammatory diseases. N Engl J Med. 2009 Jun 04; 360(23):2467-70. PMID: 19494224.
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van der Meer JH, Netea MG, Dinarello CA. Modulation of muramyl dipeptide stimulation of cytokine production by blood components. Clin Exp Immunol. 2009 Jun; 156(3):428-33. PMID: 19438594.
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Sun Y, Chin YE, Weisiger E, Malter C, Tawara I, Toubai T, Gatza E, Mascagni P, Dinarello CA, Reddy P. Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J Immunol. 2009 May 15; 182(10):5899-903. PMID: 19414739.
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Olson JL, Courtney RJ, Rouhani B, Mandava N, Dinarello CA. Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model. Ocul Immunol Inflamm. 2009 May-Jun; 17(3):195-200. PMID: 19585363.
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Dinarello CA. Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation. Semin Dial. 2009 May-Jun; 22(3):256-9. PMID: 19573005.
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Elkabets M, Krelin Y, Dotan S, Cerwenka A, Porgador A, Lichtenstein RG, White MR, Zoller M, Iwakura Y, Dinarello CA, Voronov E, Apte RN. Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells. J Immunol. 2009 Apr 15; 182(8):4874-81. PMID: 19342666.
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Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7119-24. PMID: 19359475.
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van de Veerdonk FL, Joosten LA, Devesa I, Mora-Montes HM, Kanneganti TD, Dinarello CA, van der Meer JW, Gow NA, Kullberg BJ, Netea MG. Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans. J Infect Dis. 2009 Apr 01; 199(7):1087-96. PMID: 19222370.
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Nold-Petry CA, Nold MF, Zepp JA, Kim SH, Voelkel NF, Dinarello CA. IL-32-dependent effects of IL-1beta on endothelial cell functions. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3883-8. PMID: 19228941.
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Pott GB, Chan ED, Dinarello CA, Shapiro L. Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol. 2009 May; 85(5):886-95. PMID: 19197072.
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Dinarello CA. Targeting the pathogenic role of interleukin 1{beta} in the progression of smoldering/indolent myeloma to active disease. Mayo Clin Proc. 2009 Feb; 84(2):105-7. PMID: 19181642.
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Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009; 27:519-50. PMID: 19302047.
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Dinarello CA. Inflammation in human disease: anticytokine therapy. Biol Blood Marrow Transplant. 2009 Jan; 15(1 Suppl):134-6. PMID: 19147092.
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Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood. 2009 Mar 05; 113(10):2324-35. PMID: 19104081.
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Kim S, Lee S, Her E, Bae S, Choi J, Hong J, Jaekal J, Yoon D, Azam T, Dinarello CA, Kim S. Proteinase 3-processed form of the recombinant IL-32 separate domain. BMB Rep. 2008 Nov 30; 41(11):814-9. PMID: 19017495.
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Moore CC, Martin EN, Lee G, Taylor C, Dondero R, Reznikov LL, Dinarello C, Thompson J, Scheld WM. Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury. J Infect Dis. 2008 Nov 01; 198(9):1407-14. PMID: 18793104.
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Arcaroli JJ, Hokanson JE, Abraham E, Geraci M, Murphy JR, Bowler RP, Dinarello CA, Silveira L, Sankoff J, Heyland D, Wischmeyer P, Crapo JD. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med. 2009 Jan 15; 179(2):105-12. PMID: 18948423.
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Lewis EC, Mizrahi M, Toledano M, Defelice N, Wright JL, Churg A, Shapiro L, Dinarello CA. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16236-41. PMID: 18852465.
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Bosisio D, Vulcano M, Del Prete A, Sironi M, Salvi V, Salogni L, Riboldi E, Leoni F, Dinarello CA, Girolomoni G, Sozzani S. Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. J Leukoc Biol. 2008 Dec; 84(6):1540-8. PMID: 18780875.
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Choi JD, Bae SY, Hong JW, Azam T, Dinarello CA, Her E, Choi WS, Kim BK, Lee CK, Yoon DY, Kim SJ, Kim SH. Identification of the most active interleukin-32 isoform. Immunology. 2009 Apr; 126(4):535-42. PMID: 18771438.
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He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1414-21. PMID: 18753296.
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Botsios C, Sfriso P, Furlan A, Punzi L, Dinarello CA. Resistant Beh?et disease responsive to anakinra. Ann Intern Med. 2008 Aug 19; 149(4):284-6. PMID: 18711165.
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Calabrese F, Baraldo S, Bazzan E, Lunardi F, Rea F, Maestrelli P, Turato G, Lokar-Oliani K, Papi A, Zuin R, Sfriso P, Balestro E, Dinarello CA, Saetta M. IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):894-901. PMID: 18703789.
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Novick D, Elbirt D, Dinarello CA, Rubinstein M, Sthoeger ZM. Interleukin-18 binding protein in the sera of patients with Wegener's granulomatosis. J Clin Immunol. 2009 Jan; 29(1):38-45. PMID: 18594952.
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Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA. Endogenous IL-32 controls cytokine and HIV-1 production. J Immunol. 2008 Jul 01; 181(1):557-65. PMID: 18566422.
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Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest. 2008 Jul; 118(7):2562-73. PMID: 18568076.
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Sennello JA, Fayad R, Pini M, Gove ME, Ponemone V, Cabay RJ, Siegmund B, Dinarello CA, Fantuzzi G. Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8085-90. PMID: 18515422.
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Cha J, Wang Z, Ao L, Zou N, Dinarello CA, Banerjee A, Fullerton DA, Meng X. Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann Thorac Surg. 2008 May; 85(5):1678-85. PMID: 18442564.
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Sharma S, Kulk N, Nold MF, Gr?f R, Kim SH, Reinhardt D, Dinarello CA, Bufler P. The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol. 2008 Apr 15; 180(8):5477-82. PMID: 18390730.
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Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA, Kim SH. Interleukin-32 induces the differentiation of monocytes into macrophage-like cells. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3515-20. PMID: 18296636.
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Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2865-70. PMID: 18287021.
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Kim KH, Shim JH, Seo EH, Cho MC, Kang JW, Kim SH, Yu DY, Song EY, Lee HG, Sohn JH, Kim J, Dinarello CA, Yoon DY. Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA. J Immunol Methods. 2008 Apr 20; 333(1-2):38-50. PMID: 18252253.
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Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):679-88. PMID: 18218994.
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Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut. 2008 May; 57(5):613-22. PMID: 18194985.
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Ludwiczek O, Vannier E, Moschen A, Salazar-Montes A, Borggraefe I, Gabay C, Enrich B, Kaser A, Siegmund B, Dinarello C, Tilg H. Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease. Scand J Gastroenterol. 2008; 43(11):1360-5. PMID: 18609176.
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Jaekal J, Abraham E, Azam T, Netea MG, Dinarello CA, Lim JS, Yang Y, Yoon DY, Kim SH. Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level. J Microbiol Biotechnol. 2007 Nov; 17(11):1862-7. PMID: 18092472.
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Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007 Nov; 37 Suppl 1:S34-45. PMID: 17972343.
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Meng X, Ao L, Song Y, Babu A, Yang X, Wang M, Weyant MJ, Dinarello CA, Cleveland JC, Fullerton DA. Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C29-35. PMID: 17942642.
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Manzer R, Dinarello CA, McConville G, Mason RJ. Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):318-23. PMID: 17901407.
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Dinarello CA. Mutations in cryopyrin: bypassing roadblocks in the caspase 1 inflammasome for interleukin-1beta secretion and disease activity. Arthritis Rheum. 2007 Sep; 56(9):2817-22. PMID: 17763412.
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Lavi G, Voronov E, Dinarello CA, Apte RN, Cohen S. Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. J Control Release. 2007 Nov 06; 123(2):123-30. PMID: 17900737.
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Ao L, Song Y, Fullerton DA, Dinarello CA, Meng X. The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression. Cytokine. 2007 Jun; 38(3):124-9. PMID: 17683945.
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Yoon DY, Dinarello CA. Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells. J Biochem Mol Biol. 2007 Jul 31; 40(4):562-70. PMID: 17669273.
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Pott GB, Sailer CA, Porat R, Peskind RL, Fuchs AC, Angel JB, Skolnik PR, Jacobson MA, Giordano MF, Lebeaut A, Grint PC, Dinarello CA, Shapiro L. Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects. Eur Cytokine Netw. 2007 Jun; 18(2):49-58. PMID: 17594937.
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Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 2007 May 29; 68(22):1902-8. PMID: 17536046.
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Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911. J Immunol. 2007 May 01; 178(9):5413-7. PMID: 17442920.
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Dinarello CA. A signal for the caspase-1 inflammasome free of TLR. Immunity. 2007 Apr; 26(4):383-5. PMID: 17459804.
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Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007 Jul; 322(1):8-15. PMID: 17400889.
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Hurgin V, Novick D, Werman A, Dinarello CA, Rubinstein M. Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5044-9. PMID: 17360358.
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Krelin Y, Voronov E, Dotan S, Elkabets M, Reich E, Fogel M, Huszar M, Iwakura Y, Segal S, Dinarello CA, Apte RN. Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res. 2007 Feb 01; 67(3):1062-71. PMID: 17283139.
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Larsen L, Tonnesen M, Ronn SG, St?rling J, J?rgensen S, Mascagni P, Dinarello CA, Billestrup N, Mandrup-Poulsen T. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia. 2007 Apr; 50(4):779-89. PMID: 17265033.
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Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello CA, Faubel S. Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant. 2007 Apr; 22(4):1052-61. PMID: 17255124.
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Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 01; 195(5):734-8. PMID: 17262717.
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Dinarello CA. Interleukin-18 and the pathogenesis of inflammatory diseases. Semin Nephrol. 2007 Jan; 27(1):98-114. PMID: 17336692.
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Meldrum KK, Misseri R, Metcalfe P, Dinarello CA, Hile KL, Meldrum DR. TNF-alpha neutralization ameliorates obstruction-induced renal fibrosis and dysfunction. Am J Physiol Regul Integr Comp Physiol. 2007 Apr; 292(4):R1456-64. PMID: 17170233.
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Kamari Y, Werman-Venkert R, Shaish A, Werman A, Harari A, Gonen A, Voronov E, Grosskopf I, Sharabi Y, Grossman E, Iwakura Y, Dinarello CA, Apte RN, Harats D. Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism. Atherosclerosis. 2007 Nov; 195(1):31-8. PMID: 17173923.
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Boraschi D, Dinarello CA. IL-18 in autoimmunity: review. Eur Cytokine Netw. 2006 Dec; 17(4):224-52. PMID: 17353157.
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Dinarello CA, Kim SH. IL-32, a novel cytokine with a possible role in disease. Ann Rheum Dis. 2006 Nov; 65 Suppl 3:iii61-4. PMID: 17038476.
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Lewis EC, Dinarello CA. Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16852-7. PMID: 17075045.
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Edwards CK, Bendele AM, Reznikov LI, Fantuzzi G, Chlipala ES, Li L, Moldawer LL, Mountz JD, Li YY, Dinarello CA. Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha. Arthritis Rheum. 2006 Sep; 54(9):2872-85. PMID: 16947419.
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Vidal-Vanaclocha F, Mendoza L, Telleria N, Salado C, Valc?rcel M, Gallot N, Carrascal T, Egilegor E, Beaskoetxea J, Dinarello CA. Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression. Cancer Metastasis Rev. 2006 Sep; 25(3):417-34. PMID: 17001512.
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Dinarello CA. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev. 2006 Sep; 25(3):307-13. PMID: 17029030.
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Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol. 2006 Dec; 80(6):1454-61. PMID: 16940328.
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Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA. Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med. 2006 Aug; 3(8):e277. PMID: 16903774.
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Abraham E, Nick JA, Azam T, Kim SH, Mira JP, Svetkauskaite D, He Q, Zamora M, Murphy J, Park JS, Overdier K, Dinarello CA. Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans. J Immunol. 2006 Jun 15; 176(12):7753-60. PMID: 16751423.
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Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med. 2006 Jun; 12(6):650-6. PMID: 16732281.
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Dvorkin T, Song X, Argov S, White RM, Zoller M, Segal S, Dinarello CA, Voronov E, Apte RN. Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha. J Leukoc Biol. 2006 Jul; 80(1):96-106. PMID: 16707560.
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Carta S, Tassi S, Semino C, Fossati G, Mascagni P, Dinarello CA, Rubartelli A. Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood. 2006 Sep 01; 108(5):1618-26. PMID: 16684958.
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Glauben R, Batra A, Fedke I, Zeitz M, Lehr HA, Leoni F, Mascagni P, Fantuzzi G, Dinarello CA, Siegmund B. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol. 2006 Apr 15; 176(8):5015-22. PMID: 16585598.
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Morris AM, Sennello JA, Fayad RA, Eckel RH, Dinarello CA, Fantuzzi G. T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha. Metabolism. 2006 Apr; 55(4):555-9. PMID: 16546488.
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Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, Barrera P, van de Loo FA, Dinarello CA, van den Berg WB. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3298-303. PMID: 16492735.
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Novick D, Rubinstein M, Azam T, Rabinkov A, Dinarello CA, Kim SH. Proteinase 3 is an IL-32 binding protein. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3316-21. PMID: 16488976.
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Dinarello CA. Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am J Clin Nutr. 2006 Feb; 83(2):447S-455S. PMID: 16470011.
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Rodriguez RM, Abdullah R, Miller R, Barry L, Lungstras-Bufler K, Bufler P, Dinarello CA, Abraham E. A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. Am J Emerg Med. 2006 Jan; 24(1):58-61. PMID: 16338511.
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Dinarello CA. Inhibitors of histone deacetylases as anti-inflammatory drugs. Ernst Schering Res Found Workshop. 2006; (56):45-60. PMID: 16331856.
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Song X, Krelin Y, Dvorkin T, Bjorkdahl O, Segal S, Dinarello CA, Voronov E, Apte RN. CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells. J Immunol. 2005 Dec 15; 175(12):8200-8. PMID: 16339559.
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Dinarello CA. Interleukin-1beta. Crit Care Med. 2005 Dec; 33(12 Suppl):S460-2. PMID: 16340421.
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Dinarello CA. An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor. Immunity. 2005 Nov; 23(5):461-2. PMID: 16286013.
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Dinarello CA, Kaplanski G. Interleukin-18 treatment options for inflammatory diseases. Expert Rev Clin Immunol. 2005 Nov; 1(4):619-32. PMID: 20477603.
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Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, Abraham E, Kim JM, Yoon DY, Dinarello CA, Kim SH. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16309-14. PMID: 16260731.
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Portnoy J, Pan T, Dinarello CA, Shannon JM, Westcott JY, Zhang L, Mason RJ. Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L307-16. PMID: 16169897.
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Clarke JH, Cha JY, Walsh MD, Gamboni-Robertson F, Banerjee A, Reznikov LL, Dinarello CA, Harken AH, McCarter MD. Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. J Am Coll Surg. 2005 Sep; 201(3):418-25. PMID: 16125076.
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Lee KA, Cho KJ, Kim SH, Shim JH, Lim JS, Cho DH, Song MS, Dinarello CA, Yoon DY. IL-18 E42A mutant is resistant to the inhibitory effects of HPV-16 E6 and E7 oncogenes on the IL-18-mediated immune response. Cancer Lett. 2005 Nov 18; 229(2):261-70. PMID: 16125299.
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Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12153-8. PMID: 16093309.
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Jones-Carson J, Fantuzzi G, Siegmund B, Dinarello C, Tracey KJ, Wang H, Fang FC, Vazquez-Torres A. Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock. J Infect Dis. 2005 Sep 15; 192(6):1039-46. PMID: 16107957.
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Fayad R, Sennello JA, Kim SH, Pini M, Dinarello CA, Fantuzzi G. Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids. Eur J Immunol. 2005 Aug; 35(8):2304-12. PMID: 16047339.
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Mazodier K, Marin V, Novick D, Farnarier C, Robitail S, Schleinitz N, Veit V, Paul P, Rubinstein M, Dinarello CA, Harl? JR, Kaplanski G. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 2005 Nov 15; 106(10):3483-9. PMID: 16020503.
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Dinarello CA. The many worlds of reducing interleukin-1. Arthritis Rheum. 2005 Jul; 52(7):1960-7. PMID: 15986340.
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Fitzgerald AA, Leclercq SA, Yan A, Homik JE, Dinarello CA. Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum. 2005 Jun; 52(6):1794-803. PMID: 15934079.
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Numerof RP, Dinarello CA, Asadullah K. Cytokines as potential therapeutic targets for inflammatory skin diseases. Eur Cytokine Netw. 2005 Jun; 16(2):101-3. PMID: 15941680.
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Dinarello CA. Blocking IL-1 in systemic inflammation. J Exp Med. 2005 May 02; 201(9):1355-9. PMID: 15867089.
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Dinarello CA. Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment. J Rheumatol Suppl. 2005 Mar; 74:40-7. PMID: 15742464.
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Kumar A, Zanotti S, Bunnell G, Habet K, A?el R, Neumann A, Cheang M, Dinarello CA, Cutler D, Parrillo JE. Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response. Crit Care Med. 2005 Feb; 33(2):331-40. PMID: 15699836.
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Sennello JA, Fayad R, Morris AM, Eckel RH, Asilmaz E, Montez J, Friedman JM, Dinarello CA, Fantuzzi G. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology. 2005 May; 146(5):2157-64. PMID: 15677756.
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Wang W, Faubel S, Ljubanovic D, Mitra A, Falk SA, Kim J, Tao Y, Soloviev A, Reznikov LL, Dinarello CA, Schrier RW, Edelstein CL. Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol. 2005 May; 288(5):F997-1004. PMID: 15644489.
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Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 2005 Jan; 22(1):131-42. PMID: 15664165.
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Ludwiczek O, Kaser A, Novick D, Dinarello CA, Rubinstein M, Tilg H. Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease. Eur Cytokine Netw. 2005 Jan-Mar; 16(1):27-33. PMID: 15809203.
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Stuyt RJ, Netea MG, Verschueren I, Dinarello CA, Kullberg BJ, van der Meer JW. Interleukin-18 does not modulate the acute-phase response. J Endotoxin Res. 2005; 11(2):85-8. PMID: 15949134.
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Leoni F, Fossati G, Lewis EC, Lee JK, Porro G, Pagani P, Modena D, Moras ML, Pozzi P, Reznikov LL, Siegmund B, Fantuzzi G, Dinarello CA, Mascagni P. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec; 11(1-12):1-15. PMID: 16557334.
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Lee HG, Kim H, Oh WK, Yu KA, Choe YK, Ahn JS, Kim DS, Kim SH, Dinarello CA, Kim K, Yoon DY. Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB. Ann N Y Acad Sci. 2004 Dec; 1030:555-68. PMID: 15659838.
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Faubel S, Ljubanovic D, Reznikov L, Somerset H, Dinarello CA, Edelstein CL. Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis. Kidney Int. 2004 Dec; 66(6):2202-13. PMID: 15569309.
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Ludwiczek O, Vannier E, Borggraefe I, Kaser A, Siegmund B, Dinarello CA, Tilg H. Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease. Clin Exp Immunol. 2004 Nov; 138(2):323-9. PMID: 15498044.
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Misseri R, Meldrum DR, Dinarello CA, Dagher P, Hile KL, Rink RC, Meldrum KK. TNF-alpha mediates obstruction-induced renal tubular cell apoptosis and proapoptotic signaling. Am J Physiol Renal Physiol. 2005 Feb; 288(2):F406-11. PMID: 15507546.
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Siegmund B, Sennello JA, Lehr HA, Senaldi G, Dinarello CA, Fantuzzi G. Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Eur J Immunol. 2004 Sep; 34(9):2356-64. PMID: 15307168.
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Dinarello CA. Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation. Curr Opin Pharmacol. 2004 Aug; 4(4):378-85. PMID: 15251132.
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Netea MG, Kullberg BJ, Jacobs LE, Verver-Jansen TJ, van der Ven-Jongekrijg J, Galama JM, Stalenhoef AF, Dinarello CA, Van der Meer JW. Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol. 2004 Jul 15; 173(2):1477-82. PMID: 15240744.
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Bufler P, Gamboni-Robertson F, Azam T, Kim SH, Dinarello CA. Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J. 2004 Jul 15; 381(Pt 2):503-10. PMID: 15046617.
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Lee JK, Kim SH, Lewis EC, Azam T, Reznikov LL, Dinarello CA. Differences in signaling pathways by IL-1beta and IL-18. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8815-20. PMID: 15161979.
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Reznikov LL, Waksman J, Azam T, Kim SH, Bufler P, Niwa T, Werman A, Zhang X, Pischetsrieder M, Shaldon S, Dinarello CA. Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells. Clin Nephrol. 2004 May; 61(5):324-36. PMID: 15182127.
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Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis. Rheum Dis Clin North Am. 2004 May; 30(2):417-34, ix. PMID: 15172050.
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Lungstras-Bufler K, Bufler P, Abdullah R, Rutherford C, Endres S, Abraham E, Dinarello CA, Rodriguez RM. High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis. Eur Cytokine Netw. 2004 Apr-Jun; 15(2):135-8. PMID: 15319173.
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Schottelius AJ, Moldawer LL, Dinarello CA, Asadullah K, Sterry W, Edwards CK. Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol. 2004 Apr; 13(4):193-222. PMID: 15086336.
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Reddy P, Maeda Y, Hotary K, Liu C, Reznikov LL, Dinarello CA, Ferrara JL. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3921-6. PMID: 15001702.
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Dinarello CA. Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation. Immunity. 2004 Mar; 20(3):243-4. PMID: 15030767.
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Werman A, Werman-Venkert R, White R, Lee JK, Werman B, Krelin Y, Voronov E, Dinarello CA, Apte RN. The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2434-9. PMID: 14983027.
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Wang M, Sankula R, Tsai BM, Meldrum KK, Turrentine M, March KL, Brown JW, Dinarello CA, Meldrum DR. P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock. 2004 Feb; 21(2):170-4. PMID: 14752292.
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Park JW, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim SH, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):830-6. PMID: 14754758.
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Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha YH, Park JW, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):837-43. PMID: 14742296.
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Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res. 2004; 10(4):201-22. PMID: 15373964.
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Song X, Voronov E, Dvorkin T, Fima E, Cagnano E, Benharroch D, Shendler Y, Bjorkdahl O, Segal S, Dinarello CA, Apte RN. Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness. J Immunol. 2003 Dec 15; 171(12):6448-56. PMID: 14662844.
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Azam T, Novick D, Bufler P, Yoon DY, Rubinstein M, Dinarello CA, Kim SH. Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex. J Immunol. 2003 Dec 15; 171(12):6574-80. PMID: 14662859.
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Boss? P, Neumann D, Del Giudice E, Ciaramella A, Gloaguen I, Fantuzzi G, Dinarello CA, Di Carlo E, Musiani P, Meroni PL, Caselli G, Ruggiero P, Boraschi D. IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14181-6. PMID: 14615579.
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Bar D, Apte RN, Voronov E, Dinarello CA, Cohen S. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. FASEB J. 2004 Jan; 18(1):161-3. PMID: 14597552.
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Lonnemann G, Novick D, Rubinstein M, Dinarello CA. Interleukin-18, interleukin-18 binding protein and impaired production of interferon-gamma in chronic renal failure. Clin Nephrol. 2003 Nov; 60(5):327-34. PMID: 14640238.
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Stuyt RJ, Netea MG, Geijtenbeek TB, Kullberg BJ, Dinarello CA, van der Meer JW. Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes. Immunology. 2003 Nov; 110(3):329-34. PMID: 14632660.
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Nols?e RL, Pociot F, Novick D, Rubinstein M, Kim SH, Dinarello CA, Mandrup-Poulsen T. Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene. Ann N Y Acad Sci. 2003 Nov; 1005:332-9. PMID: 14679086.
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Roubenoff R, Parise H, Payette HA, Abad LW, D'Agostino R, Jacques PF, Wilson PW, Dinarello CA, Harris TB. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med. 2003 Oct 15; 115(6):429-35. PMID: 14563498.
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Rijneveld AW, Florquin S, Speelman P, Edwards CK, Dinarello CA, van der Poll T. Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia. Eur Cytokine Netw. 2003 Oct-Dec; 14(4):242-5. PMID: 14715417.
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Feezor RJ, Oberholzer C, Baker HV, Novick D, Rubinstein M, Moldawer LL, Pribble J, Souza S, Dinarello CA, Ertel W, Oberholzer A. Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun. 2003 Oct; 71(10):5803-13. PMID: 14500502.
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Selzman CH, Netea MG, Zimmerman MA, Weinberg A, Reznikov LL, Grover FL, Dinarello CA. Atherogenic effects of Chlamydia pneumoniae: refuting the innocent bystander hypothesis. J Thorac Cardiovasc Surg. 2003 Sep; 126(3):688-93. PMID: 14502140.
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Payette H, Roubenoff R, Jacques PF, Dinarello CA, Wilson PW, Abad LW, Harris T. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. J Am Geriatr Soc. 2003 Sep; 51(9):1237-43. PMID: 12919235.
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Fantuzzi G, Banda NK, Guthridge C, Vondracek A, Kim SH, Siegmund B, Azam T, Sennello JA, Dinarello CA, Arend WP. Generation and characterization of mice transgenic for human IL-18-binding protein isoform a. J Leukoc Biol. 2003 Nov; 74(5):889-96. PMID: 12960225.
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Dinarello CA, Fantuzzi G. Interleukin-18 and host defense against infection. J Infect Dis. 2003 Jun 15; 187 Suppl 2:S370-84. PMID: 12792854.
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Dinarello CA. Anti-cytokine therapeutics and infections. Vaccine. 2003 Jun 01; 21 Suppl 2:S24-34. PMID: 12763679.
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Gangemi S, Basile G, Merendino RA, Minciullo PL, Novick D, Rubinstein M, Dinarello CA, Lo Balbo C, Franceschi C, Basili S, D' Urbano E, Dav? G, Nicita-Mauro V, Romano M. Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity? Exp Gerontol. 2003 Jun; 38(6):669-72. PMID: 12814802.
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Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, Sawyer DB, Levy D, Wilson PW, D'Agostino RB. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation. 2003 Mar 25; 107(11):1486-91. PMID: 12654604.
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Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. PMID: 12595442.
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Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2645-50. PMID: 12598651.
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Banda NK, Vondracek A, Kraus D, Dinarello CA, Kim SH, Bendele A, Senaldi G, Arend WP. Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein. J Immunol. 2003 Feb 15; 170(4):2100-5. PMID: 12574381.
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Stuyt RJ, Kim SH, Reznikov LL, Fantuzzi G, Novick D, Rubinstein M, Kullberg BJ, van der Meer JW, Dinarello CA, Netea MG. Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF. Cytokine. 2003 Jan 21; 21(2):65-73. PMID: 12670445.
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Carrascal MT, Mendoza L, Valc?rcel M, Salado C, Egilegor E, Teller?a N, Vidal-Vanaclocha F, Dinarello CA. Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium. Cancer Res. 2003 Jan 15; 63(2):491-7. PMID: 12543807.
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Dinarello CA. Setting the cytokine trap for autoimmunity. Nat Med. 2003 Jan; 9(1):20-2. PMID: 12514715.
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Dinarello CA, Novick D, Rubinstein M, Lonnemann G. Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure. Blood Purif. 2003; 21(3):258-70. PMID: 12784053.
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Lonnemann G, Novick D, Rubinstein M, Passlick-Deetjen J, Lang D, Dinarello CA. A switch to high-flux helixone membranes reverses suppressed interferon-gamma production in patients on low-flux dialysis. Blood Purif. 2003; 21(3):225-31. PMID: 12784048.
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Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol. 2002 Sep-Oct; 20(5 Suppl 27):S1-13. PMID: 14989423.
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Kaser A, Novick D, Rubinstein M, Siegmund B, Enrich B, Koch RO, Vogel W, Kim SH, Dinarello CA, Tilg H. Interferon-alpha induces interleukin-18 binding protein in chronic hepatitis C patients. Clin Exp Immunol. 2002 Aug; 129(2):332-8. PMID: 12165091.
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Wyman TH, Dinarello CA, Banerjee A, Gamboni-Robertson F, Hiester AA, England KM, Kelher M, Silliman CC. Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation. J Leukoc Biol. 2002 Aug; 72(2):401-9. PMID: 12149432.
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Raeburn CD, Dinarello CA, Zimmerman MA, Calkins CM, Pomerantz BJ, McIntyre RC, Harken AH, Meng X. Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H650-7. PMID: 12124212.
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Yatsiv I, Morganti-Kossmann MC, Perez D, Dinarello CA, Novick D, Rubinstein M, Otto VI, Rancan M, Kossmann T, Redaelli CA, Trentz O, Shohami E, Stahel PF. Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab. 2002 Aug; 22(8):971-8. PMID: 12172382.
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Ariel A, Novick D, Rubinstein M, Dinarello CA, Lider O, Hershkoviz R. IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components. J Leukoc Biol. 2002 Jul; 72(1):192-8. PMID: 12101280.
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Stuyt RJ, Netea MG, Verschueren I, Fantuzzi G, Dinarello CA, Van Der Meer JW, Kullberg BJ. Role of interleukin-18 in host defense against disseminated Candida albicans infection. Infect Immun. 2002 Jun; 70(6):3284-6. PMID: 12011026.
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Corbaz A, ten Hove T, Herren S, Graber P, Schwartsburd B, Belzer I, Harrison J, Plitz T, Kosco-Vilbois MH, Kim SH, Dinarello CA, Novick D, van Deventer S, Chvatchko Y. IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease. J Immunol. 2002 Apr 01; 168(7):3608-16. PMID: 11907126.
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Netea MG, Kullberg BJ, Galama JM, Stalenhoef AF, Dinarello CA, Van der Meer JW. Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways. Eur J Immunol. 2002 04; 32(4):1188-95. PMID: 11932927.
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Netea MG, Stuyt RJ, Kim SH, Van der Meer JW, Kullberg BJ, Dinarello CA. The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures. J Infect Dis. 2002 Apr 01; 185(7):963-70. PMID: 11920321.
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Wieland CW, Siegmund B, Senaldi G, Vasil ML, Dinarello CA, Fantuzzi G. Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1. Infect Immun. 2002 Mar; 70(3):1352-8. PMID: 11854220.
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Im SH, Kim SH, Azam T, Venkatesh N, Dinarello CA, Fuchs S, Souroujon MC. Rat interleukin-18 binding protein: cloning, expression, and characterization. J Interferon Cytokine Res. 2002 Mar; 22(3):321-8. PMID: 12034039.
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Leoni F, Zaliani A, Bertolini G, Porro G, Pagani P, Pozzi P, Don? G, Fossati G, Sozzani S, Azam T, Bufler P, Fantuzzi G, Goncharov I, Kim SH, Pomerantz BJ, Reznikov LL, Siegmund B, Dinarello CA, Mascagni P. The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2995-3000. PMID: 11867742.
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Schultz MJ, Rijneveld AW, Florquin S, Edwards CK, Dinarello CA, van der Poll T. Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L285-90. PMID: 11792633.
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Kim SH, Azam T, Novick D, Yoon DY, Reznikov LL, Bufler P, Rubinstein M, Dinarello CA. Identification of amino acid residues critical for biological activity in human interleukin-18. J Biol Chem. 2002 Mar 29; 277(13):10998-1003. PMID: 11790772.
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Calkins CM, Bensard DD, Shames BD, Pulido EJ, Abraham E, Fernandez N, Meng X, Dinarello CA, McIntyre RC. IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res. 2002; 8(1):59-67. PMID: 11981446.
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Perales MA, Fantuzzi G, Goldberg SM, Turk MJ, Mortazavi F, Busam K, Houghton AN, Dinarello CA, Wolchok JD. GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines. Cytokines Cell Mol Ther. 2002; 7(3):125-33. PMID: 12850812.
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Zecchina G, Novick D, Rubinstein M, Barak V, Dinarello C, Nagler A. Interleukin-18 binding protein in acute graft versus host disease and engraftment following allogeneic peripheral blood stem cell transplants. J Hematother Stem Cell Res. 2001 Dec; 10(6):769-76. PMID: 11798503.
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Dinarello CA. Anti-cytokine therapies in response to systemic infection. J Investig Dermatol Symp Proc. 2001 Dec; 6(3):244-50. PMID: 11924836.
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Plater-Zyberk C, Joosten LA, Helsen MM, Sattonnet-Roche P, Siegfried C, Alouani S, van De Loo FA, Graber P, Aloni S, Cirillo R, Lubberts E, Dinarello CA, van Den Berg WB, Chvatchko Y. Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. J Clin Invest. 2001 Dec; 108(12):1825-32. PMID: 11748266.
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Dinarello CA. Novel targets for interleukin 18 binding protein. Ann Rheum Dis. 2001 Nov; 60 Suppl 3:iii18-24. PMID: 11890646.
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Siegmund B, Lehr HA, Fantuzzi G, Dinarello CA. IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13249-54. PMID: 11606779.
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Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, Dinarello CA, Endres S, Eigler A. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol. 2001 Oct; 281(4):R1264-73. PMID: 11557635.
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Marin V, Farnarier C, Gr?s S, Kaplanski S, Su MS, Dinarello CA, Kaplanski G. The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment. Blood. 2001 Aug 01; 98(3):667-73. PMID: 11468165.
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Stuyt RJ, Netea MG, Kim SH, Novick D, Rubinstein M, Kullberg BJ, Van der Meer JW, Dinarello CA. Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens. Infect Immun. 2001 Aug; 69(8):5025-30. PMID: 11447182.
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Cho YS, Kang JW, Cho M, Cho CW, Lee S, Choe YK, Kim Y, Choi I, Park SN, Kim S, Dinarello CA, Yoon DY. Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18. FEBS Lett. 2001 Jul 20; 501(2-3):139-45. PMID: 11470273.
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Lee SJ, Cho YS, Cho MC, Shim JH, Lee KA, Ko KK, Choe YK, Park SN, Hoshino T, Kim S, Dinarello CA, Yoon DY. Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells. J Immunol. 2001 Jul 01; 167(1):497-504. PMID: 11418688.
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Melnikov VY, Ecder T, Fantuzzi G, Siegmund B, Lucia MS, Dinarello CA, Schrier RW, Edelstein CL. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest. 2001 May; 107(9):1145-52. PMID: 11342578.
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Dinarello CA, Muegge K, Durum SK. Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay. Curr Protoc Immunol. 2001 May; Chapter 6:Unit 6.2. PMID: 18432810.
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Kim SH, Azam T, Yoon DY, Reznikov LL, Novick D, Rubinstein M, Dinarello CA. Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3304-9. PMID: 11248074.
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Pomerantz BJ, Reznikov LL, Harken AH, Dinarello CA. Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2871-6. PMID: 11226333.
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V?zquez-Torres A, Fantuzzi G, Edwards CK, Dinarello CA, Fang FC. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2561-5. PMID: 11226278.
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Fantuzzi G, Reed D, Qi M, Scully S, Dinarello CA, Senaldi G. Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity. Eur J Immunol. 2001 Feb; 31(2):369-75. PMID: 11180100.
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Kim SH, Reznikov LL, Stuyt RJ, Selzman CH, Fantuzzi G, Hoshino T, Young HA, Dinarello CA. Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. J Immunol. 2001 Jan 01; 166(1):148-54. PMID: 11123287.
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Dinarello CA, Pomerantz BJ. Proinflammatory cytokines in heart disease. Blood Purif. 2001; 19(3):314-21. PMID: 11244192.
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Joosten LA, van De Loo FA, Lubberts E, Helsen MM, Netea MG, van Der Meer JW, Dinarello CA, van Den Berg WB. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J Immunol. 2000 Dec 01; 165(11):6553-8. PMID: 11086098.
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Frishman JI, Edwards CK, Sonnenberg MG, Kohno T, Cohen AM, Dinarello CA. Tumor necrosis factor (TNF)-alpha-induced interleukin-8 in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors. J Infect Dis. 2000 Dec; 182(6):1722-30. PMID: 11069245.
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Dinarello CA. Targeting interleukin 18 with interleukin 18 binding protein. Ann Rheum Dis. 2000 Nov; 59 Suppl 1:i17-20. PMID: 11053080.
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Dinarello CA. The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N Engl J Med. 2000 Sep 07; 343(10):732-4. PMID: 10974140.
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Netea MG, Puren AJ, Dinarello CA. A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures. Eur Cytokine Netw. 2000 Sep; 11(3):379-82. PMID: 11022121.
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Dinarello CA. Proinflammatory cytokines. Chest. 2000 Aug; 118(2):503-8. PMID: 10936147.
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Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T. Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma. Eur Cytokine Netw. 2000 Jun; 11(2):193-205. PMID: 10903798.
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O'Neill LA, Dinarello CA. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today. 2000 May; 21(5):206-9. PMID: 10782049.
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Netea MG, Dinarello CA, Kullberg BJ, Jansen T, Jacobs L, Stalenhoef AF, Van Der Meer JW. Oxidation of low-density lipoproteins by acellular components of Chlamydia pneumoniae. J Infect Dis. 2000 May; 181(5):1868-70. PMID: 10823809.
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Netea MG, Fantuzzi G, Kullberg BJ, Stuyt RJ, Pulido EJ, McIntyre RC, Joosten LA, Van der Meer JW, Dinarello CA. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J Immunol. 2000 Mar 01; 164(5):2644-9. PMID: 10679104.
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Reznikov LL, Kim SH, Westcott JY, Frishman J, Fantuzzi G, Novick D, Rubinstein M, Dinarello CA. IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2174-9. PMID: 10681439.
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Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C, Fantuzzi G. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2367-72. PMID: 10681432.
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Kristiansen OP, Pociot F, Johannesen J, Bergholdt R, Dinarello CA, Nerup J, Mandrup-Poulsen T. Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus. Cytokine. 2000 Feb; 12(2):171-5. PMID: 10671304.
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Netea MG, Selzman CH, Kullberg BJ, Galama JM, Weinberg A, Stalenhoef AF, Van der Meer JW, Dinarello CA. Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells. Eur J Immunol. 2000 Feb; 30(2):541-9. PMID: 10671210.
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Kim SH, Eisenstein M, Reznikov L, Fantuzzi G, Novick D, Rubinstein M, Dinarello CA. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1190-5. PMID: 10655506.
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Vidal-Vanaclocha F, Fantuzzi G, Mendoza L, Fuentes AM, Anasagasti MJ, Mart?n J, Carrascal T, Walsh P, Reznikov LL, Kim SH, Novick D, Rubinstein M, Dinarello CA. IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):734-9. PMID: 10639148.
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Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med. 2000 Jan; 28(1):232-5. PMID: 10667529.
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Reznikov LL, Shames BD, Barton HA, Selzman CH, Fantuzzi G, Kim SH, Johnson SM, Dinarello CA. Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice. Am J Physiol Regul Integr Comp Physiol. 2000 Jan; 278(1):R263-70. PMID: 10644648.
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Sheridan BC, Dinarello CA, Meldrum DR, Fullerton DA, Selzman CH, McIntyre RC. Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury. Am J Physiol. 1999 11; 277(5):L861-7. PMID: 10564168.
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Fantuzzi G, Reed DA, Dinarello CA. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest. 1999 Sep; 104(6):761-7. PMID: 10491411.
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Dinarello CA. Interleukin-18. Methods. 1999 Sep; 19(1):121-32. PMID: 10525448.
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Dinarello CA. Is there an interleukin-1 genetic predisposition to developing severe sepsis? Crit Care Med. 1999 Jul; 27(7):1397-8. PMID: 10446846.
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Cain BS, Meldrum DR, Dinarello CA, Meng X, Joo KS, Banerjee A, Harken AH. Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit Care Med. 1999 Jul; 27(7):1309-18. PMID: 10446825.
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Stosic-Grujicic S, Basara N, Dinarello CA. Modulatory in vitro effects of interleukin-1 receptor antagonist (IL-1Ra) or antisense oligonucleotide to interleukin-1 beta converting enzyme (ICE) on acute myeloid leukaemia (AML) cell growth. Clin Lab Haematol. 1999 Jun; 21(3):173-85. PMID: 10448599.
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Granowitz EV, Porat R, Dinarello CA. Circulating leptin during experimental endotoxemia in humans. J Infect Dis. 1999 May; 179(5):1313-4. PMID: 10191247.
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Cain BS, Meldrum DR, Meng X, Dinarello CA, Shames BD, Banerjee A, Harken AH. p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function. J Surg Res. 1999 May 01; 83(1):7-12. PMID: 10210635.
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Reznikov LL, Fantuzzi G, Selzman CH, Shames BD, Barton HA, Bell H, McGregor JA, Dinarello CA. Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta. Biol Reprod. 1999 May; 60(5):1231-8. PMID: 10208989.
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Selzman CH, Shames BD, Reznikov LL, Miller SA, Meng X, Barton HA, Werman A, Harken AH, Dinarello CA, Banerjee A. Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation. Circ Res. 1999 Apr 30; 84(8):867-75. PMID: 10222332.
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Biasucci LM, Liuzzo G, Fantuzzi G, Caligiuri G, Rebuzzi AG, Ginnetti F, Dinarello CA, Maseri A. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation. 1999 Apr 27; 99(16):2079-84. PMID: 10217645.
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Netea MG, Kullberg BJ, Boerman OC, Verschueren I, Dinarello CA, Van der Meer JW. Soluble murine IL-1 receptor type I induces release of constitutive IL-1 alpha. J Immunol. 1999 Apr 15; 162(8):4876-81. PMID: 10202032.
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Puren AJ, Fantuzzi G, Dinarello CA. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2256-61. PMID: 10051628.
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Vannier E, Kaser A, Atkins MB, Fantuzzi G, Dinarello CA, Mier JW, Tilg H. Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy. Eur Cytokine Netw. 1999 Mar; 10(1):37-42. PMID: 10210771.
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Dinarello CA. Cytokines as endogenous pyrogens. J Infect Dis. 1999 Mar; 179 Suppl 2:S294-304. PMID: 10081499.
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Dinarello CA, Gatti S, Bartfai T. Fever: links with an ancient receptor. Curr Biol. 1999 Feb 25; 9(4):R147-50. PMID: 10074418.
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Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity. 1999 Jan; 10(1):127-36. PMID: 10023777.
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Faggioni R, Fantuzzi G, Gabay C, Moser A, Dinarello CA, Feingold KR, Grunfeld C. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol. 1999 01; 276(1):R136-42. PMID: 9887187.
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Dinarello CA. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 1999 Jan; 103(1 Pt 1):11-24. PMID: 9893178.
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Fantuzzi G, Dinarello CA. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J Clin Immunol. 1999 Jan; 19(1):1-11. PMID: 10080100.
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Puren AJ, Razeghi P, Fantuzzi G, Dinarello CA. Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures. J Infect Dis. 1998 Dec; 178(6):1830-4. PMID: 9815245.
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Meldrum DR, Dinarello CA, Shames BD, Cleveland JC, Cain BS, Banerjee A, Meng X, Harken AH. Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning. Circulation. 1998 Nov 10; 98(19 Suppl):II214-8; discussion II218-9. PMID: 9852905.
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Freeman LM, Rush JE, Kehayias JJ, Ross JN, Meydani SN, Brown DJ, Dolnikowski GG, Marmor BN, White ME, Dinarello CA, Roubenoff R. Nutritional alterations and the effect of fish oil supplementation in dogs with heart failure. J Vet Intern Med. 1998 Nov-Dec; 12(6):440-8. PMID: 9857337.
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Shapiro L, Puren AJ, Barton HA, Novick D, Peskind RL, Shenkar R, Gu Y, Su MS, Dinarello CA. Interleukin 18 stimulates HIV type 1 in monocytic cells. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12550-5. PMID: 9770523.
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Reznikov LL, Puren AJ, Fantuzzi G, M?hl H, Shapiro L, Yoon DY, Cutler DL, Dinarello CA. Spontaneous and inducible cytokine responses in healthy humans receiving a single dose of IFN-alpha2b: increased production of interleukin-1 receptor antagonist and suppression of IL-1-induced IL-8. J Interferon Cytokine Res. 1998 Oct; 18(10):897-903. PMID: 9809626.
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Dinarello CA. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci. 1998 Sep 29; 856:1-11. PMID: 9917859.
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Fraenkel L, Roubenoff R, LaValley M, McAlindon T, Chaisson C, Evans S, Harris T, Dinarello CA, Felson DT. The association of peripheral monocyte derived interleukin 1beta (IL-1beta), IL-1 receptor antagonist, and tumor necrosis factor-alpha with osteoarthritis in the elderly. J Rheumatol. 1998 Sep; 25(9):1820-6. PMID: 9733466.
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Meldrum DR, Meng X, Dinarello CA, Ayala A, Cain BS, Shames BD, Ao L, Banerjee A, Harken AH. Human myocardial tissue TNFalpha expression following acute global ischemia in vivo. J Mol Cell Cardiol. 1998 Sep; 30(9):1683-9. PMID: 9769224.
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Meldrum DR, Dinarello CA, Cleveland JC, Cain BS, Shames BD, Meng X, Harken AH. Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism. Surgery. 1998 Aug; 124(2):291-6; discussion 297. PMID: 9706151.
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Shapiro L, Heidenreich KA, Meintzer MK, Dinarello CA. Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7422-6. PMID: 9636165.
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Pfeffer LM, Dinarello CA, Herberman RB, Williams BR, Borden EC, Bordens R, Walter MR, Nagabhushan TL, Trotta PP, Pestka S. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 1998 Jun 15; 58(12):2489-99. PMID: 9635566.
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Larsen CM, Wadt KA, Juhl LF, Andersen HU, Karlsen AE, Su MS, Seedorf K, Shapiro L, Dinarello CA, Mandrup-Poulsen T. Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem. 1998 Jun 12; 273(24):15294-300. PMID: 9614146.
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Dinarello CA, Novick D, Puren AJ, Fantuzzi G, Shapiro L, M?hl H, Yoon DY, Reznikov LL, Kim SH, Rubinstein M. Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol. 1998 Jun; 63(6):658-64. PMID: 9620656.
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Jouvenne P, Vannier E, Dinarello CA, Miossec P. Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: correlations with markers of inflammation and joint destruction. Arthritis Rheum. 1998 Jun; 41(6):1083-9. PMID: 9627018.
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Rubinstein M, Dinarello CA, Oppenheim JJ, Hertzog P. Recent advances in cytokines, cytokine receptors and signal transduction. Cytokine Growth Factor Rev. 1998 Jun; 9(2):175-81. PMID: 9754711.
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Walter MR, Bordens R, Nagabhushan TL, Williams BR, Herberman RB, Dinarello CA, Borden EC, Trotta PP, Pestka S, Pfeffer LM. Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon. Cancer Biother Radiopharm. 1998 Jun; 13(3):143-54. PMID: 10850350.
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Badovinac V, Mostarica-Stojkovic M, Dinarello CA, Stosic-Grujicic S. Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of encephalitogenic cells. J Neuroimmunol. 1998 May 01; 85(1):87-95. PMID: 9627001.
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Cain BS, Meldrum DR, Dinarello CA, Meng X, Banerjee A, Harken AH. Adenosine reduces cardiac TNF-alpha production and human myocardial injury following ischemia-reperfusion. J Surg Res. 1998 May; 76(2):117-23. PMID: 9698510.
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Yoon DY, Dinarello CA. Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein. J Immunol. 1998 Apr 01; 160(7):3170-9. PMID: 9531272.
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Fantuzzi G, Puren AJ, Harding MW, Livingston DJ, Dinarello CA. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood. 1998 Mar 15; 91(6):2118-25. PMID: 9490698.
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Barak V, Nisman B, Polliack A, Vannier E, Dinarello CA. Correlation of serum levels of interleukin-1 family members with disease activity and response to treatment in hairy cell leukemia. Eur Cytokine Netw. 1998 Mar; 9(1):33-9. PMID: 9613675.
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Fantuzzi G, Dinarello CA. Stem cell factor-deficient mice have a dysregulation of cytokine production during local inflammation. Eur Cytokine Netw. 1998 Mar; 9(1):85-92. PMID: 9613682.
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Puren AJ, Fantuzzi G, Gu Y, Su MS, Dinarello CA. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest. 1998 Feb 01; 101(3):711-21. PMID: 9449707.
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Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR, Grunfeld C. IL-1 beta mediates leptin induction during inflammation. Am J Physiol. 1998 01; 274(1):R204-8. PMID: 9458919.
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Jaber BL, Gonski JA, Cendoroglo M, Balakrishnan VS, Razeghi P, Dinarello CA, Pereira BJ. New polyether sulfone dialyzers attenuate passage of cytokine-inducing substances from pseudomonas aeruginosa contaminated dialysate. Blood Purif. 1998; 16(4):210-9. PMID: 9736790.
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Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA. Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci. 1998 Jan; 53(1):M20-6. PMID: 9467429.
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Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol. 1998; 16(5-6):457-99. PMID: 9646173.
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Dinarello CA. Interleukin-1. Cytokine Growth Factor Rev. 1997 Dec; 8(4):253-65. PMID: 9620641.
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Chernow B, Dinarello CA. Introduction: surviving septic shock. Chest. 1997 Dec; 112(6 Suppl):320S. PMID: 9400896.
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Dinarello CA. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest. 1997 Dec; 112(6 Suppl):321S-329S. PMID: 9400897.
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M?hl H, Dinarello CA. Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine. J Immunol. 1997 Nov 15; 159(10):5063-9. PMID: 9366434.
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Dinarello CA. Blocking interleukin-1 and tumor necrosis factor in disease. Eur Cytokine Netw. 1997 Sep; 8(3):294-6. PMID: 9346365.
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Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today. 1997 Sep; 18(9):428-32. PMID: 9293158.
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van Deuren M, van der Ven-Jongekrijg J, Vannier E, van Dalen R, Pesman G, Bartelink AK, Dinarello CA, van der Meer JW. The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections. Blood. 1997 Aug 01; 90(3):1101-8. PMID: 9242541.
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Fantuzzi G, Sacco S, Ghezzi P, Dinarello CA. Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation. Am J Physiol. 1997 Jul; 273(1 Pt 2):R400-6. PMID: 9249578.
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Dinarello CA. Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings. J Biol Regul Homeost Agents. 1997 Jul-Sep; 11(3):91-103. PMID: 9498158.
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Dinarello CA. Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 1997 Jun; 24(3 Suppl 9):S9-81-S9-93. PMID: 9208877.
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Kaplanski G, Fabrigoule M, Boulay V, Dinarello CA, Bongrand P, Kaplanski S, Farnarier C. Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression. J Immunol. 1997 Jun 01; 158(11):5435-41. PMID: 9164965.
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Dinarello CA, Bunn PA. Fever. Semin Oncol. 1997 Jun; 24(3):288-98. PMID: 9208885.
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Le Tulzo Y, Shenkar R, Kaneko D, Moine P, Fantuzzi G, Dinarello CA, Abraham E. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. J Clin Invest. 1997 Apr 01; 99(7):1516-24. PMID: 9119995.
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Alheim K, Chai Z, Fantuzzi G, Hasanvan H, Malinowsky D, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T. Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2681-6. PMID: 9122256.
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Shapiro L, Dinarello CA. Hyperosmotic stress as a stimulant for proinflammatory cytokine production. Exp Cell Res. 1997 Mar 15; 231(2):354-62. PMID: 9087177.
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Roubenoff R, Freeman LM, Smith DE, Abad LW, Dinarello CA, Kehayias JJ. Adjuvant arthritis as a model of inflammatory cachexia. Arthritis Rheum. 1997 Mar; 40(3):534-9. PMID: 9082942.
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Du Bois JS, Trehu EG, Mier JW, Shapiro L, Epstein M, Klempner M, Dinarello C, Kappler K, Ronayne L, Rand W, Atkins MB. Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma. J Clin Oncol. 1997 Mar; 15(3):1052-62. PMID: 9060545.
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Fantuzzi G, Ku G, Harding MW, Livingston DJ, Sipe JD, Kuida K, Flavell RA, Dinarello CA. Response to local inflammation of IL-1 beta-converting enzyme- deficient mice. J Immunol. 1997 Feb 15; 158(4):1818-24. PMID: 9029121.
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Aiura K, Clark BD, Dinarello CA, Margolis NH, Kaplanski G, Burke JF, Tompkins RG, Gelfand JA. Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells. J Infect Dis. 1997 Jan; 175(1):123-9. PMID: 8985205.
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Clark BD, Ikejima T, Mancilla J, Orencole SF, Sirko SP, Ishii N, Okuda K, Dinarello CA. An antibody to a 17 amino acid synthetic peptide of the type I interleukin-1 receptor preferentially blocks interleukin-1 beta binding. J Interferon Cytokine Res. 1996 Dec; 16(12):1079-88. PMID: 8974012.
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Pereira BJ, Sundaram S, Barrett TW, Butt NK, Porat R, King AJ, Dinarello CA. Transfer of cytokine-inducing bacterial products across hemodialyzer membranes in the presence of plasma or whole blood. Clin Nephrol. 1996 Dec; 46(6):394-401. PMID: 8982556.
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Rall LC, Roubenoff R, Cannon JG, Abad LW, Dinarello CA, Meydani SN. Effects of progressive resistance training on immune response in aging and chronic inflammation. Med Sci Sports Exerc. 1996 Nov; 28(11):1356-65. PMID: 8933485.
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Fuchs AC, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Radwanski E, Affrime MB, Cutler DL, Grint PC, Dinarello CA. Clinical, hematologic, and immunologic effects of interleukin-10 in humans. J Clin Immunol. 1996 Sep; 16(5):291-303. PMID: 8886999.
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Trehu EG, Mier JW, Dubois JS, Sorce D, Klempner MS, Epstein M, Dinarello CA, Shapiro L, Kappler K, Ronayne L, Atkins MB. Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera. Clin Cancer Res. 1996 Aug; 2(8):1341-51. PMID: 9816306.
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Fantuzzi G, Zheng H, Faggioni R, Benigni F, Ghezzi P, Sipe JD, Shaw AR, Dinarello CA. Effect of endotoxin in IL-1 beta-deficient mice. J Immunol. 1996 Jul 01; 157(1):291-6. PMID: 8683129.
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Torcia M, Lucibello M, Vannier E, Fabiani S, Miliani A, Guidi G, Spada O, Dower SK, Sims JE, Shaw AR, Dinarello CA, Garaci E, Cozzolino F. Modulation of osteoclast-activating factor activity of multiple myeloma bone marrow cells by different interleukin-1 inhibitors. Exp Hematol. 1996 Jul; 24(8):868-74. PMID: 8690044.
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Rall LC, Rosen CJ, Dolnikowski G, Hartman WJ, Lundgren N, Abad LW, Dinarello CA, Roubenoff R. Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha. Arthritis Rheum. 1996 Jul; 39(7):1115-24. PMID: 8670319.
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Ye K, Vannier E, Clark BD, Sims JE, Dinarello CA. Three distinct promoters direct transcription of different 5' untranslated regions of the human interleukin 1 type I receptor: a possible mechanism for control of translation. Cytokine. 1996 Jun; 8(6):421-9. PMID: 8818538.
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Dinarello CA. Thermoregulation and the pathogenesis of fever. Infect Dis Clin North Am. 1996 Jun; 10(2):433-49. PMID: 8803628.
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Takabayashi T, Vannier E, Clark BD, Margolis NH, Dinarello CA, Burke JF, Gelfand JA. A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis. J Immunol. 1996 May 01; 156(9):3455-60. PMID: 8617973.
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Granowitz EV, Saget BM, Angel JB, Wang MZ, Wang A, Dinarello CA, Skolnik PR. Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Apr 15; 11(5):430-7. PMID: 8605587.
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Vannier E, de Waal Malefyt R, Salazar-Montes A, de Vries JE, Dinarello CA. Interleukin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein. Blood. 1996 Apr 15; 87(8):3307-15. PMID: 8605347.
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Thea DM, Porat R, Nagimbi K, Baangi M, St Louis ME, Kaplan G, Dinarello CA, Keusch GT. Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann Intern Med. 1996 Apr 15; 124(8):757-62. PMID: 8633837.
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Fantuzzi G, Dinarello CA. The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice. J Leukoc Biol. 1996 Apr; 59(4):489-93. PMID: 8613694.
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Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996 Mar 15; 87(6):2095-147. PMID: 8630372.
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Benigni F, Fantuzzi G, Sacco S, Sironi M, Pozzi P, Dinarello CA, Sipe JD, Poli V, Cappelletti M, Paonessa G, Pennica D, Panayotatos N, Ghezzi P. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Blood. 1996 Mar 01; 87(5):1851-4. PMID: 8634432.
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Vidal-Vanaclocha F, Alvarez A, Asumendi A, Urcelay B, Tonino P, Dinarello CA. Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro. J Natl Cancer Inst. 1996 Feb 21; 88(3-4):198-205. PMID: 8632494.
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Endres S, Whitaker RE, Ghorbani R, Meydani SN, Dinarello CA. Oral aspirin and ibuprofen increase cytokine-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo. Immunology. 1996 Feb; 87(2):264-70. PMID: 8698389.
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Dinarello CA, Roubenoff RA. Mechanisms of loss of lean body mass in patients on chronic dialysis. Blood Purif. 1996; 14(5):388-94. PMID: 8894134.
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Dinarello CA, Roubenoff R. George Clowes' classic paper and the search for "muscle proteolysis factor". Nutrition. 1996 Jan; 12(1):67-8. PMID: 8838846.
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Dinarello CA. Cytokines as mediators in the pathogenesis of septic shock. Curr Top Microbiol Immunol. 1996; 216:133-65. PMID: 8791739.
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Pomianek MJ, Colton CK, Dinarello CA, Miller LC. Synthesis of tumor necrosis factor alpha and interleukin-1 receptor antagonist, but not interleukin-1, by human mononuclear cells is enhanced by exposure of whole blood to shear stress. ASAIO J. 1996 Jan-Feb; 42(1):52-9. PMID: 8808459.
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McKenzie RC, Oran A, Dinarello CA, Sauder DN. Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo. Anticancer Res. 1996 Jan-Feb; 16(1):437-41. PMID: 8615650.
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Shapiro L, Dinarello CA. Osmotic regulation of cytokine synthesis in vitro. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12230-4. PMID: 8618875.
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Kaplanski G, Teysseire N, Farnarier C, Kaplanski S, Lissitzky JC, Durand JM, Soubeyrand J, Dinarello CA, Bongrand P. IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway. J Clin Invest. 1995 Dec; 96(6):2839-44. PMID: 8675654.
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Beasley D, McGuiggin ME, Dinarello CA. Human vascular smooth muscle cells produce an intracellular form of interleukin-1 receptor antagonist. Am J Physiol. 1995 Oct; 269(4 Pt 1):C961-8. PMID: 7485466.
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Tilg H, Atkins MB, Dinarello CA, Mier JW. Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy. Cytokine. 1995 Oct; 7(7):734-9. PMID: 8580384.
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Angel JB, Saget BM, Walsh SP, Greten TF, Dinarello CA, Skolnik PR, Endres S. Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication. AIDS. 1995 Oct; 9(10):1137-44. PMID: 8519449.
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Bergholdt R, Karlsen AE, Johannesen J, Hansen PM, Dinarello CA, Nerup J, Pociot F. Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood. Cytokine. 1995 Oct; 7(7):727-33. PMID: 8580383.
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Dinarello CA. Controlling the production of interleukin-1 and tumor necrosis factor in disease. Nutrition. 1995 Sep-Oct; 11(5 Suppl):695-7. PMID: 8748255.
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Dinarello CA. Interleukin-1 and interleukin-1 receptor antagonist. Nutrition. 1995 Sep-Oct; 11(5 Suppl):492-4. PMID: 8748206.
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Granowitz EV, Saget BM, Wang MZ, Dinarello CA, Skolnik PR. Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1. Mol Med. 1995 Sep; 1(6):667-77. PMID: 8529133.
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Kondo S, Pastore S, Fujisawa H, Shivji GM, McKenzie RC, Dinarello CA, Sauder DN. Interleukin-1 receptor antagonist suppresses contact hypersensitivity. J Invest Dermatol. 1995 Sep; 105(3):334-8. PMID: 7665908.
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Miller LC, Sharma A, McKusick AF, Tassoni JP, Dinarello CA, Kaplan MM. Synthesis of interleukin-1 beta in primary biliary cirrhosis: relationship to treatment with methotrexate or colchicine and disease progression. Hepatology. 1995 Aug; 22(2):518-24. PMID: 7635420.
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Schindler R, Dinarello CA, Koch KM. Angiotensin-converting-enzyme inhibitors suppress synthesis of tumour necrosis factor and interleukin 1 by human peripheral blood mononuclear cells. Cytokine. 1995 Aug; 7(6):526-33. PMID: 8580368.
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Mileno MD, Margolis NH, Clark BD, Dinarello CA, Burke JF, Gelfand JA. Coagulation of whole blood stimulates interleukin-1 beta gene expression. J Infect Dis. 1995 Jul; 172(1):308-11. PMID: 7797938.
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Angel JB, Saget BM, Wang MZ, Wang A, Dinarello CA, Skolnik PR. Interleukin-10 enhances human immunodeficiency virus type 1 expression in a chronically infected promonocytic cell line (U1) by a tumor necrosis factor alpha-independent mechanism. J Interferon Cytokine Res. 1995 Jun; 15(6):575-84. PMID: 7553227.
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Dinarello CA, Margolis NH. Cytokine-processing enzymes. Stopping the cuts. Curr Biol. 1995 Jun 01; 5(6):587-90. PMID: 7552162.
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Pereira BJ, Dinarello CA. Role of cytokines in patients on dialysis. Int J Artif Organs. 1995 Jun; 18(6):293-304. PMID: 8593963.
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Chernoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, Angel JB, Kennedy JS, Rabson AR, Wolff SM, Dinarello CA. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J Immunol. 1995 May 15; 154(10):5492-9. PMID: 7730651.
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Lonnemann G, Shapiro L, Engler-Blum G, M?ller GA, Koch KM, Dinarello CA. Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts. Kidney Int. 1995 Mar; 47(3):837-44. PMID: 7752582.
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Lonnemann G, Engler-Blum G, M?ller GA, Koch KM, Dinarello CA. Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts. Kidney Int. 1995 Mar; 47(3):845-54. PMID: 7752583.
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Stosic-Grujicic S, Basara N, Milenkovic P, Dinarello CA. Modulation of acute myeloblastic leukemia (AML) cell proliferation and blast colony formation by antisense oligomer for IL-1 beta converting enzyme (ICE) and IL-1 receptor antagonist (IL-1ra). J Chemother. 1995 Feb; 7(1):67-70. PMID: 7629564.
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Fantuzzi G, Benigni F, Sironi M, Conni M, Carelli M, Cantoni L, Shapiro L, Dinarello CA, Sipe JD, Ghezzi P. Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice. Cytokine. 1995 Feb; 7(2):150-6. PMID: 7780034.
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Chomarat P, Vannier E, Dechanet J, Rissoan MC, Banchereau J, Dinarello CA, Miossec P. Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10. J Immunol. 1995 Feb 01; 154(3):1432-9. PMID: 7822808.
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Tilg H, Vogel W, Dinarello CA. Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans. Blood. 1995 Jan 15; 85(2):433-5. PMID: 7811997.
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Dinarello CA. Interleukin-1 and interleukin-1 receptor antagonist production during haemodialysis: which cytokine is a surrogate marker for dialysis-related complications? Nephrol Dial Transplant. 1995; 10 Suppl 3:25-8. PMID: 7494610.
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Mandrup-Poulsen T, Wogensen LD, Jensen M, Svensson P, Nilsson P, Emdal T, M?lvig J, Dinarello CA, Nerup J. Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Crit Care Med. 1995 Jan; 23(1):26-33. PMID: 8001382.
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Mancilla-Ram?rez J, Dinarello CA, Santos-Preciado JI. [Phosphatidylcholine induces an increase in the production of interleukin-6 and improves survival of rats with neonatal sepsis caused by Klebsiella pneumoniae]. Gac Med Mex. 1995 Jan-Feb; 131(1):14-22. PMID: 7493735.
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Roubenoff R, Roubenoff RA, Selhub J, Nadeau MR, Cannon JG, Freeman LM, Dinarello CA, Rosenberg IH. Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation. Arthritis Rheum. 1995 Jan; 38(1):105-9. PMID: 7818558.
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Vogels MT, Mensink EJ, Ye K, Boerman OC, Verschueren CM, Dinarello CA, van der Meer JW. Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection. J Immunol. 1994 Dec 15; 153(12):5772-80. PMID: 7989774.
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Kaplanski G, Farnarier C, Kaplanski S, Porat R, Shapiro L, Bongrand P, Dinarello CA. Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism. Blood. 1994 Dec 15; 84(12):4242-8. PMID: 7994038.
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Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994 Dec; 8(15):1314-25. PMID: 8001745.
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Shapiro L, Panayotatos N, Meydani SN, Wu D, Dinarello CA. Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro. Exp Cell Res. 1994 Nov; 215(1):51-6. PMID: 7957680.
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Dinarello CA. The biological properties of interleukin-1. Eur Cytokine Netw. 1994 Nov-Dec; 5(6):517-31. PMID: 7727685.
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Dinarello CA. To Sheldon M. Wolff, as we commemorate the 10th anniversary of the clonings of IL-1 alpha and IL-1 beta. Eur Cytokine Netw. 1994 Nov-Dec; 5(6):513-6. PMID: 7727684.
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Mandrup-Poulsen T, Pociot F, M?lvig J, Shapiro L, Nilsson P, Emdal T, R?der M, Kjems LL, Dinarello CA, Nerup J. Monokine antagonism is reduced in patients with IDDM. Diabetes. 1994 Oct; 43(10):1242-7. PMID: 7926295.
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Dinarello CA. Interleukin-1 antagonists. J Interferon Res. 1994 Oct; 14(5):307. PMID: 7861041.
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Dinarello CA. Interleukin-1 in disease. Keio J Med. 1994 Sep; 43(3):131-6. PMID: 7967307.
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Dirkes K, Harris BH, Connolly RJ, Schwaitzberg SD, Dinarello CA, Gelfand JA. Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia. J Pediatr Surg. 1994 Aug; 29(8):1055-7; discussion 1057-8. PMID: 7965505.
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Santos AA, Rodrick ML, Jacobs DO, Dinarello CA, Wolff SM, Mannick JA, Wilmore DW. Does the route of feeding modify the inflammatory response? Ann Surg. 1994 Aug; 220(2):155-63. PMID: 8053737.
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Wakabayashi G, Cannon JG, Gelfand JA, Clark BD, Aiura K, Burke JF, Wolff SM, Dinarello CA. Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits. Am J Physiol. 1994 Jul; 267(1 Pt 2):R329-36. PMID: 8048640.
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Lynch EA, Dinarello CA, Cannon JG. Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion. J Immunol. 1994 Jul 01; 153(1):300-6. PMID: 8207243.
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Dinarello CA. Is there a role for interleukin-1 blockade in intravenous immunoglobulin therapy? Immunol Rev. 1994 Jun; 139:173-88. PMID: 7927411.
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Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, Dinarello CA, Rosenberg IH. Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest. 1994 Jun; 93(6):2379-86. PMID: 8200971.
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Vidal-Vanaclocha F, Am?zaga C, Asumendi A, Kaplanski G, Dinarello CA. Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Res. 1994 May 15; 54(10):2667-72. PMID: 8168095.
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Proud D, Gwaltney JM, Hendley JO, Dinarello CA, Gillis S, Schleimer RP. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds. J Infect Dis. 1994 May; 169(5):1007-13. PMID: 8169385.
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Mester M, Carter EA, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD. Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia. Surgery. 1994 May; 115(5):588-96. PMID: 8178258.
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Vannier E, Dinarello CA. Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. J Biol Chem. 1994 Apr 01; 269(13):9952-6. PMID: 7511596.
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Tilg H, Shapiro L, Vannier E, Poutsiaka DD, Trehu E, Atkins MB, Dinarello CA, Mier JW. Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro. J Immunol. 1994 Mar 15; 152(6):3189-98. PMID: 8144913.
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Pereira BJ, Shapiro L, King AJ, Falagas ME, Strom JA, Dinarello CA. Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients. Kidney Int. 1994 Mar; 45(3):890-6. PMID: 8196293.
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Tilg H, Trehu E, Shapiro L, Pape D, Atkins MB, Dinarello CA, Mier JW. Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans. Cytokine. 1994 Mar; 6(2):215-9. PMID: 8032003.
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Santos AA, Browning JL, Scheltinga MR, Lynch EA, Brown EF, Lawton P, Chambers E, Dougas I, Benjamin CD, Dinarello CA, et al. Are events after endotoxemia related to circulating phospholipase A2? Ann Surg. 1994 Feb; 219(2):183-92. PMID: 8129489.
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Manetti R, Barak V, Piccinni MP, Sampognaro S, Parronchi P, Maggi E, Dinarello CA, Romagnani S. Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones. Res Immunol. 1994 Feb; 145(2):93-100. PMID: 8079050.
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Granowitz EV, Porat R, Gelfand JA, Wolff SM, Dinarello CA. Administration of low-dose endotoxin to healthy humans increases C5a binding to circulating neutrophils. J Infect Dis. 1994 Feb; 169(2):480-2. PMID: 8106792.
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Reinisch N, Wolkersdorfer M, K?hler CM, Ye K, Dinarello CA, Wiedermann CJ. Interleukin-1 receptor type I mRNA in mouse brain as affected by peripheral administration of bacterial lipopolysaccharide. Neurosci Lett. 1994 Jan 31; 166(2):165-7. PMID: 8177494.
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Schir? R, Longoni D, Rossi V, Maglia O, Doni A, Arsura M, Carrara G, Masera G, Vannier E, Dinarello CA, et al. Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist. Blood. 1994 Jan 15; 83(2):460-5. PMID: 8286744.
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Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 1994 Jan 01; 83(1):113-8. PMID: 8274730.
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Dinarello CA. Blocking interleukin-1 receptors. Int J Clin Lab Res. 1994; 24(2):61-79. PMID: 7919431.
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Latini R, Bianchi M, Correale E, Dinarello CA, Fantuzzi G, Fresco C, Maggioni AP, Mengozzi M, Romano S, Shapiro L, et al. Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist. J Cardiovasc Pharmacol. 1994 Jan; 23(1):1-6. PMID: 7511719.
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Pereira BJ, Dinarello CA. Production of cytokines and cytokine inhibitory proteins in patients on dialysis. Nephrol Dial Transplant. 1994; 9 Suppl 2:60-71. PMID: 8065618.
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Pociot F, R?nningen KS, Bergholdt R, Lorenzen T, Johannesen J, Ye K, Dinarello CA, Nerup J. Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood. Autoimmunity. 1994; 19(3):169-78. PMID: 7605869.
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Dinarello CA. Interleukin-1. Adv Pharmacol. 1994; 25:21-51. PMID: 8204502.
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Pereira BJ, King AJ, Falagas ME, Dinarello CA. Interleukin-1 receptor antagonist: an index of dialysis-induced interleukin-1 production. Nephron. 1994; 67(3):358-61. PMID: 7936030.
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Poutsiaka DD, Mengozzi M, Vannier E, Sinha B, Dinarello CA. Cross-linking of the beta-glucan receptor on human monocytes results in interleukin-1 receptor antagonist but not interleukin-1 production. Blood. 1993 Dec 15; 82(12):3695-700. PMID: 7505123.
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Endres S, Meydani SN, Ghorbani R, Schindler R, Dinarello CA. Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J Leukoc Biol. 1993 Dec; 54(6):599-603. PMID: 8245713.
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Tilg H, Vogel W, Wiedermann CJ, Shapiro L, Herold M, Judmaier G, Dinarello CA. Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease. Hepatology. 1993 Nov; 18(5):1132-8. PMID: 8225219.
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Tilg H, Vannier E, Vachino G, Dinarello CA, Mier JW. Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells. J Exp Med. 1993 Nov 01; 178(5):1629-36. PMID: 7693853.
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Dinarello CA, Cannon JG. Cytokine measurements in septic shock. Ann Intern Med. 1993 Oct 15; 119(8):853-4. PMID: 8379607.
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Cannon JG, Nerad JL, Poutsiaka DD, Dinarello CA. Measuring circulating cytokines. J Appl Physiol (1985). 1993 Oct; 75(4):1897-902. PMID: 8282648.
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Erroi A, Fantuzzi G, Mengozzi M, Sironi M, Orencole SF, Clark BD, Dinarello CA, Isetta A, Gnocchi P, Giovarelli M, et al. Differential regulation of cytokine production in lipopolysaccharide tolerance in mice. Infect Immun. 1993 Oct; 61(10):4356-9. PMID: 8406825.
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Shapiro L, Zhang XX, Rupp RG, Wolff SM, Dinarello CA. Ciliary neurotrophic factor is an endogenous pyrogen. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8614-8. PMID: 8378338.
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Tilg H, Shapiro L, Atkins MB, Dinarello CA, Mier JW. Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1 receptor antagonist and soluble tumor necrosis factor receptor (p75) chimera. J Immunol. 1993 Sep 15; 151(6):3299-307. PMID: 8397255.
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Mancilla-Ram?rez J, Ram?rez-Herrera M, Portillo-G?mez L, Gait?n-Meza J, Dinarello CA. [Antagonists in neonatal sepsis]. Bol Med Hosp Infant Mex. 1993 Sep; 50(9):691-3. PMID: 7690571.
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Tilg H, Pape D, Trehu E, Shapiro L, Atkins MB, Dinarello CA, Mier JW. A method for the detection of erythrocyte-bound interleukin-8 in humans during interleukin-1 immunotherapy. J Immunol Methods. 1993 Aug 09; 163(2):253-8. PMID: 8354894.
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Granowitz EV, Porat R, Mier JW, Orencole SF, Kaplanski G, Lynch EA, Ye K, Vannier E, Wolff SM, Dinarello CA. Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans. J Immunol. 1993 Aug 01; 151(3):1637-45. PMID: 7687636.
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Aiura K, Gelfand JA, Burke JF, Thompson RC, Dinarello CA. Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits. Infect Immun. 1993 Aug; 61(8):3342-50. PMID: 8335365.
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Rambaldi A, Torcia M, Dinarello CA, Barbui T, Cozzolino F. Modulation of cell proliferation and cytokine production in AML by recombinant interleukin-1 receptor antagonist. Leukemia. 1993 Aug; 7 Suppl 2:S10-2. PMID: 8361209.
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Zumsteg U, Reimers JI, Pociot F, M?rch L, Helqvist S, Brendel M, Alejandro R, Mandrup-Poulsen T, Dinarello CA, Nerup J. Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats. Diabetologia. 1993 Aug; 36(8):759-66. PMID: 8405744.
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Pereira BJ, King AJ, Poutsiaka DD, Strom JA, Dinarello CA. Comparison of first use and reuse of cuprophan membranes on interleukin-1 receptor antagonist and interleukin-1 beta production by blood mononuclear cells. Am J Kidney Dis. 1993 Aug; 22(2):288-95. PMID: 8352255.
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Meydani SN, Lichtenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA, Schaefer EJ. Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment. J Clin Invest. 1993 Jul; 92(1):105-13. PMID: 8325975.
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Vannier E, Dinarello CA. Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. J Clin Invest. 1993 Jul; 92(1):281-7. PMID: 8325995.
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Mester M, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD. Intestinal production of interleukin-1 alpha during endotoxemia in the mouse. J Surg Res. 1993 Jun; 54(6):584-91. PMID: 8412068.
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Shapiro L, Clark BD, Orencole SF, Poutsiaka DD, Granowitz EV, Dinarello CA. Detection of tumor necrosis factor soluble receptor p55 in blood samples from healthy and endotoxemic humans. J Infect Dis. 1993 Jun; 167(6):1344-50. PMID: 8388902.
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Dinarello CA. Modalities for reducing interleukin 1 activity in disease. Immunol Today. 1993 Jun; 14(6):260-4. PMID: 8397767.
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Coceani F, Lees J, Mancilla J, Belizario J, Dinarello CA. Interleukin-6 and tumor necrosis factor in cerebrospinal fluid: changes during pyrogen fever. Brain Res. 1993 May 28; 612(1-2):165-71. PMID: 8330197.
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Kaplanski G, Porat R, Aiura K, Erban JK, Gelfand JA, Dinarello CA. Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood. 1993 May 15; 81(10):2492-5. PMID: 8490165.
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Tilg H, Mier JW, Vogel W, Aulitzky WE, Wiedermann CJ, Vannier E, Huber C, Dinarello CA. Induction of circulating IL-1 receptor antagonist by IFN treatment. J Immunol. 1993 May 15; 150(10):4687-92. PMID: 8482853.
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Dinarello CA. Modalities for reducing interleukin 1 activity in disease. Trends Pharmacol Sci. 1993 May; 14(5):155-9. PMID: 8212310.
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Mandrup-Poulsen T, Zumsteg U, Reimers J, Pociot F, M?rch L, Helqvist S, Dinarello CA, Nerup J. Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic beta-cell destruction in insulin-dependent diabetes mellitus. Cytokine. 1993 May; 5(3):185-91. PMID: 8218929.
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Romero LI, Schettini G, Lechan RM, Dinarello CA, Reichlin S. Bacterial lipopolysaccharide induction of IL-6 in rat telencephalic cells is mediated in part by IL-1. Neuroendocrinology. 1993 May; 57(5):892-7. PMID: 8413826.
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Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 1993 Apr 14; 269(14):1829-35. PMID: 8459516.
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Meydani SN, Dinarello CA. Influence of dietary fatty acids on cytokine production and its clinical implications. Nutr Clin Pract. 1993 Apr; 8(2):65-72. PMID: 8326925.
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Ye K, Dinarello CA, Clark BD. Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2295-9. PMID: 8460136.
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Schindler R, Linnenweber S, Schulze M, Oppermann M, Dinarello CA, Shaldon S, Koch KM. Gene expression of interleukin-1 beta during hemodialysis. Kidney Int. 1993 Mar; 43(3):712-21. PMID: 8455371.
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Mancilla J, Garc?a P, Dinarello CA. The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats. Infect Immun. 1993 Mar; 61(3):926-32. PMID: 8432613.
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Santos AA, Scheltinga MR, Lynch E, Brown EF, Lawton P, Chambers E, Browning J, Dinarello CA, Wolff SM, Wilmore DW. Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch Surg. 1993 Feb; 128(2):138-43; discussion 143-4. PMID: 8431115.
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Re F, Mengozzi M, Muzio M, Dinarello CA, Mantovani A, Colotta F. Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells. Eur J Immunol. 1993 Feb; 23(2):570-3. PMID: 8436189.
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Miller LC, Lynch EA, Isa S, Logan JW, Dinarello CA, Steere AC. Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet. 1993 Jan 16; 341(8838):146-8. PMID: 8093746.
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Dinarello CA, Wolff SM. The role of interleukin-1 in disease. N Engl J Med. 1993 Jan 14; 328(2):106-13. PMID: 8439348.
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Kaplan E, Dinarello CA, Wakabayashi G, Burke JF, Connolly RS, Gelfand JA. Interleukin-1 pretreatment protects against endotoxin-induced hypotension in rabbits: association with decreased tumor necrosis factor levels. J Infect Dis. 1993 Jan; 167(1):244-7. PMID: 8418176.
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Dinarello CA. Blocking interleukin-1 in disease. Blood Purif. 1993; 11(2):118-27. PMID: 8274243.
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Feingold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, Dinarello CA, Grunfeld C. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res. 1992 Dec; 33(12):1765-76. PMID: 1479286.
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Nerad JL, Griffiths JK, Van der Meer JW, Endres S, Poutsiaka DD, Keusch GT, Bennish M, Salam MA, Dinarello CA, Cannon JG. Interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist, and TNF alpha production in whole blood. J Leukoc Biol. 1992 Dec; 52(6):687-92. PMID: 1464740.
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Pereira BJ, Poutsiaka DD, King AJ, Strom JA, Narayan G, Levey AS, Dinarello CA. In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD. Kidney Int. 1992 Dec; 42(6):1419-24. PMID: 1474775.
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Numerof RP, Sipe JD, Trehu EG, Dinarello CA, Mier JW. Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist. Cytokine. 1992 Nov; 4(6):555-60. PMID: 1292638.
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Granowitz EV, Porat R, Orencole SF, Callahan MV, Lynch EA, Wolff SM, Dinarello CA. Granulocyte-macrophage colony-stimulating factor synthesis during experimental endotoxemia in humans. J Infect Dis. 1992 Nov; 166(5):1204-5. PMID: 1402042.
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Dinarello CA. Interleukin-1 and tumor necrosis factor and their naturally occurring antagonists during hemodialysis. Kidney Int Suppl. 1992 Oct; 38:S68-77. PMID: 1328757.
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Romero R, Sepulveda W, Mazor M, Brandt F, Cotton DB, Dinarello CA, Mitchell MD. The natural interleukin-1 receptor antagonist in term and preterm parturition. Am J Obstet Gynecol. 1992 Oct; 167(4 Pt 1):863-72. PMID: 1415417.
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Dinarello CA. The role of interleukin-1 in host responses to infectious diseases. Infect Agents Dis. 1992 Oct; 1(5):227-36. PMID: 1344662.
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Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med. 1992 Oct; 20(10):1414-9. PMID: 1395662.
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Andersson J, Bj?rk L, Dinarello CA, Towbin H, Andersson U. Lipopolysaccharide induces human interleukin-1 receptor antagonist and interleukin-1 production in the same cell. Eur J Immunol. 1992 Oct; 22(10):2617-23. PMID: 1396967.
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Miller LC, Isa S, Vannier E, Georgilis K, Steere AC, Dinarello CA. Live Borrelia burgdorferi preferentially activate interleukin-1 beta gene expression and protein synthesis over the interleukin-1 receptor antagonist. J Clin Invest. 1992 Sep; 90(3):906-12. PMID: 1387885.
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Granowitz EV, Porat R, Mier JW, Pribble JP, Stiles DM, Bloedow DC, Catalano MA, Wolff SM, Dinarello CA. Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. Cytokine. 1992 Sep; 4(5):353-60. PMID: 1420996.
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Memon RA, Feingold KR, Moser AH, Doerrler W, Adi S, Dinarello CA, Grunfeld C. Differential effects of interleukin-1 and tumor necrosis factor on ketogenesis. Am J Physiol. 1992 Aug; 263(2 Pt 1):E301-9. PMID: 1514611.
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Mancilla J, Ikejima T, Dinarello CA. Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1. Lymphokine Cytokine Res. 1992 Aug; 11(4):197-205. PMID: 1420598.
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Katzen NA, Segal GM, Vannier E, Nerad JL, Klempner MS, Dinarello CA. Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radioimmunoassays. Eur Cytokine Netw. 1992 Jul-Aug; 3(4):365-72. PMID: 1421010.
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Ho JL, Badar? R, Schwartz A, Dinarello CA, Gelfand JA, Sobel J, Barral A, Netto MB, Carvalho EM, Reed SG, et al. Diminished in vitro production of interleukin-1 and tumor necrosis factor-alpha during acute visceral leishmaniasis and recovery after therapy. J Infect Dis. 1992 Jun; 165(6):1094-102. PMID: 1583328.
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Dinarello CA. Role of interleukin-1 in infectious diseases. Immunol Rev. 1992 Jun; 127:119-46. PMID: 1506003.
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Dinarello CA. Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases. Semin Immunol. 1992 Jun; 4(3):133-45. PMID: 1320950.
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Dinarello CA. Dissociation of transcription from translation of human IL-1 beta: induction of steady state mRNA by adherence or recombinant C5a in the absence of translation. Proc Soc Exp Biol Med. 1992 Jun; 200(2):228-32. PMID: 1533718.
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Fischer E, Van Zee KJ, Marano MA, Rock CS, Kenney JS, Poutsiaka DD, Dinarello CA, Lowry SF, Moldawer LL. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood. 1992 May 01; 79(9):2196-200. PMID: 1533321.
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Vannier E, Miller LC, Dinarello CA. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4076-80. PMID: 1533284.
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Granowitz EV, Vannier E, Poutsiaka DD, Dinarello CA. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: II. IL-1 receptor antagonist inhibits lipopolysaccharide-induced cytokine synthesis by human monocytes. Blood. 1992 May 01; 79(9):2364-9. PMID: 1533323.
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Granowitz EV, Clark BD, Vannier E, Callahan MV, Dinarello CA. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. Blood. 1992 May 01; 79(9):2356-63. PMID: 1533322.
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Dinarello CA. ELISA kits based on monoclonal antibodies do not measure total IL-1 beta synthesis. J Immunol Methods. 1992 Apr 08; 148(1-2):255-9. PMID: 1564330.
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Romero R, Mazor M, Brandt F, Sepulveda W, Avila C, Cotton DB, Dinarello CA. Interleukin-1 alpha and interleukin-1 beta in preterm and term human parturition. Am J Reprod Immunol. 1992 Apr-May; 27(3-4):117-23. PMID: 1418402.
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Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA. Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. FASEB J. 1992 Apr; 6(7):2482-6. PMID: 1532945.
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Ye K, Koch KC, Clark BD, Dinarello CA. Interleukin-1 down-regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression. Immunology. 1992 Mar; 75(3):427-34. PMID: 1533388.
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Avraham H, Vannier E, Chi SY, Dinarello CA, Groopman JE. Cytokine gene expression and synthesis by human megakaryocytic cells. Int J Cell Cloning. 1992 Mar; 10(2):70-9. PMID: 1545152.
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Dinarello CA. Cytokines: agents provocateurs in hemodialysis? Kidney Int. 1992 Mar; 41(3):683-94. PMID: 1573847.
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Avraham H, Vannier E, Cowley S, Jiang SX, Chi S, Dinarello CA, Zsebo KM, Groopman JE. Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood. 1992 Jan 15; 79(2):365-71. PMID: 1370386.
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Houba V, Berger FM, Dinarello CA, Johnson AG, Le J, Mau?l J, Van der Meer JW, Philippeaux MM, Vilcek J, Vogels MT. Protodyne: an immunostimulatory protein component, prepared from gram-positive Bacillus subtilis. Dev Biol Stand. 1992; 77:121-8. PMID: 1426652.
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Dinarello CA. Anti-cytokine strategies. Eur Cytokine Netw. 1992 Jan-Feb; 3(1):7-17. PMID: 1581558.
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Dinarello CA. The biology of interleukin-1. Chem Immunol. 1992; 51:1-32. PMID: 1533127.
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Feingold KR, Doerrler W, Dinarello CA, Fiers W, Grunfeld C. Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. Endocrinology. 1992 Jan; 130(1):10-6. PMID: 1370149.
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Koch KC, Ye K, Clark BD, Dinarello CA. Interleukin 4 (IL) 4 up-regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells. Eur J Immunol. 1992 Jan; 22(1):153-7. PMID: 1530915.
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Dinarello CA. Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism. Int J Tissue React. 1992; 14(2):65-75. PMID: 1399323.
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Rambaldi A, Torcia M, Bettoni S, Vannier E, Barbui T, Shaw AR, Dinarello CA, Cozzolino F. Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells. Blood. 1991 Dec 15; 78(12):3248-53. PMID: 1835893.
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Granowitz EV, Santos AA, Poutsiaka DD, Cannon JG, Wilmore DW, Wolff SM, Dinarello CA. Production of interleukin-1-receptor antagonist during experimental endotoxaemia. Lancet. 1991 Dec 07; 338(8780):1423-4. PMID: 1683422.
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Barak V, Peritt D, Flechner I, Yanai P, Halperin T, Treves AJ, Dinarello CA. The specific IL-1 inhibitor from the human M20 cell line is distinct from the IL-1 receptor antagonist. Lymphokine Cytokine Res. 1991 Dec; 10(6):437-42. PMID: 1839505.
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Clark BD, Bedrosian I, Schindler R, Cominelli F, Cannon JG, Shaw AR, Dinarello CA. Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays. J Appl Physiol (1985). 1991 Dec; 71(6):2412-8. PMID: 1778940.
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Dinarello CA. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases. Curr Opin Immunol. 1991 Dec; 3(6):941-8. PMID: 1665333.
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Dinarello CA, Thompson RC. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today. 1991 Nov; 12(11):404-10. PMID: 1838480.
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Bedrosian I, Sofia RD, Wolff SM, Dinarello CA. Taurolidine, an analogue of the amino acid taurine, suppresses interleukin 1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells. Cytokine. 1991 Nov; 3(6):568-75. PMID: 1790304.
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Dinarello CA, Cannon JG, Mancilla J, Bishai I, Lees J, Coceani F. Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res. 1991 Oct 25; 562(2):199-206. PMID: 1773338.
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Porat R, Clark BD, Wolff SM, Dinarello CA. Enhancement of growth of virulent strains of Escherichia coli by interleukin-1. Science. 1991 Oct 18; 254(5030):430-2. PMID: 1833820.
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Keane WF, Hirata-Dulas CA, Bullock ML, Ney AL, Guay DR, Kalil RS, Dinarello CA, Halstenson CE, Peterson PK. Adjunctive therapy with intravenous human immunoglobulin G improves survival of patients with acute renal failure. J Am Soc Nephrol. 1991 Oct; 2(4):841-7. PMID: 1751787.
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Grunfeld C, Dinarello CA, Feingold KR. Tumor necrosis factor-alpha, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells. Metabolism. 1991 Sep; 40(9):894-8. PMID: 1654497.
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Cohan VL, Scott AL, Dinarello CA, Prendergast RA. Interleukin-1 is a mucus secretagogue. Cell Immunol. 1991 Sep; 136(2):425-34. PMID: 1873825.
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Poutsiaka DD, Clark BD, Vannier E, Dinarello CA. Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated. Blood. 1991 Sep 01; 78(5):1275-81. PMID: 1831680.
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Granowitz EV, Clark BD, Mancilla J, Dinarello CA. Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor. J Biol Chem. 1991 Aug 05; 266(22):14147-50. PMID: 1830582.
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Vannier E, Miller LC, Dinarello CA. Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors. J Exp Med. 1991 Jul 01; 174(1):281-4. PMID: 2056280.
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Gu?nard V, Dinarello CA, Weston PJ, Aebischer P. Peripheral nerve regeneration is impeded by interleukin-1 receptor antagonist released from a polymeric guidance channel. J Neurosci Res. 1991 Jul; 29(3):396-400. PMID: 1833560.
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Wakabayashi G, Gelfand JA, Jung WK, Connolly RJ, Burke JF, Dinarello CA. Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli. J Clin Invest. 1991 Jun; 87(6):1925-35. PMID: 2040686.
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Dinarello CA. The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J Infect Dis. 1991 Jun; 163(6):1177-84. PMID: 2037782.
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Grunfeld C, Soued M, Adi S, Moser AH, Fiers W, Dinarello CA, Feingold KR. Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-alpha. Cancer Res. 1991 Jun 01; 51(11):2803-7. PMID: 2032220.
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Belizario JE, Dinarello CA. Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle. Cancer Res. 1991 May 01; 51(9):2379-85. PMID: 2015601.
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Ghezzi P, Dinarello CA, Bianchi M, Rosandich ME, Repine JE, White CW. Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cytokine. 1991 May; 3(3):189-94. PMID: 1883957.
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Feingold KR, Soued M, Adi S, Staprans I, Neese R, Shigenaga J, Doerrler W, Moser A, Dinarello CA, Grunfeld C. Effect of interleukin-1 on lipid metabolism in the rat. Similarities to and differences from tumor necrosis factor. Arterioscler Thromb. 1991 May-Jun; 11(3):495-500. PMID: 2029492.
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Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood. 1991 Apr 15; 77(8):1627-52. PMID: 1826616.
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Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morrill-Labrode A, Dinarello CA, Gorbach SL. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr. 1991 Apr; 121(4):547-55. PMID: 2007907.
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Conti P, Reale M, Barbacane RC, Panara MR, Bongrazio M, Dempsey RA, Dinarello CA. Reduced mitogen stimulation of DNA synthesis in human lymphocytes by a human recombinant interleukin-1 receptor antagonist. Immunol Lett. 1991 Apr; 28(1):19-25. PMID: 1830027.
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Clinton SK, Fleet JC, Loppnow H, Salomon RN, Clark BD, Cannon JG, Shaw AR, Dinarello CA, Libby P. Interleukin-1 gene expression in rabbit vascular tissue in vivo. Am J Pathol. 1991 Apr; 138(4):1005-14. PMID: 2012168.
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Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA. A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J. 1991 Mar 01; 5(3):338-43. PMID: 1825816.
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Miller LG, Galpern WR, Dunlap K, Dinarello CA, Turner TJ. Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain. Mol Pharmacol. 1991 Feb; 39(2):105-8. PMID: 1847488.
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Sirko SP, Schindler R, Doyle MJ, Weisman SM, Dinarello CA. Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. Eur J Immunol. 1991 Feb; 21(2):243-50. PMID: 1847874.
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Endres S, F?lle HJ, Sinha B, Stoll D, Dinarello CA, Gerzer R, Weber PC. Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology. 1991 Jan; 72(1):56-60. PMID: 1847694.
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Morin M, Schindler R, Wakabayashi G, Daumy G, Dinarello CA, Gelfand JA. Picogram concentrations of endotoxin stimulate synthesis of IL-1 beta and TNF alpha by human peripheral blood mononuclear cells exposed to recombinant human C5a. Eur Cytokine Netw. 1991 Jan-Feb; 2(1):27-30. PMID: 1873491.
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Endres S, Meydani SN, Dinarello CA. Effects of omega 3 fatty acid supplements on ex vivo synthesis of cytokines in human volunteers. Comparison with oral aspirin and ibuprofen. World Rev Nutr Diet. 1991; 66:401-6. PMID: 2053356.
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Meydani SN, Endres S, Woods MM, Goldin BR, Soo C, Morrill-Labrode A, Dinarello CA, Gorbach SL. Effect of oral n-3 fatty acid supplementation on the immune response of young and older women. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:245-8. PMID: 1825548.
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Miller LC, Isa S, LoPreste G, Schaller JG, Dinarello CA. Neonatal interleukin-1 beta, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production. J Pediatr. 1990 Dec; 117(6):961-5. PMID: 2246700.
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Bochner BS, Charlesworth EN, Lichtenstein LM, Derse CP, Gillis S, Dinarello CA, Schleimer RP. Interleukin-1 is released at sites of human cutaneous allergic reactions. J Allergy Clin Immunol. 1990 Dec; 86(6 Pt 1):830-9. PMID: 2262641.
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Bianchi M, Mantovani A, Erroi A, Dinarello CA, Ghezzi P. Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells. Agents Actions. 1990 Nov; 31(3-4):275-9. PMID: 2085143.
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Hauser SL, Doolittle TH, Lincoln R, Brown RH, Dinarello CA. Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6. Neurology. 1990 Nov; 40(11):1735-9. PMID: 2234430.
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Schindler R, Gelfand JA, Dinarello CA. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood. 1990 Oct 15; 76(8):1631-8. PMID: 2207333.
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Numerof RP, Kotik AN, Dinarello CA, Mier JW. Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2. Cell Immunol. 1990 Oct 01; 130(1):118-28. PMID: 2144468.
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Zucali JR, Morse C, Dinarello CA. The role of protein kinase C in interleukin 1 and tumor necrosis factor alpha induction of fibroblasts to produce and release granulocyte-macrophage colony-stimulating activity. Exp Hematol. 1990 Sep; 18(8):888-92. PMID: 2167234.
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Cominelli F, Nast CC, Clark BD, Schindler R, Lierena R, Eysselein VE, Thompson RC, Dinarello CA. Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J Clin Invest. 1990 Sep; 86(3):972-80. PMID: 2168444.
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Galy AH, Dinarello CA, Kupper TS, Kameda A, Hadden JW. Effects of cytokines on human thymic epithelial cells in culture. II. Recombinant IL 1 stimulates thymic epithelial cells to produce IL6 and GM-CSF. Cell Immunol. 1990 Aug; 129(1):161-75. PMID: 2194677.
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Kandel RA, Petelycky M, Dinarello CA, Minden M, Pritzker KP, Cruz TF. Comparison of the effect of interleukin 6 and interleukin 1 on collagenase and proteoglycan production by chondrocytes. J Rheumatol. 1990 Jul; 17(7):953-7. PMID: 2170644.
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Grunfeld C, Soued M, Adi S, Moser AH, Dinarello CA, Feingold KR. Evidence for two classes of cytokines that stimulate hepatic lipogenesis: relationships among tumor necrosis factor, interleukin-1 and interferon-alpha. Endocrinology. 1990 Jul; 127(1):46-54. PMID: 1972922.
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Munoz C, Endres S, van der Meer J, Schlesinger L, Arevalo M, Dinarello C. Interleukin-1 beta in human colostrum. Res Immunol. 1990 Jul-Aug; 141(6):505-13. PMID: 2284496.
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Ikejima T, Okusawa S, Ghezzi P, van der Meer JW, Dinarello CA. Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits. J Infect Dis. 1990 Jul; 162(1):215-23. PMID: 2113076.
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Schindler R, Clark BD, Dinarello CA. Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells. J Biol Chem. 1990 Jun 25; 265(18):10232-7. PMID: 2354999.
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Molina JM, Scadden DT, Amirault C, Woon A, Vannier E, Dinarello CA, Groopman JE. Human immunodeficiency virus does not induce interleukin-1, interleukin-6, or tumor necrosis factor in mononuclear cells. J Virol. 1990 Jun; 64(6):2901-6. PMID: 2335821.
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Koenig JI, Snow K, Clark BD, Toni R, Cannon JG, Shaw AR, Dinarello CA, Reichlin S, Lee SL, Lechan RM. Intrinsic pituitary interleukin-1 beta is induced by bacterial lipopolysaccharide. Endocrinology. 1990 Jun; 126(6):3053-8. PMID: 2190803.
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Molina JM, Schindler R, Ferriani R, Sakaguchi M, Vannier E, Dinarello CA, Groopman JE. Production of cytokines by peripheral blood monocytes/macrophages infected with human immunodeficiency virus type 1 (HIV-1). J Infect Dis. 1990 May; 161(5):888-93. PMID: 2182729.
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Lechan RM, Toni R, Clark BD, Cannon JG, Shaw AR, Dinarello CA, Reichlin S. Immunoreactive interleukin-1 beta localization in the rat forebrain. Brain Res. 1990 Apr 23; 514(1):135-40. PMID: 2357520.
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Schindler R, Dinarello CA. Ultrafiltration to remove endotoxins and other cytokine-inducing materials from tissue culture media and parenteral fluids. Biotechniques. 1990 Apr; 8(4):408-13. PMID: 1692717.
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Schindler R, Ghezzi P, Dinarello CA. IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1. J Immunol. 1990 Mar 15; 144(6):2216-22. PMID: 2107255.
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Dinarello CA, Clark BD, Ikejima T, Puren AJ, Savage N, Rosoff PM. Interleukin 1 receptors and biological responses. Yale J Biol Med. 1990 Mar-Apr; 63(2):87-93. PMID: 2144681.
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Wilson CS, Ellner JJ, Dinarello CA, Keusch GT, el Kholy A. Dissociation of immunoregulatory function of blood monocytes from maturational state and expression of interleukin-1 in humans chronically infected with Schistosoma mansoni. Am J Trop Med Hyg. 1990 Mar; 42(3):234-42. PMID: 2107769.
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Salem P, Deryckx S, Dulioust A, Vivier E, Denizot Y, Damais C, Dinarello CA, Thomas Y. Immunoregulatory functions of paf-acether. IV. Enhancement of IL-1 production by muramyl dipeptide-stimulated monocytes. J Immunol. 1990 Feb 15; 144(4):1338-44. PMID: 2105995.
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Cominelli F, Nast CC, Llerena R, Dinarello CA, Zipser RD. Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins. J Clin Invest. 1990 Feb; 85(2):582-6. PMID: 2298922.
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Dinarello CA, Endres S, Meydani SN, Meydani M, Hellerstein MK. Interleukin-1, anorexia, and dietary fatty acids. Ann N Y Acad Sci. 1990; 587:332-8. PMID: 2193579.
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Dinarello CA. Cytokines and biocompatibility. Blood Purif. 1990; 8(4):208-13. PMID: 1964790.
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Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 1990 Jan 01; 75(1):40-7. PMID: 2294996.
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Dinarello CA. The pathophysiology of the pro-inflammatory cytokines. Biotherapy. 1990; 2(3):189-91. PMID: 2206771.
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Park MM, Hornback NB, Endres S, Dinarello CA. The effect of whole body hyperthermia on the immune cell activity of cancer patients. Lymphokine Res. 1990; 9(2):213-23. PMID: 2110991.
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Dinarello CA. Interleukin-1 and inhibition of interleukin-1 in hemodialysis patients. Contrib Nephrol. 1990; 86:48-69; discussion 69-72. PMID: 1706650.
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Wogensen LD, Kolb-Bachofen V, Christensen P, Dinarello CA, Mandrup-Poulsen T, Martin S, Nerup J. Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas. Diabetologia. 1990 Jan; 33(1):15-23. PMID: 2406177.
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Dinarello CA, Schindler R. Dissociation of transcription from translation of human IL-1-beta: the induction of steady state mRNA by adherence or recombinant C5a in the absence of translation. Prog Clin Biol Res. 1990; 349:195-204. PMID: 2204928.
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Loppnow H, D?rrbaum I, Brade H, Dinarello CA, Kusumoto S, Rietschel ET, Flad HD. Lipid A, the immunostimulatory principle of lipopolysaccharides? Adv Exp Med Biol. 1990; 256:561-6. PMID: 2327301.
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Schindler R, Lonnemann G, Shaldon S, Koch KM, Dinarello CA. Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement. Kidney Int. 1990 Jan; 37(1):85-93. PMID: 2299810.
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Endres S, Cannon JG, Ghorbani R, Dempsey RA, Sisson SD, Lonnemann G, Van der Meer JW, Wolff SM, Dinarello CA. In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation. Eur J Immunol. 1989 Dec; 19(12):2327-33. PMID: 2514105.
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Straus SE, Dale JK, Peter JB, Dinarello CA. Circulating lymphokine levels in the chronic fatigue syndrome. J Infect Dis. 1989 Dec; 160(6):1085-6. PMID: 2584758.
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Cominelli F, Nast CC, Dinarello CA, Gentilini P, Zipser RD. Regulation of eicosanoid production in rabbit colon by interleukin-1. Gastroenterology. 1989 Dec; 97(6):1400-5. PMID: 2583407.
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Dinarello CA. The endogenous pyrogens in host-defense interactions. Hosp Pract (Off Ed). 1989 Nov 15; 24(11):111-5, 118, 121 passim. PMID: 2509496.
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Orencole SF, Dinarello CA. Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens. Cytokine. 1989 Nov; 1(1):14-22. PMID: 2535250.
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Savage N, Puren AJ, Orencole SF, Ikejima T, Clark BD, Dinarello CA. Studies on IL-1 receptors on D10S T-helper cells: demonstration of two molecularly and antigenically distinct IL-1 binding proteins. Cytokine. 1989 Nov; 1(1):23-35. PMID: 2535251.
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Molina JM, Scadden DT, Byrn R, Dinarello CA, Groopman JE. Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus. J Clin Invest. 1989 Sep; 84(3):733-7. PMID: 2474573.
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Kwiatkowski D, Cannon JG, Manogue KR, Cerami A, Dinarello CA, Greenwood BM. Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clin Exp Immunol. 1989 Sep; 77(3):361-6. PMID: 2680183.
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Lonnemann G, Endres S, Van der Meer JW, Cannon JG, Koch KM, Dinarello CA. Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells. Eur J Immunol. 1989 Sep; 19(9):1531-6. PMID: 2792179.
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Cannon JG, Fielding RA, Fiatarone MA, Orencole SF, Dinarello CA, Evans WJ. Increased interleukin 1 beta in human skeletal muscle after exercise. Am J Physiol. 1989 Aug; 257(2 Pt 2):R451-5. PMID: 2669532.
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Fibbe WE, van der Meer JW, Falkenburg JH, Hamilton MS, Kluin PM, Dinarello CA. A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia. Exp Hematol. 1989 Aug; 17(7):805-8. PMID: 2787754.
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Andrews HJ, Bunning RA, Dinarello CA, Russell RG. Modulation of human chondrocyte metabolism by recombinant human interferon gamma: in-vitro effects on basal and IL-1-stimulated proteinase production, cartilage degradation and DNA synthesis. Biochim Biophys Acta. 1989 Jul 11; 1012(2):128-34. PMID: 2500974.
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Feingold KR, Soued M, Serio MK, Moser AH, Dinarello CA, Grunfeld C. Multiple cytokines stimulate hepatic lipid synthesis in vivo. Endocrinology. 1989 Jul; 125(1):267-74. PMID: 2661207.
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Tsoukas CD, Watry D, Escobar SS, Provvedini DM, Dinarello CA, Hustmyer FG, Manolagas SC. Inhibition of interleukin-1 production by 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 1989 Jul; 69(1):127-33. PMID: 2525134.
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Hellerstein MK, Meydani SN, Meydani M, Wu K, Dinarello CA. Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. J Clin Invest. 1989 Jul; 84(1):228-35. PMID: 2786888.
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Gottlieb RA, Lennarz WJ, Knowles RD, Cianciolo GJ, Dinarello CA, Lachman LB, Kleinerman ES. Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. J Immunol. 1989 Jun 15; 142(12):4321-8. PMID: 2524528.
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Endres S, van der Meer JW, Dinarello CA. [Cytokines in the pathogenesis of fever]. Internist (Berl). 1989 Jun; 30(6):358-61. PMID: 2668211.
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Drapkin MS, Wisch JS, Gelfand JA, Cannon JG, Dinarello CA. Plasmapheresis for fulminant meningococcemia. Pediatr Infect Dis J. 1989 Jun; 8(6):399-400. PMID: 2501752.
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Whitcomb EA, Dinarello CA, Pincus SH. Differential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils. Blood. 1989 May 15; 73(7):1904-8. PMID: 2540858.
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Flores EA, Bistrian BR, Pomposelli JJ, Dinarello CA, Blackburn GL, Istfan NW. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J Clin Invest. 1989 May; 83(5):1614-22. PMID: 2785120.
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Loppnow H, Brade H, D?rrbaum I, Dinarello CA, Kusumoto S, Rietschel ET, Flad HD. IL-1 induction-capacity of defined lipopolysaccharide partial structures. J Immunol. 1989 May 01; 142(9):3229-38. PMID: 2651523.
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Cannon JG, Clark BD, Wingfield P, Schmeissner U, Losberger C, Dinarello CA, Shaw AR. Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia. J Immunol. 1989 Apr 01; 142(7):2299-306. PMID: 2784458.
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Prakash S, Dinarello CA, Danko K, Stadecker MJ, Wyler DJ. Schistosomal egg granuloma-derived fibroblast-stimulating factor is apparently distinct from interleukin-1. Infect Immun. 1989 Mar; 57(3):679-84. PMID: 2492969.
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Dinarello CA, Endres S. Role for interleukin-1 in the pathogenesis of hypersensitivity diseases. J Cell Biochem. 1989 Mar; 39(3):229-38. PMID: 2651462.
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White CW, Ghezzi P, McMahon S, Dinarello CA, Repine JE. Cytokines increase rat lung antioxidant enzymes during exposure to hyperoxia. J Appl Physiol (1985). 1989 Feb; 66(2):1003-7. PMID: 2651381.
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Konnikov N, Pincus SH, Dinarello CA. Elevated plasma interleukin-1 levels in humans following ultraviolet light therapy for psoriasis. J Invest Dermatol. 1989 Feb; 92(2):235-9. PMID: 2783951.
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Dinarello CA, Clark BD, Puren AJ, Savage N, Rosoff PM. The interleukin 1 receptor. Immunol Today. 1989 Feb; 10(2):49-51. PMID: 2526640.
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Flores EA, Drabik M, Gauldie J, Blackburn GL, Dinarello CA, Bistrian BR. Leukocyte endogenous mediator fails to alter protein dynamics in a model of liver dysfunction. J Lab Clin Med. 1989 Feb; 113(2):211-20. PMID: 2464659.
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Schindler R, Dinarello CA. A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone. J Immunol Methods. 1989 Jan 17; 116(2):159-65. PMID: 2642948.
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Dinarello CA, Savage N. Interleukin-1 and its receptor. Crit Rev Immunol. 1989; 9(1):1-20. PMID: 2523282.
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Romero R, Durum S, Dinarello CA, Oyarzun E, Hobbins JC, Mitchell MD. Interleukin-1 stimulates prostaglandin biosynthesis by human amnion. Prostaglandins. 1989 Jan; 37(1):13-22. PMID: 2785698.
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Gothelf Y, Dinarello CA, Yamin M, Sharon N, Milner Y, Gazit E. IL-1 production by T6 (CD1a) positive cord blood mononuclear cells (Langerhan's cell precursors?). Lymphokine Res. 1989; 8(4):373-82. PMID: 2478842.
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Dinarello CA, Orencole SF, Savage N. Interleukin-1 induced T-lymphocyte proliferation and its relation to IL-1 receptors. Adv Exp Med Biol. 1989; 254:45-53. PMID: 2530853.
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Scarborough DE, Lee SL, Dinarello CA, Reichlin S. Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain. Endocrinology. 1989 Jan; 124(1):549-51. PMID: 2562827.
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Dinarello CA, Okusawa S, Gelfand JA. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of ibuprofen. Prog Clin Biol Res. 1989; 299:203-15. PMID: 2786217.
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Dinarello CA, Okusawa S, Gelfand JA. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. Prog Clin Biol Res. 1989; 286:243-63. PMID: 2494673.
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Schindler R, Lonnemann G, Shaldon S, Koch KM, Dinarello CA. Induction of interleukin-1 and tumor necrosis factor during in vitro hemodialysis with different membranes. Contrib Nephrol. 1989; 74:58-65. PMID: 2702147.
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Dinarello CA. Interleukin-1 and its biologically related cytokines. Adv Immunol. 1989; 44:153-205. PMID: 2466396.
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Cady AB, Riveau G, Chedid L, Dinarello CA, Johannsen L, Krueger JM. Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative. Int J Immunopharmacol. 1989; 11(8):887-93. PMID: 2613394.
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Cominelli F, Dinarello CA. Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease. Biotherapy. 1989; 1(4):369-75. PMID: 2701650.
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van der Meer JW, Rubin RH, Pasternack M, Medearis DN, Lynch P, Dinarello CA. The in vivo and in vitro effects of interleukin-1 and tumor necrosis factor on murine cytomegalovirus infection. Biotherapy. 1989; 1(3):227-31. PMID: 2561979.
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Kaplan E, Dinarello CA, Gelfand JA. Interleukin-1 and the response to injury. Immunol Res. 1989; 8(2):118-29. PMID: 2659688.
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Schindler R, Ghezzi P, Dinarello CA. Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis. Lymphokine Res. 1989; 8(3):275-80. PMID: 2476637.
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Dinarello CA. Interleukin-1 and the effects of cyclooxygenase inhibitors on its biological activities. Bull N Y Acad Med. 1989 Jan; 65(1):80-92. PMID: 2513997.
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Dinarello CA, Neta R. An overview on interleukin-1 as a therapeutic agent. Biotherapy. 1989; 1(4):245-54. PMID: 2701640.
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Schweizer A, Feige U, Fontana A, M?ller K, Dinarello CA. Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels. Agents Actions. 1988 Dec; 25(3-4):246-51. PMID: 3265268.
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Endres S, Ghorbani R, Lonnemann G, van der Meer JW, Dinarello CA. Measurement of immunoreactive interleukin-1 beta from human mononuclear cells: optimization of recovery, intrasubject consistency, and comparison with interleukin-1 alpha and tumor necrosis factor. Clin Immunol Immunopathol. 1988 Dec; 49(3):424-38. PMID: 2461270.
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Tredget EE, Yu YM, Zhong S, Burini R, Okusawa S, Gelfand JA, Dinarello CA, Young VR, Burke JF. Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. Am J Physiol. 1988 Dec; 255(6 Pt 1):E760-8. PMID: 3144180.
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Ikejima T, Okusawa S, van der Meer JW, Dinarello CA. Induction by toxic-shock-syndrome toxin-1 of a circulating tumor necrosis factor-like substance in rabbits and of immunoreactive tumor necrosis factor and interleukin-1 from human mononuclear cells. J Infect Dis. 1988 Nov; 158(5):1017-25. PMID: 3263446.
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Mier JW, Vachino G, van der Meer JW, Numerof RP, Adams S, Cannon JG, Bernheim HA, Atkins MB, Parkinson DR, Dinarello CA. Induction of circulating tumor necrosis factor (TNF alpha) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients. J Clin Immunol. 1988 Nov; 8(6):426-36. PMID: 3265420.
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Sisson SD, Dinarello CA. Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte-macrophage colony-stimulating factor. Blood. 1988 Oct; 72(4):1368-74. PMID: 3139106.
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Bagby GC, Dinarello CA, Neerhout RC, Ridgway D, McCall E. Interleukin 1-dependent paracrine granulopoiesis in chronic granulocytic leukemia of the juvenile type. J Clin Invest. 1988 Oct; 82(4):1430-6. PMID: 3262628.
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Haak-Frendscho M, Dinarello C, Kaplan AP. Recombinant human interleukin-1 beta causes histamine release from human basophils. J Allergy Clin Immunol. 1988 Aug; 82(2):218-23. PMID: 3261306.
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Michie HR, Spriggs DR, Manogue KR, Sherman ML, Revhaug A, O'Dwyer ST, Arthur K, Dinarello CA, Cerami A, Wolff SM, et al. Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings. Surgery. 1988 Aug; 104(2):280-6. PMID: 2456628.
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Krogh Rasmussen A, Bech K, Feldt-Rasmussen U, Poulsen S, Holten I, Ryberg M, Dinarello CA, Siersbaek-Nielsen K, Friis T, Bendtzen K. Interleukin-1 affects the function of cultured human thyroid cells. Allergy. 1988 Aug; 43(6):435-41. PMID: 2847577.
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Okusawa S, Yancey KB, van der Meer JW, Endres S, Lonnemann G, Hefter K, Frank MM, Burke JF, Dinarello CA, Gelfand JA. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha. J Exp Med. 1988 Jul 01; 168(1):443-8. PMID: 3260938.
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Van't Wout JW, Van der Meer JW, Barza M, Dinarello CA. Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1. Eur J Immunol. 1988 Jul; 18(7):1143-6. PMID: 3261247.
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Lonnemann G, Koch KM, Shaldon S, Dinarello CA. Studies on the ability of hemodialysis membranes to induce, bind, and clear human interleukin-1. J Lab Clin Med. 1988 Jul; 112(1):76-86. PMID: 3260615.
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Rosoff PM, Savage N, Dinarello CA. Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Cell. 1988 Jul 01; 54(1):73-81. PMID: 2898301.
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Ghezzi P, Dinarello CA. IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma. J Immunol. 1988 Jun 15; 140(12):4238-44. PMID: 3131429.
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Vlassara H, Brownlee M, Manogue KR, Dinarello CA, Pasagian A. Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling. Science. 1988 Jun 10; 240(4858):1546-8. PMID: 3259727.
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Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med. 1988 Jun 09; 318(23):1481-6. PMID: 2835680.
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Shaldon S, Dinarello C, Port F, Kluger M. Interleukin-1: the pros and cons of its clinical relevance. Artif Organs. 1988 Jun; 12(3):221. PMID: 3260477.
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Beasley D, Dinarello CA, Cannon JG. Interleukin-1 induces natriuresis in conscious rats: role of renal prostaglandins. Kidney Int. 1988 Jun; 33(6):1059-65. PMID: 3136271.
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Cohen AB, MacArthur C, Idell S, Maunder R, Martin T, Dinarello CA, Griffith D, McLarty J. A peptide from alveolar macrophages that releases neutrophil enzymes into the lungs in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1988 May; 137(5):1151-8. PMID: 2848427.
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Coceani F, Lees J, Dinarello CA. Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res. 1988 Apr 19; 446(2):245-50. PMID: 3259449.
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Tagaya Y, Okada M, Sugie K, Kasahara T, Kondo N, Hamuro J, Matsushima K, Dinarello CA, Yodoi J. IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor. J Immunol. 1988 Apr 15; 140(8):2614-20. PMID: 2895791.
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Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science. 1988 Apr 15; 240(4850):321-4. PMID: 3258444.
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Domer FR, Mori K, Dinarello CA, Sokoloff L. Effects of leukocytic pyrogen (interleukin-1) on local cerebral glucose utilization in rats with and without premedication with indomethacin or dexamethasone. J Cereb Blood Flow Metab. 1988 Apr; 8(2):173-8. PMID: 3257761.
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Ranges GE, Zlotnik A, Espevik T, Dinarello CA, Cerami A, Palladino MA. Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines. J Exp Med. 1988 Apr 01; 167(4):1472-8. PMID: 3282023.
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Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest. 1988 Apr; 81(4):1162-72. PMID: 3258319.
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Dinarello CA, Koch KM, Shaldon S. Interleukin-1 and its relevance in patients treated with hemodialysis. Kidney Int Suppl. 1988 Mar; 24:S21-6. PMID: 3283410.
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Wogensen LD, Mandrup-Poulsen T, Markholst H, M?lvig J, Lernmark A, Holst JJ, Dinarello CA, Nerup J. Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas. Acta Endocrinol (Copenh). 1988 Mar; 117(3):302-6. PMID: 3289298.
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van der Meer JW, Endres S, Lonnemann G, Cannon JG, Ikejima T, Okusawa S, Gelfand JA, Dinarello CA. Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro. J Leukoc Biol. 1988 Mar; 43(3):216-23. PMID: 3257788.
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Dinarello CA. Interleukin-1. Dig Dis Sci. 1988 Mar; 33(3 Suppl):25S-35S. PMID: 3126028.
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van der Meer JW, Barza M, Wolff SM, Dinarello CA. A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1620-3. PMID: 3125553.
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Dinarello CA. Biology of interleukin 1. FASEB J. 1988 Feb; 2(2):108-15. PMID: 3277884.
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Revhaug A, Michie HR, Manson JM, Watters JM, Dinarello CA, Wolff SM, Wilmore DW. Inhibition of cyclo-oxygenase attenuates the metabolic response to endotoxin in humans. Arch Surg. 1988 Feb; 123(2):162-70. PMID: 2893597.
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Zucali JR, Broxmeyer HE, Gross MA, Dinarello CA. Recombinant human tumor necrosis factors alpha and beta stimulate fibroblasts to produce hemopoietic growth factors in vitro. J Immunol. 1988 Feb 01; 140(3):840-4. PMID: 3276782.
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Dinarello CA, Cannon JG, Wolff SM. New concepts on the pathogenesis of fever. Rev Infect Dis. 1988 Jan-Feb; 10(1):168-89. PMID: 2451266.
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Conti P, Reale M, Fiore S, Cancelli A, Angeletti PU, Dinarello CA. Recombinant interleukin 1 and tumor necrosis factor acting in synergy to release thromboxane, 6-KETO-PGF1 alpha and PGE2 by human neutrophils. Scand J Rheumatol Suppl. 1988; 75:318-24. PMID: 3266363.
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Dinarello CA. Interleukin-1. Ann N Y Acad Sci. 1988; 546:122-32. PMID: 3073692.
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Cannon JG, van der Meer JW, Kwiatkowski D, Endres S, Lonnemann G, Burke JF, Dinarello CA. Interleukin-1 beta in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods. Lymphokine Res. 1988; 7(4):457-67. PMID: 3145372.
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Ruwe WD, Naylor AM, Dinarello CA, Veale WL. Characteristics of pyrogen fevers are altered in the aged rabbit. Exp Gerontol. 1988; 23(2):103-13. PMID: 3402551.
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Conti P, Reale M, Angeletti PU, Dinarello CA. Restoration of anti-interleukin-1 depressed natural killer activity by human recombinant interferon alpha or gamma, human recombinant interleukin-2 and indomethacin. Int J Immunopharmacol. 1988; 10(8):907-11. PMID: 3145923.
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Shaldon S, Dinarello C, Elie M, Koch KM. Interleukin-1 and biocompatibility in haemodialysis. Contrib Nephrol. 1988; 62:128-31. PMID: 3282793.
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Shaldon S, Koch KM, Dinarello CA. Interleukin-1 activation and acute phase response during hemodialysis. Contrib Nephrol. 1988; 61:18-26. PMID: 3129233.
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Shaldon S, Dinarello CA, Koch KM, Lonnemann G, Bingel M, Granolleras C, Deschodt G, Branger B, Oul?s R, Fourcade J. Interleukin-1 and dialysis. Adv Nephrol Necker Hosp. 1988; 17:423-34. PMID: 3124551.
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Dinarello CA. Interleukin-1--its multiple biological effects and its association with hemodialysis. Blood Purif. 1988; 6(3):164-72. PMID: 3293622.
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Bingel M, Lonnemann G, Koch KM, Dinarello CA, Shaldon S. Plasma interleukin-1 activity during hemodialysis: the influence of dialysis membranes. Nephron. 1988; 50(4):273-6. PMID: 3266309.
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Lonnemann G, Endres S, van der Meer JW, Cannon JG, Dinarello CA. A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin. Lymphokine Res. 1988; 7(2):75-84. PMID: 3261380.
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Dinarello CA. Endogenous pyrogens. Methods Enzymol. 1988; 163:495-510. PMID: 3266286.
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Lonnemann G, Bingel M, Floege J, Koch KM, Shaldon S, Dinarello CA. Detection of endotoxin-like interleukin-1-inducing activity during in vitro dialysis. Kidney Int. 1988 Jan; 33(1):29-35. PMID: 3280853.
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Zsebo KM, Yuschenkoff VN, Schiffer S, Chang D, McCall E, Dinarello CA, Brown MA, Altrock B, Bagby GC. Vascular endothelial cells and granulopoiesis: interleukin-1 stimulates release of G-CSF and GM-CSF. Blood. 1988 Jan; 71(1):99-103. PMID: 3257150.
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Knudsen PJ, Dinarello CA, Strom TB. Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol. 1987 Dec 15; 139(12):4129-34. PMID: 2826581.
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Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J Immunol. 1987 Dec 15; 139(12):4077-82. PMID: 3320203.
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Movat HZ, Burrowes CE, Cybulsky MI, Dinarello CA. Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am J Pathol. 1987 Dec; 129(3):463-76. PMID: 3501244.
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Tocco-Bradley R, Georgieff M, Jones CT, Moldawer LL, Dinarello CA, Blackburn GL, Bistrian BR. Changes in energy expenditure and fat metabolism in rats infused with interleukin-1. Eur J Clin Invest. 1987 Dec; 17(6):504-10. PMID: 3123250.
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Dinarello CA. The biology of interleukin 1 and comparison to tumor necrosis factor. Immunol Lett. 1987 Dec; 16(3-4):227-31. PMID: 3127333.
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Jandl RC, George JL, Dinarello CA, Schur PH. The effect of interleukin 1 on IgG synthesis in systemic lupus erythematosus. Clin Immunol Immunopathol. 1987 Dec; 45(3):384-94. PMID: 3119264.
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Endres S, van der Meer JW, Dinarello CA. Interleukin-1 in the pathogenesis of fever. Eur J Clin Invest. 1987 Dec; 17(6):469-74. PMID: 3123245.
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Woo P, Sipe J, Dinarello CA, Colten HR. Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells. J Biol Chem. 1987 Nov 15; 262(32):15790-5. PMID: 2890635.
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Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science. 1987 Nov 06; 238(4828):800-2. PMID: 3313729.
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Bishai I, Dinarello CA, Coceani F. Prostaglandin formation in feline cerebral microvessels: effect of endotoxin and interleukin-1. Can J Physiol Pharmacol. 1987 Nov; 65(11):2225-30. PMID: 3502394.
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Kandel RA, Dinarello CA, Biswas C. The stimulation of collagenase production in rabbit articular chondrocytes by interleukin-1 is increased by collagens. Biochem Int. 1987 Nov; 15(5):1021-31. PMID: 2829908.
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Okusawa S, Dinarello CA, Yancey KB, Endres S, Lawley TJ, Frank MM, Burke JF, Gelfand JA. C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma. J Immunol. 1987 Oct 15; 139(8):2635-40. PMID: 3116090.
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Lonnemann G, van der Meer JW, Cannon JG, Dinarello CA, Koch KM, Granolleras C, Deschodt G, Shaldon S. Induction of tumor necrosis factor during extracorporeal blood purification. N Engl J Med. 1987 Oct 08; 317(15):963-4. PMID: 3627217.
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Dinarello CA, Mier JW. Lymphokines. N Engl J Med. 1987 Oct 08; 317(15):940-5. PMID: 2442611.
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Shaldon S, Dinarello CA. The relationship between biocompatibility and interleukin-1. Life Support Syst. 1987 Oct-Dec; 5(4):341-5. PMID: 3501505.
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Shaldon S, Elie M, Koch KM, Dinarello CA. Interleukin-1 stimulation in the ESRD patient: potential long-term consequences. Transplant Proc. 1987 Oct; 19(5):4353-7. PMID: 3118543.
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Bochner BS, Landy SD, Plaut M, Dinarello CA, Schleimer RP. Interleukin 1 production by human lung tissue. I. Identification and characterization. J Immunol. 1987 Oct 01; 139(7):2297-302. PMID: 3498757.
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Van Damme J, De Ley M, Van Snick J, Dinarello CA, Billiau A. The role of interferon-beta 1 and the 26-kDa protein (interferon-beta 2) as mediators of the antiviral effect of interleukin 1 and tumor necrosis factor. J Immunol. 1987 Sep 15; 139(6):1867-72. PMID: 3305707.
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Dinarello CA, Ikejima T, Warner SJ, Orencole SF, Lonnemann G, Cannon JG, Libby P. Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol. 1987 Sep 15; 139(6):1902-10. PMID: 3497982.
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Lorenzo JA, Sousa SL, Alander C, Raisz LG, Dinarello CA. Comparison of the bone-resorbing activity in the supernatants from phytohemagglutinin-stimulated human peripheral blood mononuclear cells with that of cytokines through the use of an antiserum to interleukin 1. Endocrinology. 1987 Sep; 121(3):1164-70. PMID: 3497797.
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Zucali JR, Elfenbein GJ, Barth KC, Dinarello CA. Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation. J Clin Invest. 1987 Sep; 80(3):772-7. PMID: 3497951.
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Mier JW, Dinarello CA, Atkins MB, Punsal PI, Perlmutter DH. Regulation of hepatic acute phase protein synthesis by products of interleukin 2 (IL 2)-stimulated human peripheral blood mononuclear cells. J Immunol. 1987 Aug 15; 139(4):1268-72. PMID: 2440951.
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Roh MS, Drazenovich KA, Barbose JJ, Dinarello CA, Cobb CF. Direct stimulation of the adrenal cortex by interleukin-1. Surgery. 1987 Aug; 102(2):140-6. PMID: 3497458.
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Dinarello CA, Lonnemann G, Maxwell R, Shaldon S. Ultrafiltration to reject human interleukin-1-inducing substances derived from bacterial cultures. J Clin Microbiol. 1987 Jul; 25(7):1233-8. PMID: 3112179.
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McClain CJ, Cohen D, Ott L, Dinarello CA, Young B. Ventricular fluid interleukin-1 activity in patients with head injury. J Lab Clin Med. 1987 Jul; 110(1):48-54. PMID: 3496408.
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Spinas GA, Hansen BS, Linde S, Kastern W, M?lvig J, Mandrup-Poulsen T, Dinarello CA, Nielsen JH, Nerup J. Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans. Diabetologia. 1987 Jul; 30(7):474-80. PMID: 3311860.
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Shoham S, Davenne D, Cady AB, Dinarello CA, Krueger JM. Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am J Physiol. 1987 Jul; 253(1 Pt 2):R142-9. PMID: 3496800.
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Mannie MD, Dinarello CA, Paterson PY. Interleukin 1 and myelin basic protein synergistically augment adoptive transfer activity of lymphocytes mediating experimental autoimmune encephalomyelitis in Lewis rats. J Immunol. 1987 Jun 15; 138(12):4229-35. PMID: 2438337.
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White CW, Ghezzi P, Dinarello CA, Caldwell SA, McMurtry IF, Repine JE. Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J Clin Invest. 1987 Jun; 79(6):1868-73. PMID: 3495553.
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Rustgi VK, Jones DB, Dinarello CA, Hoofnagle JH. Lymphokines and bile secretion in the rat. Liver. 1987 Jun; 7(3):149-54. PMID: 2956476.
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Ree HJ, Crowley JP, Dinarello CA. Anti-interleukin-1 reactive cells in Hodgkin's disease. Cancer. 1987 May 15; 59(10):1717-20. PMID: 2435398.
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Georgilis K, Schaefer C, Dinarello CA, Klempner MS. Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils. J Immunol. 1987 May 15; 138(10):3403-7. PMID: 3033074.
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Mu?oz CG, Keusch GT, Dinarello CA. A new micromethod for determination of interleukin-1 production from frozen human blood mononuclear cells. J Immunol Methods. 1987 May 04; 99(1):123-7. PMID: 3494787.
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Lachman LB, Brown DC, Dinarello CA. Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line. J Immunol. 1987 May 01; 138(9):2913-6. PMID: 3494774.
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Cybulsky MI, Movat HZ, Dinarello CA. Role of interleukin-1 and tumour necrosis factor-alpha in acute inflammation. Ann Inst Pasteur Immunol. 1987 May-Jun; 138(3):505-12. PMID: 3498503.
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Riveau GR, Novitsky TJ, Roslansky PF, Dinarello CA, Warren HS. Role of interleukin-1 in augmenting serum neutralization of bacterial lipopolysaccharide. J Clin Microbiol. 1987 May; 25(5):889-92. PMID: 3495548.
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Le PT, Tuck DT, Dinarello CA, Haynes BF, Singer KH. Human thymic epithelial cells produce interleukin 1. J Immunol. 1987 Apr 15; 138(8):2520-6. PMID: 3494074.
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Mandrup-Poulsen T, Egeberg J, Nerup J, Bendtzen K, Nielsen JH, Dinarello CA. Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity. Acta Pathol Microbiol Immunol Scand C. 1987 Apr; 95(2):55-63. PMID: 3300162.
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Drabik MD, Schnure FC, Mok KT, Moldawer LL, Dinarello CA, Blackburn GL, Bistrian BR. Effect of protein depletion and short-term parenteral refeeding on the host response to interleukin 1 administration. J Lab Clin Med. 1987 Apr; 109(4):509-16. PMID: 3102661.
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Fauci AS, Rosenberg SA, Sherwin SA, Dinarello CA, Longo DL, Lane HC. NIH conference. Immunomodulators in clinical medicine. Ann Intern Med. 1987 Mar; 106(3):421-33. PMID: 2433978.
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Auron PE, Warner SJ, Webb AC, Cannon JG, Bernheim HA, McAdam KJ, Rosenwasser LJ, LoPreste G, Mucci SF, Dinarello CA. Studies on the molecular nature of human interleukin 1. J Immunol. 1987 Mar 01; 138(5):1447-56. PMID: 3492551.
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Dejana E, Breviario F, Erroi A, Bussolino F, Mussoni L, Gramse M, Pintucci G, Casali B, Dinarello CA, Van Damme J, et al. Modulation of endothelial cell functions by different molecular species of interleukin 1. Blood. 1987 Feb; 69(2):695-9. PMID: 3542082.
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Gauldie J, Sauder DN, McAdam KP, Dinarello CA. Purified interleukin-1 (IL-1) from human monocytes stimulates acute-phase protein synthesis by rodent hepatocytes in vitro. Immunology. 1987 Feb; 60(2):203-7. PMID: 2434417.
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Schnyder J, Payne T, Dinarello CA. Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. J Immunol. 1987 Jan 15; 138(2):496-503. PMID: 3098847.
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Naylor AM, Gubitz GJ, Dinarello CA, Veale WL. Central effects of vasopressin and 1-desamino-8-D-arginine vasopressin (DDAVP) on interleukin-1 fever in the rat. Brain Res. 1987 Jan 13; 401(1):173-7. PMID: 2949799.
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Bingel M, Lonnemann G, Koch KM, Dinarello CA, Shaldon S. Enhancement of in-vitro human interleukin-1 production by sodium acetate. Lancet. 1987 Jan 03; 1(8523):14-6. PMID: 2879093.
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Dinarello CA. Interleukin-1: multiple biological properties and mechanisms of action. Adv Prostaglandin Thromboxane Leukot Res. 1987; 17B:900-4. PMID: 2445184.
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Dinarello CA, Lonnemann G, Bingel M, Koch KM, Shaldon S. Biological consequences of monocyte activation during hemodialysis. Contrib Nephrol. 1987; 59:1-9. PMID: 3127115.
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Shaldon S, Dinarello CA, Wyler DJ. Induction of interleukin-1 during CAPD. Contrib Nephrol. 1987; 57:207-12. PMID: 3315440.
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Hunninghake GW, Glazier AJ, Monick MM, Dinarello CA. Interleukin-1 is a chemotactic factor for human T-lymphocytes. Am Rev Respir Dis. 1987 Jan; 135(1):66-71. PMID: 2948432.
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Movat HZ, Cybulsky MI, Colditz IG, Chan MK, Dinarello CA. Acute inflammation in gram-negative infection: endotoxin, interleukin 1, tumor necrosis factor, and neutrophils. Fed Proc. 1987 Jan; 46(1):97-104. PMID: 3542580.
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Lonnemann G, Bingel M, Koch KM, Shaldon S, Dinarello CA. Plasma interleukin-1 activity in humans undergoing hemodialysis with regenerated cellulosic membranes. Lymphokine Res. 1987; 6(2):63-70. PMID: 3495707.
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Dinarello CA. The multiple biological properties of interleukin-1 influencing immunocompetent cells. Adv Exp Med Biol. 1987; 213:103-14. PMID: 3498292.
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Zucali JR, Broxmeyer HE, Dinarello CA, Gross MA, Weiner RS. Regulation of early human hematopoietic (BFU-E and CFU-GEMM) progenitor cells in vitro by interleukin 1-induced fibroblast-conditioned medium. Blood. 1987 Jan; 69(1):33-7. PMID: 3491640.
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Del Rey A, Besedovsky H, Sorkin E, Dinarello CA. Interleukin-1 and glucocorticoid hormones integrate an immunoregulatory feedback circuit. Ann N Y Acad Sci. 1987; 496:85-90. PMID: 3037979.
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Lisi PJ, Chu CW, Koch GA, Endres S, Lonnemann G, Dinarello CA. Development and use of a radioimmunoassay for human interleukin-1 beta. Lymphokine Res. 1987; 6(3):229-44. PMID: 3498100.
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Yodoi J, Okada M, Tagaya Y, Taniguchi Y, Teshigawara K, Kasahara T, Dinarello CA, Matsushima K, Honko T, Uchiyama T, et al. IL-2 receptor gene activation by ATL-derived factor (ADF). Adv Exp Med Biol. 1987; 213:139-48. PMID: 2888270.
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Krueger JM, Dinarello CA, Shoham S, Davenne D, Walter J, Kubillus S. Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol. 1987; 9(1):23-30. PMID: 3583502.
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Miller LC, Dinarello CA. Biologic activities of interleukin-1 relevant to rheumatic diseases. Pathol Immunopathol Res. 1987; 6(1):22-36. PMID: 3128783.
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Ghezzi P, Saccardo B, Villa P, Rossi V, Bianchi M, Dinarello CA. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun. 1986 Dec; 54(3):837-40. PMID: 3491050.
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Dinarello CA, Dempsey RA, Allegretta M, LoPreste G, Dainiak N, Parkinson DR, Mier JW. Inhibitory effects of elevated temperature on human cytokine production and natural killer activity. Cancer Res. 1986 Dec; 46(12 Pt 1):6236-41. PMID: 2430693.
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Libby P, Ordovas JM, Birinyi LK, Auger KR, Dinarello CA. Inducible interleukin-1 gene expression in human vascular smooth muscle cells. J Clin Invest. 1986 Dec; 78(6):1432-8. PMID: 3491091.
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Pincus SH, Whitcomb EA, Dinarello CA. Interaction of IL 1 and TPA in modulation of eosinophil function. J Immunol. 1986 Dec 01; 137(11):3509-14. PMID: 3023484.
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Spinas GA, Mandrup-Poulsen T, M?lvig J, Baek L, Bendtzen K, Dinarello CA, Nerup J. Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans. Acta Endocrinol (Copenh). 1986 Dec; 113(4):551-8. PMID: 3538741.
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Knudsen PJ, Dinarello CA, Strom TB. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol. 1986 Nov 15; 137(10):3189-94. PMID: 3021848.
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Cannon JG, Evans WJ, Hughes VA, Meredith CN, Dinarello CA. Physiological mechanisms contributing to increased interleukin-1 secretion. J Appl Physiol (1985). 1986 Nov; 61(5):1869-74. PMID: 3491062.
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Bagby GC, Dinarello CA, Wallace P, Wagner C, Hefeneider S, McCall E. Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells. J Clin Invest. 1986 Nov; 78(5):1316-23. PMID: 3490494.
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Evans WJ, Meredith CN, Cannon JG, Dinarello CA, Frontera WR, Hughes VA, Jones BH, Knuttgen HG. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol (1985). 1986 Nov; 61(5):1864-8. PMID: 3491061.
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Perlmutter DH, Dinarello CA, Punsal PI, Colten HR. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest. 1986 Nov; 78(5):1349-54. PMID: 2429991.
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McClain CJ, Cohen DA, Dinarello CA, Cannon JG, Shedlofsky SI, Kaplan AM. Serum interleukin-1 (IL-1) activity in alcoholic hepatitis. Life Sci. 1986 Oct 20; 39(16):1479-85. PMID: 3490610.
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Dinarello CA, Krueger JM. Induction of interleukin 1 by synthetic and naturally occurring muramyl peptides. Fed Proc. 1986 Oct; 45(11):2545-8. PMID: 3489643.
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Cannon JG, Tatro JB, Reichlin S, Dinarello CA. Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1. J Immunol. 1986 Oct 01; 137(7):2232-6. PMID: 3489761.
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Lotz M, Tsoukas CD, Robinson CA, Dinarello CA, Carson DA, Vaughan JH. Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. J Clin Invest. 1986 Sep; 78(3):713-21. PMID: 3091636.
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Dinarello CA. Multiple biological properties of recombinant human interleukin 1 (beta). Immunobiology. 1986 Sep; 172(3-5):301-15. PMID: 3100431.
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Besedovsky H, del Rey A, Sorkin E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986 Aug 08; 233(4764):652-4. PMID: 3014662.
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Libby P, Ordovas JM, Auger KR, Robbins AH, Birinyi LK, Dinarello CA. Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am J Pathol. 1986 Aug; 124(2):179-85. PMID: 3526909.
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Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 01; 137(1):245-54. PMID: 3086451.
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Rosenwasser LJ, Webb AC, Clark BD, Irie S, Chang L, Dinarello CA, Gehrke L, Wolff SM, Rich A, Auron PE. Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5243-6. PMID: 3487789.
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Conti P, Cifone MG, Alesse E, Reale M, Fieschi C, Dinarello CA. In vitro enhanced thromboxane B2 release by polymorphonuclear leukocytes and macrophages after treatment with human recombinant interleukin 1. Prostaglandins. 1986 Jul; 32(1):111-5. PMID: 3489956.
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Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen JH, Dinarello CA, Svenson M. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science. 1986 Jun 20; 232(4757):1545-7. PMID: 3086977.
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Nachman RL, Hajjar KA, Silverstein RL, Dinarello CA. Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. J Exp Med. 1986 Jun 01; 163(6):1595-600. PMID: 3086483.
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Dinarello CA, Cannon JG, Mier JW, Bernheim HA, LoPreste G, Lynn DL, Love RN, Webb AC, Auron PE, Reuben RC, et al. Multiple biological activities of human recombinant interleukin 1. J Clin Invest. 1986 Jun; 77(6):1734-9. PMID: 3519678.
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Zucali JR, Dinarello CA, Oblon DJ, Gross MA, Anderson L, Weiner RS. Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. J Clin Invest. 1986 Jun; 77(6):1857-63. PMID: 3486886.
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Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA, O'Connor JV. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med. 1986 Jun 01; 163(6):1433-50. PMID: 3486936.
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Perlmutter DH, Goldberger G, Dinarello CA, Mizel SB, Colten HR. Regulation of class III major histocompatibility complex gene products by interleukin-1. Science. 1986 May 16; 232(4752):850-2. PMID: 3010455.
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Lotz M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans. J Immunol. 1986 May 15; 136(10):3636-42. PMID: 3009608.
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Lotz M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. J Immunol. 1986 May 15; 136(10):3643-8. PMID: 3009609.
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Roh MS, Moldawer LL, Ekman LG, Dinarello CA, Bistrian BR, Jeevanandam M, Brennan MF. Stimulatory effect of interleukin-1 upon hepatic metabolism. Metabolism. 1986 May; 35(5):419-24. PMID: 3486338.
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Knudsen PJ, Dinarello CA, Strom TB. Purification and characterization of a unique human interleukin 1 from the tumor cell line U937. J Immunol. 1986 May 01; 136(9):3311-6. PMID: 3485687.
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Hofman FM, von Hanwehr RI, Dinarello CA, Mizel SB, Hinton D, Merrill JE. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J Immunol. 1986 May 01; 136(9):3239-45. PMID: 3082983.
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Lachman LB, Dinarello CA, Llansa ND, Fidler IJ. Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells. J Immunol. 1986 Apr 15; 136(8):3098-102. PMID: 3485680.
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Miossec P, Dinarello CA, Ziff M. Interleukin-1 lymphocyte chemotactic activity in rheumatoid arthritis synovial fluid. Arthritis Rheum. 1986 Apr; 29(4):461-70. PMID: 3486662.
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Dinarello CA, Conti P, Mier JW. Effects of human interleukin-1 on natural killer cell activity: is fever a host defense mechanism for tumor killing? Yale J Biol Med. 1986 Mar-Apr; 59(2):97-106. PMID: 3488622.
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Hamawy KJ, Yamazaki K, Georgieff M, Dinarello CA, Moldawer LL, Blackburn GL, Bistrian BR. Improvements in host immunity by partially purified interleukin 1 in rats with portacaval anastomosis and splenectomy. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr; 10(2):146-50. PMID: 3485731.
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Telzak E, Wolff SM, Dinarello CA, Conlon T, el Kholy A, Bahr GM, Choay JP, Morin A, Chedid L. Clinical evaluation of the immunoadjuvant murabutide, a derivative of MDP, administered with a tetanus toxoid vaccine. J Infect Dis. 1986 Mar; 153(3):628-33. PMID: 3950444.
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Dinarello CA. Studies on the biological properties of purified and recombinant human interleukin-1. Methods Find Exp Clin Pharmacol. 1986 Feb; 8(2):57-61. PMID: 3487013.
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Watters JM, Bessey PQ, Dinarello CA, Wolff SM, Wilmore DW. Both inflammatory and endocrine mediators stimulate host responses to sepsis. Arch Surg. 1986 Feb; 121(2):179-90. PMID: 3511887.
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Dayer JM, de Rochemonteix B, Burrus B, Demczuk S, Dinarello CA. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest. 1986 Feb; 77(2):645-8. PMID: 3003163.
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Hamby BA, Huggins EM, Lachman LB, Dinarello CA, Sigel MM. Fish lymphocytes respond to human IL-1. Lymphokine Res. 1986; 5(2):157-62. PMID: 3486331.
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Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M, Nielsen JH. Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia. 1986 Jan; 29(1):63-7. PMID: 3514344.
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Valentine M, Lotz M, Dinarello CA, Carson DA, Vaughan JH. Lymphoblastoid B cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1. Lymphokine Res. 1986; 5(3):173-83. PMID: 3018386.
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Bingel M, Lonnemann G, Shaldon S, Koch KM, Dinarello CA. Human interleukin-1 production during hemodialysis. Nephron. 1986; 43(3):161-3. PMID: 3487741.
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Dinarello CA. Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin). Year Immunol. 1986; 2:68-89. PMID: 3107241.
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Walter J, Davenne D, Shoham S, Dinarello CA, Krueger JM. Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep. Am J Physiol. 1986 Jan; 250(1 Pt 2):R96-103. PMID: 3484616.
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Wolff SM, Auron PE, Dinarello CA, Rosenwasser LJ, Webb AC, Rich A. Clone controversy at Immunex. Nature. 1986 Jan 23-29; 319(6051):270. PMID: 3484544.
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Dinarello CA, Mier JW. Interleukins. Annu Rev Med. 1986; 37:173-8. PMID: 3518604.
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Ahmed MS, Llanos-Q J, Dinarello CA, Blatteis CM. Interleukin 1 reduces opioid binding in guinea pig brain. Peptides. 1985 Nov-Dec; 6(6):1149-54. PMID: 3010257.
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Stern DM, Bank I, Nawroth PP, Cassimeris J, Kisiel W, Fenton JW, Dinarello C, Chess L, Jaffe EA. Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med. 1985 Oct 01; 162(4):1223-35. PMID: 3876401.
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Herman J, Dinarello CA, Kew MC, Rabson AR. The role of interleukin 1 (IL 1) in tumor-NK cell interactions: correction of defective NK cell activity in cancer patients by treating target cells with IL 1. J Immunol. 1985 Oct; 135(4):2882-6. PMID: 2993420.
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Williams JM, Deloria D, Hansen JA, Dinarello CA, Loertscher R, Shapiro HM, Strom TB. The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1. J Immunol. 1985 Oct; 135(4):2249-55. PMID: 3928742.
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Kaplan AP, Haak-Frendscho M, Fauci A, Dinarello C, Halbert E. A histamine-releasing factor from activated human mononuclear cells. J Immunol. 1985 Sep; 135(3):2027-32. PMID: 2410512.
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Dinarello CA. An update on human interleukin-1: from molecular biology to clinical relevance. J Clin Immunol. 1985 Sep; 5(5):287-97. PMID: 3902871.
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Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med. 1985 Sep 01; 162(3):930-42. PMID: 2411843.
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Crawford GD, Wyler DJ, Dinarello CA. Parasite-monocyte interactions in human leishmaniasis: production of interleukin-1 in vitro. J Infect Dis. 1985 Aug; 152(2):315-22. PMID: 3875664.
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Watters JM, Bessey PQ, Dinarello CA, Wolff SM, Wilmore DW. The induction of interleukin-1 in humans and its metabolic effects. Surgery. 1985 Aug; 98(2):298-306. PMID: 3895542.
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Cannon JG, Dinarello CA. Increased plasma interleukin-1 activity in women after ovulation. Science. 1985 Mar 08; 227(4691):1247-9. PMID: 3871966.
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Libby P, Wyler DJ, Janicka MW, Dinarello CA. Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells. Arteriosclerosis. 1985 Mar-Apr; 5(2):186-91. PMID: 3872118.
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Dinarello CA, Kent EF. Chemical characterization of an interleukin-1-inducing substance derived from human mixed leukocyte reactions: IL-1-inducing substance is not gamma interferon. Yale J Biol Med. 1985 Mar-Apr; 58(2):101-13. PMID: 2930955.
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Peters M, Butler JL, Margolick JB, Gerrard TL, Dinarello CA, Fauci AS. Synergy of helper factors in the differentiation of in vivo-preactivated antigen-specific human B cells. Cell Immunol. 1985 Mar; 91(1):33-42. PMID: 2578896.
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Bernheim HA, Dinarello CA. Effect of protein synthesis inhibitors on leukocytic pyrogen-induced in vitro hypothalamic prostaglandin production. Yale J Biol Med. 1985 Mar-Apr; 58(2):179-87. PMID: 3862287.
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Chu ET, Lareau M, Rosenwasser LJ, Dinarello CA, Geha RS. Antigen presentation by EBV-B cells to resting and activated T cells: role of interleukin 1. J Immunol. 1985 Mar; 134(3):1676-81. PMID: 2981918.
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Mier JW, Souza LM, Allegretta M, Boone T, Bernheim HA, Dinarello CA. Dissimilarities between purified human interleukin-1 and recombinant human interleukin-2 in the induction of fever, brain prostaglandin, and acute-phase protein synthesis. J Biol Response Mod. 1985 Feb; 4(1):35-45. PMID: 3872345.
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Shaldon S, Koch KM, Quellhorst E, Lonnemann G, Dinarello CA. CAPD is a second-class treatment. Contrib Nephrol. 1985; 44:163-72. PMID: 3872770.
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Auron PE, Rosenwasser LJ, Matsushima K, Copeland T, Dinarello CA, Oppenheim JJ, Webb AC. Human and murine interleukin 1 possess sequence and structural similarities. J Mol Cell Immunol. 1985; 2(3):169-77. PMID: 3880507.
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Sahasrabuddhe CG, Dinarello C, Martin B, Maizel AL. Intracellular human IL-1: a precursor for the secreted monokine. Lymphokine Res. 1985; 4(3):205-13. PMID: 3875766.
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Williams JM, Dinarello CA, Rosenwasser LJ, Kelley V, Reddish M, Strom TB. Phorbol myristate acetate-protein complex mimics bioactivity of human IL-1. 1. Direct evidence that PMA temporarily enters and is released from cellular compartment during superinduction protocol. Lymphokine Res. 1985; 4(4):275-97. PMID: 3876490.
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Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7907-11. PMID: 6083565.
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Pearson FC, Bohon J, Lee W, Bruszer G, Sagona M, Jakubowski G, Dawe R, Morrison D, Dinarello C. Characterization of Limulus amoebocyte lysate-reactive material from hollow-fiber dialyzers. Appl Environ Microbiol. 1984 Dec; 48(6):1189-96. PMID: 6517586.
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Dinarello CA. Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med. 1984 Nov 29; 311(22):1413-8. PMID: 6208485.
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Hirose-Kumagai A, Whipple FH, Ikejima T, Dinarello CA, Gill DM, Ritz HL, Bond GG. A comparison of neutralizing and antigen-binding assays for human antibodies against toxic-shock-syndrome toxin 1. J Infect Dis. 1984 Nov; 150(5):788. PMID: 6491386.
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Dinarello CA, Bernheim HA, Duff GW, Le HV, Nagabhushan TL, Hamilton NC, Coceani F. Mechanisms of fever induced by recombinant human interferon. J Clin Invest. 1984 Sep; 74(3):906-13. PMID: 6590569.
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Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA. Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol. 1984 Sep; 133(3):1339-45. PMID: 6235287.
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Dinarello CA, Clowes GH, Gordon AH, Saravis CA, Wolff SM. Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes. J Immunol. 1984 Sep; 133(3):1332-8. PMID: 6611371.
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Dinarello CA, O'Connor JV, LoPreste G, Swift RL. Human leukocytic pyrogen test for detection of pyrogenic material in growth hormone produced by recombinant Escherichia coli. J Clin Microbiol. 1984 Sep; 20(3):323-9. PMID: 6386853.
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Loda M, Clowes GH, Dinarello CA, George BC, Lane B, Richardson W. Induction of hepatic protein synthesis by a peptide in blood plasma of patients with sepsis and trauma. Surgery. 1984 Aug; 96(2):204-13. PMID: 6611596.
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Falkoff RJ, Butler JL, Dinarello CA, Fauci AS. Direct effects of a monoclonal B cell differentiation factor and of purified interleukin 1 on B cell differentiation. J Immunol. 1984 Aug; 133(2):692-6. PMID: 6610708.
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Chu ET, Rosenwasser LJ, Dinarello CA, Rosen FS, Geha RS. Immunodeficiency with defective T-cell response to interleukin 1. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4945-9. PMID: 6611555.
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Pearson FC, Bohon J, Lee W, Bruszer G, Sagona M, Dawe R, Jakubowski G, Morrison D, Dinarello C. Comparison of chemical analyses of hollow-fiber dialyzer extracts. Artif Organs. 1984 Aug; 8(3):291-8. PMID: 6383298.
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Bendtzen K, Dinarello CA. Mechanism of action of cyclosporin A. Effect on T-cell-binding of interleukin 1 and antagonizing effect of insulin. Scand J Immunol. 1984 Jul; 20(1):43-51. PMID: 6379854.
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Wyler DJ, Stadecker MJ, Dinarello CA, O'Dea JF. Fibroblast stimulation in schistosomiasis. V. Egg granuloma macrophages spontaneously secrete a fibroblast-stimulating factor. J Immunol. 1984 Jun; 132(6):3142-8. PMID: 6609969.
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Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L. Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol. 1984 Jun; 246(6 Pt 2):R994-9. PMID: 6611091.
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Sauder DN, Dinarello CA, Morhenn VB. Langerhans cell production of interleukin-1. J Invest Dermatol. 1984 Jun; 82(6):605-7. PMID: 6373957.
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Ikejima T, Dinarello CA, Gill DM, Wolff SM. Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome. J Clin Invest. 1984 May; 73(5):1312-20. PMID: 6609169.
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Goldberg AL, Baracos V, Rodemann P, Waxman L, Dinarello C. Control of protein degradation in muscle by prostaglandins, Ca2+, and leukocytic pyrogen (interleukin 1). Fed Proc. 1984 Apr; 43(5):1301-6. PMID: 6323220.
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Chu E, Rosenwasser LJ, Dinarello CA, Lareau M, Geha RS. Role of interleukin 1 in antigen-specific T cell proliferation. J Immunol. 1984 Mar; 132(3):1311-6. PMID: 6198387.
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Bendtzen K, Baek L, Berild D, Hasselbach H, Dinarello CA, Wolff SM. Demonstration of circulating leukocytic pyrogen/interleukin-1 during fever. N Engl J Med. 1984 Mar 01; 310(9):596. PMID: 6607415.
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Sauder DN, Mounessa NL, Katz SI, Dinarello CA, Gallin JI. Chemotactic cytokines: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis. J Immunol. 1984 Feb; 132(2):828-32. PMID: 6361134.
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Dinarello CA. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb; 6(1):51-95. PMID: 6369481.
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Dinarello CA, Bishai I, Rosenwasser LJ, Coceani F. The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1). Int J Immunopharmacol. 1984; 6(1):43-50. PMID: 6427123.
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Dinarello CA. Interleukin 1 as mediator of the acute-phase response. Surv Immunol Res. 1984; 3(1):29-33. PMID: 6609399.
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Shaldon S, Koch KM, Quellhorst E, Dinarello CA. Pathogenesis of sclerosing peritonitis in CAPD. Trans Am Soc Artif Intern Organs. 1984; 30:193-4. PMID: 6335930.
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Sobrado J, Moldawer LL, Bistrian BR, Dinarello CA, Blackburn GL. Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin. Infect Immun. 1983 Dec; 42(3):997-1005. PMID: 6358043.
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Wood DD, Ihrie EJ, Dinarello CA, Cohen PL. Isolation of an interleukin-1-like factor from human joint effusions. Arthritis Rheum. 1983 Aug; 26(8):975-83. PMID: 6603852.
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Dinarello CA. Molecular mechanisms in endotoxin fever. Agents Actions. 1983 Aug; 13(5-6):470-86. PMID: 6416039.
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Falkoff RJ, Muraguchi A, Hong JX, Butler JL, Dinarello CA, Fauci AS. The effects of interleukin 1 on human B cell activation and proliferation. J Immunol. 1983 Aug; 131(2):801-5. PMID: 6602846.
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Coceani F, Bishai I, Dinarello CA, Fitzpatrick FA. Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. Am J Physiol. 1983 Jun; 244(6):R785-93. PMID: 6574712.
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Lipsky PE, Thompson PA, Rosenwasser LJ, Dinarello CA. The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen. J Immunol. 1983 Jun; 130(6):2708-14. PMID: 6222114.
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Baracos V, Rodemann HP, Dinarello CA, Goldberg AL. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. N Engl J Med. 1983 Mar 10; 308(10):553-8. PMID: 6402699.
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Dinarello CA, Marnoy SO, Rosenwasser LJ. Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1. J Immunol. 1983 Feb; 130(2):890-5. PMID: 6401308.
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Dinarello CA. Pathogenesis of fever during hemodialysis. Contrib Nephrol. 1983; 36:90-9. PMID: 6839779.
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Chedid L, Bahr GM, Modabber FZ, Dinarello CA, Wolff SM. [Demonstration of a bacterial structure in two human mediators: a sleep facilitating factor and a monokine]. C R Seances Acad Sci III. 1983; 297(4):209-12. PMID: 6419996.
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Dempsey RA, Dinarello CA, Mier JW, Rosenwasser LJ, Allegretta M, Brown TE, Parkinson DR. The differential effects of human leukocyte pyrogen/lymphocyte-activating factor, T cell growth factor, and interferon on human natural killer activity. J Immunol. 1982 Dec; 129(6):2504-10. PMID: 6982930.
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Beer DJ, Dinarello CA, Rosenwasser LJ, Rocklin RE. Human monocyte-derived soluble product(s) has an accessory function in the generation of histamine- and concanavalin A-induced suppressor T cells. J Clin Invest. 1982 Aug; 70(2):393-400. PMID: 6212597.
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Dinarello CA, Wolff SM. Production of fever and its effects on the host. Klin Wochenschr. 1982 Jul 15; 60(14):727-30. PMID: 6750226.
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Dinarello CA, Wolff SM. Molecular basis of fever in humans. Am J Med. 1982 May; 72(5):799-819. PMID: 6805324.
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Beer DJ, Rosenwasser LJ, Dinarello CA, Rocklin RE. Cellular interactions in the generation and expression of histamine-induced suppressor activity. Cell Immunol. 1982 May 01; 69(1):101-12. PMID: 6213308.
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Dinarello CA, Bendtzen K, Wolff SM. Studies on the active site of human leukocytic pyrogen. Inflammation. 1982 Mar; 6(1):63-78. PMID: 7085045.
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McAdam KP, Li J, Knowles J, Foss NT, Dinarello CA, Rosenwasser LJ, Selinger MJ, Kaplan MM, Goodman R, Herbert PN, Bausserman LL, Nadler LM. The biology of SAA: identification of the inducer, in vitro synthesis, and heterogeneity demonstrated with monoclonal antibodies. Ann N Y Acad Sci. 1982; 389:126-36. PMID: 6807176.
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Dinarello CA, Dempsey RA, Mier JW, Rosenwasser LJ, Parkinson DR. Fever, interleukin-1 and host defense against malignancy. Lymphokine Res. 1982; 1(3):59-67. PMID: 6083420.
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Dinarello CA, Rosenwasser LJ, Wolff SM. Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans. J Immunol. 1981 Dec; 127(6):2517-9. PMID: 6795276.
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Dinarello CA, Shparber M, Kent EF, Wolff SM. Production of leukocytic pyrogen from phagocytes of neonates. J Infect Dis. 1981 Oct; 144(4):337-43. PMID: 7288214.
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Dinarello CA, Bernheim HA. Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J Neurochem. 1981 Sep; 37(3):702-8. PMID: 7276950.
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Rosenwasser LJ, Dinarello CA. Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation. Cell Immunol. 1981 Sep 01; 63(1):134-42. PMID: 6791835.
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Dinarello CA. Demonstration of a human pyrogen-inducing factor during mixed leukocyte reactions. J Exp Med. 1981 May 01; 153(5):1215-24. PMID: 6454745.
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Hooper DC, Steer CJ, Dinarello CA, Peacock AC. Haptoglobin and albumin synthesis in isolated rat hepatocytes. Response to potential mediators of the acute-phase reaction. Biochim Biophys Acta. 1981 Mar 26; 653(1):118-29. PMID: 7013808.
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Parant M, Riveau G, Parant F, Dinarello CA, Wolff SM, Chedid L. Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide. J Infect Dis. 1980 Nov; 142(5):708-15. PMID: 7462686.
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Wolff SM, Dinarello CA. The Jeremiah Metzger Lecture. The pathogenesis of fever in human subjects. Trans Am Clin Climatol Assoc. 1980; 91:159-66. PMID: 552177.
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Klempner MS, Dinarello CA, Henderson WR, Gallin JI. Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen. J Clin Invest. 1979 Oct; 64(4):996-1002. PMID: 90061.
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Rosenwasser LJ, Dinarello CA, Rosenthal AS. Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen. J Exp Med. 1979 Sep 19; 150(3):709-14. PMID: 314491.
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Lipton JM, Dinarello CA, Kennedy JI. Fever produced in the squirrel monkey by human leukocytic pyrogen. Proc Soc Exp Biol Med. 1979 Apr; 160(4):426-8. PMID: 109842.
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Dinarello CA. Production of endogenous pyrogen. Fed Proc. 1979 Jan; 38(1):52-6. PMID: 759239.
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Dinarello CA, Elin RJ, Chedid L, Wolff SM. The pyrogenicity of the synthetic adjuvant muramyl dipeptide and two structural analogues. J Infect Dis. 1978 Dec; 138(6):760-7. PMID: 368262.
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Klempner MS, Dinarello CA, Gallin JI. Human leukocytic pyrogen induces release of specific granule contents from human neutrophils. J Clin Invest. 1978 May; 61(5):1330-6. PMID: 659595.
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Dinarello CA, Wolff SM. Partial purification of human leukocytic pyrogen. Inflammation. 1977 Sep; 2(3):179-89. PMID: 617807.
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Dinarello CA, Renfer L, Wolff SM. The production of antibody against human leukocytic pyrogen. J Clin Invest. 1977 Aug; 60(2):465-72. PMID: 559692.
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Dinarello CA, Chusid MJ, Fauci AS, Gallin JI, Dale DC, Wolff SM. Effect of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever. Arthritis Rheum. 1976 May-Jun; 19(3):618-22. PMID: 779797.
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Perlow M, Dinarello CA, Wolff SM. A primate model for the study of human fever. J Infect Dis. 1975 Aug; 132(2):157-64. PMID: 808582.
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Dinarello CA, Wolff SM, Goldfinger SE, Dale DC, Alling DW. Colchicine therapy for familial mediterranean fever. A double-blind trial. N Engl J Med. 1974 Oct 31; 291(18):934-7. PMID: 4606353.
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Dinarello CA, Goldin NP, Wolff SM. Demonstration and characterization of two distinct human leukocytic pyrogens. J Exp Med. 1974 Jun 01; 139(6):1369-81. PMID: 4829934.
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Wolff SM, Dinarello CA, Dale DC, Goldfinger SE, Alling DW. Colchicine therapy of familial Mediterranean fever. Trans Assoc Am Physicians. 1974; 87:186-94. PMID: 4617366.
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Dinarello CA, Ward SB, Wolff SM. Pyrogenic properties of bleomycin (NSC-125066). Cancer Chemother Rep. 1973 Nov-Dec; 57(4):393-8. PMID: 4128421.
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Bujak JS, Ottesen EA, Dinarello CA, Brenner VJ. Nocardiosis in a child with chronic granulomatous disease. J Pediatr. 1973 Jul; 83(1):98-100. PMID: 4768944.
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Dinarello CA, Bodel PT, Atkins E. The role of the liver in the production of fever and in pyrogenic tolerance. Trans Assoc Am Physicians. 1968; 81:334-44. PMID: 5721410.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
|---|
| 1994 | 34 | | 1995 | 27 | | 1996 | 24 | | 1997 | 19 | | 1998 | 27 | | 1999 | 20 | | 2000 | 18 | | 2001 | 18 | | 2002 | 17 | | 2003 | 25 | | 2004 | 20 | | 2005 | 24 | | 2006 | 21 | | 2007 | 19 | | 2008 | 22 | | 2009 | 27 | | 2010 | 24 | | 2011 | 31 | | 2012 | 16 | | 2013 | 29 | | 2014 | 27 | | 2015 | 27 | | 2016 | 25 | | 2017 | 27 | | 2018 | 26 | | 2019 | 18 | | 2020 | 13 | | 2021 | 23 | | 2022 | 10 | | 2023 | 8 |
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