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Edward David Chan

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/315-7767

    Collapse Research 
    Collapse research activities and funding
    I01BX005651     (CHAN, EDWARD D)Jul 1, 2023 - Jun 30, 2027
    NIH
    Establishing the Therapeutic Efficacy of Alpha-1-Antitrypsin and Enoxaparin Against COVID-19
    Role: Principal Investigator
    I01CX001452     (CHAN, EDWARD D)Oct 1, 2017 - Sep 30, 2021
    NIH
    How Does Nicotine Impair Macrophage Killing of Mycobacterium Tuberculosis? 
    Role: Principal Investigator
    R21AI121605     (CHAN, EDWARD D)Jun 14, 2016 - May 31, 2019
    NIH
    The role of T regulatory cells in cigarette smoke-induced susceptibility to tuberculosis
    Role: Principal Investigator
    I01BX001028     (CHAN, EDWARD D)Oct 1, 2011 - Sep 30, 2015
    NIH
    Mechanistic study of the host defense functions of IL-32 in tuberculosis
    Role: Principal Investigator
    R01HL066112     (CHAN, EDWARD D)Jul 15, 2001 - Nov 30, 2007
    NIH
    Host defense functions of M. tuberculosis lipoglycan
    Role: Principal Investigator
    K08HL003625     (CHAN, EDWARD D)Jan 1, 1997 - Dec 31, 2001
    NIH
    REGULATION OF INSULIN LIKE GROWTH FACTOR I
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chan ED. Identification of AAT-Deficient Subjects with Normal Spirometry Who May Benefit from AAT Replacement. Am J Respir Crit Care Med. 2024 Jan 18. PMID: 38237158.
      View in: PubMed
    2. Dawrs SN, Virdi R, Norton GJ, Elias T, Hasan NA, Robinson S, Matriz J, Epperson LE, Glickman CM, Beagle S, Crooks JL, Nelson ST, Chan ED, Damby DE, Strong M, Honda JR. Hawaiian Volcanic Ash, an Airborne Fomite for Nontuberculous Mycobacteria. Geohealth. 2024 Jan; 8(1):e2023GH000889. PMID: 38161597.
      View in: PubMed
    3. Bai X, Verma D, Garcia C, Musheyev A, Kim K, Fornis L, Griffith DE, Li L, Whittel N, Gadwa J, Ohanjanyan T, Eggleston MJ, Galvan M, Freed BM, Ordway D, Chan ED. Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis. Front Cell Infect Microbiol. 2023; 13:1216492. PMID: 37965256.
      View in: PubMed
    4. Hendrix J, Epperson LE, Tong EI, Chan YL, Hasan NA, Dawrs SN, Norton GJ, Virdi R, Crooks JL, Chan ED, Honda JR, Strong M. Complete genome assembly of Hawai'i environmental nontuberculous mycobacteria reveals unexpected co-isolation with methylobacteria. PLoS One. 2023; 18(9):e0291072. PMID: 37703253.
      View in: PubMed
    5. Dawrs SN, Virdi R, Islam MN, Hasan NA, Norton GJ, Crooks JL, Parr J, Heinz D, Cool CD, Belisle JT, Chan ED, Honda JR. Immunological and metabolic characterization of environmental Mycobacterium chimaera infection in a murine model. Microbes Infect. 2023 Nov-Dec; 25(8):105184. PMID: 37453489.
      View in: PubMed
    6. Bai X, Schountz T, Buckle AM, Talbert JL, Sandhaus RA, Chan ED. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. Biochem Soc Trans. 2023 06 28; 51(3):1361-1375. PMID: 37294003.
      View in: PubMed
    7. Dow CT, Lin NW, Chan ED. Sarcoidosis, Mycobacterium paratuberculosis and Noncaseating Granulomas: Who Moved My Cheese. Microorganisms. 2023 Mar 24; 11(4). PMID: 37110254.
      View in: PubMed
    8. Peters J, Maselli DJ, Mangat M, Coalson JJ, Hinojosa C, Giavedoni L, Brown-Elliott BA, Chan E, Griffith D. A marmoset model for Mycobacterium avium complex pulmonary disease. PLoS One. 2023; 18(3):e0260563. PMID: 36893126.
      View in: PubMed
    9. Rockstrom M, Lutz R, Dickeson K, O'Rorke EV, Narita M, Amram O, Chan ED. Fulminant pulmonary tuberculosis in a previously healthy young woman from the Marshall Islands: Potential risk factors. J Clin Tuberc Other Mycobact Dis. 2023 May; 31:100351. PMID: 36923241.
      View in: PubMed
    10. Arguinchona LM, Zagona-Prizio C, Joyce ME, Chan ED, Maloney JP. Microvascular significance of TGF-? axis activation in COVID-19. Front Cardiovasc Med. 2022; 9:1054690. PMID: 36684608.
      View in: PubMed
    11. Lu M, Chen W, Lei Z, Dai S, Hou C, Du S, Geake J, Bhurayanontachai R, Karamchand S, Chan ED, Jin Q, Li H. Image-guided percutaneous biopsy and pathological diagnosis in atypical tuberculous spondylitis: a case series and clinical outcomes. Ann Transl Med. 2022 Oct; 10(20):1140. PMID: 36388828.
      View in: PubMed
    12. Bai X, Bai A, Tomasicchio M, Hagman JR, Buckle AM, Gupta A, Kadiyala V, Bevers S, Serban KA, Kim K, Feng Z, Spendier K, Hagen G, Fornis L, Griffith DE, Dzieciatkowska M, Sandhaus RA, Gerber AN, Chan ED. a1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages. J Immunol. 2022 11 01; 209(9):1746-1759. PMID: 36162872.
      View in: PubMed
    13. Youssefnia A, Pierre A, Hoder JM, MacDonald M, Shaffer MJB, Friedman J, Mehler PS, Bontempo A, da Silva FCN, Chan ED. Ancillary treatment of patients with lung disease due to non-tuberculous mycobacteria: a narrative review. J Thorac Dis. 2022 Sep; 14(9):3575-3597. PMID: 36245600.
      View in: PubMed
    14. Abdelaal HFM, Chan ED, Young L, Baldwin SL, Coler RN. Mycobacterium abscessus: It's Complex. Microorganisms. 2022 Jul 19; 10(7). PMID: 35889173.
      View in: PubMed
    15. Byrd TF, Chan ED. Editorial: Mycobacterium abscessus; The Paradox of Low Pathogenicity and High Virulence. Front Microbiol. 2022; 13:943694. PMID: 35756056.
      View in: PubMed
    16. Campbell JR, Chan ED, Falzon D, Trajman A, Keshavjee S, Leung CC, Miller AC, Monedero-Recuero I, Rodrigues DS, Seo H, Baghaei P, Udwadia Z, Viiklepp P, Bastos M, Menzies D. Low Body Mass Index at Treatment Initiation and Rifampicin-Resistant Tuberculosis Treatment Outcomes: An Individual Participant Data Meta-Analysis. Clin Infect Dis. 2022 Apr 27. PMID: 35476134.
      View in: PubMed
    17. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19; 12(1):6466. PMID: 35440617.
      View in: PubMed
    18. Parsons AW, Dawrs SN, Nelson ST, Norton GJ, Virdi R, Hasan NA, Epperson LE, Holst B, Chan ED, Leos-Barajas V, Reich BJ, Crooks JL, Strong M, Pacifici K, Honda JR. Soil Properties and Moisture Synergistically Influence Nontuberculous Mycobacterial Prevalence in Natural Environments of Hawai'i. Appl Environ Microbiol. 2022 05 10; 88(9):e0001822. PMID: 35435715.
      View in: PubMed
    19. Schenkel AR, Mitchell JD, Cool CD, Bai X, Groshong S, Koelsch T, Verma D, Ordway D, Chan ED. Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or Pseudomonas aeruginosa Infection. Immune Netw. 2022 Jun; 22(3):e27. PMID: 35799709.
      View in: PubMed
    20. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 03 25; 12(1):5207. PMID: 35338216.
      View in: PubMed
    21. Dow CT, Greenblatt CL, Chan ED, Dow JF. Evaluation of BCG Vaccination and Plasma Amyloid: A Prospective, Pilot Study with Implications for Alzheimer's Disease. Microorganisms. 2022 Feb 12; 10(2). PMID: 35208878.
      View in: PubMed
    22. Choi S, Potts KJ, Althoff MD, Jimenez G, Bai X, Calhoun KM, Cool CD, Chan ED. Histopathologic Analysis of Surgically Resected Lungs of Patients with Non-tuberculous Mycobacterial Lung Disease: a Retrospective and Hypothesis-generating Study. Yale J Biol Med. 2021 12; 94(4):527-535. PMID: 34970090.
      View in: PubMed
    23. Johara FT, Benedetti A, Platt R, Menzies D, Viiklepp P, Schaaf S, Chan E. Evaluating the performance of propensity score matching based approaches in individual patient data meta-analysis. BMC Med Res Methodol. 2021 11 23; 21(1):257. PMID: 34814845.
      View in: PubMed
    24. Tun MH, Borg B, Godfrey M, Hadley-Miller N, Chan ED. Respiratory manifestations of Marfan syndrome: a narrative review. J Thorac Dis. 2021 Oct; 13(10):6012-6025. PMID: 34795948.
      View in: PubMed
    25. Chen J, Xie F, Zheng X, Li Y, Liu S, Ma KC, Goto T, M?ller T, Chan ED, Sun J. Mobile 3-dimensional (3D) C-arm system-assisted transbronchial biopsy and ablation for ground-glass opacity pulmonary nodules: a case report. Transl Lung Cancer Res. 2021 Jul; 10(7):3312-3319. PMID: 34430367.
      View in: PubMed
    26. Dempers L, Lane T, Moubry RM, Chan ED. Taking Extra Steps in Evaluating a Lung Nodule. Ann Am Thorac Soc. 2021 06; 18(6):1063-1065. PMID: 34076558.
      View in: PubMed
    27. Ha DM, Zeng C, Chan ED, Gray M, Mazzone PJ, Samet JM, Steiner JF. Association of Exercise Behavior with Overall Survival in Stage I-IIIA Lung Cancer. Ann Am Thorac Soc. 2021 06; 18(6):1034-1042. PMID: 33326358.
      View in: PubMed
    28. Chan ED, Cota-Gomez A, Podell B. Adding Another Piece to the Puzzle of Why NTM Infections Are Relatively Uncommon despite Their Ubiquitous Nature. mBio. 2021 04 20; 12(2). PMID: 33879587.
      View in: PubMed
    29. Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 04; 9(4). PMID: 33883256.
      View in: PubMed
    30. Nelson ST, Robinson S, Rey K, Brown L, Jones N, Dawrs SN, Virdi R, Norton GJ, Epperson LE, Hasan NA, Chan ED, Strong M, Honda JR. Exposure Pathways of Nontuberculous Mycobacteria Through Soil, Streams, and Groundwater, Hawai'i, USA. Geohealth. 2021 Apr; 5(4):e2020GH000350. PMID: 33855248.
      View in: PubMed
    31. Verma D, Chan ED, Ordway DJ. The double-edged sword of Tregs in M tuberculosis, M avium, and M absessus infection. Immunol Rev. 2021 05; 301(1):48-61. PMID: 33713043.
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    32. Chan ED, Majluf-Cruz A. Is the Angioedema Associated with COVID-19 a Real Entity, a Mimic, or Both? Am J Respir Crit Care Med. 2021 03 01; 203(5):645-646. PMID: 33357169.
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    33. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
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    34. Dow CT, Chan ED. What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome? J Transl Autoimmun. 2021; 4:100085. PMID: 33665595.
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    35. Yiang GT, Tzeng IS, Shui HA, Wu MY, Peng MY, Chan CY, Chan ED, Wu YK, Lan CC, Yang MC, Huang KL, Wu CW, Chang CH, Su WL. Early Screening of Risk for Multidrug-Resistant Organisms in the Emergency Department in Patients With Pneumonia and Early Septic Shock: Single-Center, Retrospective Cohort Study. Shock. 2021 02 01; 55(2):198-209. PMID: 32694392.
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    36. Grayeb DE, Chan ED, Swanson LM, Gibson DG, Mehler PS. Nontuberculous mycobacterial lung infections in patients with eating disorders: plausible mechanistic links in a case series. AME Case Rep. 2021; 5:9. PMID: 33634249.
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    37. Ha DM, Prochazka AV, Bekelman DB, Stevens-Lapsley JE, Chan ED, Keith RL. Association of Leisure-Time Physical Activity With Health-Related Quality of Life Among US Lung Cancer Survivors. JNCI Cancer Spectr. 2021 02; 5(1). PMID: 35075444.
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    38. Virdi R, Lowe ME, Norton GJ, Dawrs SN, Hasan NA, Epperson LE, Glickman CM, Chan ED, Strong M, Crooks JL, Honda JR. Lower Recovery of Nontuberculous Mycobacteria from Outdoor Hawai'i Environmental Water Biofilms Compared to Indoor Samples. Microorganisms. 2021 Jan 22; 9(2). PMID: 33499212.
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    39. Chan ED, Sharma V. Does Hypoxia Itself Beget Worsening Hypoxemia in COVID-19? Mayo Clin Proc. 2021 03; 96(3):824-825. PMID: 33673937.
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    40. Hasan NA, Norton GJ, Virdi R, Epperson LE, Vang CK, Hellbusch B, Bai X, Chan ED, Strong M, Honda JR. Measurable genomic changes in Mycobacterium avium subsp. hominissuis after long-term adaptation in Acanthamoeba lenticulata and reduced persistence in macrophages. J Bacteriol. 2021 03 15; 203(6). PMID: 33431432.
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    41. Weingart MF, Li Q, Choi S, Maleki-Fischbach M, Kwon YS, Koelsch T, Dow CT, Truong TQ, Chan ED. Analysis of Non-TB Mycobacterial Lung Disease in Patients With Primary Sj?gren's Syndrome at a Referral Center. Chest. 2021 06; 159(6):2218-2221. PMID: 33440182.
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    42. Odackal J, Milinic T, Amass T, Chan ED, Hua J, Krefft S. A 28-Year-Old Man With Chest Pain, Shortness of Breath, and Hemoptysis After Recovery From Coronavirus Disease 2019 Pneumonia. Chest. 2021 01; 159(1):e35-e38. PMID: 33422238.
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    43. Chan ED, Bai X. Further evidence that cigarette smoke and nicotine compromise host immunity against tuberculosis (invited editorial). Tuberculosis (Edinb). 2021 03; 127:102035. PMID: 33317928.
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    44. Verma D, Chan ED, Ordway DJ. Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions. Vaccines (Basel). 2020 Nov 16; 8(4). PMID: 33207695.
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    45. Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan; 146:110394. PMID: 33239231.
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    46. Kwak N, Winters N, Campbell JR, Chan ED, Gegia M, Lange C, Lee M, Milanov V, Menzies D, Yim JJ. Changes in treatment for multidrug-resistant tuberculosis according to national income. Eur Respir J. 2020 11; 56(5). PMID: 32586878.
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    47. Kim S, Lee JH, Lee S, Shim S, Nguyen TT, Hwang J, Kim H, Choi YO, Hong J, Bae S, Jhun H, Yum H, Lee Y, Chan ED, Yu L, Azam T, Kim YD, Yeom SC, Yoo KH, Kang LW, Shin KC, Kim S. The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene. Immune Netw. 2020 Oct; 20(5):e41. PMID: 33163249.
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    48. Glickman CM, Virdi R, Hasan NA, Epperson LE, Brown L, Dawrs SN, Crooks JL, Chan ED, Strong M, Nelson ST, Honda JR. Assessment of Soil Features on the Growth of Environmental Nontuberculous Mycobacterial Isolates from Hawai'i. Appl Environ Microbiol. 2020 10 15; 86(21). PMID: 32859599.
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    49. Honda JR, Chan YL, Tong EI, Kawatachi M, Virdi R, Norton GJ, Dawrs SN, Hasan NA, Epperson LE, Crooks JT, Chan ED, Strong M. Inaugural nontuberculous mycobacterial lung disease education and research conference, Honolulu, Hawai'i, February 1-2, 2020. Microbes Infect. 2021 Jan-Feb; 23(1):104763. PMID: 33035706.
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    50. Davidson KR, Ha DM, Schwarz MI, Chan ED. Bronchoalveolar lavage as a diagnostic procedure: a review of known cellular and molecular findings in various lung diseases. J Thorac Dis. 2020 Sep; 12(9):4991-5019. PMID: 33145073.
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    51. Moon P, Guillaumin E, Chan ED. Non-tuberculous mycobacterial lung disease due to multiple "minor" risk factors: an illustrative case and a review of these "lesser elements". J Thorac Dis. 2020 Sep; 12(9):4960-4972. PMID: 33145070.
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    52. Li T, Taba ST, Khong PL, Tan TX, Trieu PDY, Chan E, Suleiman ME, Li Y, Brennan P, Lewis S. Reading High Breast Density Mammograms: Differences in Diagnostic Performance between Radiologists from Hong Kong SAR/Guangdong Province in China and Australia. Asian Pac J Cancer Prev. 2020 Sep 01; 21(9):2623-2629. PMID: 32986361.
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    53. King M, Hurley H, Davidson KR, Dempsey EC, Barron MA, Chan ED, Frey A. The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence. Immune Netw. 2020 Aug; 20(4):e30. PMID: 32895617.
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    54. Dawrs SN, Kautz M, Chan ED, Honda JR. Mycobacteriumabscessus and Gastroesophageal Reflux: An In Vitro Study. Am J Respir Crit Care Med. 2020 08 01; 202(3):466-469. PMID: 32298605.
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    55. Chan ED, Majluf-Cruz A. Hereditary Angioedema. N Engl J Med. 2020 07 23; 383(4):e20. PMID: 32706544.
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    56. Chan ED, Verma D, Ordway DJ. Animal Models of Mycobacteria Infection. Curr Protoc Immunol. 2020 06; 129(1):e98. PMID: 32497414.
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    57. Chan ED. Are there common threads in the susceptibility to cancer and tuberculosis? J Thorac Dis. 2020 May; 12(5):1776-1780. PMID: 32642083.
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    58. Honda JR, Hess T, Carlson R, Kandasamy P, Nieto Ramirez LM, Norton GJ, Virdi R, Islam MN, Mehaffy C, Hasan NA, Epperson LE, Hesser D, Alper S, Strong M, Flores SC, Voelker DR, Dobos KM, Chan ED. Nontuberculous Mycobacteria Show Differential Infectivity and Use Phospholipids to Antagonize LL-37. Am J Respir Cell Mol Biol. 2020 03; 62(3):354-363. PMID: 31545652.
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    59. Feng Z, Bai X, Wang T, Garcia C, Bai A, Li L, Honda JR, Nie X, Chan ED. Differential Responses by Human Macrophages to Infection With Mycobacterium tuberculosis and Non-tuberculous Mycobacteria. Front Microbiol. 2020; 11:116. PMID: 32117140.
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    60. Choi S, Richards JC, Chan ED. Can physics principles help explain why non-tuberculous mycobacterial lung disease is more severe in the right middle lobe and lingula? J Thorac Dis. 2019 Nov; 11(11):4847-4854. PMID: 31903275.
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    61. Chan ED, Chan MM, Chan MM, Marik PE. Use of glucocorticoids in the critical care setting: Science and clinical evidence. Pharmacol Ther. 2020 02; 206:107428. PMID: 31626870.
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    62. Damen MSMA, Ballak D, Sapinsley Z, Bai X, Chan ED, Seals DR, Popa CD, Joosten LAB. Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes. Cytokine. 2020 01; 125:154793. PMID: 31398626.
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    63. Bai X, Bai A, Honda JR, Eichstaedt C, Musheyev A, Feng Z, Huitt G, Harbeck R, Kosmider B, Sandhaus RA, Chan ED. Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria. Front Immunol. 2019; 10:1417. PMID: 31293581.
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    64. Marras TK, Mirsaeidi M, Vinnard C, Chan ED, Eagle G, Zhang R, Wang P, Zhang Q. Guidelines-based treatment associated with improved economic outcomes in nontuberculous mycobacterial lung disease. J Med Econ. 2019 Nov; 22(11):1126-1133. PMID: 31094592.
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    65. Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis. mSphere. 2019 06 05; 4(3). PMID: 31167948.
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    66. Verma D, Stapleton M, Gadwa J, Vongtongsalee K, Schenkel AR, Chan ED, Ordway D. Mycobacterium avium Infection in a C3HeB/FeJ Mouse Model. Front Microbiol. 2019; 10:693. PMID: 31001241.
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    67. Tran T, Bonham AJ, Chan ED, Honda JR. A paucity of knowledge regarding nontuberculous mycobacterial lipids compared to the tubercle bacillus. Tuberculosis (Edinb). 2019 03; 115:96-107. PMID: 30948183.
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    68. Gebert MJ, Delgado-Baquerizo M, Oliverio AM, Webster TM, Nichols LM, Honda JR, Chan ED, Adjemian J, Dunn RR, Fierer N. Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health. mBio. 2018 10 30; 9(5). PMID: 30377276.
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    69. Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fr?chet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Labor?n R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 09 08; 392(10150):821-834. PMID: 30215381.
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    70. Ketai L, Currie BJ, Holt MR, Chan ED. Radiology of Chronic Cavitary Infections. J Thorac Imaging. 2018 Sep; 33(5):334-343. PMID: 30048346.
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    71. Holt MR, Chan ED. Chronic Cavitary Infections Other than Tuberculosis: Clinical Aspects. J Thorac Imaging. 2018 Sep; 33(5):322-333. PMID: 30036298.
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    72. Honda JR, Virdi R, Chan ED. Global Environmental Nontuberculous Mycobacteria and Their Contemporaneous Man-Made and Natural Niches. Front Microbiol. 2018; 9:2029. PMID: 30214436.
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    73. Chan ED. Thin body habitus is a risk factor for active pulmonary tuberculosis, but not for infection. Int J Tuberc Lung Dis. 2018 08 01; 22(8):967-968. PMID: 29991410.
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    74. Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, M?ndez-Echevarr?a A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC. Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis. PLoS Med. 2018 07; 15(7):e1002591. PMID: 29995958.
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    75. Chan ED. Reduced IFN-? in Patients with Pulmonary Nontuberculous Mycobacterial Disease: Potentially Multiple Causes. Am J Respir Cell Mol Biol. 2018 07; 59(1):130-131. PMID: 29957052.
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    76. Bai X, Aerts SL, Verma D, Ordway DJ, Chan ED. Epidemiologic Evidence of and Potential Mechanisms by Which Second-Hand Smoke Causes Predisposition to Latent and Active Tuberculosis. Immune Netw. 2018 Jun; 18(3):e22. PMID: 29984040.
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    77. Honda JR, Alper S, Bai X, Chan ED. Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections. Curr Opin Immunol. 2018 10; 54:66-73. PMID: 29936307.
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    78. Gomes RS, Silva MVT, Dos Santos JC, van Linge C, Reis JM, Teixeira MM, Pinto SA, Dorta ML, Bai X, Chan ED, Dinarello CA, Oliveira MAP, Joosten LAB, Ribeiro-Dias F. Human Interleukin-32? Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice. Infect Immun. 2018 05; 86(5). PMID: 29483288.
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    79. Brown JK, Singh K, Dumitru R, Chan E, Kim MP. The Benefits of Enhanced Recovery After Surgery Programs and Their Application in Cardiothoracic Surgery. Methodist Debakey Cardiovasc J. 2018 Apr-Jun; 14(2):77-88. PMID: 29977464.
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    80. Honda JR, Bai X, Chan ED. Elucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the Elephant. Am J Respir Cell Mol Biol. 2018 02; 58(2):142-143. PMID: 29388833.
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    81. Malcolm KC, Caceres SM, Honda JR, Davidson RM, Epperson LE, Strong M, Chan ED, Nick JA. Mycobacterium abscessus Displays Fitness for Fomite Transmission. Appl Environ Microbiol. 2017 10 01; 83(19). PMID: 28754702.
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    82. Bai X, Stitzel JA, Bai A, Zambrano CA, Phillips M, Marrack P, Chan ED. Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol. 2017 09; 57(3):324-333. PMID: 28398760.
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    83. Zhao X, Epperson LE, Hasan NA, Honda JR, Chan ED, Strong M, Walter ND, Davidson RM. Complete Genome Sequence of Mycobacterium avium subsp. hominissuis Strain H87 Isolated from an Indoor Water Sample. Genome Announc. 2017 Apr 20; 5(16). PMID: 28428297.
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    84. Lee S, Choi DK, Kwak A, Kim S, Nguyen TT, Gil G, Kim E, Yoo KH, Kim IA, Lee Y, Jhun H, Chan ED, Bai X, Kim H, Kim YS, Kim S. IL-32-induced Inflammatory Cytokines Are Selectively Suppressed by a1-antitrypsin in Mouse Bone Marrow Cells. Immune Netw. 2017 Apr; 17(2):116-120. PMID: 28458623.
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    85. Farabaugh KT, Majumder M, Guan BJ, Jobava R, Wu J, Krokowski D, Gao XH, Schuster A, Longworth M, Chan ED, Bianchi M, Dey M, Koromilas AE, Ramakrishnan P, Hatzoglou M. Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress. Mol Cell Biol. 2017 02 15; 37(4). PMID: 27920257.
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    86. Williams JG, Phan H, Winston HR, Fugit RV, Graney B, Jamroz B, English B, Chan ED. A 27-Year-Old Man With Acute Severe Low Back Pain and Bilateral Leg Swelling That Prompted Renting a Wheelchair for Mobility. Chest. 2017 Feb; 151(2):e35-e39. PMID: 28183502.
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    87. Becker KL, Arts P, Jaeger M, Plantinga TS, Gilissen C, van Laarhoven A, van Ingen J, Veltman JA, Joosten LA, Hoischen A, Netea MG, Iseman MD, Chan ED, van de Veerdonk FL. MST1R mutation as a genetic cause of Lady Windermere syndrome. Eur Respir J. 2017 01; 49(1). PMID: 28100548.
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    88. Honda JR, Hasan NA, Davidson RM, Williams MD, Epperson LE, Reynolds PR, Smith T, Iakhiaeva E, Bankowski MJ, Wallace RJ, Chan ED, Falkinham JO, Strong M. Correction: Environmental Nontuberculous Mycobacteria in the Hawaiian Islands. PLoS Negl Trop Dis. 2016 Dec; 10(12):e0005200. PMID: 27911953.
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    89. Hasan NA, Honda JR, Davidson RM, Epperson LE, Bankowski MJ, Chan ED, Strong M. Complete Genome Sequence of Mycobacterium chimaera Strain AH16. Genome Announc. 2016 Nov 23; 4(6). PMID: 27881537.
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    90. Honda JR, Hasan NA, Davidson RM, Williams MD, Epperson LE, Reynolds PR, Smith T, Iakhiaeva E, Bankowski MJ, Wallace RJ, Chan ED, Falkinham JO, Strong M. Environmental Nontuberculous Mycobacteria in the Hawaiian Islands. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005068. PMID: 27780201.
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    91. Philley JV, DeGroote MA, Honda JR, Chan MM, Kasperbauer S, Walter ND, Chan ED. Treatment of Non-Tuberculous Mycobacterial Lung Disease. Curr Treat Options Infect Dis. 2016 Dec; 8(4):275-296. PMID: 28529461.
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    92. Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK. Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients. J Infect Dis. 2016 10 15; 214(8):1205-11. PMID: 27534685.
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    93. Foster CL, Badlam J, De Groote MA, Chan ED. A 65-Year-Old Groundskeeper With High Fever, Pulmonary Nodules, and Thoracic Lymphadenopathy. Chest. 2016 Jun; 149(6):e191-4. PMID: 27287596.
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    94. Bai X, Oberley-Deegan RE, Bai A, Ovrutsky AR, Kinney WH, Weaver M, Zhang G, Honda JR, Chan ED. Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection. Respirology. 2016 Jul; 21(5):951-7. PMID: 27012592.
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    95. Fox GJ, Mitnick CD, Benedetti A, Chan ED, Becerra M, Chiang CY, Keshavjee S, Koh WJ, Shiraishi Y, Viiklepp P, Yim JJ, Pasvol G, Robert J, Shim TS, Shin SS, Menzies D, Ahuja S, Ashkin D, Avenda?o M, Banerjee R, Bauer M, Burgos M, Centis R, Cobelens F, Cox H, D'Ambrosio L, de Lange WCM, DeRiemer K, Enarson D, Falzon D, Flanagan K, Flood J, Gandhi N, Garcia-Garcia L, Granich RM, Hollm-Delgado MG, Holtz TH, Hopewell P, Iseman M, Jarlsberg LG, Kim HR, Lancaster J, Lange C, Leimane V, Leung CC, Li J, Menzies D, Migliori GB, Narita M, Nathanson E, Odendaal R, O'Riordan P, Pai M, Palmero D, Park SK, Pena J, P?rez-Guzm?n C, Ponce-de-Leon A, Quelapio MID, Quy HT, Riekstina V, Royce S, Salim M, Schaaf HS, Seung KJ, Shah L, Shean K, Sifuentes-Osornio J, Sotgiu G, Strand MJ, Sung SW, Tabarsi P, Tupasi TE, Vargas MH, van Altena R, van der Walt M, van der Werf TS, Westenhouse J, Yew WW. Surgery as an Adjunctive Treatment for Multidrug-Resistant Tuberculosis: An Individual Patient Data Metaanalysis. Clin Infect Dis. 2016 Apr 01; 62(7):887-895. PMID: 26757804.
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    96. Abe J, Alop-Mabuti A, Burger P, Button J, Ellsberry M, Hitzeman J, Morgenstern D, Nunies K, Strother M, Darling-Munson J, Chan YL, Cassady R, Vasconcellos SM, Iseman MD, Chan ED, Honda JR. Comparing the temporal colonization and microbial diversity of showerhead biofilms in Hawai'i and Colorado. FEMS Microbiol Lett. 2016 Feb; 363(4). PMID: 26764424.
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    97. Bai X, Dinarello CA, Chan ED. The role of interleukin-32 against tuberculosis. Cytokine. 2015 Dec; 76(2):585-587. PMID: 26144292.
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    98. Honda JR, Hess T, Malcolm KC, Ovrutsky AR, Bai X, Irani VR, Dobos KM, Chan ED, Flores SC. Pathogenic nontuberculous mycobacteria resist and inactivate cathelicidin: implication of a novel role for polar mycobacterial lipids. PLoS One. 2015; 10(5):e0126994. PMID: 25993058.
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    99. Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL, Takeda K, Chan MM, Dakhama A, Kinney WH, Trostel J, Bai A, Honda JR, Achcar R, Hartney J, Joosten LA, Kim SH, Orme I, Dinarello CA, Ordway DJ, Chan ED. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5111-6. PMID: 25820174.
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    100. Bishwakarma R, Kinney WH, Honda JR, Mya J, Strand MJ, Gangavelli A, Bai X, Ordway DJ, Iseman MD, Chan ED. Epidemiologic link between tuberculosis and cigarette/biomass smoke exposure: Limitations despite the vast literature. Respirology. 2015 May; 20(4):556-68. PMID: 25808744.
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    101. Bai X, Kinney WH, Su WL, Bai A, Ovrutsky AR, Honda JR, Netea MG, Henao-Tamayo M, Ordway DJ, Dinarello CA, Chan ED. Caspase-3-independent apoptotic pathways contribute to interleukin-32?-mediated control of Mycobacterium tuberculosis infection in THP-1 cells. BMC Microbiol. 2015 Feb 21; 15:39. PMID: 25887904.
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    102. Chan E, Anderson CS, Wang X, Arima H, Saxena A, Moullaali TJ, Heeley E, Delcourt C, Wu G, Wang J, Chen G, Lavados PM, Stapf C, Robinson T, Chalmers J, Huang Y. Significance of intraventricular hemorrhage in acute intracerebral hemorrhage: intensive blood pressure reduction in acute cerebral hemorrhage trial results. Stroke. 2015 Mar; 46(3):653-8. PMID: 25677598.
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    103. Honda JR, Bernhard JN, Chan ED. Natural disasters and nontuberculous mycobacteria: a recipe for increased disease? Chest. 2015 Feb; 147(2):304-308. PMID: 25644904.
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    104. Honda JR, Wallace RJ, Chan ED. First you have to row a little boat. Respirology. 2015 Feb; 20(2):181-2. PMID: 25581353.
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    105. Honda JR, Knight V, Chan ED. Pathogenesis and risk factors for nontuberculous mycobacterial lung disease. Clin Chest Med. 2015 Mar; 36(1):1-11. PMID: 25676515.
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    106. Chan ED, Kinney WH, Honda JR, Bishwakarma R, Gangavelli A, Mya J, Bai X, Ordway DJ. Tobacco exposure and susceptibility to tuberculosis: is there a smoking gun? Tuberculosis (Edinb). 2014 Dec; 94(6):544-50. PMID: 25305002.
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    107. Kim E, Kinney WH, Ovrutsky AR, Vo D, Bai X, Honda JR, Marx G, Peck E, Lindberg L, Falkinham JO, May RM, Chan ED. A surface with a biomimetic micropattern reduces colonization of Mycobacterium abscessus. FEMS Microbiol Lett. 2014 Nov; 360(1):17-22. PMID: 25155501.
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    108. Wu GC, Chan ED, Chou YC, Yu CY, Hsieh TY, Hsieh CB, Chian CF, Ke FC, Dai YL, Su WL. Risk factors for the development of pulmonary oil embolism after transcatheter arterial chemoembolization of hepatic tumors. Anticancer Drugs. 2014 Sep; 25(8):976-81. PMID: 24736105.
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    109. Honda JR, Connick E, MaWhinney S, Chan ED, Flores SC. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy. J Med Microbiol. 2014 Jul; 63(Pt 7):997-1003. PMID: 24821067.
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    110. Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar; 58(6):e115-8. PMID: 24336756.
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    111. Chan MM, Chan MM, Mengshol JA, Fish DN, Chan ED. Octreotide: a drug often used in the critical care setting but not well understood. Chest. 2013 Dec; 144(6):1937-1945. PMID: 24297127.
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    112. Ovrutsky AR, Merkel PA, Schonteich E, Bai X, Kinney W, Iseman MD, Kartalija M, Knight V, Chan ED. Patients with non-tuberculous mycobacterial lung disease have elevated transforming growth factor-beta following ex vivo stimulation of blood with live Mycobacterium intracellulare. Scand J Infect Dis. 2013 Sep; 45(9):711-4. PMID: 23808720.
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    113. Talbert J, Chan ED. The association between body shape and nontuberculous mycobacterial lung disease. Expert Rev Respir Med. 2013 Jun; 7(3):201-4. PMID: 23734642.
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    114. Chan ED, Iseman MD. Surgery for MDR-TB? Int J Tuberc Lung Dis. 2013 May; 17(5):710. PMID: 23575341.
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    115. Bai X, Feldman NE, Chmura K, Ovrutsky AR, Su WL, Griffin L, Pyeon D, McGibney MT, Strand MJ, Numata M, Murakami S, Gaido L, Honda JR, Kinney WH, Oberley-Deegan RE, Voelker DR, Ordway DJ, Chan ED. Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages. PLoS One. 2013; 8(4):e61925. PMID: 23634218.
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    116. Chan ED, Chan MM, Chan MM. Pulse oximetry: understanding its basic principles facilitates appreciation of its limitations. Respir Med. 2013 Jun; 107(6):789-99. PMID: 23490227.
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    117. Ovrutsky AR, Chan ED, Kartalija M, Bai X, Jackson M, Gibbs S, Falkinham JO, Iseman MD, Reynolds PR, McDonnell G, Thomas V. Cooccurrence of free-living amoebae and nontuberculous Mycobacteria in hospital water networks, and preferential growth of Mycobacterium avium in Acanthamoeba lenticulata. Appl Environ Microbiol. 2013 May; 79(10):3185-92. PMID: 23475613.
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    118. Chan ED, Iseman MD. Underlying host risk factors for nontuberculous mycobacterial lung disease. Semin Respir Crit Care Med. 2013 Feb; 34(1):110-23. PMID: 23460011.
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    119. Malcolm KC, Nichols EM, Caceres SM, Kret JE, Martiniano SL, Sagel SD, Chan ED, Caverly L, Solomon GM, Reynolds P, Bratton DL, Taylor-Cousar JL, Nichols DP, Saavedra MT, Nick JA. Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival. PLoS One. 2013; 8(2):e57402. PMID: 23451220.
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    120. Wang CH, Chan ED, Perng CL, Chian CF, Chen CW, Perng WC, Su WL. Intravenous immunoglobulin replacement therapy to prevent pulmonary infection in a patient with Good's syndrome. J Microbiol Immunol Infect. 2015 Apr; 48(2):229-32. PMID: 23200552.
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    121. Kartalija M, Ovrutsky AR, Bryan CL, Pott GB, Fantuzzi G, Thomas J, Strand MJ, Bai X, Ramamoorthy P, Rothman MS, Nagabhushanam V, McDermott M, Levin AR, Frazer-Abel A, Giclas PC, Korner J, Iseman MD, Shapiro L, Chan ED. Patients with nontuberculous mycobacterial lung disease exhibit unique body and immune phenotypes. Am J Respir Crit Care Med. 2013 Jan 15; 187(2):197-205. PMID: 23144328.
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    122. Chan ED, Pott GB, Silkoff PE, Ralston AH, Bryan CL, Shapiro L. Alpha-1-antitrypsin inhibits nitric oxide production. J Leukoc Biol. 2012 Dec; 92(6):1251-60. PMID: 22975343.
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    123. Walter ND, Strong M, Belknap R, Ordway DJ, Daley CL, Chan ED. Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis. Respirology. 2012 Jul; 17(5):772-91. PMID: 22458269.
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    124. Marx GE, Chan ED. Tuberculous meningitis: diagnosis and treatment overview. Tuberc Res Treat. 2011; 2011:798764. PMID: 22567269.
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    125. Bai X, Ovrutsky AR, Kartalija M, Chmura K, Kamali A, Honda JR, Oberley-Deegan RE, Dinarello CA, Crapo JD, Chang LY, Chan ED. IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease. Int Immunol. 2011 Nov; 23(11):679-91. PMID: 22033195.
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    126. Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. Open AIDS J. 2011; 5:86-95. PMID: 22046211.
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    127. Ovrutsky AR, Kartalija M, Bai X, Chan ED. A trojan horse strategy to deliver amikacin to mycobacterial granulomas. Am J Respir Crit Care Med. 2011 Oct 01; 184(7):860; author reply 860-1. PMID: 21965019.
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    128. Coffey D, Fain B, Thompson C, Chan ED, Nawaz S. Liver failure as the only clinical manifestation of multiple myeloma. Ann Hematol. 2012 Apr; 91(4):625-7. PMID: 21732087.
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    129. Shang S, Harton M, Tamayo MH, Shanley C, Palanisamy GS, Caraway M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ. Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis (Edinb). 2011 Sep; 91(5):378-85. PMID: 21737349.
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    130. Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, Freed BM, Iseman MD, Basaraba RJ, Chan ED. Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models. J Infect Dis. 2011 May 01; 203(9):1240-8. PMID: 21357942.
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    131. Kandasamy P, Zarini S, Chan ED, Leslie CC, Murphy RC, Voelker DR. Pulmonary surfactant phosphatidylglycerol inhibits Mycoplasma pneumoniae-stimulated eicosanoid production from human and mouse macrophages. J Biol Chem. 2011 Mar 11; 286(10):7841-7853. PMID: 21205826.
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    132. Walter ND, Rice PL, Redente EF, Kauvar EF, Lemond L, Aly T, Wanebo K, Chan ED. Wound healing after trauma may predispose to lung cancer metastasis: review of potential mechanisms. Am J Respir Cell Mol Biol. 2011 May; 44(5):591-6. PMID: 21177982.
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    133. Bai X, Chmura K, Ovrutsky AR, Bowler RP, Scheinman RI, Oberley-Deegan RE, Liu H, Shang S, Ordway D, Chan ED. Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription. Tuberculosis (Edinb). 2011 Jan; 91(1):26-35. PMID: 21167783.
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    134. Mor? JM, Voelker DR, Silveira LJ, Edwards MG, Chan ED, Bowler RP. Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease. BMC Pulm Med. 2010 Oct 25; 10:53. PMID: 20973980.
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    135. Chan ED, Keane J, Iseman MD. Should cigarette smoke exposure be a criterion to treat latent tuberculous infection? Am J Respir Crit Care Med. 2010 Oct 15; 182(8):990-2. PMID: 20947905.
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    136. Oberley-Deegan RE, Rebits BW, Weaver MR, Tollefson AK, Bai X, McGibney M, Ovrutsky AR, Chan ED, Crapo JD. An oxidative environment promotes growth of Mycobacterium abscessus. Free Radic Biol Med. 2010 Dec 01; 49(11):1666-73. PMID: 20807564.
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    137. Gingo M, Risbano MG, Russ PD, Chan ED. Not your otitis media 101. Am J Med. 2010 Aug; 123(8):e9-e11. PMID: 20670714.
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    138. Bai X, Kim SH, Azam T, McGibney MT, Huang H, Dinarello CA, Chan ED. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol. 2010 Apr 01; 184(7):3830-40. PMID: 20190143.
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    139. Chan ED, Iseman MD. Slender, older women appear to be more susceptible to nontuberculous mycobacterial lung disease. Gend Med. 2010 Feb; 7(1):5-18. PMID: 20189150.
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    140. Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ. Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):387-93. PMID: 20081053.
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    141. Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, Azam T, Dinarello CA, Lee S, Her E, Rho G, Kim S. Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta. Cytokine. 2010 Feb; 49(2):171-6. PMID: 19880327.
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    142. Bedient TJ, Schwarz MI, Groshong SD, Chan ED. A 45-year-old man with a history of hepatitis C and testicular cancer presents with cavitary lung lesions and palpable purpura. Chest. 2009 Oct; 136(4):1168-1174. PMID: 19809061.
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    143. Kuronuma K, Mitsuzawa H, Takeda K, Nishitani C, Chan ED, Kuroki Y, Nakamura M, Voelker DR. Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2. J Biol Chem. 2009 Sep 18; 284(38):25488-500. PMID: 19584052.
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    144. Morris KR, Lutz RD, Bai X, McGibney MT, Cook D, Ordway D, Chan ED. Suppression of IFNgamma+mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression. Tuberculosis (Edinb). 2009 Jul; 89(4):294-303. PMID: 19556165.
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    145. Bai X, Silvius D, Chan ED, Escalier D, Xu SX. Identification and characterization of a novel testis-specific gene CKT2, which encodes a substrate for protein kinase CK2. Nucleic Acids Res. 2009 May; 37(8):2699-711. PMID: 19273531.
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    146. Chan ED, Strand MJ, Iseman MD. Multidrug-resistant tuberculosis (TB) resistant to fluoroquinolones and streptomycin but susceptible to second-line injection therapy has a better prognosis than extensively drug-resistant TB. Clin Infect Dis. 2009 Mar 01; 48(5):e50-2. PMID: 19191632.
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    147. Pott GB, Chan ED, Dinarello CA, Shapiro L. Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol. 2009 May; 85(5):886-95. PMID: 19197072.
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    148. Oberley-Deegan RE, Lee YM, Morey GE, Cook DM, Chan ED, Crapo JD. The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):170-8. PMID: 19097985.
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    149. Chan ED, Iseman MD. Multidrug-resistant and extensively drug-resistant tuberculosis: a review. Curr Opin Infect Dis. 2008 Dec; 21(6):587-95. PMID: 18978526.
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    150. Chan ED, Strand MJ, Iseman MD. Treatment outcomes in extensively resistant tuberculosis. N Engl J Med. 2008 Aug 07; 359(6):657-9. PMID: 18687654.
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    151. Chan ED, Iseman MD. Significance of bronchiectasis in patients with alpha1-antitrypsin deficiency. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):208; author reply 208-9. PMID: 18594121.
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    152. Chmura K, Bai X, Nakamura M, Kandasamy P, McGibney M, Kuronuma K, Mitsuzawa H, Voelker DR, Chan ED. Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L220-30. PMID: 18487355.
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    153. Miller RM, Tomaras AP, Barker AP, Voelker DR, Chan ED, Vasil AI, Vasil ML. Pseudomonas aeruginosa twitching motility-mediated chemotaxis towards phospholipids and fatty acids: specificity and metabolic requirements. J Bacteriol. 2008 Jun; 190(11):4038-49. PMID: 18390654.
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    154. Chan ED. Corticosteroids for bacterial meningitis. N Engl J Med. 2008 Mar 27; 358(13):1399; author reply 1400-1. PMID: 18367746.
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    155. Sergew A, Merrick D, Chan ED. A 64-year-old man with joint swelling and an abnormal chest radiograph. Chest. 2008 Mar; 133(3):805-8. PMID: 18321909.
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    156. Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol. 2008 Jun; 83(6):1502-11. PMID: 18310351.
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    157. Liu L, Bastien N, Sidaway F, Chan E, Li Y. Seroprevalence of human metapneumovirus (hMPV) in the Canadian province of Saskatchewan analyzed by a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay. J Med Virol. 2007 Mar; 79(3):308-13. PMID: 17245714.
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    158. Morimoto Y, Chan ED, Heifets L, Routes JM. Pulmonary infection with Mycobacterium neoaurum identified by 16S ribosomal DNA sequence. J Infect. 2007 Apr; 54(4):e227-31. PMID: 17306883.
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    159. Chan ED, Kaminska AM, Gill W, Chmura K, Feldman NE, Bai X, Floyd CM, Fulton KE, Huitt GA, Strand MJ, Iseman MD, Shapiro L. Alpha-1-antitrypsin (AAT) anomalies are associated with lung disease due to rapidly growing mycobacteria and AAT inhibits Mycobacterium abscessus infection of macrophages. Scand J Infect Dis. 2007; 39(8):690-6. PMID: 17654345.
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    160. Gray K, Chan ED, Alvarado J. A 48-year-old woman with multiple pulmonary nodules and a right ventricular mass. Chest. 2006 Oct; 130(4):1248-51. PMID: 17035464.
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    161. Netea MG, Azam T, Lewis EC, Joosten LA, Wang M, Langenberg D, Meng X, Chan ED, Yoon DY, Ottenhoff T, Kim SH, Dinarello CA. Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med. 2006 Aug; 3(8):e277. PMID: 16903774.
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    162. Sullivan A, Chmura K, Cool CD, Keith R, Schwartz GG, Chan ED. Pulmonary capillary hemangiomatosis: an immunohistochemical analysis of vascular remodeling. Eur J Med Res. 2006 May 05; 11(5):187-93. PMID: 16723291.
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    163. Chan MM, Chmura K, Chan ED. Increased NaCl-induced interleukin-8 production by human bronchial epithelial cells is enhanced by the DeltaF508/W1282X mutation of the cystic fibrosis transmembrane conductance regulator gene. Cytokine. 2006 Mar 21; 33(6):309-16. PMID: 16647268.
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    164. Sullivan A, Chmura K, Cool CD, Voelkel N, Chan ED. Pulmonary capillary hemangiomatosis: an immunohistochemical analysis of vascular remodeling in a fatal case. Chest. 2005 Dec; 128(6 Suppl):576S. PMID: 16373838.
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    165. Wieland CW, Florquin S, Chan ED, Leemans JC, Weijer S, Verbon A, Fantuzzi G, van der Poll T. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol. 2005 Nov; 17(11):1399-408. PMID: 16141243.
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    166. Chmura K, Chan ED, Noone PG, Zariwala M, Winn RA, Knowles MR, Iseman MD, Gardner EM. A middle-aged woman with recurrent respiratory infections. Respiration. 2005 Jul-Aug; 72(4):427-30. PMID: 16088289.
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    167. Gruber MP, Nana-Sinkam SP, Chan ED. Airflow limitation and dynamic gas trapping in a bone marrow transplant recipient. Respir Care. 2004 Dec; 49(12):1542-5. PMID: 15603056.
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    168. Winn RA, Chan ED, Langmack EL, Kotaru C, Aronsen E. Dysphagia, chest pain, and refractory asthma in a 42-year-old woman. Chest. 2004 Nov; 126(5):1694-7. PMID: 15539746.
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    169. Bowler RP, Duda B, Vu KO, Byers T, Franklin W, Chan ED, Miller YE. Airway antioxidants and oxidative stress as predictors of sputum atypia and airflow obstruction. Chest. 2004 May; 125(5 Suppl):127S-8S. PMID: 15136460.
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    170. Kalman D, Lee A, Chan E, Miller DR, Spiro A, Ren XS, Kazis LE. Alcohol dependence, other psychiatric disorders, and health-related quality of life: a replication study in a large random sample of enrollees in the Veterans Health Administration. Am J Drug Alcohol Abuse. 2004 May; 30(2):473-87. PMID: 15230087.
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    171. Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1095-104. PMID: 14742308.
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    172. Chan ED, Laurel V, Strand MJ, Chan JF, Huynh ML, Goble M, Iseman MD. Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis. Am J Respir Crit Care Med. 2004 May 15; 169(10):1103-9. PMID: 14742301.
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    173. Bai X, Wilson SE, Chmura K, Feldman NE, Chan ED. Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis. Tuberculosis (Edinb). 2004; 84(6):375-85. PMID: 15525561.
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    174. Bastien N, Ward D, Van Caeseele P, Brandt K, Lee SH, McNabb G, Klisko B, Chan E, Li Y. Human metapneumovirus infection in the Canadian population. J Clin Microbiol. 2003 Oct; 41(10):4642-6. PMID: 14532196.
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    175. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
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    176. Bai X, Chan ED, Xu X. The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis. Biochem Biophys Res Commun. 2003 Jul 18; 307(1):86-91. PMID: 12849985.
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    177. Chmura K, Cool C, Kircher T, Chan ED. Painful lymphadenopathy and fulminant sepsis in a previously healthy 16-year-old girl. Chest. 2003 Jul; 124(1):379-82. PMID: 12853549.
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    178. Chan MM, Chan MM, Chan ED. What is the effect of fingernail polish on pulse oximetry? Chest. 2003 Jun; 123(6):2163-4. PMID: 12796214.
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    179. Morris KR, Lutz RD, Choi HS, Kamitani T, Chmura K, Chan ED. Role of the NF-kappaB signaling pathway and kappaB cis-regulatory elements on the IRF-1 and iNOS promoter regions in mycobacterial lipoarabinomannan induction of nitric oxide. Infect Immun. 2003 Mar; 71(3):1442-52. PMID: 12595462.
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    180. Chmura K, Lutz RD, Chiba H, Numata MS, Choi HJ, Fantuzzi G, Voelker DR, Chan ED. Mycoplasma pneumoniae antigens stimulate interleukin-8. Chest. 2003 Mar; 123(3 Suppl):425S. PMID: 12629012.
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    181. Choi HS, Rai PR, Chu HW, Cool C, Chan ED. Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):178-86. PMID: 12119230.
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    182. Chan ED, Choi HS, Cool C, Accurso FJ, Fantuzzi G. Interleukin-18 expression in cystic fibrosis lungs. Chest. 2002 Mar; 121(3 Suppl):84S-85S. PMID: 11893709.
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    183. Tse HM, Josephy SI, Chan ED, Fouts D, Cooper AM. Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J Immunol. 2002 Jan 15; 168(2):825-33. PMID: 11777978.
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