 Interleukin-4
"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
| Descriptor ID |
D015847
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| MeSH Number(s) |
D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
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| Concept/Terms |
Interleukin-4- Interleukin-4
- Interleukin 4
- B-Cell Growth Factor-1
- B Cell Growth Factor 1
- B-Cell Growth Factor-I
- B Cell Growth Factor I
- B-Cell Proliferating Factor
- B Cell Proliferating Factor
- B-Cell Stimulating Factor-1
- B Cell Stimulating Factor 1
- B-Cell Stimulatory Factor 1
- B-Cell Stimulatory Factor-1
- BCGF-1
- Binetrakin
- BSF-1
- IL-4
- IL4
- Mast Cell Growth Factor-2
- Mast Cell Growth Factor 2
- MCGF-2
- B Cell Stimulatory Factor-1
- B Cell Stimulatory Factor 1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-4".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".
This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 3 | 4 | | 1995 | 3 | 2 | 5 | | 1996 | 3 | 1 | 4 | | 1997 | 1 | 4 | 5 | | 1998 | 1 | 3 | 4 | | 1999 | 1 | 3 | 4 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 4 | 5 | | 2003 | 4 | 1 | 5 | | 2004 | 3 | 2 | 5 | | 2005 | 1 | 4 | 5 | | 2006 | 2 | 0 | 2 | | 2007 | 1 | 2 | 3 | | 2008 | 3 | 5 | 8 | | 2009 | 3 | 2 | 5 | | 2010 | 1 | 8 | 9 | | 2011 | 1 | 1 | 2 | | 2012 | 0 | 3 | 3 | | 2013 | 2 | 4 | 6 | | 2014 | 3 | 6 | 9 | | 2015 | 2 | 5 | 7 | | 2016 | 0 | 3 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 3 | 0 | 3 | | 2019 | 2 | 2 | 4 | | 2020 | 2 | 2 | 4 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 5 | 5 |
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Below are the most recent publications written about "Interleukin-4" by people in Profiles.
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Scott TE, Lewis CV, Zhu M, Wang C, Samuel CS, Drummond GR, Kemp-Harper BK. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages. Sci Rep. 2023 11 10; 13(1):19589.
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Rajeswaren V, Wagner BD, Patnaik JL, Mandava N, Mathias MT, Manoharan N, De Carlo Forest TE, Gnanaraj R, Lynch AM, Palestine AG. Interleukin-4 Plasma Levels Stratified by Sex in Intermediate Age-Related Macular Degeneration and Geographic Atrophy. Transl Vis Sci Technol. 2023 08 01; 12(8):1.
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Plecit?-Hlavat? L, Br?zdov? A, Krivonoskov? M, Hu CJ, Phang T, Tauber J, Li M, Zhang H, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Stenmark KR. Microenvironmental regulation of T-cells in pulmonary hypertension. Front Immunol. 2023; 14:1223122.
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Leung DYM, Bissonnette R, Kreimer S, Berdyshev E, Bafna S, Lyubchenko T, Richers BN, Garcia S, Ramirez-Gama M, Hall CF, Xiao O, Taylor P, Boguniewicz M, Levit NA, Agueusop I, Zhang A, Goleva E. Dupilumab Inhibits Vascular Leakage of Blood Proteins Into Atopic Dermatitis Skin. J Allergy Clin Immunol Pract. 2023 05; 11(5):1421-1428.
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Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. The IL-4Ra Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. J Allergy Clin Immunol. 2023 05; 151(5):1296-1306.e7.
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Zegallai HM, Abu-El-Rub E, Mejia EM, Sparagna GC, Cole LK, Marshall AJ, Hatch GM. Tafazzin deficiency attenuates anti-cluster of differentiation 40 and interleukin-4 activation of mouse B lymphocytes. Cell Tissue Res. 2022 Dec; 390(3):429-439.
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Berdyshev E, Goleva E, Bissonnette R, Bronova I, Bronoff AS, Richers BN, Garcia S, Ramirez-Gama M, Taylor P, Praestgaard A, Agueusop I, Jurvilliers P, Boguniewicz M, Levit NA, Rossi AB, Zhang A, Leung DYM. Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis. Allergy. 2022 Nov; 77(11):3388-3397.
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Havele SA, Khurana MC, McMahon P, Murthy AS, Perman MJ, Treat JR. Safety of dupilumab in a 5-month-old infant with severe atopic dermatitis. Pediatr Dermatol. 2022 Mar; 39(2):291-294.
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Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI Insight. 2021 11 08; 6(21).
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Kopper TJ, Zhang B, Bailey WM, Bethel KE, Gensel JC. The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation. Sci Rep. 2021 03 18; 11(1):6341.
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