 Interleukin-15
"Interleukin-15" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cytokine that stimulates the proliferation of T-LYMPHOCYTES and shares biological activities with IL-2. IL-15 also can induce proliferation and differentiation of B-LYMPHOCYTES.
| Descriptor ID |
D019409
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| MeSH Number(s) |
D12.644.276.374.465.515 D12.776.467.374.465.515 D23.529.374.465.515
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Interleukin-15".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-15".
This graph shows the total number of publications written about "Interleukin-15" by people in this website by year, and whether "Interleukin-15" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 | | 1999 | 0 | 2 | 2 | | 2000 | 2 | 0 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 5 | 1 | 6 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 3 | 3 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 2 | 4 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 2 | 1 | 3 | | 2018 | 1 | 2 | 3 | | 2019 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 2 | 3 | | 2025 | 1 | 4 | 5 | | 2026 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-15" by people in Profiles.
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Berger JN, Rosales A, Heiden D, Merrick C, Monogue B, Beckham JD, Berg L. Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection. J Immunol. 2026 May 14; 215(5).
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Piper M, Hodgson CA, Gadwa J, Hoen M, Knitz MW, Yu J, Corbo S, Olimpo NA, Yee EJ, Zhu Y, Larson KY, Klein C, Amann M, Saviola AJ, Karam SD. IL15/IL15Ra Complex Induces an Antitumor Immune Response following Radiotherapy only in the Absence of Tregs and Fails to Expand Progenitor TCF1+ CD8 T Cells. Mol Cancer Ther. 2026 Jan 02; 25(1):168-182.
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Rebhun RB, Cruz SM, York D, Mazcko CN, Razmara AM, Patkar S, Judge SJ, Sholevar CJ, Shah RK, Zamora AE, Al-Nadaf S, Vail DM, Fan TM, Burton JH, Luker ME, Skorupski KA, Lejeune AT, Woolard K, Stewart SL, Sparger EE, Young J, Cohen-Davidyan T, Huang E, Beck JA, Murphy WJ, Kent MS, Culp WTN, LeBlanc AK, Canter RJ. Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma. Front Immunol. 2025; 16:1672790.
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Cabrera-Martinez B, Garcia-Perez JE, Baxter RM, Lui VG, Ghosh T, Eken A, Kostka-Newman Z, Garcia JRM, Rahkola J, Gessner RL, Dutmer CM, Klarquist J, Pietras EM, Ghosh D, Johnson SA, Kedl RM, Hsieh EWY. A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rß deficiency. Cell Rep. 2025 Jul 22; 44(7):115902.
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Niehaus C, Geanon D, Lietzau A, Jankovic M, Maucourant C, Maasoumy B, Sparrelid E, Wedemeyer H, Kahlhöfer J, Falk CS, Andrade IM, Ponzetta A, Björkström NK, Kraft ARM, Cornberg M, Strunz B. Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites. Eur J Immunol. 2025 06; 55(6):e51311.
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Corral D, Ansaldo E, Delaleu J, Pichler AC, Kabat J, Oguz C, Teijeiro A, Yong D, Abid M, Rivera CA, Link VM, Yang K, Chi L, Nie J, Kamenyeva O, Fan Y, Chan JKY, Ginhoux F, Bosselut R, Belkaid Y. Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness. Cell. 2025 Mar 20; 188(6):1662-1680.e24.
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Phung SK, Zorko NA, Soignier Y, Waller RL, Shackelford M, Walker JT, Nelson TD, Selleck C, Bendzick LE, Kotz LE, Kile QM, Bozicevich AJ, Miller SE, Khaw M, Shetty M, Hinderlie P, Ehrhardt M, Li Y, Luo X, Dehm SM, Antonarakis ES, Kennedy PR, Miller JS, Felices M. A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity against Prostate Cancer. Cancer Immunol Res. 2025 02 03; 13(2):258-272.
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Okurut S, Boulware DR, Okafor E, Rhein J, Kajumbula H, Bagaya BS, Bwanga F, Olobo JO, Manabe YC, Meya DB, Janoff EN. Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis. Front Immunol. 2023; 14:1275443.
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Yomogida K, Trsan T, Sudan R, Rodrigues PF, Ulezko Antonova A, Ingle H, Luccia BD, Collins PL, Cella M, Gilfillan S, Baldridge MT, Oltz EM, Colonna M. The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes. Nat Immunol. 2024 01; 25(1):77-87.
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Zhang C, Kadu S, Xiao Y, Johnson O, Kelly A, O'Connor RS, Lai M, Kong H, Srivatsa S, Tai V, Greenblatt E, Holmes M, Riley JL, June CH, Sheppard NC. Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function. Cancer Immunol Res. 2023 11 01; 11(11):1524-1537.
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