 Interleukin-3
"Interleukin-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.
| Descriptor ID |
D007377
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| MeSH Number(s) |
D12.644.276.374.410.240.400 D12.644.276.374.465.032 D12.776.395.240.400 D12.776.467.374.410.240.400 D12.776.467.374.465.032 D23.529.374.410.240.400 D23.529.374.465.169
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| Concept/Terms |
Interleukin-3- Interleukin-3
- Interleukin 3
- IL-3
- Mast-Cell Colony-Stimulating Factor
- Multipotential Colony-Stimulating Factor
- Multipotential Colony Stimulating Factor
- Erythrocyte Burst-Promoting Factor
- Erythrocyte Burst Promoting Factor
- Burst-Promoting Factor, Erythrocyte
- Burst Promoting Factor, Erythrocyte
- Colony-Stimulating Factor 2 Alpha
- Colony-Stimulating Factor, Mast-Cell
- Colony Stimulating Factor, Mast Cell
- Colony-Stimulating Factor, Multipotential
- Colony Stimulating Factor, Multipotential
- Eosinophil-Mast Cell Growth-Factor
- Eosinophil Mast Cell Growth Factor
- Hematopoietin-2
- Hematopoietin 2
- P-Cell Stimulating Factor
- P Cell Stimulating Factor
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Below are MeSH descriptors whose meaning is more general than "Interleukin-3".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-3".
This graph shows the total number of publications written about "Interleukin-3" by people in this website by year, and whether "Interleukin-3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 1 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-3" by people in Profiles.
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Li Y, Qi X, Zhao D, Urban JF, Huang H. IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression. Cell Immunol. 2022 04; 374:104498.
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Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ. The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets. Oncotarget. 2014 Sep 30; 5(18):8503-14.
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Frankel AE, Woo JH, Ahn C, Pemmaraju N, Medeiros BC, Carraway HE, Frankfurt O, Forman SJ, Yang XA, Konopleva M, Garnache-Ottou F, Angelot-Delettre F, Brooks C, Szarek M, Rowinsky E. Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients. Blood. 2014 Jul 17; 124(3):385-92.
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Nandakumar V, Chou Y, Zang L, Huang XF, Chen SY. Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):E3927-36.
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Hermanrud CE, Pathiraja V, Matar A, Duran-Struuck R, Crepeau RL, Srinivasan S, Sachs DH, Huang CA, Wang Z. Expression and purification of non-N-glycosylated porcine interleukin 3 in yeast Pichia pastoris. Protein Expr Purif. 2012 Mar; 82(1):70-4.
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Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J Immunol. 2009 Mar 01; 182(5):2835-41.
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Horita H, Frankel AE, Thorburn A. Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death. Leukemia. 2008 Mar; 22(3):652-5.
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Jiang X, Zhao Y, Smith C, Gasparetto M, Turhan A, Eaves A, Eaves C. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia. 2007 May; 21(5):926-35.
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Liu TF, Urieto JO, Moore JE, Miller MS, Lowe AC, Thorburn A, Frankel AE. Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity. Exp Hematol. 2004 Mar; 32(3):277-81.
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Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003 Nov 14; 278(46):45358-67.
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