 Interleukin 1 Receptor Antagonist Protein
"Interleukin 1 Receptor Antagonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
| Descriptor ID |
D053590
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| MeSH Number(s) |
D12.644.276.374.460 D12.776.467.374.460 D23.529.374.460
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| Concept/Terms |
Interleukin 1 Receptor Antagonist Protein- Interleukin 1 Receptor Antagonist Protein
- IL1 Febrile Inhibitor
- Febrile Inhibitor, IL1
- IL-1Ra
- Urine-Derived IL1 Inhibitor
- IL1 Inhibitor, Urine-Derived
- Urine Derived IL1 Inhibitor
- IL-1 Inhibitor, Urine
- IL 1 Inhibitor, Urine
- Urine IL-1 Inhibitor
- Interleukin 1 Inhibitor, Urine
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Below are MeSH descriptors whose meaning is more general than "Interleukin 1 Receptor Antagonist Protein".
Below are MeSH descriptors whose meaning is more specific than "Interleukin 1 Receptor Antagonist Protein".
This graph shows the total number of publications written about "Interleukin 1 Receptor Antagonist Protein" by people in this website by year, and whether "Interleukin 1 Receptor Antagonist Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 9 | 9 | | 1996 | 0 | 9 | 9 | | 1997 | 0 | 8 | 8 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 5 | 5 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 10 | 10 | | 2005 | 0 | 8 | 8 | | 2006 | 0 | 3 | 3 | | 2007 | 3 | 3 | 6 | | 2008 | 4 | 2 | 6 | | 2009 | 7 | 1 | 8 | | 2010 | 4 | 2 | 6 | | 2011 | 4 | 2 | 6 | | 2012 | 2 | 2 | 4 | | 2013 | 6 | 4 | 10 | | 2014 | 9 | 1 | 10 | | 2015 | 5 | 1 | 6 | | 2016 | 6 | 1 | 7 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2020 | 3 | 0 | 3 | | 2021 | 1 | 2 | 3 | | 2022 | 2 | 0 | 2 | | 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Interleukin 1 Receptor Antagonist Protein" by people in Profiles.
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Thampi P, Seabaugh KA, Pezzanite LM, Chu CR, Phillips JN, Grieger JC, McIlwraith CW, Samulski RJ, Goodrich LR. A pilot study to determine the optimal dose of scAAVIL-1ra in a large animal model of post-traumatic osteoarthritis. Gene Ther. 2023 12; 30(12):792-800.
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VanBuren JM, Hall M, Zuppa AF, Mourani PM, Carcillo J, Dean JM, Watt K, Holubkov R. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study. Pediatr Crit Care Med. 2023 Dec 01; 24(12):e635-e646.
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Jia X, Toda K, He L, Miao D, Yamada S, Yu L, Kodama K. Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children. J Clin Endocrinol Metab. 2022 06 16; 107(7):1825-1832.
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van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2022 01 18; 132(2).
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Javan H, Li L, Schaaf CL, Lee YS, Salama ME, Dinarello CA, Selzman CH. Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure. Ann Thorac Surg. 2022 07; 114(1):98-107.
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Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nat Immunol. 2021 09; 22(9):1118-1126.
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Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA. Interleukin 1a: a comprehensive review on the role of IL-1a in the pathogenesis and treatment of autoimmune and inflammatory diseases. Autoimmun Rev. 2021 Mar; 20(3):102763.
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Koh S, Wirrell E, Vezzani A, Nabbout R, Muscal E, Kaliakatsos M, Wickstr?m R, Riviello JJ, Brunklaus A, Payne E, Valentin A, Wells E, Carpenter JL, Lee K, Lai YC, Eschbach K, Press CA, Gorman M, Stredny CM, Roche W, Mangum T. Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021 03; 6(1):62-72.
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Lai YC, Muscal E, Wells E, Shukla N, Eschbach K, Hyeong Lee K, Kaliakatsos M, Desai N, Wickstr?m R, Viri M, Freri E, Granata T, Nangia S, Dilena R, Brunklaus A, Wainwright MS, Gorman MP, Stredny CM, Asiri A, Hundallah K, Doja A, Payne E, Wirrell E, Koh S, Carpenter JL, Riviello J. Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. Ann Clin Transl Neurol. 2020 12; 7(12):2467-2474.
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Kuemmerle-Deschner JB, Welzel T, Hoertnagel K, Tsiflikas I, Hospach A, Liu X, Schlipf S, Hansmann S, Samba SD, Griesinger A, Benseler SM, Weber AN. New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology (Oxford). 2020 Nov 01; 59(11):3259-3263.
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