 Interleukin 1 Receptor Antagonist Protein
"Interleukin 1 Receptor Antagonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
| Descriptor ID |
D053590
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| MeSH Number(s) |
D12.644.276.374.460 D12.776.467.374.460 D23.529.374.460
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| Concept/Terms |
Interleukin 1 Receptor Antagonist Protein- Interleukin 1 Receptor Antagonist Protein
- IL1 Febrile Inhibitor
- Febrile Inhibitor, IL1
- IL-1Ra
- Urine-Derived IL1 Inhibitor
- IL1 Inhibitor, Urine-Derived
- Urine Derived IL1 Inhibitor
- IL-1 Inhibitor, Urine
- IL 1 Inhibitor, Urine
- Urine IL-1 Inhibitor
- Interleukin 1 Inhibitor, Urine
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Below are MeSH descriptors whose meaning is more general than "Interleukin 1 Receptor Antagonist Protein".
Below are MeSH descriptors whose meaning is more specific than "Interleukin 1 Receptor Antagonist Protein".
This graph shows the total number of publications written about "Interleukin 1 Receptor Antagonist Protein" by people in this website by year, and whether "Interleukin 1 Receptor Antagonist Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 10 | 10 | | 1997 | 0 | 8 | 8 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 4 | 4 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 9 | 9 | | 2005 | 0 | 8 | 8 | | 2006 | 0 | 3 | 3 | | 2007 | 3 | 3 | 6 | | 2008 | 4 | 2 | 6 | | 2009 | 7 | 1 | 8 | | 2010 | 4 | 2 | 6 | | 2011 | 4 | 2 | 6 | | 2012 | 2 | 2 | 4 | | 2013 | 6 | 4 | 10 | | 2014 | 9 | 1 | 10 | | 2015 | 6 | 1 | 7 | | 2016 | 6 | 1 | 7 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 1 | 3 | | 2019 | 2 | 0 | 2 | | 2020 | 3 | 1 | 4 | | 2021 | 2 | 2 | 4 | | 2022 | 2 | 0 | 2 | | 2023 | 1 | 2 | 3 | | 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Interleukin 1 Receptor Antagonist Protein" by people in Profiles.
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Luo Y, Su B, Hung V, Luo Y, Shi Y, Wang G, de Graaf D, Dinarello CA, Spaner DE. IL-1 receptor antagonism reveals a yin-yang relationship between NF?B and interferon signaling in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2024 Aug 13; 121(33):e2405644121.
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Goodrich LR, McIlwraith CW, Grieger J, Kraus VB, Stabler T, Werpy N, Phillips J, Samulski RJ, Frisbie D. IL-1ra gene therapy in equine osteoarthritis improves physiological, anatomical, and biological outcomes of joint degeneration. J Am Vet Med Assoc. 2024 Jun 01; 262(S1):S109-S120.
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Collins MS, Imbrogno MA, Kopras EJ, Howard JA, Zhang N, Kramer EL, Hudock KM. Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects. Int J Mol Sci. 2023 Dec 30; 25(1).
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Thampi P, Seabaugh KA, Pezzanite LM, Chu CR, Phillips JN, Grieger JC, McIlwraith CW, Samulski RJ, Goodrich LR. A pilot study to determine the optimal dose of scAAVIL-1ra in a large animal model of post-traumatic osteoarthritis. Gene Ther. 2023 12; 30(12):792-800.
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VanBuren JM, Hall M, Zuppa AF, Mourani PM, Carcillo J, Dean JM, Watt K, Holubkov R. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study. Pediatr Crit Care Med. 2023 12 01; 24(12):e635-e646.
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Jia X, Toda K, He L, Miao D, Yamada S, Yu L, Kodama K. Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children. J Clin Endocrinol Metab. 2022 06 16; 107(7):1825-1832.
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van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L. Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy. J Clin Invest. 2022 01 18; 132(2).
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Javan H, Li L, Schaaf CL, Lee YS, Salama ME, Dinarello CA, Selzman CH. Interleukin-1 Receptor Antagonism Abrogates Acute Pressure Overload-Induced Murine Heart Failure. Ann Thorac Surg. 2022 07; 114(1):98-107.
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Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nat Immunol. 2021 09; 22(9):1118-1126.
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Siegal-Willott JL, Anikis P, Neiffer DL, Barthel T, Goodrich LR. USE OF INTRACARPAL INTERLEUKIN RECEPTOR ANTAGONIST PROTEIN (IRAP) AND HYALURONIC ACID IN A MULTIMODAL THERAPEUTIC REGIME FOR OSTEOARTHRITIS IN AN ASIAN ELEPHANT (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2021 Apr; 52(1):401-405.
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