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Kimberly Kremer

TitleSenior Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Torres RM, Turner JA, D'Antonio M, Pelanda R, Kremer KN. Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid. Immunol Rev. 2023 08; 317(1):203-222. PMID: 37096808.
      View in: PubMed
    2. Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2118816119. PMID: 35394866.
      View in: PubMed
    3. Mathew D, Kremer KN, Strauch P, Tigyi G, Pelanda R, Torres RM. LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. Front Immunol. 2019; 10:1159. PMID: 31231367.
      View in: PubMed
    4. Mathew D, Kremer KN, Torres RM. ARHGEF1 deficiency reveals Ga13-associated GPCRs are critical regulators of human lymphocyte function. J Clin Invest. 2019 03 01; 129(3):965-968. PMID: 30714991.
      View in: PubMed
    5. Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3K?/PREX1 signaling and T cell cytokine secretion. J Biol Chem. 2018 09 07; 293(36):14022-14039. PMID: 30018141.
      View in: PubMed
    6. Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, van Wijnen AJ, Hedin KE. Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis. J Immunol. 2018 08 01; 201(3):1086-1096. PMID: 29914885.
      View in: PubMed
    7. Sterner RM, Kremer KN, Al-Kali A, Patnaik MM, Gangat N, Litzow MR, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE. Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine. Oncotarget. 2017 Nov 07; 8(55):94569-94579. PMID: 29212250.
      View in: PubMed
    8. Kremer KN, Dinkel BA, Sterner RM, Osborne DG, Jevremovic D, Hedin KE. TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL. Blood. 2017 08 24; 130(8):982-994. PMID: 28694325.
      View in: PubMed
    9. Kremer KN, Dudakovic A, Hess AD, Smith BD, Karp JE, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE. Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1a-TAZ Signaling Pathway in Osteoblasts. J Biol Chem. 2015 Dec 04; 290(49):29478-92. PMID: 26491017.
      View in: PubMed
    10. Bamidele AO, Kremer KN, Hirsova P, Clift IC, Gores GJ, Billadeau DD, Hedin KE. IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes. J Cell Biol. 2015 Jul 20; 210(2):257-72. PMID: 26195666.
      View in: PubMed
    11. Kremer KN, Dudakovic A, McGee-Lawrence ME, Philips RL, Hess AD, Smith BD, van Wijnen AJ, Karp JE, Kaufmann SH, Westendorf JJ, Hedin KE. Osteoblasts protect AML cells from SDF-1-induced apoptosis. J Cell Biochem. 2014 Jun; 115(6):1128-37. PMID: 24851270.
      View in: PubMed
    12. Clift IC, Bamidele AO, Rodriguez-Ramirez C, Kremer KN, Hedin KE. ?-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma. Mol Pharmacol. 2014 Apr; 85(4):542-52. PMID: 24452472.
      View in: PubMed
    13. Kremer KN, Peterson KL, Schneider PA, Meng XW, Dai H, Hess AD, Smith BD, Rodriguez-Ramirez C, Karp JE, Kaufmann SH, Hedin KE. CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. J Biol Chem. 2013 Aug 09; 288(32):22899-914. PMID: 23798675.
      View in: PubMed
    14. Kremer KN, Kumar A, Hedin KE. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J Immunol. 2011 Sep 15; 187(6):3177-85. PMID: 21856938.
      View in: PubMed
    15. Kremer KN, Clift IC, Miamen AG, Bamidele AO, Qian NX, Humphreys TD, Hedin KE. Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-?3 and phospholipase C-?1 for distinct cellular responses. J Immunol. 2011 Aug 01; 187(3):1440-7. PMID: 21705626.
      View in: PubMed
    16. Kumar A, Kremer KN, Dominguez D, Tadi M, Hedin KE. Ga13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation. J Immunol. 2011 Jan 15; 186(2):951-8. PMID: 21148034.
      View in: PubMed
    17. Kumar A, Kremer KN, Sims OL, Hedin KE. Measuring the proximity of T-lymphocyte CXCR4 and TCR by fluorescence resonance energy transfer (FRET). Methods Enzymol. 2009; 460:379-97. PMID: 19446736.
      View in: PubMed
    18. Kremer KN, Kumar A, Hedin KE. Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter. J Immunol. 2007 Feb 01; 178(3):1581-8. PMID: 17237407.
      View in: PubMed
    19. Kumar A, Humphreys TD, Kremer KN, Bramati PS, Bradfield L, Edgar CE, Hedin KE. CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity. 2006 Aug; 25(2):213-24. PMID: 16919488.
      View in: PubMed
    20. Kremer KN, Humphreys TD, Kumar A, Qian NX, Hedin KE. Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine. J Immunol. 2003 Jul 01; 171(1):360-7. PMID: 12817019.
      View in: PubMed
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