 Killer Cells, Natural
"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
| Descriptor ID |
D007694
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| MeSH Number(s) |
A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
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| Concept/Terms |
Killer Cells, Natural- Killer Cells, Natural
- NK Cells
- Cell, NK
- Cells, NK
- NK Cell
- Natural Killer Cells
- Cell, Natural Killer
- Cells, Natural Killer
- Killer Cell, Natural
- Natural Killer Cell
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Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".
Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".
This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 3 | 0 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 3 | 4 | | 1999 | 0 | 2 | 2 | | 2000 | 7 | 3 | 10 | | 2001 | 7 | 1 | 8 | | 2002 | 6 | 5 | 11 | | 2003 | 7 | 5 | 12 | | 2004 | 7 | 6 | 13 | | 2005 | 6 | 5 | 11 | | 2006 | 1 | 4 | 5 | | 2007 | 10 | 6 | 16 | | 2008 | 9 | 10 | 19 | | 2009 | 6 | 8 | 14 | | 2010 | 11 | 1 | 12 | | 2011 | 8 | 3 | 11 | | 2012 | 9 | 2 | 11 | | 2013 | 9 | 3 | 12 | | 2014 | 17 | 4 | 21 | | 2015 | 11 | 6 | 17 | | 2016 | 7 | 11 | 18 | | 2017 | 9 | 5 | 14 | | 2018 | 8 | 6 | 14 | | 2019 | 8 | 6 | 14 | | 2020 | 8 | 5 | 13 | | 2021 | 7 | 5 | 12 | | 2022 | 2 | 3 | 5 | | 2023 | 4 | 4 | 8 | | 2024 | 8 | 4 | 12 | | 2025 | 10 | 7 | 17 |
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Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.
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Johnson MJ, Crotteau M, Ghosh D, Vu T, Trinity L, Marches R, Ucar D, Levin MJ, Weinberg A. The recombinant zoster vaccine induces trained immunity in monocytes through persistent downregulation of TGFß. PLoS Pathog. 2025 Dec; 21(12):e1013759.
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Henrich IC, Billingsley MM, Jain K, Mondal S, Quick LN, Young R, Nguyen N, Oliveira AM, Blobel GA, Mitchell MJ, Chou MM. Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma. Mol Cancer Ther. 2025 Nov 03; 24(11):1802-1814.
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D'Antonio MA, Ware BC, DiLisio JE, Michaels MJ, Turner JA, Habenicht LM, Davenport BJ, Morrison TE, Pelanda R, Gapin L, Torres RM. Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression. J Immunol. 2025 Nov 01; 214(11):3055-3068.
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Niehrs A, Hertwig L, Buggert M, Nordström I, Statzu M, Pampena MB, Samer S, Knox JJ, Strunz B, Sun D, Nguyen S, Janoschka C, Xing Y, Wu VH, Sparrelid E, Alisjahbana A, Gao Y, Sleiers N, Strauss O, Filipovic I, Ponzetta A, Medina-Andrade I, Nilsén V, Jorns C, Cornillet M, Maucourant C, Ziegenhain C, Hengst J, Tweet G, Kroll K, Golden GJ, Wedemeyer H, Kürtüncü M, Dori Y, Itkin MG, Klotz L, Schaffer M, Ericzon BG, Ivarsson MA, Paiardini M, Nowak G, Willinger T, Reeves RK, Betts MR, Björkström NK. Transient tissue residency and lymphatic egress define human CD56bright NK cell homeostasis. Nat Immunol. 2025 Nov; 26(11):2004-2015.
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Guo Y, Li Z, Parsels LA, Wang Z, Parsels JD, Dalvi A, The S, Hu N, Valvo VM, Doherty R, Peterson E, Wang X, Venkataraman S, Agnihotri S, Venneti S, Wahl DR, Green MD, Lawrence TS, Koschmann C, Morgan MA, Zhang Q. H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition. Neuro Oncol. 2025 Sep 17; 27(8):2129-2146.
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Ramadan DJ, Kichula KM, Tao S, Porfilio T, Lande A, Fluge Ø, Mella O, Strand EB, Saugstad OD, Norman PJ, Lie BA, Viken MK. Killer cell immunoglobulin-like receptor (KIR) alleles suggested to be associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Brain Behav Immun. 2025 Nov; 130:106098.
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Weis AM, Bauer KM, Tang WW, Stephen-Victor E, Bell R, Brown DG, Ekiz HA, Tran V, Klag KA, Swanson EA, Barrios L, Harwood M, Hill JH, Ost KS, Gigic B, Schneider M, Ose J, Hardikar S, Toriola AT, Shibata D, Li CI, Figueiredo JC, Byrd DA, Siegel EM, Arnolds K, Lozupone C, Ulrich CM, O'Connell RM, Stephens WZ, Round JL. A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy. Cell Rep. 2025 Sep 23; 44(9):116172.
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Schäfer A, Buhler S, Farias TDJ, Kichula KM, Baldomero H, Sollet ZC, Ferrari-Lacraz S, Micheli B, Masouridi-Levrat S, Mesquita V, Kürsteiner O, Nair G, Halter J, Güngör T, Schneidawind D, Chalandon Y, Passweg JR, Norman PJ, Villard J. Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation. Haematologica. 2026 Mar 01; 111(3):971-980.
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Akabane M, Kawashima J, Woldesenbet S, Cauchy F, Aucejo F, Popescu I, Kitago M, Martel G, Ratti F, Aldrighetti L, Poultsides GA, Imaoka Y, Ruzzenente A, Endo I, Gleisner A, Marques HP, Lam V, Hugh T, Bhimani N, Shen F, Pawlik TM. International validation of a natural-killer-cell-based model to predict recurrence-free survival in hepatocellular carcinoma. HPB (Oxford). 2025 Oct; 27(10):1259-1269.
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Strati P, Castro J, Goodman A, Bachanova V, Kamdar M, Awan FT, Solomon SR, Wong L, Wong C, Patel D, Bickers C, Zhao W, Bashir Z, Valamehr B, Elstrom RL, Patel K. Off-the-shelf induced pluripotent stem-cell-derived natural killer-cell therapy in relapsed or refractory B-cell lymphoma: a multicentre, open-label, phase 1 study. Lancet Haematol. 2025 Jul; 12(7):e505-e515.
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