 Killer Cells, Natural
"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
| Descriptor ID |
D007694
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| MeSH Number(s) |
A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
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| Concept/Terms |
Killer Cells, Natural- Killer Cells, Natural
- NK Cells
- Cell, NK
- Cells, NK
- NK Cell
- Natural Killer Cells
- Cell, Natural Killer
- Cells, Natural Killer
- Killer Cell, Natural
- Natural Killer Cell
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Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".
Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".
This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 3 | 0 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 2 | 3 | | 1999 | 0 | 2 | 2 | | 2000 | 5 | 2 | 7 | | 2001 | 5 | 0 | 5 | | 2002 | 4 | 2 | 6 | | 2003 | 7 | 5 | 12 | | 2004 | 6 | 6 | 12 | | 2005 | 6 | 5 | 11 | | 2006 | 1 | 4 | 5 | | 2007 | 10 | 6 | 16 | | 2008 | 8 | 11 | 19 | | 2009 | 6 | 8 | 14 | | 2010 | 10 | 1 | 11 | | 2011 | 7 | 3 | 10 | | 2012 | 9 | 2 | 11 | | 2013 | 8 | 3 | 11 | | 2014 | 16 | 4 | 20 | | 2015 | 9 | 6 | 15 | | 2016 | 8 | 10 | 18 | | 2017 | 7 | 5 | 12 | | 2018 | 7 | 6 | 13 | | 2019 | 7 | 6 | 13 | | 2020 | 5 | 6 | 11 | | 2021 | 3 | 8 | 11 | | 2022 | 2 | 3 | 5 | | 2023 | 3 | 0 | 3 | | 2024 | 3 | 2 | 5 |
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Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.
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Sch?fer A, Calderin Sollet Z, Herv? MP, Buhler S, Ferrari-Lacraz S, Norman PJ, Kichula KM, Farias TDJ, Masouridi-Levrat S, Mamez AC, Pradier A, Simonetta F, Chalandon Y, Villard J. NK- and T-cell repertoire is established early after allogeneic HSCT and is imprinted by CMV reactivation. Blood Adv. 2024 11 12; 8(21):5612-5624.
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Loh L, Saunders PM, Faoro C, Font-Porterias N, Nemat-Gorgani N, Harrison GF, Sadeeq S, Hensen L, Wong SC, Widjaja J, Clemens EB, Zhu S, Kichula KM, Tao S, Zhu F, Montero-Martin G, Fernandez-Vina M, Guethlein LA, Vivian JP, Davies J, Mentzer AJ, Oppenheimer SJ, Pomat W, Ioannidis AG, Barberena-Jonas C, Moreno-Estrada A, Miller A, Parham P, Rossjohn J, Tong SYC, Kedzierska K, Brooks AG, Norman PJ. An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania. Cell. 2024 Nov 27; 187(24):7008-7024.e19.
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Peris Sempere V, Luo G, Mu?iz-Castrillo S, Pinto AL, Picard G, Rogemond V, Titulaer MJ, Finke C, Leypoldt F, Kuhlenb?umer G, Jones HF, Dale RC, Binks S, Irani SR, Bastiaansen AE, de Vries JM, de Bruijn MAAM, Roelen DL, Kim TJ, Chu K, Lee ST, Kanbayashi T, Pollock NR, Kichula KM, Mumme-Monheit A, Honnorat J, Norman PJ, Mignot E. HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis. Front Immunol. 2024; 15:1423149.
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Bhansali RS, Ellin F, Relander T, Cao M, Li W, Long Q, Ganesan N, Stuver R, Horwitz SM, Wudhikarn K, Hwang SR, Bennani NN, Chavez J, Sokol L, Saeed H, Duan F, Porcu P, Pullarkat P, Mehta-Shah N, Zain JM, Ruiz M, Brammer JE, Prakash R, Iyer SP, Olszewski AJ, Major A, Riedell PA, Smith SM, Goldin C, Haverkos B, Hu B, Zhuang TZ, Allen PB, Toama W, Janakiram M, Brooks TR, Jagadeesh D, Hariharan N, Goodman AM, Hartman G, Ghione P, Fayyaz F, Rhodes JM, Chong EA, Gerson JN, Landsburg DJ, Nasta SD, Schuster SJ, Svoboda J, Jerkeman M, Barta SK. The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas. Blood Adv. 2024 07 09; 8(13):3507-3518.
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Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. J Immunol. 2024 Mar 01; 212(5):785-800.
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Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, ?nfelt B, Norman PJ, Malmberg KJ. Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires. Blood Adv. 2023 08 22; 7(16):4492-4504.
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Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ. Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Sci Immunol. 2023 06 30; 8(84):eade5343.
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Zhang Y, Yan AW, Boelen L, Hadcocks L, Salam A, Gispert DP, Spanos L, Bitria LM, Nemat-Gorgani N, Traherne JA, Roberts C, Koftori D, Taylor GP, Forton D, Norman PJ, Marsh SG, Busch R, Macallan DC, Asquith B. KIR-HLA interactions extend human CD8+ T cell lifespan in vivo. J Clin Invest. 2023 06 15; 133(12).
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Tomar MS, Singh RK, Ulasov IV, Acharya A. Refurbishment of NK cell effector functions through their receptors by depleting the activity of nTreg cells in Dalton's Lymphoma-induced tumor microenvironment: an in vitro and in vivo study. Cancer Immunol Immunother. 2023 Jun; 72(6):1429-1444.
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Vollmers S, Lobermeyer A, Niehrs A, Fittje P, Indenbirken D, Nakel J, Virdi S, Brias S, Trenkner T, Sauer G, Peine S, Behrens GMN, Lehmann C, Meurer A, Pauli R, Postel N, Roider J, Scholten S, Spinner CD, Stephan C, Wolf E, Wyen C, Richert L, Norman PJ, Sauter J, Schmidt AH, Hoelzemer A, Altfeld M, K?rner C. Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C. Front Immunol. 2022; 13:922252.
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