 Histocompatibility Antigens Class I
"Histocompatibility Antigens Class I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
| Descriptor ID |
D015395
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| MeSH Number(s) |
D12.776.395.550.489 D12.776.543.550.439 D23.050.301.500.100 D23.050.705.552.100
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| Concept/Terms |
Histocompatibility Antigens Class I- Histocompatibility Antigens Class I
- Class I Histocompatibility Antigens
- Class I Antigens
- Antigens, Class I
- I Antigens, Class
- Class I Major Histocompatibility Antigens
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Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class I".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class I".
This graph shows the total number of publications written about "Histocompatibility Antigens Class I" by people in this website by year, and whether "Histocompatibility Antigens Class I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1994 | 2 | 1 | 3 | | 1996 | 3 | 0 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 3 | 4 | | 1999 | 1 | 1 | 2 | | 2000 | 1 | 2 | 3 | | 2001 | 3 | 1 | 4 | | 2002 | 2 | 4 | 6 | | 2003 | 2 | 1 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 3 | 1 | 4 | | 2006 | 1 | 1 | 2 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 2 | 3 | | 2009 | 4 | 3 | 7 | | 2010 | 2 | 2 | 4 | | 2011 | 3 | 2 | 5 | | 2012 | 6 | 3 | 9 | | 2013 | 2 | 2 | 4 | | 2014 | 1 | 2 | 3 | | 2015 | 5 | 5 | 10 | | 2016 | 6 | 2 | 8 | | 2017 | 3 | 0 | 3 | | 2018 | 3 | 2 | 5 | | 2019 | 3 | 2 | 5 | | 2020 | 2 | 2 | 4 | | 2021 | 3 | 0 | 3 | | 2022 | 2 | 4 | 6 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Histocompatibility Antigens Class I" by people in Profiles.
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Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, ?nfelt B, Norman PJ, Malmberg KJ. Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires. Blood Adv. 2023 08 22; 7(16):4492-4504.
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Haddad G, Dylewski J, Evans R, Lewis L, Blaine J. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. PLoS One. 2023; 18(4):e0284636.
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Olson TS, Frost BF, Duke JL, Dribus M, Xie HM, Prudowsky ZD, Furutani E, Gudera J, Shah YB, Ferriola D, Dinou A, Pagkrati I, Kim S, Xu Y, He M, Zheng S, Nijim S, Lin P, Xu C, Nakano TA, Oved JH, Carreno BM, Bolon YT, Gadalla SM, Marsh SG, Paczesny S, Lee SJ, Monos DS, Shimamura A, Bertuch AA, Gragert L, Spellman SR, Babushok DV. Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities. JCI Insight. 2022 11 22; 7(22).
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Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct; 83(10):730-735.
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Vollmers S, Lobermeyer A, Niehrs A, Fittje P, Indenbirken D, Nakel J, Virdi S, Brias S, Trenkner T, Sauer G, Peine S, Behrens GMN, Lehmann C, Meurer A, Pauli R, Postel N, Roider J, Scholten S, Spinner CD, Stephan C, Wolf E, Wyen C, Richert L, Norman PJ, Sauter J, Schmidt AH, Hoelzemer A, Altfeld M, K?rner C. Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C. Front Immunol. 2022; 13:922252.
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Pollock NR, Harrison GF, Norman PJ. Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health. J Allergy Clin Immunol Pract. 2022 07; 10(7):1763-1775.
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Palmer WH, Telford M, Navarro A, Santpere G, Norman PJ. Human herpesvirus diversity is altered in HLA class I binding peptides. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2123248119.
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Suliman S, Kjer-Nielsen L, Iwany SK, Lopez Tamara K, Loh L, Grzelak L, Kedzierska K, Ocampo TA, Corbett AJ, McCluskey J, Rossjohn J, Le?n SR, Calderon R, Lecca-Garcia L, Murray MB, Moody DB, Van Rhijn I. Dual TCR-a Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation. J Immunol. 2022 03 15; 208(6):1389-1395.
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Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition. Front Endocrinol (Lausanne). 2021; 12:707881.
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Tao S, He Y, Kichula KM, Wang J, He J, Norman PJ, Zhu F. High-Resolution Analysis Identifies High Frequency of KIR-A Haplotypes and Inhibitory Interactions of KIR With HLA Class I in Zhejiang Han. Front Immunol. 2021; 12:640334.
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