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Sarah Elizabeth Clark

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OTO General Operations
Phone303/724-9561
    Other Positions
    TitleAssoc Director-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-OTO General Operations


    Collapse Research 
    Collapse research activities and funding
    R01AI172958     (CLARK, SARAH E)Mar 20, 2023 - Feb 29, 2028
    NIH
    Airway Prevotella enhance innate immune-mediated protection against lung infection
    Role: Principal Investigator
    R21DC019169     (CLARK, SARAH E)Feb 1, 2022 - Jan 31, 2025
    NIH
    Host factors influencing early clearance of Streptococcus pneumoniae from the middle ear following invasion from the nasopharynx
    Role: Principal Investigator
    K22AI143922     (CLARK, SARAH E)Sep 1, 2019 - Feb 28, 2022
    NIH
    Bacterial-driven immune suppression in the lung
    Role: Principal Investigator
    F32AI114075     (CLARK, SARAH E)Sep 1, 2014 - Aug 31, 2017
    NIH
    Natural killer cell-derived IL-10 and immunity to Listeria
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Sarosiek K, Hughes PE, Hata AN. LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers. Nat Commun. 2025 May 02; 16(1):4112. PMID: 40316540.
      View in: PubMed
    2. Lee E, Saviola A, Bevers S, Redzic JS, Maroney SP, Shaw S, Tamkin E, Fulte S, Nemkov T, Meyer N, D'Alessandro A, Hansen KC, Clark SE, Eisenmesser E. Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection. Protein Sci. 2025 Jan; 34(1):e5253. PMID: 39660954.
      View in: PubMed
    3. Tamkin E, Lorenz BP, McCarty A, Fulte S, Eisenmesser E, Horswill AR, Clark SE. Airway Corynebacterium interfere with Streptococcus pneumoniae and Staphylococcus aureus infection and express secreted factors selectively targeting each pathogen. Infect Immun. 2025 Feb 18; 93(2):e0044524. PMID: 39705185.
      View in: PubMed
    4. Fulte S, Atto B, McCarty A, Horn KJ, Redzic JS, Eisenmesser E, Yang M, Marsh RL, Tristram S, Clark SE. Heme sequestration by hemophilin from Haemophilus haemolyticus reduces respiratory tract colonization and infection with non-typeable Haemophilus influenzae. mSphere. 2024 Mar 26; 9(3):e0000624. PMID: 38380941.
      View in: PubMed
    5. Drigot ZG, Clark SE. Insights into the role of the respiratory tract microbiome in defense against bacterial pneumonia. Curr Opin Microbiol. 2024 02; 77:102428. PMID: 38277901.
      View in: PubMed
    6. Horn KJ, Fulte S, Yang M, Lorenz BP, Clark SE. Neutrophil responsiveness to IL-10 impairs clearance of Streptococcus pneumoniae from the lungs. J Leukoc Biol. 2024 01 05; 115(1):4-15. PMID: 37381945.
      View in: PubMed
    7. Horn KJ, Schopper MA, Drigot ZG, Clark SE. Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung. Nat Commun. 2022 06 09; 13(1):3321. PMID: 35680890.
      View in: PubMed
    8. Horn KJ, Jaberi Vivar AC, Arenas V, Andani S, Janoff EN, Clark SE. Corynebacterium Species Inhibit Streptococcus pneumoniae Colonization and Infection of the Mouse Airway. Front Microbiol. 2021; 12:804935. PMID: 35082772.
      View in: PubMed
    9. Clark SE, Schmidt RL, Aguilera ER, Lenz LL. IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung. Transl Res. 2020 12; 226:70-82. PMID: 32634590.
      View in: PubMed
    10. Clark SE. Commensal bacteria in the upper respiratory tract regulate susceptibility to infection. Curr Opin Immunol. 2020 10; 66:42-49. PMID: 32416468.
      View in: PubMed
    11. Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL. NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation. Front Immunol. 2019; 10:2087. PMID: 31552035.
      View in: PubMed
    12. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
      View in: PubMed
    13. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
      View in: PubMed
    14. Clark SE, Schmidt RL, McDermott DS, Lenz LL. A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection. Cell Rep. 2018 05 29; 23(9):2582-2594. PMID: 29847790.
      View in: PubMed
    15. Clark SE, Filak HC, Guthrie BS, Schmidt RL, Jamieson A, Merkel P, Knight V, Cole CM, Raulet DH, Lenz LL. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection. PLoS Pathog. 2016 06; 12(6):e1005708. PMID: 27295349.
      View in: PubMed
    16. Clark SE, Eichelberger KR, Weiser JN. Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae. Mol Microbiol. 2013 May; 88(3):603-18. PMID: 23577840.
      View in: PubMed
    17. Clark SE, Weiser JN. Microbial modulation of host immunity with the small molecule phosphorylcholine. Infect Immun. 2013 Feb; 81(2):392-401. PMID: 23230294.
      View in: PubMed
    18. Clark SE, Snow J, Li J, Zola TA, Weiser JN. Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae. PLoS Pathog. 2012; 8(3):e1002521. PMID: 22396641.
      View in: PubMed
    19. Nakamura S, Shchepetov M, Dalia AB, Clark SE, Murphy TF, Sethi S, Gilsdorf JR, Smith AL, Weiser JN. Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae. PLoS Pathog. 2011 Jan 06; 7(1):e1001247. PMID: 21253576.
      View in: PubMed
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