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Laurel Lawson Lenz Jr.

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8676

    Collapse Research 
    Collapse research activities and funding
    R01AI178925     (LENZ, LAUREL L)Aug 1, 2023 - Jul 31, 2028
    NIH
    Dendritic cell targeting by bacterial LysM proteins to suppress inflammation
    Role: Principal Investigator
    R21AI161827     (LENZ, LAUREL L)Feb 22, 2021 - Jan 31, 2023
    NIH
    Role of IFNs and IFNGR in susceptibility to bacteria in Down syndrome
    Role: Principal Investigator
    R21AI140499     (LENZ, LAUREL L)May 10, 2018 - Apr 30, 2020
    NIH
    Myeloid cell IFNGR regulation in persistent viral and secondary bacterial infections
    Role: Principal Investigator
    R01AI131662     (LENZ, LAUREL L)May 10, 2017 - Apr 30, 2022
    NIH
    NK cell IL-10 production during bacterial infections
    Role: Principal Investigator
    R33AI102264     (LENZ, LAUREL L)Aug 15, 2014 - Jul 31, 2017
    NIH
    IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Role: Principal Investigator
    R21AI103782     (LENZ, LAUREL L)Apr 15, 2013 - Mar 31, 2016
    NIH
    Non-canonical responses to IFNab in the suppression of macrophage immunity
    Role: Principal Investigator
    R21AI102264     (LENZ, LAUREL L)Jul 1, 2012 - Jun 30, 2014
    NIH
    IFNGR Down Regulation as a Host Target for Therapy of Infectious Diseases
    Role: Principal Investigator
    R56AI065638     (LENZ, LAUREL L)Aug 1, 2011 - Feb 14, 2012
    NIH
    Active Subversion of Innate Immunity by Bacterial LysM Protein
    Role: Principal Investigator
    R01AI065638     (LENZ, LAUREL L)Jul 1, 2005 - Jan 31, 2018
    NIH
    Active Subversion of Innate Immunity by Bacterial LysM Protein
    Role: Principal Investigator
    R01AI055701     (LENZ, LAUREL L)Dec 1, 2004 - Nov 30, 2010
    NIH
    CD8 Mediated Apoptosis During T Cell Development
    Role: Principal Investigator
    F32AI010481     (LENZ, LAUREL L)May 1, 2000
    NIH
    PHASE VARIATION IN LISTERIA MONOCYTOGENES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vickery JM, Toperzer JD, Raab JE, Lenz LL, Colgan SP, Russo BC. Synaptopodin is necessary for Shigella flexneri intercellular spread. bioRxiv. 2023 Jun 26. PMID: 37163027.
      View in: PubMed
    2. Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2022 Mar 01; 28(5):1013-1026. PMID: 34862244.
      View in: PubMed
    3. Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2022 03 02; 30(3):1149-1162. PMID: 34793974.
      View in: PubMed
    4. Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 11 15; 27(22):6235-6249. PMID: 34518311.
      View in: PubMed
    5. Bortell N, Aguilera ER, Lenz LL. Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells. PLoS Pathog. 2021 04; 17(4):e1009531. PMID: 33878120.
      View in: PubMed
    6. Larson SR, Bortell N, Illies A, Crisler WJ, Matsuda JL, Lenz LL. Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection. Front Immunol. 2020; 11:590266. PMID: 33363536.
      View in: PubMed
    7. Clark SE, Schmidt RL, Aguilera ER, Lenz LL. IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung. Transl Res. 2020 12; 226:70-82. PMID: 32634590.
      View in: PubMed
    8. Eshleman EM, Bortell N, McDermott DS, Crisler WJ, Lenz LL. Myeloid cell responsiveness to interferon-gamma is sufficient for initial resistance to Listeria monocytogenes. Curr Res Immunol. 2020 Dec; 1:1-9. PMID: 34337387.
      View in: PubMed
    9. Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020; 11:238. PMID: 32153571.
      View in: PubMed
    10. Aguilera ER, Lenz LL. Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections. Front Immunol. 2020; 11:105. PMID: 32117259.
      View in: PubMed
    11. Yang C, McDermot DS, Pasricha S, Brown AS, Bedoui S, Lenz LL, van Driel IR, Hartland EL. IFN? receptor down-regulation facilitates Legionella survival in alveolar macrophages. J Leukoc Biol. 2020 02; 107(2):273-284. PMID: 31793076.
      View in: PubMed
    12. Crisler WJ, Eshleman EM, Lenz LL. Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFN? responsiveness. Life Sci Alliance. 2019 10; 2(5). PMID: 31585982.
      View in: PubMed
    13. Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL. NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation. Front Immunol. 2019; 10:2087. PMID: 31552035.
      View in: PubMed
    14. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
      View in: PubMed
    15. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
      View in: PubMed
    16. Alper S, Lenz LL. Editorial overview: Tuning the innate immune response to pathogens. Curr Opin Immunol. 2018 10; 54:vi-ix. PMID: 30342707.
      View in: PubMed
    17. Crisler WJ, Lenz LL. Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection. Curr Opin Immunol. 2018 10; 54:35-41. PMID: 29886270.
      View in: PubMed
    18. Clark SE, Schmidt RL, McDermott DS, Lenz LL. A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection. Cell Rep. 2018 05 29; 23(9):2582-2594. PMID: 29847790.
      View in: PubMed
    19. Ortiz AL, Lenz LL. A Listeria-derived polypeptide promotes in vivo activation of NK cells for antitumor therapy. Immunohorizons. 2017 Jun 01; 1(4):53-62. PMID: 29658011.
      View in: PubMed
    20. Eshleman EM, Delgado C, Kearney SJ, Friedman RS, Lenz LL. Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection. PLoS Pathog. 2017 May; 13(5):e1006388. PMID: 28542482.
      View in: PubMed
    21. Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017; 8:470. PMID: 28484464.
      View in: PubMed
    22. Clark SE, Filak HC, Guthrie BS, Schmidt RL, Jamieson A, Merkel P, Knight V, Cole CM, Raulet DH, Lenz LL. Bacterial Manipulation of NK Cell Regulatory Activity Increases Susceptibility to Listeria monocytogenes Infection. PLoS Pathog. 2016 06; 12(6):e1005708. PMID: 27295349.
      View in: PubMed
    23. Mills CD, Lenz LL, Harris RA. A Breakthrough: Macrophage-Directed Cancer Immunotherapy. Cancer Res. 2016 Feb 01; 76(3):513-6. PMID: 26772756.
      View in: PubMed
    24. Mills CD, Lenz LL, Ley K. Macrophages at the fork in the road to health or disease. Front Immunol. 2015; 6:59. PMID: 25762997.
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    25. Mills CD, Thomas AC, Lenz LL, Munder M. Macrophage: SHIP of Immunity. Front Immunol. 2014; 5:620. PMID: 25538705.
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    26. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356.
      View in: PubMed
    27. Eshleman EM, Lenz LL. Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol. 2014; 5:431. PMID: 25309533.
      View in: PubMed
    28. Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar; 58(6):e115-8. PMID: 24336756.
      View in: PubMed
    29. Schmidt R, Lenz LL. Biological DNA Sensor: The impact of Nucleic Acids on Diseases and Vaccinology, Ken Ishii and Choon Kit Tang, editors. Adjuvants Targeting the DNA Sensing Pathways – Cyclic-di-GMP and Other Cyclic-di-Nucleotides. 2013; 313-336.
    30. Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP, Lenz LL. Type I IFNs downregulate myeloid cell IFN-? receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol. 2013 Sep 15; 191(6):3384-92. PMID: 23935197.
      View in: PubMed
    31. Kearney S, Delgado C, Lenz LL. Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections. Immunol Res. 2013 Mar; 55(1-3):187-200. PMID: 22983898.
      View in: PubMed
    32. Schmidt RL, Lenz LL. Distinct licensing of IL-18 and IL-1? secretion in response to NLRP3 inflammasome activation. PLoS One. 2012; 7(9):e45186. PMID: 23028835.
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    33. Williams MA, Schmidt RL, Lenz LL. Early events regulating immunity and pathogenesis during Listeria monocytogenes infection. Trends Immunol. 2012 Oct; 33(10):488-95. PMID: 22677184.
      View in: PubMed
    34. Cole C, Thomas S, Filak H, Henson PM, Lenz LL. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity. 2012 May 25; 36(5):807-20. PMID: 22542147.
      View in: PubMed
    35. Rayamajhi M, Delgado C, Condon TV, Riches DW, Lenz LL. Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. Mucosal Immunol. 2012 Jul; 5(4):444-54. PMID: 22472773.
      View in: PubMed
    36. Schmidt RL, Filak HC, Lemon JD, Potter TA, Lenz LL. A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog. 2011 Nov; 7(11):e1002368. PMID: 22072975.
      View in: PubMed
    37. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776.
      View in: PubMed
    38. Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11578-83. PMID: 21709234.
      View in: PubMed
    39. Rayamajhi M, Redente EF, Condon TV, Gonzalez-Juarrero M, Riches DW, Lenz LL. Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry. J Vis Exp. 2011 May 02; (51). PMID: 21587154.
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    40. Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL, Bramson JL, Lichty BD, Wan Y. IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res. 2011 Apr 01; 71(7):2497-506. PMID: 21307131.
      View in: PubMed
    41. Jin L, Lenz LL, Cambier JC. Cellular reactive oxygen species inhibit MPYS induction of IFN?. PLoS One. 2010 Dec 10; 5(12):e15142. PMID: 21170271.
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    42. Rayamajhi M, Humann J, Kearney S, Hill KK, Lenz LL. Antagonistic crosstalk between type I and II interferons and increased host susceptibility to bacterial infections. Virulence. 2010 Sep-Oct; 1(5):418-22. PMID: 21178482.
      View in: PubMed
    43. Humann J, Lenz LL. Activation of naive NK cells in response to Listeria monocytogenes requires IL-18 and contact with infected dendritic cells. J Immunol. 2010 May 01; 184(9):5172-8. PMID: 20351186.
      View in: PubMed
    44. Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz LL. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med. 2010 Feb 15; 207(2):327-37. PMID: 20123961.
      View in: PubMed
    45. Lenz LL. CD5 sweetens lymphocyte responses. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1303-4. PMID: 19174525.
      View in: PubMed
    46. Humann J, Lenz LL. Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Immun. 2009; 1(2):88-97. PMID: 19319201.
      View in: PubMed
    47. Lenz LL. Encyclopedia of Pestilence, Pandemics, and Plagues, Joseph P. Byrne, editor. Human Immunity and Resistance to Disease. 2008; 282-284.
    48. Lenz LL. Encyclopedia of Pestilence, Pandemics, and Plagues, Joseph P. Byrne, editor. Immunology. 2008; 1:297-299.
    49. Lenz LL, Huang WA, Zhou C, Li Z, Calendar R. Stable integration vector for nutrient broth-based selection of attenuated Listeria monocytogenes strains with recombinant antigen expression. Clin Vaccine Immunol. 2008 Sep; 15(9):1414-9. PMID: 18650400.
      View in: PubMed
    50. Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC. Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2. J Biol Chem. 2008 Feb 22; 283(8):4744-55. PMID: 18083708.
      View in: PubMed
    51. Lenz LL, Andrews-Polymenis HL. Silencing the alarm: insights into the interaction between host and pathogen. Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease. EMBO Rep. 2008 Jan; 9(1):27-32. PMID: 18084188.
      View in: PubMed
    52. Humann J, Bjordahl R, Andreasen K, Lenz LL. Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice. J Immunol. 2007 Feb 15; 178(4):2407-14. PMID: 17277147.
      View in: PubMed
    53. Lenz LL. Everything you always wanted to know about NK cells but were afraid to ask, Laurent Brossay, Ed. NK cells and the innate response to intracellular bacterial infections. 2007; 147-166.
    54. Muraille E, Narni-Mancinelli E, Gounon P, Bassand D, Glaichenhaus N, Lenz LL, Lauvau G. Cytosolic expression of SecA2 is a prerequisite for long-term protective immunity. Cell Microbiol. 2007 Jun; 9(6):1445-54. PMID: 17244189.
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    55. Arrunategui-Correa V, Lenz L, Kim HS. CD1d-independent regulation of NKT cell migration and cytokine production upon Listeria monocytogenes infection. Cell Immunol. 2004 Nov-Dec; 232(1-2):38-48. PMID: 15922714.
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    56. Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A. TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 2004 Dec; 21(6):877-89. PMID: 15589175.
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    57. Ploss A, Lauvau G, Contos B, Kerksiek KM, Guirnalda PD, Leiner I, Lenz LL, Bevan MJ, Pamer EG. Promiscuity of MHC class Ib-restricted T cell responses. J Immunol. 2003 Dec 01; 171(11):5948-55. PMID: 14634106.
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    58. Lenz LL, Mohammadi S, Geissler A, Portnoy DA. SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12432-7. PMID: 14527997.
      View in: PubMed
    59. Lenz LL, Butz EA, Bevan MJ. Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens. J Exp Med. 2000 Oct 16; 192(8):1135-42. PMID: 11034603.
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    60. Princiotta MF, Lenz LL, Bevan MJ, Staerz UD. H2-M3 restricted presentation of a Listeria-derived leader peptide. J Exp Med. 1998 May 18; 187(10):1711-9. PMID: 9584149.
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    61. Lenz LL, Bevan MJ. CTL responses to H2-M3-restricted Listeria epitopes. Immunol Rev. 1997 Aug; 158:115-21. PMID: 9314079.
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    62. Harty JT, Lenz LL, Bevan MJ. Primary and secondary immune responses to Listeria monocytogenes. Curr Opin Immunol. 1996 Aug; 8(4):526-30. PMID: 8794012.
      View in: PubMed
    63. Lenz LL, Dere B, Bevan MJ. Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. Immunity. 1996 Jul; 5(1):63-72. PMID: 8758895.
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    64. Lenz LL, Bevan MJ. H2-M3 restricted presentation of Listeria monocytogenes antigens. Immunol Rev. 1996 Jun; 151:107-21. PMID: 8872487.
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    65. Fattaey A, Lenz L, Consigli RA. Production and characterization of monoclonal antibodies to budgerigar fledgling disease virus major capsid protein VP. Avian Dis. 1992 Jul-Sep; 36(3):543-53. PMID: 1417586.
      View in: PubMed
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