Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Wyles

Concepts (252)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Antiviral Agents
60
2026
768
11.240
Why?
Hepatitis C, Chronic
32
2025
152
9.010
Why?
Hepacivirus
49
2026
243
8.370
Why?
Hepatitis C
30
2026
254
8.160
Why?
Benzimidazoles
19
2026
190
4.390
Why?
Drug Resistance, Viral
18
2025
123
3.860
Why?
Coinfection
15
2020
141
2.860
Why?
HIV Infections
28
2022
3154
2.750
Why?
Quinoxalines
8
2026
65
2.390
Why?
Ribavirin
15
2020
80
2.280
Why?
Sulfonamides
14
2026
581
2.280
Why?
Sofosbuvir
16
2022
61
2.190
Why?
Fluorenes
7
2020
46
2.130
Why?
Liver Cirrhosis
8
2020
288
2.080
Why?
Viral Nonstructural Proteins
10
2025
67
2.080
Why?
Drug Therapy, Combination
26
2020
1048
1.750
Why?
Uridine Monophosphate
5
2016
16
1.610
Why?
Carbamates
9
2020
52
1.390
Why?
Anti-Retroviral Agents
5
2019
250
1.360
Why?
Protease Inhibitors
10
2020
102
1.330
Why?
Pyrrolidines
10
2026
125
1.330
Why?
Hepatitis B, Chronic
3
2019
22
1.280
Why?
Proline
12
2026
83
1.260
Why?
Genotype
21
2025
1835
1.150
Why?
Sustained Virologic Response
12
2026
46
1.150
Why?
Congresses as Topic
3
2021
221
1.130
Why?
Hepatitis, Viral, Human
3
2021
20
1.100
Why?
Cyclopropanes
12
2026
83
0.990
Why?
Lactams, Macrocyclic
11
2026
51
0.920
Why?
Drug Users
2
2024
42
0.920
Why?
Heterocyclic Compounds, 4 or More Rings
3
2017
23
0.760
Why?
HIV-1
8
2020
896
0.740
Why?
Respiratory Insufficiency
1
2026
326
0.730
Why?
Treatment Failure
6
2025
365
0.710
Why?
Virus Replication
7
2012
529
0.700
Why?
Pyridines
1
2026
605
0.700
Why?
RNA, Viral
10
2026
688
0.670
Why?
Disease Eradication
1
2020
5
0.670
Why?
Organophosphonates
4
2011
97
0.650
Why?
Humans
79
2026
144957
0.650
Why?
Homosexuality, Male
2
2021
222
0.620
Why?
Valine
7
2020
80
0.600
Why?
Anti-HIV Agents
6
2020
888
0.580
Why?
Treatment Outcome
20
2026
11695
0.560
Why?
Aminoisobutyric Acids
6
2026
9
0.550
Why?
Middle Aged
34
2026
35928
0.550
Why?
Nucleic Acid Synthesis Inhibitors
2
2015
16
0.530
Why?
Leucine
6
2026
116
0.520
Why?
Ritonavir
6
2020
75
0.510
Why?
Imidazoles
2
2015
254
0.510
Why?
Darunavir
1
2017
20
0.510
Why?
Male
43
2026
72406
0.500
Why?
Adult
33
2026
40506
0.480
Why?
Uracil
5
2020
36
0.480
Why?
Antiretroviral Therapy, Highly Active
3
2015
278
0.470
Why?
Anilides
5
2020
84
0.460
Why?
Education, Medical, Continuing
1
2016
132
0.450
Why?
Female
41
2026
78376
0.450
Why?
Biomedical Research
1
2021
710
0.430
Why?
Oligopeptides
2
2013
269
0.420
Why?
Pyridazines
1
2014
57
0.410
Why?
Adenine
4
2020
339
0.410
Why?
2-Naphthylamine
5
2020
6
0.400
Why?
Viral Load
7
2020
526
0.400
Why?
Macrocyclic Compounds
3
2019
15
0.400
Why?
Purines
1
2014
187
0.380
Why?
Aged
18
2026
25947
0.380
Why?
Quinolines
1
2014
193
0.380
Why?
Replicon
3
2009
15
0.380
Why?
Liver
1
2021
1888
0.370
Why?
Scavenger Receptors, Class B
1
2012
14
0.360
Why?
Disease Management
1
2016
647
0.360
Why?
Mass Screening
4
2025
1348
0.320
Why?
Retreatment
2
2021
77
0.320
Why?
Drug Synergism
3
2008
357
0.310
Why?
Acquired Immunodeficiency Syndrome
2
2020
235
0.280
Why?
Dideoxynucleosides
2
2005
24
0.280
Why?
Liver Diseases
2
2016
304
0.270
Why?
Interferon-alpha
4
2013
197
0.270
Why?
Nucleoside-Triphosphatase
3
2017
14
0.270
Why?
Cytokines
1
2015
2065
0.260
Why?
DEAD-box RNA Helicases
3
2017
90
0.250
Why?
Serine Endopeptidases
3
2017
128
0.250
Why?
Amino Acid Substitution
2
2018
304
0.250
Why?
Cytosine
2
2009
51
0.250
Why?
Indolizines
1
2026
13
0.240
Why?
Global Health
2
2020
401
0.240
Why?
Hospitalization
3
2026
2434
0.240
Why?
Hepatitis B virus
2
2019
33
0.220
Why?
HIV
2
2019
250
0.220
Why?
Double-Blind Method
3
2026
2029
0.220
Why?
Hepatitis
1
2004
43
0.210
Why?
Herpes Simplex
1
2005
98
0.210
Why?
Alanine
2
2021
171
0.200
Why?
Interferons
2
2015
188
0.190
Why?
Prevalence
3
2019
2836
0.190
Why?
Mutation, Missense
3
2014
340
0.180
Why?
Pyrazoles
1
2026
510
0.180
Why?
Hospitals
2
2024
732
0.180
Why?
Interferon beta-1a
1
2021
14
0.180
Why?
Young Adult
10
2019
14126
0.170
Why?
Hepatitis A
1
2021
25
0.170
Why?
Adenosine Monophosphate
1
2021
86
0.170
Why?
Phylogeny
1
2025
1019
0.160
Why?
Feasibility Studies
1
2025
1095
0.160
Why?
Tenofovir
2
2020
295
0.160
Why?
Hepatitis B
1
2021
66
0.160
Why?
World Health Organization
1
2020
105
0.160
Why?
Benzopyrans
2
2017
30
0.160
Why?
Disease Progression
2
2019
2852
0.150
Why?
Data Interpretation, Statistical
2
2018
372
0.150
Why?
Drug Combinations
4
2026
392
0.150
Why?
Polyethylene Glycols
2
2015
655
0.150
Why?
Esters
2
2009
78
0.140
Why?
CD4 Lymphocyte Count
2
2017
277
0.140
Why?
Ribosomes
2
2010
191
0.140
Why?
United States
10
2025
15988
0.140
Why?
Immunologic Factors
1
2020
255
0.140
Why?
Emergency Service, Hospital
3
2025
2313
0.140
Why?
Nucleic Acid Conformation
4
2014
726
0.130
Why?
Alanine Transaminase
1
2018
151
0.130
Why?
DNA, Viral
1
2019
358
0.130
Why?
Genes, Viral
1
2016
90
0.120
Why?
DNA Mutational Analysis
1
2018
409
0.120
Why?
Molecular Structure
2
2008
501
0.120
Why?
High-Throughput Nucleotide Sequencing
2
2016
550
0.120
Why?
Mutation
2
2018
4099
0.120
Why?
Patient Compliance
1
2020
589
0.120
Why?
Survival Analysis
1
2019
1385
0.120
Why?
Dose-Response Relationship, Drug
2
2017
2032
0.110
Why?
Adolescent
5
2022
22453
0.110
Why?
Regulatory Sequences, Ribonucleic Acid
1
2014
18
0.110
Why?
AIDS-Related Opportunistic Infections
1
2015
130
0.110
Why?
Chemokines
1
2015
218
0.110
Why?
Chemokine CXCL10
1
2014
39
0.100
Why?
Risk Assessment
2
2025
3676
0.100
Why?
Drug Interactions
1
2015
401
0.100
Why?
Phenylenediamines
1
2013
12
0.100
Why?
Fibrosis
1
2016
548
0.100
Why?
Opiate Substitution Treatment
1
2016
187
0.100
Why?
Viral Proteins
2
2014
355
0.100
Why?
Prospective Studies
5
2025
7997
0.100
Why?
Microbial Sensitivity Tests
2
2012
371
0.100
Why?
Prognosis
2
2019
4293
0.090
Why?
Equivalence Trials as Topic
2
2023
36
0.090
Why?
Quality of Life
1
2025
3192
0.090
Why?
Drug Discovery
1
2013
155
0.090
Why?
Administration, Oral
1
2014
848
0.090
Why?
Drug-Related Side Effects and Adverse Reactions
1
2013
257
0.080
Why?
Case-Control Studies
2
2017
3608
0.080
Why?
Cohort Studies
5
2024
5965
0.080
Why?
Models, Molecular
3
2012
1619
0.080
Why?
Prodrugs
1
2011
52
0.080
Why?
Mental Disorders
1
2020
1172
0.080
Why?
Nucleosides
1
2010
25
0.080
Why?
Riboswitch
1
2012
63
0.080
Why?
Telemedicine
1
2020
948
0.080
Why?
Japan
2
2021
143
0.080
Why?
Drug Administration Schedule
3
2017
783
0.080
Why?
Cell Line, Tumor
2
2008
3550
0.070
Why?
Drug Design
1
2010
173
0.070
Why?
Biomarkers
1
2020
4275
0.070
Why?
Cell Line
2
2012
2882
0.070
Why?
Randomized Controlled Trials as Topic
3
2023
1721
0.070
Why?
Piperidines
1
2010
217
0.070
Why?
Phenylthiourea
1
2008
5
0.070
Why?
Practice Guidelines as Topic
1
2016
1563
0.070
Why?
Body Mass Index
1
2017
2438
0.070
Why?
Immunity, Innate
1
2014
846
0.070
Why?
Plasmids
1
2009
379
0.070
Why?
Structure-Activity Relationship
1
2009
570
0.070
Why?
Inhibitory Concentration 50
1
2006
91
0.060
Why?
Luciferases
1
2006
152
0.060
Why?
Genes, Reporter
1
2006
276
0.060
Why?
Thailand
1
2025
18
0.060
Why?
Saquinavir
1
2004
1
0.060
Why?
Simplexvirus
1
2005
82
0.060
Why?
Indinavir
1
2004
7
0.060
Why?
Drug Labeling
1
2005
37
0.060
Why?
Nelfinavir
1
2004
8
0.060
Why?
Nevirapine
1
2004
18
0.050
Why?
Uganda
1
2025
93
0.050
Why?
Benzoxazines
1
2004
31
0.050
Why?
Oxazines
1
2004
37
0.050
Why?
Lopinavir
1
2004
30
0.050
Why?
Pandemics
2
2024
1695
0.050
Why?
Brazil
1
2025
180
0.050
Why?
Zidovudine
1
2004
77
0.050
Why?
Liver Function Tests
1
2004
106
0.050
Why?
Alkynes
1
2004
66
0.050
Why?
Reverse Transcriptase Inhibitors
1
2004
87
0.050
Why?
Transfection
1
2006
940
0.050
Why?
Time Factors
1
2015
7183
0.050
Why?
Bone Marrow Transplantation
1
2005
294
0.050
Why?
Pregnancy
1
2017
7191
0.050
Why?
Pyrimidinones
1
2004
126
0.050
Why?
South Africa
1
2025
261
0.050
Why?
Recombinant Fusion Proteins
1
2006
675
0.050
Why?
Carcinoma, Hepatocellular
1
2006
372
0.050
Why?
Polyphosphates
1
2022
45
0.050
Why?
Singapore
1
2021
27
0.040
Why?
Republic of Korea
1
2021
42
0.040
Why?
Pragmatic Clinical Trials as Topic
1
2022
133
0.040
Why?
Dried Blood Spot Testing
1
2022
126
0.040
Why?
Mexico
1
2021
233
0.040
Why?
Retrospective Studies
5
2019
17101
0.040
Why?
Multicenter Studies as Topic
1
2022
405
0.040
Why?
Protein Biosynthesis
2
2014
458
0.040
Why?
Liver Neoplasms
1
2006
783
0.040
Why?
Raltegravir Potassium
1
2019
18
0.040
Why?
Clinical Trials, Phase II as Topic
1
2019
77
0.040
Why?
Clinical Trials, Phase III as Topic
1
2019
117
0.040
Why?
Intensive Care Units
1
2024
916
0.030
Why?
Drug Resistance, Multiple, Viral
1
2017
10
0.030
Why?
Kinetics
1
2020
1629
0.030
Why?
Longitudinal Studies
1
2024
2947
0.030
Why?
Oxygen
1
2021
995
0.030
Why?
Medicaid
1
2020
462
0.030
Why?
Program Evaluation
1
2020
949
0.030
Why?
Incidence
2
2013
2883
0.030
Why?
RNA
1
2022
940
0.030
Why?
Cell-Free System
1
2014
53
0.030
Why?
Hepatitis C Antibodies
1
2014
11
0.030
Why?
Spain
1
2014
48
0.030
Why?
Polymorphism, Genetic
1
2017
612
0.030
Why?
Enzyme-Linked Immunosorbent Assay
1
2016
851
0.030
Why?
Withholding Treatment
1
2013
81
0.020
Why?
Patient Care
1
2014
118
0.020
Why?
Patient Acceptance of Health Care
1
2020
886
0.020
Why?
Risk Factors
2
2020
10792
0.020
Why?
Early Diagnosis
1
2014
249
0.020
Why?
Aged, 80 and over
2
2019
8279
0.020
Why?
Patient Reported Outcome Measures
1
2017
489
0.020
Why?
Plasma
1
2014
225
0.020
Why?
Fluorescence Resonance Energy Transfer
1
2012
178
0.020
Why?
Virus Internalization
1
2010
65
0.020
Why?
Ligands
1
2012
674
0.020
Why?
Recombinant Proteins
1
2013
1371
0.020
Why?
Magnesium
1
2009
155
0.020
Why?
Lamivudine
1
2009
65
0.020
Why?
Pilot Projects
1
2015
1890
0.020
Why?
Referral and Consultation
1
2014
853
0.020
Why?
Logistic Models
1
2013
2119
0.020
Why?
Genome, Viral
1
2009
218
0.020
Why?
Phenotype
1
2014
3164
0.010
Why?
Base Sequence
1
2009
2191
0.010
Why?
Severity of Illness Index
1
2013
2925
0.010
Why?
Mice, Transgenic
1
2009
2185
0.010
Why?
Animals
2
2018
38109
0.010
Why?
Substance-Related Disorders
1
2011
1094
0.010
Why?
Signal Transduction
1
2009
5233
0.010
Why?
Mice
1
2009
18365
0.010
Why?
Wyles's Networks
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