Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Wyles

Concepts (241)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Antiviral Agents
59
2025
741
11.780
Why?
Hepatitis C, Chronic
32
2025
163
9.340
Why?
Hepacivirus
48
2025
259
8.630
Why?
Hepatitis C
29
2025
265
8.300
Why?
Benzimidazoles
16
2020
168
4.300
Why?
Drug Resistance, Viral
18
2025
115
4.100
Why?
Coinfection
15
2020
137
3.060
Why?
HIV Infections
28
2022
2820
3.050
Why?
Ribavirin
15
2020
91
2.370
Why?
Sofosbuvir
16
2022
59
2.300
Why?
Quinoxalines
7
2019
66
2.280
Why?
Fluorenes
7
2020
42
2.250
Why?
Sulfonamides
13
2020
512
2.250
Why?
Viral Nonstructural Proteins
10
2025
65
2.180
Why?
Liver Cirrhosis
8
2020
316
2.160
Why?
Drug Therapy, Combination
26
2020
1063
1.830
Why?
Uridine Monophosphate
5
2016
15
1.700
Why?
Carbamates
9
2020
49
1.470
Why?
Anti-Retroviral Agents
5
2019
232
1.450
Why?
Protease Inhibitors
10
2020
106
1.390
Why?
Hepatitis B, Chronic
3
2019
23
1.350
Why?
Proline
11
2020
79
1.270
Why?
Pyrrolidines
9
2019
80
1.210
Why?
Genotype
21
2025
1923
1.200
Why?
Congresses as Topic
3
2021
234
1.180
Why?
Sustained Virologic Response
11
2025
40
1.160
Why?
Hepatitis, Viral, Human
3
2021
25
1.160
Why?
Cyclopropanes
11
2020
90
0.980
Why?
Drug Users
2
2024
39
0.970
Why?
Lactams, Macrocyclic
10
2020
49
0.910
Why?
Heterocyclic Compounds, 4 or More Rings
3
2017
20
0.810
Why?
HIV-1
8
2020
861
0.790
Why?
Treatment Failure
6
2025
354
0.750
Why?
Virus Replication
7
2012
484
0.740
Why?
Disease Eradication
1
2020
4
0.700
Why?
Organophosphonates
4
2011
92
0.690
Why?
Homosexuality, Male
2
2021
184
0.680
Why?
RNA, Viral
9
2025
654
0.670
Why?
Humans
77
2025
137294
0.660
Why?
Anti-HIV Agents
6
2020
772
0.650
Why?
Valine
7
2020
82
0.640
Why?
Nucleic Acid Synthesis Inhibitors
2
2015
16
0.560
Why?
Imidazoles
2
2015
239
0.540
Why?
Ritonavir
6
2020
73
0.540
Why?
Middle Aged
32
2025
33310
0.540
Why?
Darunavir
1
2017
18
0.530
Why?
Aminoisobutyric Acids
5
2019
7
0.520
Why?
Uracil
5
2020
31
0.510
Why?
Antiretroviral Therapy, Highly Active
3
2015
270
0.500
Why?
Male
41
2025
67560
0.490
Why?
Leucine
5
2019
111
0.490
Why?
Treatment Outcome
18
2023
10800
0.490
Why?
Anilides
5
2020
73
0.490
Why?
Education, Medical, Continuing
1
2016
128
0.470
Why?
Adult
31
2025
37724
0.460
Why?
Biomedical Research
1
2021
693
0.450
Why?
Adenine
4
2020
267
0.450
Why?
Female
39
2025
73052
0.440
Why?
Oligopeptides
2
2013
272
0.440
Why?
Viral Load
7
2020
464
0.430
Why?
Pyridazines
1
2014
56
0.430
Why?
2-Naphthylamine
5
2020
7
0.420
Why?
Macrocyclic Compounds
3
2019
9
0.420
Why?
Purines
1
2014
176
0.410
Why?
Quinolines
1
2014
177
0.400
Why?
Replicon
3
2009
14
0.400
Why?
Liver
1
2021
1941
0.390
Why?
Scavenger Receptors, Class B
1
2012
14
0.380
Why?
Disease Management
1
2016
627
0.380
Why?
Aged
17
2024
23851
0.350
Why?
Mass Screening
4
2025
1268
0.350
Why?
Retreatment
2
2021
72
0.340
Why?
Drug Synergism
3
2008
383
0.330
Why?
Acquired Immunodeficiency Syndrome
2
2020
232
0.300
Why?
Dideoxynucleosides
2
2005
21
0.290
Why?
Liver Diseases
2
2016
311
0.290
Why?
Interferon-alpha
4
2013
198
0.280
Why?
Cytokines
1
2015
2090
0.270
Why?
Amino Acid Substitution
2
2018
309
0.260
Why?
Cytosine
2
2009
49
0.260
Why?
Global Health
2
2020
386
0.250
Why?
Hepatitis B virus
2
2019
40
0.230
Why?
HIV
2
2019
234
0.230
Why?
Herpes Simplex
1
2005
95
0.230
Why?
Hepatitis
1
2004
48
0.230
Why?
Alanine
2
2021
151
0.210
Why?
Prevalence
3
2019
2715
0.200
Why?
Interferons
2
2015
202
0.200
Why?
Mutation, Missense
3
2014
338
0.190
Why?
Young Adult
10
2019
13163
0.190
Why?
Interferon beta-1a
1
2021
12
0.190
Why?
Hospitals
2
2024
689
0.190
Why?
Hepatitis A
1
2021
26
0.180
Why?
Feasibility Studies
1
2025
949
0.180
Why?
Phylogeny
1
2025
900
0.180
Why?
Adenosine Monophosphate
1
2021
66
0.180
Why?
Tenofovir
2
2020
240
0.180
Why?
Hepatitis B
1
2021
70
0.170
Why?
World Health Organization
1
2020
123
0.170
Why?
Disease Progression
2
2019
2752
0.160
Why?
Data Interpretation, Statistical
2
2018
363
0.160
Why?
Polyethylene Glycols
2
2015
640
0.150
Why?
Emergency Service, Hospital
3
2025
2054
0.150
Why?
Esters
2
2009
76
0.150
Why?
United States
10
2025
14742
0.150
Why?
CD4 Lymphocyte Count
2
2017
268
0.150
Why?
Ribosomes
2
2010
186
0.150
Why?
Immunologic Factors
1
2020
237
0.150
Why?
Nucleic Acid Conformation
4
2014
730
0.140
Why?
Hospitalization
2
2024
2214
0.140
Why?
Alanine Transaminase
1
2018
157
0.130
Why?
DNA, Viral
1
2019
363
0.130
Why?
Genes, Viral
1
2016
88
0.130
Why?
DNA Mutational Analysis
1
2018
400
0.130
Why?
Molecular Structure
2
2008
498
0.120
Why?
Mutation
2
2018
3956
0.120
Why?
Patient Compliance
1
2020
577
0.120
Why?
Survival Analysis
1
2019
1321
0.120
Why?
High-Throughput Nucleotide Sequencing
2
2016
537
0.120
Why?
Adolescent
5
2022
21499
0.120
Why?
Dose-Response Relationship, Drug
2
2017
2052
0.120
Why?
Regulatory Sequences, Ribonucleic Acid
1
2014
19
0.110
Why?
AIDS-Related Opportunistic Infections
1
2015
126
0.110
Why?
Opiate Substitution Treatment
1
2016
147
0.110
Why?
Chemokines
1
2015
228
0.110
Why?
Risk Assessment
2
2025
3439
0.110
Why?
Chemokine CXCL10
1
2014
39
0.110
Why?
Drug Interactions
1
2015
406
0.110
Why?
Phenylenediamines
1
2013
10
0.110
Why?
Prospective Studies
5
2025
7595
0.110
Why?
Fibrosis
1
2016
552
0.100
Why?
Viral Proteins
2
2014
343
0.100
Why?
Prognosis
2
2019
4026
0.100
Why?
Microbial Sensitivity Tests
2
2012
359
0.100
Why?
Drug Combinations
3
2019
344
0.100
Why?
Quality of Life
1
2025
2885
0.100
Why?
Drug Discovery
1
2013
141
0.090
Why?
Administration, Oral
1
2014
812
0.090
Why?
Mental Disorders
1
2020
1077
0.090
Why?
Cohort Studies
5
2024
5726
0.090
Why?
Drug-Related Side Effects and Adverse Reactions
1
2013
251
0.090
Why?
Case-Control Studies
2
2017
3546
0.090
Why?
Telemedicine
1
2020
854
0.090
Why?
Models, Molecular
3
2012
1594
0.090
Why?
Prodrugs
1
2011
52
0.090
Why?
Nucleosides
1
2010
27
0.090
Why?
Riboswitch
1
2012
67
0.080
Why?
Japan
2
2021
116
0.080
Why?
Drug Administration Schedule
3
2017
786
0.080
Why?
Cell Line, Tumor
2
2008
3414
0.080
Why?
Drug Design
1
2010
167
0.080
Why?
Biomarkers
1
2020
4164
0.080
Why?
Cell Line
2
2012
2841
0.080
Why?
Piperidines
1
2010
206
0.070
Why?
Phenylthiourea
1
2008
5
0.070
Why?
Practice Guidelines as Topic
1
2016
1577
0.070
Why?
Body Mass Index
1
2017
2373
0.070
Why?
Immunity, Innate
1
2014
827
0.070
Why?
Plasmids
1
2009
362
0.070
Why?
Structure-Activity Relationship
1
2009
574
0.070
Why?
Inhibitory Concentration 50
1
2006
90
0.070
Why?
Luciferases
1
2006
150
0.060
Why?
Genes, Reporter
1
2006
269
0.060
Why?
Thailand
1
2025
17
0.060
Why?
Saquinavir
1
2004
1
0.060
Why?
Simplexvirus
1
2005
80
0.060
Why?
Indinavir
1
2004
7
0.060
Why?
Uganda
1
2025
73
0.060
Why?
Nelfinavir
1
2004
9
0.060
Why?
Drug Labeling
1
2005
40
0.060
Why?
Nevirapine
1
2004
17
0.060
Why?
Oxazines
1
2004
30
0.060
Why?
Pandemics
2
2024
1623
0.060
Why?
Benzoxazines
1
2004
31
0.060
Why?
Lopinavir
1
2004
30
0.060
Why?
Brazil
1
2025
167
0.060
Why?
Alkynes
1
2004
56
0.060
Why?
Zidovudine
1
2004
78
0.060
Why?
Time Factors
1
2015
6818
0.060
Why?
Liver Function Tests
1
2004
114
0.060
Why?
Reverse Transcriptase Inhibitors
1
2004
84
0.060
Why?
Transfection
1
2006
947
0.060
Why?
South Africa
1
2025
219
0.060
Why?
Pregnancy
1
2017
6743
0.050
Why?
Bone Marrow Transplantation
1
2005
287
0.050
Why?
Pyrimidinones
1
2004
113
0.050
Why?
Recombinant Fusion Proteins
1
2006
664
0.050
Why?
Carcinoma, Hepatocellular
1
2006
361
0.050
Why?
Double-Blind Method
2
2021
1985
0.050
Why?
Polyphosphates
1
2022
36
0.050
Why?
Singapore
1
2021
22
0.050
Why?
Republic of Korea
1
2021
36
0.050
Why?
Dried Blood Spot Testing
1
2022
103
0.050
Why?
Mexico
1
2021
225
0.040
Why?
Retrospective Studies
5
2019
15639
0.040
Why?
Protein Biosynthesis
2
2014
434
0.040
Why?
Liver Neoplasms
1
2006
785
0.040
Why?
Raltegravir Potassium
1
2019
17
0.040
Why?
Clinical Trials, Phase II as Topic
1
2019
75
0.040
Why?
Clinical Trials, Phase III as Topic
1
2019
105
0.040
Why?
Intensive Care Units
1
2024
802
0.040
Why?
Drug Resistance, Multiple, Viral
1
2017
10
0.030
Why?
Longitudinal Studies
1
2024
2850
0.030
Why?
Kinetics
1
2020
1674
0.030
Why?
Oxygen
1
2021
935
0.030
Why?
Medicaid
1
2020
434
0.030
Why?
Program Evaluation
1
2020
891
0.030
Why?
Incidence
2
2013
2808
0.030
Why?
RNA
1
2022
924
0.030
Why?
Cell-Free System
1
2014
53
0.030
Why?
Hepatitis C Antibodies
1
2014
11
0.030
Why?
Spain
1
2014
41
0.030
Why?
Enzyme-Linked Immunosorbent Assay
1
2016
851
0.030
Why?
Polymorphism, Genetic
1
2017
658
0.030
Why?
Patient Acceptance of Health Care
1
2020
808
0.030
Why?
Patient Care
1
2014
110
0.030
Why?
Aged, 80 and over
2
2019
7607
0.030
Why?
Patient Reported Outcome Measures
1
2017
406
0.030
Why?
Withholding Treatment
1
2013
77
0.030
Why?
Risk Factors
2
2020
10368
0.030
Why?
Early Diagnosis
1
2014
244
0.030
Why?
Plasma
1
2014
213
0.020
Why?
Fluorescence Resonance Energy Transfer
1
2012
177
0.020
Why?
Virus Internalization
1
2010
49
0.020
Why?
Ligands
1
2012
664
0.020
Why?
Recombinant Proteins
1
2013
1354
0.020
Why?
Pilot Projects
1
2015
1700
0.020
Why?
Magnesium
1
2009
158
0.020
Why?
Lamivudine
1
2009
63
0.020
Why?
Genome, Viral
1
2009
145
0.020
Why?
Referral and Consultation
1
2014
778
0.020
Why?
Logistic Models
1
2013
2071
0.020
Why?
Phenotype
1
2014
3202
0.020
Why?
Base Sequence
1
2009
2182
0.020
Why?
Severity of Illness Index
1
2013
2836
0.020
Why?
Randomized Controlled Trials as Topic
1
2011
1464
0.010
Why?
Mice, Transgenic
1
2009
2164
0.010
Why?
Animals
2
2018
36862
0.010
Why?
Substance-Related Disorders
1
2011
1073
0.010
Why?
Signal Transduction
1
2009
5078
0.010
Why?
Mice
1
2009
17774
0.010
Why?
Wyles's Networks
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