 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 16 | 19 | 35 | | 1996 | 14 | 22 | 36 | | 1997 | 16 | 28 | 44 | | 1998 | 19 | 29 | 48 | | 1999 | 15 | 25 | 40 | | 2000 | 13 | 31 | 44 | | 2001 | 20 | 35 | 55 | | 2002 | 16 | 49 | 65 | | 2003 | 26 | 55 | 81 | | 2004 | 48 | 70 | 118 | | 2005 | 32 | 77 | 109 | | 2006 | 45 | 80 | 125 | | 2007 | 32 | 68 | 100 | | 2008 | 35 | 86 | 121 | | 2009 | 46 | 83 | 129 | | 2010 | 51 | 89 | 140 | | 2011 | 48 | 107 | 155 | | 2012 | 42 | 135 | 177 | | 2013 | 57 | 135 | 192 | | 2014 | 60 | 150 | 210 | | 2015 | 53 | 130 | 183 | | 2016 | 34 | 111 | 145 | | 2017 | 45 | 106 | 151 | | 2018 | 34 | 131 | 165 | | 2019 | 43 | 125 | 168 | | 2020 | 27 | 108 | 135 | | 2021 | 25 | 83 | 108 | | 2022 | 8 | 40 | 48 | | 2023 | 5 | 32 | 37 | | 2024 | 31 | 53 | 84 | | 2025 | 9 | 25 | 34 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Campa?a MB, Perkins MR, McCabe MC, Neumann A, Larson ED, Fantauzzo KA. PDGFRa/? heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation. Nat Commun. 2025 May 22; 16(1):4754.
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Rosenbaum SR, Hughes CJ, Fields KM, Purdy SC, Gustafson AL, Wolin A, Hampton D, Shrivastava NM, Turner N, Danis E, Ebmeier C, Spoelstra N, Richer J, Jedlicka P, Costello JC, Zhao R, Ford HL. EYA3 regulation of NF-?B and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis. Sci Adv. 2025 May 09; 11(19):eadt0504.
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Hoeper MM, Gomberg-Maitland M, Badesch DB, Gibbs JSR, Gr?nig E, Kopec G, McLaughlin VV, Meyer G, Olsson KM, Preston IR, Rosenkranz S, Souza R, Waxman AB, Perchenet L, Strait J, Xing A, Manimaran S, Wang X, Miller B, Cornell AG, de Oliveira Pena J, Ghofrani HA, Humbert M. Efficacy and safety of the activin signalling inhibitor, sotatercept, in a pooled analysis of PULSAR and STELLAR studies. Eur Respir J. 2025 May; 65(5).
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Rai M, Li H, Policastro RA, Pepin R, Zentner GE, Nemkov T, D'Alessandro A, Tennessen JM. Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3. PLoS Genet. 2025 May; 21(5):e1011690.
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Schloss SS, Marshall ZQ, Santistevan NJ, Gjorcheska S, Stenzel A, Barske L, Nelson JC. Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling. PLoS Biol. 2025 May; 23(5):e3003164.
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Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Sarosiek K, Hughes PE, Hata AN. LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers. Nat Commun. 2025 May 02; 16(1):4112.
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Pacheco GG, Dzamba BJ, Endo W, Edwards BC, Khan M, Comlekoglu T, Shook DR, Quasey K, Bjerke MA, Hirsh GD, Kashatus DF, DeSimone DW. Spatial regulation of mitochondrial membrane potential by a5?1 integrin engagement in collective cell migration. J Cell Sci. 2025 May 01; 138(9).
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Mull ML, Pratt SJP, Thompson KN, Annis DA, Lee RM, Ju JA, Gilchrist DE, Stemberger MB, Boyman L, Lederer WJ, Vitolo MI, Martin SS. Disruption of P2Y2 Signaling Promotes Breast Tumor Cell Dissemination by Reducing ATP-Dependent Calcium Elevation and Actin Localization to Cell Junctions. Int J Mol Sci. 2025 May 01; 26(9).
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Lee GY, Schaunaman N, Nouri HR, Kraft M, Chu HW. Comprehensive single-cell RNA-sequencing study of Tollip deficiency effect in IL-13-stimulated human airway epithelial cells. BMC Res Notes. 2025 Apr 23; 18(1):194.
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Kanai SM, Garcia CR, Augustus MR, Sharafeldeen SA, Brooks EP, Sucharov J, Lencer ES, Nichols JT, Clouthier DE. The Gq/11 family of Ga subunits is necessary and sufficient for lower jaw development. Development. 2025 Apr 15; 152(8).
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