 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1988 | 2 | 1 | 3 | | 1989 | 5 | 3 | 8 | | 1990 | 3 | 8 | 11 | | 1991 | 3 | 8 | 11 | | 1992 | 5 | 8 | 13 | | 1993 | 15 | 12 | 27 | | 1994 | 18 | 17 | 35 | | 1995 | 21 | 27 | 48 | | 1996 | 17 | 23 | 40 | | 1997 | 20 | 32 | 52 | | 1998 | 22 | 28 | 50 | | 1999 | 25 | 38 | 63 | | 2000 | 18 | 37 | 55 | | 2001 | 26 | 49 | 75 | | 2002 | 22 | 57 | 79 | | 2003 | 30 | 61 | 91 | | 2004 | 54 | 77 | 131 | | 2005 | 37 | 77 | 114 | | 2006 | 51 | 92 | 143 | | 2007 | 42 | 89 | 131 | | 2008 | 47 | 108 | 155 | | 2009 | 55 | 94 | 149 | | 2010 | 58 | 99 | 157 | | 2011 | 47 | 123 | 170 | | 2012 | 57 | 142 | 199 | | 2013 | 59 | 149 | 208 | | 2014 | 62 | 153 | 215 | | 2015 | 48 | 149 | 197 | | 2016 | 38 | 124 | 162 | | 2017 | 23 | 80 | 103 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Hao Y, Bjerke GA, Pietrzak K, Melhuish TA, Han Y, Turner SD, Frierson HF, Wotton D. TGFß signaling limits lineage plasticity in prostate cancer. PLoS Genet. 2018 05; 14(5):e1007409.
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Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018 03 15; 92(6).
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Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017; 12(12):e0189536.
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Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ. Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Ka and PIP3 Signaling. Biophys J. 2017 Dec 05; 113(11):2396-2405.
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Oak P, Pritzke T, Thiel I, Koschlig M, Mous DS, Windhorst A, Jain N, Eickelberg O, Foerster K, Schulze A, Goepel W, Reicherzer T, Ehrhardt H, Rottier RJ, Ahnert P, Gortner L, Desai TJ, Hilgendorff A. Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease. EMBO Mol Med. 2017 11; 9(11):1504-1520.
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Towers CG, Thorburn A. Targeting the Lysosome for Cancer Therapy. Cancer Discov. 2017 11; 7(11):1218-1220.
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Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer. 2017 12; 17(12):725-737.
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Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, Ma SF, Okamoto T, John AE, Obeidat M, Yang IV, Henry A, Hubbard RB, Navaratnam V, Saini G, Thompson N, Booth HL, Hart SP, Hill MR, Hirani N, Maher TM, McAnulty RJ, Millar AB, Molyneaux PL, Parfrey H, Rassl DM, Whyte MKB, Fahy WA, Marshall RP, Oballa E, Bossé Y, Nickle DC, Sin DD, Timens W, Shrine N, Sayers I, Hall IP, Noth I, Schwartz DA, Tobin MD, Wain LV, Jenkins RG. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respir Med. 2017 11; 5(11):869-880.
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Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2ß, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. 2018 01; 188(1):111-124.
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Ellison MA, Gearheart CM, Porter CC, Ambruso DR. IFN-? alters the expression of diverse immunity related genes in a cell culture model designed to represent maturing neutrophils. PLoS One. 2017; 12(10):e0185956.
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