 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 2 | 1 | 3 | | 1989 | 5 | 3 | 8 | | 1990 | 3 | 7 | 10 | | 1991 | 3 | 8 | 11 | | 1992 | 5 | 8 | 13 | | 1993 | 15 | 12 | 27 | | 1994 | 18 | 17 | 35 | | 1995 | 21 | 28 | 49 | | 1996 | 18 | 23 | 41 | | 1997 | 20 | 32 | 52 | | 1998 | 23 | 28 | 51 | | 1999 | 25 | 36 | 61 | | 2000 | 19 | 37 | 56 | | 2001 | 26 | 48 | 74 | | 2002 | 22 | 58 | 80 | | 2003 | 30 | 61 | 91 | | 2004 | 54 | 77 | 131 | | 2005 | 39 | 78 | 117 | | 2006 | 52 | 94 | 146 | | 2007 | 43 | 91 | 134 | | 2008 | 47 | 109 | 156 | | 2009 | 56 | 95 | 151 | | 2010 | 58 | 98 | 156 | | 2011 | 44 | 121 | 165 | | 2012 | 57 | 142 | 199 | | 2013 | 57 | 147 | 204 | | 2014 | 61 | 157 | 218 | | 2015 | 50 | 150 | 200 | | 2016 | 36 | 118 | 154 | | 2017 | 15 | 56 | 71 |
To return to the timeline, click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
-
Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017; 12(12):e0189536.
-
Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ. Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Ka and PIP3 Signaling. Biophys J. 2017 Dec 05; 113(11):2396-2405.
-
Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: what we know, what we need to know and the path forward. Nat Rev Cancer. 2017 12; 17(12):725-737.
-
Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2ß, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. 2018 01; 188(1):111-124.
-
Ellison MA, Gearheart CM, Porter CC, Ambruso DR. IFN-? alters the expression of diverse immunity related genes in a cell culture model designed to represent maturing neutrophils. PLoS One. 2017; 12(10):e0185956.
-
Taylor CT, Colgan SP. Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol. 2017 Dec; 17(12):774-785.
-
Kanai SM, Edwards AJ, Rurik JG, Osei-Owusu P, Blumer KJ. Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction. J Biol Chem. 2017 Nov 24; 292(47):19266-19278.
-
Mendenhall A, Crane MM, Tedesco PM, Johnson TE, Brent R. Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression. J Gerontol A Biol Sci Med Sci. 2017 Oct 01; 72(10):1305-1310.
-
Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 10; 85(10).
-
Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S. Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L930-L939.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|