 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.820 G04.835
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 5 | 6 | | 1992 | 3 | 4 | 7 | | 1993 | 12 | 10 | 22 | | 1994 | 14 | 11 | 25 | | 1995 | 16 | 21 | 37 | | 1996 | 15 | 24 | 39 | | 1997 | 15 | 28 | 43 | | 1998 | 19 | 30 | 49 | | 1999 | 19 | 34 | 53 | | 2000 | 13 | 34 | 47 | | 2001 | 21 | 40 | 61 | | 2002 | 16 | 55 | 71 | | 2003 | 26 | 62 | 88 | | 2004 | 51 | 74 | 125 | | 2005 | 38 | 81 | 119 | | 2006 | 47 | 87 | 134 | | 2007 | 42 | 81 | 123 | | 2008 | 37 | 105 | 142 | | 2009 | 51 | 89 | 140 | | 2010 | 53 | 91 | 144 | | 2011 | 54 | 116 | 170 | | 2012 | 46 | 143 | 189 | | 2013 | 59 | 152 | 211 | | 2014 | 63 | 155 | 218 | | 2015 | 52 | 145 | 197 | | 2016 | 35 | 125 | 160 | | 2017 | 42 | 111 | 153 | | 2018 | 28 | 122 | 150 | | 2019 | 40 | 126 | 166 | | 2020 | 29 | 94 | 123 | | 2021 | 12 | 23 | 35 |
To return to the timeline, click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Improving Right Ventricular Function by Increasing BMP Signaling with FK506. Am J Respir Cell Mol Biol. 2021 09; 65(3):272-287.
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Lee MH, Mickael C, Graham BB. Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling. Am J Respir Cell Mol Biol. 2021 09; 65(3):233-235.
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Redente EF. How Do We Know What We Are Missing? Loss of Signaling through CD148 Drives Fibroblast Activation in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 08 01; 204(3):249-251.
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Tanner AR, Lynch CS, Kennedy VC, Ali A, Winger QA, Rozance PJ, Anthony RV. CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction. Int J Mol Sci. 2021 Jul 29; 22(15).
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Stancil IT, Michalski JE, Davis-Hall D, Chu HW, Park JA, Magin CM, Yang IV, Smith BJ, Dobrinskikh E, Schwartz DA. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021 07 27; 12(1):4566.
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Hook JS, Patel PA, O'Malley A, Xie L, Kavanaugh JS, Horswill AR, Moreland JG. Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner. J Immunol. 2021 08 01; 207(3):966-973.
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Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA. Srsf3 mediates alternative RNA splicing downstream of PDGFRa signaling in the facial mesenchyme. Development. 2021 07 15; 148(14).
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Stewart S, Le Bleu HK, Yette GA, Henner AL, Robbins AE, Braunstein JA, Stankunas K. longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth. Development. 2021 06 01; 148(11).
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Chan CC, Harley ITW, Pfluger PT, Trompette A, Stankiewicz TE, Allen JL, Moreno-Fernandez ME, Damen MSMA, Oates JR, Alarcon PC, Doll JR, Flick MJ, Flick LM, Sanchez-Gurmaches J, Mukherjee R, Karns R, Helmrath M, Inge TH, Weisberg SP, Pamp SJ, Relman DA, Seeley RJ, Tschöp MH, Karp CL, Divanovic S. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nat Commun. 2021 05 18; 12(1):2911.
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Shotland AM, Fontenot AP, McKee AS. Pulmonary Macrophage Cell Death in Lung Health and Disease. Am J Respir Cell Mol Biol. 2021 05; 64(5):547-556.
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