 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 2 | 1 | 3 | | 1989 | 5 | 3 | 8 | | 1990 | 3 | 8 | 11 | | 1991 | 3 | 8 | 11 | | 1992 | 5 | 8 | 13 | | 1993 | 15 | 12 | 27 | | 1994 | 18 | 17 | 35 | | 1995 | 21 | 28 | 49 | | 1996 | 17 | 23 | 40 | | 1997 | 20 | 32 | 52 | | 1998 | 22 | 28 | 50 | | 1999 | 25 | 38 | 63 | | 2000 | 18 | 37 | 55 | | 2001 | 25 | 49 | 74 | | 2002 | 22 | 60 | 82 | | 2003 | 31 | 65 | 96 | | 2004 | 55 | 77 | 132 | | 2005 | 39 | 78 | 117 | | 2006 | 51 | 88 | 139 | | 2007 | 45 | 85 | 130 | | 2008 | 46 | 108 | 154 | | 2009 | 56 | 92 | 148 | | 2010 | 56 | 95 | 151 | | 2011 | 49 | 125 | 174 | | 2012 | 55 | 147 | 202 | | 2013 | 61 | 150 | 211 | | 2014 | 64 | 151 | 215 | | 2015 | 49 | 148 | 197 | | 2016 | 37 | 128 | 165 | | 2017 | 24 | 92 | 116 | | 2018 | 3 | 7 | 10 |
To return to the timeline, click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Hao Y, Bjerke GA, Pietrzak K, Melhuish TA, Han Y, Turner SD, Frierson HF, Wotton D. TGFß signaling limits lineage plasticity in prostate cancer. PLoS Genet. 2018 05; 14(5):e1007409.
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Sherlock ME, Sudarsan N, Breaker RR. Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems. Proc Natl Acad Sci U S A. 2018 06 05; 115(23):6052-6057.
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Shi R, Cao Z, Li H, Graw J, Zhang G, Thannickal VJ, Cheng G. Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria. PLoS Pathog. 2018 05; 14(5):e1007026.
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Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. PLoS One. 2018; 13(5):e0196678.
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Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.
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Danhof R, Lewis K, Brown M. Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin. Am J Clin Dermatol. 2018 Apr; 19(2):195-207.
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Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018 03 15; 92(6).
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Dhar D, Raina K, Agarwal R. Mechanisms and Drug Targets for Pancreatic Cancer Chemoprevention. Curr Med Chem. 2018; 25(22):2545-2565.
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van de Veerdonk FL, de Graaf DM, Joosten LA, Dinarello CA. Biology of IL-38 and its role in disease. Immunol Rev. 2018 01; 281(1):191-196.
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Cavalli G, Dinarello CA. Suppression of inflammation and acquired immunity by IL-37. Immunol Rev. 2018 01; 281(1):179-190.
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