Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

David Wyles

Concepts (239)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Antiviral Agents
58
2025
709
11.530
Why?
Hepatitis C, Chronic
31
2025
156
8.790
Why?
Hepacivirus
46
2024
237
7.910
Why?
Hepatitis C
27
2025
235
7.690
Why?
Benzimidazoles
16
2020
158
4.410
Why?
Drug Resistance, Viral
17
2018
110
3.310
Why?
Coinfection
15
2020
133
3.160
Why?
HIV Infections
28
2022
2744
3.140
Why?
Ribavirin
15
2020
92
2.430
Why?
Sofosbuvir
16
2022
57
2.360
Why?
Quinoxalines
7
2019
64
2.340
Why?
Sulfonamides
13
2020
494
2.330
Why?
Fluorenes
7
2020
39
2.320
Why?
Liver Cirrhosis
8
2020
278
2.270
Why?
Viral Nonstructural Proteins
9
2018
58
2.020
Why?
Drug Therapy, Combination
26
2020
1024
1.890
Why?
Uridine Monophosphate
5
2016
15
1.750
Why?
Carbamates
9
2020
45
1.520
Why?
Anti-Retroviral Agents
5
2019
230
1.490
Why?
Protease Inhibitors
10
2020
104
1.430
Why?
Hepatitis B, Chronic
3
2019
18
1.400
Why?
Proline
11
2020
79
1.300
Why?
Pyrrolidines
9
2019
65
1.250
Why?
Congresses as Topic
3
2021
217
1.220
Why?
Hepatitis, Viral, Human
3
2021
26
1.190
Why?
Genotype
19
2022
1836
1.020
Why?
Cyclopropanes
11
2020
88
1.010
Why?
Drug Users
2
2024
44
1.000
Why?
Sustained Virologic Response
10
2020
35
0.950
Why?
Lactams, Macrocyclic
10
2020
49
0.940
Why?
Heterocyclic Compounds, 4 or More Rings
3
2017
19
0.830
Why?
HIV-1
8
2020
841
0.810
Why?
Virus Replication
7
2012
449
0.770
Why?
Disease Eradication
1
2020
4
0.720
Why?
Organophosphonates
4
2011
91
0.700
Why?
Homosexuality, Male
2
2021
180
0.700
Why?
Anti-HIV Agents
6
2020
744
0.680
Why?
Humans
75
2025
129705
0.670
Why?
Valine
7
2020
78
0.660
Why?
Nucleic Acid Synthesis Inhibitors
2
2015
16
0.570
Why?
Imidazoles
2
2015
224
0.560
Why?
Ritonavir
6
2020
73
0.550
Why?
Darunavir
1
2017
17
0.550
Why?
Treatment Failure
5
2019
347
0.540
Why?
Aminoisobutyric Acids
5
2019
7
0.540
Why?
Uracil
5
2020
29
0.520
Why?
Treatment Outcome
18
2023
10299
0.510
Why?
Leucine
5
2019
106
0.510
Why?
Antiretroviral Therapy, Highly Active
3
2015
269
0.510
Why?
Anilides
5
2020
72
0.500
Why?
Middle Aged
30
2025
31103
0.500
Why?
Education, Medical, Continuing
1
2016
126
0.480
Why?
Male
39
2025
63544
0.480
Why?
Biomedical Research
1
2021
656
0.470
Why?
Adenine
4
2020
247
0.460
Why?
RNA, Viral
7
2015
622
0.460
Why?
Oligopeptides
2
2013
256
0.450
Why?
Pyridazines
1
2014
48
0.450
Why?
Viral Load
7
2020
449
0.450
Why?
2-Naphthylamine
5
2020
7
0.440
Why?
Macrocyclic Compounds
3
2019
10
0.430
Why?
Adult
29
2025
35595
0.420
Why?
Female
37
2025
68561
0.420
Why?
Purines
1
2014
170
0.420
Why?
Quinolines
1
2014
149
0.420
Why?
Replicon
3
2009
14
0.410
Why?
Liver
1
2021
1848
0.400
Why?
Disease Management
1
2016
596
0.390
Why?
Scavenger Receptors, Class B
1
2012
10
0.390
Why?
Aged
17
2024
22113
0.370
Why?
Retreatment
2
2021
69
0.350
Why?
Drug Synergism
3
2008
354
0.340
Why?
Acquired Immunodeficiency Syndrome
2
2020
227
0.310
Why?
Dideoxynucleosides
2
2005
20
0.300
Why?
Liver Diseases
2
2016
290
0.300
Why?
Interferon-alpha
4
2013
191
0.290
Why?
Cytokines
1
2015
2008
0.280
Why?
Amino Acid Substitution
2
2018
281
0.270
Why?
Global Health
2
2020
333
0.270
Why?
Cytosine
2
2009
46
0.270
Why?
Hepatitis B virus
2
2019
35
0.240
Why?
Mass Screening
3
2023
1130
0.240
Why?
HIV
2
2019
224
0.240
Why?
Herpes Simplex
1
2005
94
0.230
Why?
Hepatitis
1
2004
49
0.230
Why?
Alanine
2
2021
134
0.220
Why?
Prevalence
3
2019
2557
0.210
Why?
Interferons
2
2015
187
0.210
Why?
Young Adult
10
2019
12363
0.200
Why?
Hospitals
2
2024
635
0.200
Why?
Mutation, Missense
3
2014
319
0.200
Why?
Interferon beta-1a
1
2021
12
0.190
Why?
Hepatitis A
1
2021
26
0.180
Why?
Adenosine Monophosphate
1
2021
62
0.180
Why?
Tenofovir
2
2020
225
0.180
Why?
Hepatitis B
1
2021
61
0.180
Why?
World Health Organization
1
2020
109
0.170
Why?
Disease Progression
2
2019
2612
0.170
Why?
Data Interpretation, Statistical
2
2018
338
0.170
Why?
Polyethylene Glycols
2
2015
598
0.160
Why?
United States
10
2025
14078
0.160
Why?
Ribosomes
2
2010
162
0.150
Why?
Esters
2
2009
74
0.150
Why?
CD4 Lymphocyte Count
2
2017
269
0.150
Why?
Immunologic Factors
1
2020
230
0.150
Why?
Nucleic Acid Conformation
4
2014
706
0.140
Why?
Hospitalization
2
2024
2091
0.140
Why?
Alanine Transaminase
1
2018
149
0.140
Why?
DNA, Viral
1
2019
381
0.140
Why?
Genes, Viral
1
2016
94
0.140
Why?
DNA Mutational Analysis
1
2018
391
0.130
Why?
Mutation
2
2018
3674
0.130
Why?
Molecular Structure
2
2008
469
0.130
Why?
High-Throughput Nucleotide Sequencing
2
2016
484
0.130
Why?
Patient Compliance
1
2020
566
0.130
Why?
Survival Analysis
1
2019
1297
0.130
Why?
Adolescent
5
2022
20355
0.130
Why?
Dose-Response Relationship, Drug
2
2017
1969
0.120
Why?
Regulatory Sequences, Ribonucleic Acid
1
2014
19
0.120
Why?
Opiate Substitution Treatment
1
2016
140
0.120
Why?
AIDS-Related Opportunistic Infections
1
2015
126
0.120
Why?
Chemokines
1
2015
230
0.110
Why?
Chemokine CXCL10
1
2014
33
0.110
Why?
Drug Interactions
1
2015
371
0.110
Why?
Phenylenediamines
1
2013
9
0.110
Why?
Viral Proteins
2
2014
330
0.110
Why?
Fibrosis
1
2016
521
0.110
Why?
Prognosis
2
2019
3801
0.110
Why?
Quality of Life
1
2025
2712
0.100
Why?
Microbial Sensitivity Tests
2
2012
351
0.100
Why?
Drug Combinations
3
2019
327
0.100
Why?
Drug Discovery
1
2013
131
0.100
Why?
Administration, Oral
1
2014
790
0.100
Why?
Mental Disorders
1
2020
1025
0.090
Why?
Cohort Studies
5
2024
5410
0.090
Why?
Case-Control Studies
2
2017
3363
0.090
Why?
Telemedicine
1
2020
792
0.090
Why?
Models, Molecular
3
2012
1480
0.090
Why?
Drug-Related Side Effects and Adverse Reactions
1
2013
259
0.090
Why?
Prodrugs
1
2011
49
0.090
Why?
Nucleosides
1
2010
25
0.090
Why?
Japan
2
2021
102
0.090
Why?
Riboswitch
1
2012
68
0.090
Why?
Cell Line, Tumor
2
2008
3106
0.080
Why?
Prospective Studies
4
2023
7130
0.080
Why?
Drug Administration Schedule
3
2017
763
0.080
Why?
Risk Assessment
1
2019
3297
0.080
Why?
Drug Design
1
2010
157
0.080
Why?
Biomarkers
1
2020
3893
0.080
Why?
Cell Line
2
2012
2768
0.080
Why?
Piperidines
1
2010
186
0.080
Why?
Body Mass Index
1
2017
2246
0.080
Why?
Phenylthiourea
1
2008
5
0.080
Why?
Practice Guidelines as Topic
1
2016
1529
0.080
Why?
Immunity, Innate
1
2014
806
0.070
Why?
Plasmids
1
2009
359
0.070
Why?
Structure-Activity Relationship
1
2009
539
0.070
Why?
Inhibitory Concentration 50
1
2006
83
0.070
Why?
Luciferases
1
2006
148
0.070
Why?
Genes, Reporter
1
2006
269
0.060
Why?
Thailand
1
2025
16
0.060
Why?
Saquinavir
1
2004
1
0.060
Why?
Indinavir
1
2004
7
0.060
Why?
Simplexvirus
1
2005
83
0.060
Why?
Nelfinavir
1
2004
8
0.060
Why?
Drug Labeling
1
2005
42
0.060
Why?
Uganda
1
2025
80
0.060
Why?
Brazil
1
2025
102
0.060
Why?
Nevirapine
1
2004
16
0.060
Why?
Oxazines
1
2004
26
0.060
Why?
Pandemics
2
2024
1526
0.060
Why?
Benzoxazines
1
2004
31
0.060
Why?
Lopinavir
1
2004
31
0.060
Why?
Alkynes
1
2004
53
0.060
Why?
Zidovudine
1
2004
78
0.060
Why?
Time Factors
1
2015
6593
0.060
Why?
Pregnancy
1
2017
6273
0.060
Why?
Liver Function Tests
1
2004
116
0.060
Why?
Reverse Transcriptase Inhibitors
1
2004
82
0.060
Why?
Transfection
1
2006
904
0.060
Why?
Carcinoma, Hepatocellular
1
2006
267
0.060
Why?
South Africa
1
2025
199
0.060
Why?
Bone Marrow Transplantation
1
2005
267
0.060
Why?
Pyrimidinones
1
2004
102
0.060
Why?
Recombinant Fusion Proteins
1
2006
640
0.060
Why?
Double-Blind Method
2
2021
1871
0.050
Why?
Polyphosphates
1
2022
36
0.050
Why?
Republic of Korea
1
2021
28
0.050
Why?
Singapore
1
2021
20
0.050
Why?
Dried Blood Spot Testing
1
2022
84
0.050
Why?
Liver Neoplasms
1
2006
637
0.050
Why?
Retrospective Studies
5
2019
14669
0.050
Why?
Mexico
1
2021
188
0.050
Why?
Protein Biosynthesis
2
2014
409
0.050
Why?
Emergency Service, Hospital
2
2023
2044
0.050
Why?
Raltegravir Potassium
1
2019
17
0.040
Why?
Intensive Care Units
1
2024
738
0.040
Why?
Clinical Trials, Phase II as Topic
1
2019
73
0.040
Why?
Clinical Trials, Phase III as Topic
1
2019
91
0.040
Why?
Drug Resistance, Multiple, Viral
1
2017
11
0.040
Why?
Longitudinal Studies
1
2024
2670
0.030
Why?
Kinetics
1
2020
1620
0.030
Why?
Oxygen
1
2021
921
0.030
Why?
Medicaid
1
2020
447
0.030
Why?
Program Evaluation
1
2020
880
0.030
Why?
Incidence
2
2013
2658
0.030
Why?
RNA
1
2022
877
0.030
Why?
Cell-Free System
1
2014
48
0.030
Why?
Hepatitis C Antibodies
1
2014
10
0.030
Why?
Spain
1
2014
38
0.030
Why?
Enzyme-Linked Immunosorbent Assay
1
2016
828
0.030
Why?
Polymorphism, Genetic
1
2017
643
0.030
Why?
Aged, 80 and over
2
2019
7074
0.030
Why?
Patient Acceptance of Health Care
1
2020
776
0.030
Why?
Patient Reported Outcome Measures
1
2017
359
0.030
Why?
Risk Factors
2
2020
9832
0.030
Why?
Withholding Treatment
1
2013
69
0.030
Why?
Patient Care
1
2014
110
0.030
Why?
Early Diagnosis
1
2014
235
0.030
Why?
Plasma
1
2014
206
0.030
Why?
Fluorescence Resonance Energy Transfer
1
2012
175
0.020
Why?
Virus Internalization
1
2010
43
0.020
Why?
Ligands
1
2012
615
0.020
Why?
Pilot Projects
1
2015
1567
0.020
Why?
Recombinant Proteins
1
2013
1306
0.020
Why?
Magnesium
1
2009
152
0.020
Why?
Lamivudine
1
2009
61
0.020
Why?
Genome, Viral
1
2009
131
0.020
Why?
Referral and Consultation
1
2014
731
0.020
Why?
Logistic Models
1
2013
1980
0.020
Why?
Phenotype
1
2014
3063
0.020
Why?
Base Sequence
1
2009
2161
0.020
Why?
Severity of Illness Index
1
2013
2783
0.020
Why?
Randomized Controlled Trials as Topic
1
2011
1379
0.010
Why?
Mice, Transgenic
1
2009
2075
0.010
Why?
Animals
2
2018
34733
0.010
Why?
Substance-Related Disorders
1
2011
1023
0.010
Why?
Signal Transduction
1
2009
4863
0.010
Why?
Mice
1
2009
16585
0.010
Why?
Wyles's Networks
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