Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

David Wyles

Concepts (239)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Antiviral Agents
58
2025
706
11.480
Why?
Hepatitis C, Chronic
31
2025
154
8.770
Why?
Hepacivirus
46
2024
235
7.880
Why?
Hepatitis C
27
2025
234
7.670
Why?
Benzimidazoles
16
2020
158
4.380
Why?
Drug Resistance, Viral
17
2018
111
3.280
Why?
HIV Infections
28
2022
2715
3.140
Why?
Coinfection
15
2020
133
3.140
Why?
Ribavirin
15
2020
92
2.410
Why?
Sofosbuvir
16
2022
58
2.350
Why?
Quinoxalines
7
2019
65
2.330
Why?
Sulfonamides
13
2020
500
2.300
Why?
Fluorenes
7
2020
40
2.300
Why?
Liver Cirrhosis
8
2020
275
2.250
Why?
Viral Nonstructural Proteins
9
2018
58
2.010
Why?
Drug Therapy, Combination
26
2020
1013
1.880
Why?
Uridine Monophosphate
5
2016
15
1.740
Why?
Carbamates
9
2020
45
1.510
Why?
Anti-Retroviral Agents
5
2019
230
1.480
Why?
Protease Inhibitors
10
2020
104
1.420
Why?
Hepatitis B, Chronic
3
2019
18
1.390
Why?
Proline
11
2020
78
1.300
Why?
Pyrrolidines
9
2019
69
1.240
Why?
Congresses as Topic
3
2021
215
1.210
Why?
Hepatitis, Viral, Human
3
2021
25
1.190
Why?
Genotype
19
2022
1832
1.020
Why?
Cyclopropanes
11
2020
88
1.000
Why?
Drug Users
2
2024
42
0.990
Why?
Sustained Virologic Response
10
2020
37
0.950
Why?
Lactams, Macrocyclic
10
2020
49
0.930
Why?
Heterocyclic Compounds, 4 or More Rings
3
2017
19
0.830
Why?
HIV-1
8
2020
842
0.800
Why?
Virus Replication
7
2012
444
0.770
Why?
Disease Eradication
1
2020
4
0.720
Why?
Organophosphonates
4
2011
91
0.700
Why?
Homosexuality, Male
2
2021
176
0.690
Why?
Anti-HIV Agents
6
2020
748
0.670
Why?
Humans
75
2025
129136
0.660
Why?
Valine
7
2020
74
0.650
Why?
Nucleic Acid Synthesis Inhibitors
2
2015
16
0.570
Why?
Imidazoles
2
2015
229
0.560
Why?
Ritonavir
6
2020
72
0.550
Why?
Darunavir
1
2017
17
0.550
Why?
Treatment Failure
5
2019
343
0.540
Why?
Aminoisobutyric Acids
5
2019
7
0.530
Why?
Uracil
5
2020
30
0.520
Why?
Treatment Outcome
18
2023
10227
0.510
Why?
Antiretroviral Therapy, Highly Active
3
2015
266
0.510
Why?
Leucine
5
2019
108
0.500
Why?
Anilides
5
2020
73
0.500
Why?
Middle Aged
30
2025
31080
0.500
Why?
Education, Medical, Continuing
1
2016
124
0.480
Why?
Male
39
2025
63203
0.470
Why?
Biomedical Research
1
2021
647
0.470
Why?
Adenine
4
2020
255
0.460
Why?
RNA, Viral
7
2015
617
0.460
Why?
Oligopeptides
2
2013
258
0.450
Why?
Pyridazines
1
2014
50
0.440
Why?
Viral Load
7
2020
450
0.440
Why?
2-Naphthylamine
5
2020
7
0.430
Why?
Macrocyclic Compounds
3
2019
10
0.430
Why?
Adult
29
2025
35513
0.420
Why?
Female
37
2025
68519
0.420
Why?
Purines
1
2014
169
0.420
Why?
Quinolines
1
2014
154
0.410
Why?
Replicon
3
2009
14
0.410
Why?
Liver
1
2021
1833
0.400
Why?
Disease Management
1
2016
593
0.390
Why?
Scavenger Receptors, Class B
1
2012
11
0.390
Why?
Aged
17
2024
22090
0.370
Why?
Retreatment
2
2021
70
0.350
Why?
Drug Synergism
3
2008
359
0.340
Why?
Acquired Immunodeficiency Syndrome
2
2020
222
0.300
Why?
Dideoxynucleosides
2
2005
20
0.300
Why?
Liver Diseases
2
2016
285
0.300
Why?
Interferon-alpha
4
2013
192
0.290
Why?
Cytokines
1
2015
1987
0.280
Why?
Amino Acid Substitution
2
2018
281
0.270
Why?
Global Health
2
2020
328
0.270
Why?
Cytosine
2
2009
46
0.260
Why?
Hepatitis B virus
2
2019
35
0.240
Why?
HIV
2
2019
226
0.230
Why?
Mass Screening
3
2023
1159
0.230
Why?
Hepatitis
1
2004
47
0.230
Why?
Herpes Simplex
1
2005
93
0.230
Why?
Alanine
2
2021
141
0.220
Why?
Prevalence
3
2019
2565
0.210
Why?
Interferons
2
2015
192
0.200
Why?
Young Adult
10
2019
12389
0.200
Why?
Hospitals
2
2024
632
0.200
Why?
Mutation, Missense
3
2014
318
0.200
Why?
Interferon beta-1a
1
2021
12
0.190
Why?
Hepatitis A
1
2021
25
0.180
Why?
Adenosine Monophosphate
1
2021
62
0.180
Why?
Tenofovir
2
2020
231
0.180
Why?
Hepatitis B
1
2021
61
0.180
Why?
World Health Organization
1
2020
110
0.170
Why?
Disease Progression
2
2019
2613
0.170
Why?
Data Interpretation, Statistical
2
2018
335
0.170
Why?
Polyethylene Glycols
2
2015
597
0.160
Why?
United States
10
2025
13941
0.160
Why?
Ribosomes
2
2010
164
0.150
Why?
Esters
2
2009
74
0.150
Why?
CD4 Lymphocyte Count
2
2017
267
0.150
Why?
Immunologic Factors
1
2020
229
0.150
Why?
Nucleic Acid Conformation
4
2014
706
0.140
Why?
Hospitalization
2
2024
2077
0.140
Why?
Alanine Transaminase
1
2018
150
0.140
Why?
DNA, Viral
1
2019
348
0.140
Why?
Genes, Viral
1
2016
81
0.130
Why?
DNA Mutational Analysis
1
2018
386
0.130
Why?
Mutation
2
2018
3700
0.130
Why?
Molecular Structure
2
2008
466
0.130
Why?
High-Throughput Nucleotide Sequencing
2
2016
485
0.130
Why?
Patient Compliance
1
2020
562
0.130
Why?
Survival Analysis
1
2019
1265
0.130
Why?
Adolescent
5
2022
20302
0.130
Why?
Dose-Response Relationship, Drug
2
2017
1945
0.120
Why?
Opiate Substitution Treatment
1
2016
137
0.120
Why?
Regulatory Sequences, Ribonucleic Acid
1
2014
20
0.120
Why?
AIDS-Related Opportunistic Infections
1
2015
121
0.120
Why?
Chemokines
1
2015
222
0.110
Why?
Chemokine CXCL10
1
2014
34
0.110
Why?
Drug Interactions
1
2015
360
0.110
Why?
Phenylenediamines
1
2013
9
0.110
Why?
Viral Proteins
2
2014
321
0.110
Why?
Fibrosis
1
2016
522
0.110
Why?
Prognosis
2
2019
3788
0.110
Why?
Quality of Life
1
2025
2694
0.100
Why?
Microbial Sensitivity Tests
2
2012
336
0.100
Why?
Drug Combinations
3
2019
329
0.100
Why?
Drug Discovery
1
2013
130
0.100
Why?
Administration, Oral
1
2014
759
0.100
Why?
Mental Disorders
1
2020
1010
0.090
Why?
Cohort Studies
5
2024
5407
0.090
Why?
Telemedicine
1
2020
783
0.090
Why?
Case-Control Studies
2
2017
3342
0.090
Why?
Models, Molecular
3
2012
1483
0.090
Why?
Drug-Related Side Effects and Adverse Reactions
1
2013
256
0.090
Why?
Prodrugs
1
2011
45
0.090
Why?
Nucleosides
1
2010
26
0.090
Why?
Japan
2
2021
98
0.090
Why?
Riboswitch
1
2012
68
0.090
Why?
Prospective Studies
4
2023
7079
0.080
Why?
Drug Administration Schedule
3
2017
758
0.080
Why?
Cell Line, Tumor
2
2008
3188
0.080
Why?
Risk Assessment
1
2019
3260
0.080
Why?
Drug Design
1
2010
155
0.080
Why?
Biomarkers
1
2020
3897
0.080
Why?
Cell Line
2
2012
2737
0.080
Why?
Piperidines
1
2010
190
0.080
Why?
Body Mass Index
1
2017
2266
0.080
Why?
Practice Guidelines as Topic
1
2016
1493
0.080
Why?
Phenylthiourea
1
2008
5
0.070
Why?
Immunity, Innate
1
2014
805
0.070
Why?
Plasmids
1
2009
357
0.070
Why?
Structure-Activity Relationship
1
2009
531
0.070
Why?
Inhibitory Concentration 50
1
2006
81
0.070
Why?
Luciferases
1
2006
148
0.070
Why?
Genes, Reporter
1
2006
266
0.060
Why?
Thailand
1
2025
16
0.060
Why?
Pandemics
2
2024
1492
0.060
Why?
Saquinavir
1
2004
1
0.060
Why?
Simplexvirus
1
2005
80
0.060
Why?
Indinavir
1
2004
7
0.060
Why?
Uganda
1
2025
72
0.060
Why?
Nelfinavir
1
2004
9
0.060
Why?
Drug Labeling
1
2005
40
0.060
Why?
Nevirapine
1
2004
16
0.060
Why?
Oxazines
1
2004
27
0.060
Why?
Benzoxazines
1
2004
31
0.060
Why?
Lopinavir
1
2004
30
0.060
Why?
Brazil
1
2025
154
0.060
Why?
Time Factors
1
2015
6518
0.060
Why?
Alkynes
1
2004
54
0.060
Why?
Zidovudine
1
2004
77
0.060
Why?
Liver Function Tests
1
2004
109
0.060
Why?
Pregnancy
1
2017
6375
0.060
Why?
Reverse Transcriptase Inhibitors
1
2004
81
0.060
Why?
South Africa
1
2025
192
0.060
Why?
Transfection
1
2006
896
0.060
Why?
Carcinoma, Hepatocellular
1
2006
271
0.060
Why?
Bone Marrow Transplantation
1
2005
268
0.060
Why?
Pyrimidinones
1
2004
102
0.060
Why?
Recombinant Fusion Proteins
1
2006
635
0.060
Why?
Double-Blind Method
2
2021
1865
0.050
Why?
Polyphosphates
1
2022
37
0.050
Why?
Republic of Korea
1
2021
28
0.050
Why?
Singapore
1
2021
20
0.050
Why?
Dried Blood Spot Testing
1
2022
91
0.050
Why?
Liver Neoplasms
1
2006
643
0.050
Why?
Retrospective Studies
5
2019
14571
0.050
Why?
Emergency Service, Hospital
2
2023
1973
0.050
Why?
Protein Biosynthesis
2
2014
397
0.050
Why?
Mexico
1
2021
190
0.050
Why?
Raltegravir Potassium
1
2019
17
0.040
Why?
Intensive Care Units
1
2024
719
0.040
Why?
Clinical Trials, Phase II as Topic
1
2019
71
0.040
Why?
Clinical Trials, Phase III as Topic
1
2019
90
0.040
Why?
Drug Resistance, Multiple, Viral
1
2017
11
0.030
Why?
Longitudinal Studies
1
2024
2716
0.030
Why?
Kinetics
1
2020
1617
0.030
Why?
Oxygen
1
2021
902
0.030
Why?
Medicaid
1
2020
437
0.030
Why?
Program Evaluation
1
2020
876
0.030
Why?
Incidence
2
2013
2635
0.030
Why?
RNA
1
2022
883
0.030
Why?
Cell-Free System
1
2014
47
0.030
Why?
Hepatitis C Antibodies
1
2014
9
0.030
Why?
Spain
1
2014
36
0.030
Why?
Enzyme-Linked Immunosorbent Assay
1
2016
816
0.030
Why?
Polymorphism, Genetic
1
2017
639
0.030
Why?
Patient Acceptance of Health Care
1
2020
767
0.030
Why?
Aged, 80 and over
2
2019
7066
0.030
Why?
Patient Reported Outcome Measures
1
2017
369
0.030
Why?
Risk Factors
2
2020
9769
0.030
Why?
Withholding Treatment
1
2013
70
0.030
Why?
Patient Care
1
2014
110
0.030
Why?
Early Diagnosis
1
2014
236
0.030
Why?
Plasma
1
2014
201
0.030
Why?
Fluorescence Resonance Energy Transfer
1
2012
177
0.020
Why?
Virus Internalization
1
2010
46
0.020
Why?
Ligands
1
2012
614
0.020
Why?
Recombinant Proteins
1
2013
1284
0.020
Why?
Pilot Projects
1
2015
1567
0.020
Why?
Magnesium
1
2009
151
0.020
Why?
Lamivudine
1
2009
61
0.020
Why?
Genome, Viral
1
2009
127
0.020
Why?
Referral and Consultation
1
2014
732
0.020
Why?
Logistic Models
1
2013
1979
0.020
Why?
Phenotype
1
2014
3058
0.020
Why?
Base Sequence
1
2009
2135
0.020
Why?
Severity of Illness Index
1
2013
2739
0.020
Why?
Randomized Controlled Trials as Topic
1
2011
1363
0.010
Why?
Mice, Transgenic
1
2009
2079
0.010
Why?
Animals
2
2018
34610
0.010
Why?
Substance-Related Disorders
1
2011
1013
0.010
Why?
Signal Transduction
1
2009
4838
0.010
Why?
Mice
1
2009
16652
0.010
Why?
Wyles's Networks
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