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Robert Kuchta

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/492-7027

    Collapse Research 
    Collapse research activities and funding
    R21AI092540     (KUCHTA, ROBERT D)Sep 21, 2011 - Aug 31, 2014
    NIH
    Development of Novel Nucleoside Triphosphate Prodrugs
    Role: Principal Investigator
    R01AI071338     (KUCHTA, ROBERT D)Feb 1, 2006 - Jul 31, 2008
    NIH
    A High-Throughput Assay for Influenza Replicase/RNA Polymerase Inhibitors
    Role: Principal Investigator
    R03TW007372     (KUCHTA, ROBERT D)Aug 1, 2005 - Jul 31, 2008
    NIH
    Interaction of DNA Polymerase alpha with Novel Base-Pairs
    Role: Principal Investigator
    R01AI059764     (KUCHTA, ROBERT D)Dec 1, 2004 - Jun 30, 2016
    NIH
    Mechanism of Herpes DNA Replication
    Role: Principal Investigator
    R21AI052277     (KUCHTA, ROBERT D)Sep 15, 2002 - Aug 31, 2004
    NIH
    Mechanism and Inhibition of Herpes Replication
    Role: Principal Investigator
    R01GM055709     (KUCHTA, ROBERT D)Jun 1, 1997 - May 31, 2002
    NIH
    DEVELOPMENT OF NOVEL GLYCOSYLATION INHIBITORS
    Role: Principal Investigator
    R01GM054194     (KUCHTA, ROBERT D)May 1, 1996 - Nov 30, 2010
    NIH
    Mechanism of DNA Polymerase Alpha-Primase
    Role: Principal Investigator
    F32GM011309     (KUCHTA, ROBERT D)Dec 10, 1987
    NIH
    MECHANISM OF TYROSINE HYDROXULASE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kuchta R, Heim C, Herrmann A, Maiwald S, Ng YLD, Sosic I, Keuler T, Kr?nke J, G?tschow M, Hartmann MD, Steinebach C. Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC Chem Biol. 2023 Mar 08; 4(3):229-234. PMID: 36908700.
      View in: PubMed
    2. Bricelj A, Dora Ng YL, Ferber D, Kuchta R, M?ller S, Monschke M, Wagner KG, Kr?nke J, Sosic I, G?tschow M, Steinebach C. Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands. ACS Med Chem Lett. 2021 Nov 11; 12(11):1733-1738. PMID: 34795861.
      View in: PubMed
    3. Bricelj A, Steinebach C, Kuchta R, G?tschow M, Sosic I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points. Front Chem. 2021; 9:707317. PMID: 34291038.
      View in: PubMed
    4. Romaszko J, Cymes I, Draganska E, Kuchta R, Glinska-Lewczuk K. Mortality among the homeless: Causes and meteorological relationships. PLoS One. 2017; 12(12):e0189938. PMID: 29267330.
      View in: PubMed
    5. Dickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. 2017 05 30; 56(21):2651-2662. PMID: 28505413.
      View in: PubMed
    6. Okochi KD, Monfregola L, Dickerson SM, McCaffrey R, Domaille DW, Yu C, Hafenstine GR, Jin Y, Cha JN, Kuchta RD, Caruthers M, Zhang W. Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach. J Org Chem. 2017 10 20; 82(20):10803-10811. PMID: 28282138.
      View in: PubMed
    7. Romaszko J, Kuchta R, Opalach C, Bertrand-Bucinska A, Romaszko AM, Giergielewicz-Januszko B, Bucinski A. Socioeconomic Characteristics, Health Risk Factors and Alcohol Consumption among the Homeless in North-Eastern Part of Poland. Cent Eur J Public Health. 2017 Mar; 25(1):29-34. PMID: 28399352.
      View in: PubMed
    8. Opalach C, Romaszko J, Jaracz M, Kuchta R, Borkowska A, Bucinski A. Coping Styles and Alcohol Dependence among Homeless People. PLoS One. 2016; 11(9):e0162381. PMID: 27598582.
      View in: PubMed
    9. Vashishtha AK, Kuchta RD. Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA. Biochemistry. 2016 Feb 23; 55(7):1168-77. PMID: 26836009.
      View in: PubMed
    10. Vashishtha AK, Kuchta RD. Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. Biochemistry. 2015 Jan 20; 54(2):240-9. PMID: 25517265.
      View in: PubMed
    11. Rodgers BJ, Elsharif NA, Vashisht N, Mingus MM, Mulvahill MA, Stengel G, Kuchta RD, Purse BW. Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities. Chemistry. 2014 Feb 10; 20(7):2010-5. PMID: 24311229.
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    12. Weller SK, Kuchta RD. The DNA helicase-primase complex as a target for herpes viral infection. Expert Opin Ther Targets. 2013 Oct; 17(10):1119-32. PMID: 23930666.
      View in: PubMed
    13. Olson AC, Patro JN, Urban M, Kuchta RD. The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication. J Am Chem Soc. 2013 Jan 30; 135(4):1205-8. PMID: 23316816.
      View in: PubMed
    14. Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen. 2012 Apr; 17(4):421-34. PMID: 22274912.
      View in: PubMed
    15. Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS One. 2012; 7(1):e29208. PMID: 22279528.
      View in: PubMed
    16. Lund TJ, Cavanaugh NA, Joubert N, Urban M, Patro JN, Hocek M, Kuchta RD. B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry. 2011 Aug 23; 50(33):7243-50. PMID: 21761848.
      View in: PubMed
    17. Stengel G, Purse BW, Kuchta RD. Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs. Anal Biochem. 2011 Sep 01; 416(1):53-60. PMID: 21600183.
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    18. Houck JA, Hojgaard A, Piesman J, Kuchta RD. Low-density microarrays for the detection of Borrelia burgdorferi s.s. (the Lyme disease spirochete) in nymphal Ixodes scapularis. Ticks Tick Borne Dis. 2011 Mar; 2(1):27-36. PMID: 21771534.
      View in: PubMed
    19. Chen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SK. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. J Virol. 2011 Jan; 85(2):968-78. PMID: 21068246.
      View in: PubMed
    20. Stengel G, Kuchta RD. Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates. J Virol. 2011 Jan; 85(2):957-67. PMID: 21068232.
      View in: PubMed
    21. Olson AC, Rosenblum E, Kuchta RD. Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase. Biochemistry. 2010 Nov 30; 49(47):10208-15. PMID: 21033726.
      View in: PubMed
    22. Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X. Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem. 2010 Dec 03; 285(49):38730-9. PMID: 20884615.
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    23. Johnson LM, Hansen RR, Urban M, Kuchta RD, Bowman CN. Photoinitiator nucleotide for quantifying nucleic Acid hybridization. Biomacromolecules. 2010 Apr 12; 11(4):1133-8. PMID: 20337438.
      View in: PubMed
    24. Urban M, Joubert N, Purse BW, Hocek M, Kuchta RD. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry. 2010 Feb 02; 49(4):727-35. PMID: 20030400.
      View in: PubMed
    25. Stengel G, Urban M, Purse BW, Kuchta RD. Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase. Anal Chem. 2010 Feb 01; 82(3):1082-9. PMID: 20067253.
      View in: PubMed
    26. Kuchta RD. Nucleotide Analogues as Probes for DNA and RNA Polymerases. Curr Protoc Chem Biol. 2010; 2(2):111-124. PMID: 21822500.
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    27. Urban M, Joubert N, Hocek M, Alexander RE, Kuchta RD. Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry. 2009 Nov 24; 48(46):10866-81. PMID: 19835416.
      View in: PubMed
    28. Cavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RD. Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Biochemistry. 2009 Nov 03; 48(43):10199-207. PMID: 19788334.
      View in: PubMed
    29. Stengel G, Urban M, Purse BW, Kuchta RD. High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo. Anal Chem. 2009 Nov 01; 81(21):9079-85. PMID: 19810708.
      View in: PubMed
    30. Patro JN, Urban M, Kuchta RD. Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. Biochemistry. 2009 Sep 01; 48(34):8271-8. PMID: 19642651.
      View in: PubMed
    31. Stengel G, Purse BW, Wilhelmsson LM, Urban M, Kuchta RD. Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. Biochemistry. 2009 Aug 11; 48(31):7547-55. PMID: 19580325.
      View in: PubMed
    32. Shewach DS, Kuchta RD. Introduction to cancer chemotherapeutics. Chem Rev. 2009 Jul; 109(7):2859-61. PMID: 19583428.
      View in: PubMed
    33. Kuchta RD, Stengel G. Mechanism and evolution of DNA primases. Biochim Biophys Acta. 2010 May; 1804(5):1180-9. PMID: 19540940.
      View in: PubMed
    34. Trostler M, Delier A, Beckman J, Urban M, Patro JN, Spratt TE, Beese LS, Kuchta RD. Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Biochemistry. 2009 Jun 02; 48(21):4633-41. PMID: 19348507.
      View in: PubMed
    35. Cavanaugh NA, Urban M, Beckman J, Spratt TE, Kuchta RD. Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Biochemistry. 2009 Apr 21; 48(15):3554-64. PMID: 19166354.
      View in: PubMed
    36. Patro JN, Urban M, Kuchta RD. Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha. Biochemistry. 2009 Jan 13; 48(1):180-9. PMID: 19072331.
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    37. Cavanaugh NA, Kuchta RD. Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. J Biol Chem. 2009 Jan 16; 284(3):1523-32. PMID: 19028696.
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    38. Keller KE, Cavanaugh N, Kuchta RD. Interaction of herpes primase with the sugar of a NTP. Biochemistry. 2008 Aug 26; 47(34):8977-84. PMID: 18672908.
      View in: PubMed
    39. Townsend MB, Smagala JA, Dawson ED, Deyde V, Gubareva L, Klimov AI, Kuchta RD, Rowlen KL. Detection of adamantane-resistant influenza on a microarray. J Clin Virol. 2008 Jun; 42(2):117-23. PMID: 18299250.
      View in: PubMed
    40. Moore CL, Smagala JA, Smith CB, Dawson ED, Cox NJ, Kuchta RD, Rowlen KL. Evaluation of MChip with historic subtype H1N1 influenza A viruses, including the 1918 "Spanish Flu" strain. J Clin Microbiol. 2007 Nov; 45(11):3807-10. PMID: 17855577.
      View in: PubMed
    41. Dankbar DM, Dawson ED, Mehlmann M, Moore CL, Smagala JA, Shaw MW, Cox NJ, Kuchta RD, Rowlen KL. Diagnostic microarray for influenza B viruses. Anal Chem. 2007 Mar 01; 79(5):2084-90. PMID: 17326602.
      View in: PubMed
    42. Mehlmann M, Bonner AB, Williams JV, Dankbar DM, Moore CL, Kuchta RD, Podsiad AB, Tamerius JD, Dawson ED, Rowlen KL. Comparison of the MChip to viral culture, reverse transcription-PCR, and the QuickVue influenza A+B test for rapid diagnosis of influenza. J Clin Microbiol. 2007 Apr; 45(4):1234-7. PMID: 17301287.
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    43. Beckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RD. Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry. 2007 Jan 16; 46(2):448-60. PMID: 17209555.
      View in: PubMed
    44. Dawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Anal Chem. 2007 Jan 01; 79(1):378-84. PMID: 17194164.
      View in: PubMed
    45. Blair RH, Rosenblum ES, Dawson ED, Kuchta RD, Kuck LR, Rowlen KL. Real-time quantification of RNA polymerase activity using a "broken beacon". Anal Biochem. 2007 Mar 15; 362(2):213-20. PMID: 17222795.
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    46. Dawson ED, Moore CL, Smagala JA, Dankbar DM, Mehlmann M, Townsend MB, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. MChip: a tool for influenza surveillance. Anal Chem. 2006 Nov 15; 78(22):7610-5. PMID: 17105150.
      View in: PubMed
    47. Kincaid K, Kuchta RD. A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues. Nucleic Acids Res. 2006; 34(16):e109. PMID: 16945949.
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    48. Richards OC, Spagnolo JF, Lyle JM, Vleck SE, Kuchta RD, Kirkegaard K. Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase. J Virol. 2006 Aug; 80(15):7405-15. PMID: 16840321.
      View in: PubMed
    49. Mehlmann M, Dawson ED, Townsend MB, Smagala JA, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Robust sequence selection method used to develop the FluChip diagnostic microarray for influenza virus. J Clin Microbiol. 2006 Aug; 44(8):2857-62. PMID: 16891503.
      View in: PubMed
    50. Townsend MB, Dawson ED, Mehlmann M, Smagala JA, Dankbar DM, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance. J Clin Microbiol. 2006 Aug; 44(8):2863-71. PMID: 16891504.
      View in: PubMed
    51. Ramirez-Aguilar KA, Moore CL, Kuchta RD. Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates. Biochemistry. 2005 Nov 29; 44(47):15585-93. PMID: 16300408.
      View in: PubMed
    52. Smagala JA, Dawson ED, Mehlmann M, Townsend MB, Kuchta RD, Rowlen KL. ConFind: a robust tool for conserved sequence identification. Bioinformatics. 2005 Dec 15; 21(24):4420-2. PMID: 16239306.
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    53. Mehlmann M, Townsend MB, Stears RL, Kuchta RD, Rowlen KL. Optimization of fragmentation conditions for microarray analysis of viral RNA. Anal Biochem. 2005 Dec 15; 347(2):316-23. PMID: 16266686.
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    54. Kincaid K, Beckman J, Zivkovic A, Halcomb RL, Engels JW, Kuchta RD. Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. Nucleic Acids Res. 2005; 33(8):2620-8. PMID: 15879351.
      View in: PubMed
    55. Richardson KA, Vega TP, Richardson FC, Moore CL, Rohloff JC, Tomkinson B, Bendele RA, Kuchta RD. Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase. Biochem Pharmacol. 2004 Dec 15; 68(12):2337-46. PMID: 15548380.
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    56. Moore CL, Zivkovic A, Engels JW, Kuchta RD. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004 Sep 28; 43(38):12367-74. PMID: 15379576.
      View in: PubMed
    57. Ramirez-Aguilar KA, Kuchta RD. Herpes simplex virus-1 primase: a polymerase with extraordinarily low fidelity. Biochemistry. 2004 Jul 20; 43(28):9084-91. PMID: 15248765.
      View in: PubMed
    58. Ramirez-Aguilar KA, Kuchta RD. Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase. Biochemistry. 2004 Feb 17; 43(6):1754-62. PMID: 14769053.
      View in: PubMed
    59. Chiaramonte M, Moore CL, Kincaid K, Kuchta RD. Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Biochemistry. 2003 Sep 09; 42(35):10472-81. PMID: 12950174.
      View in: PubMed
    60. Zerbe LK, Kuchta RD. The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting. Biochemistry. 2002 Apr 16; 41(15):4891-900. PMID: 11939784.
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    61. Chiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melan?on P, Kuchta RD. Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates. Biochemistry. 2001 Nov 27; 40(47):14260-7. PMID: 11714280.
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    62. Arezi B, Kuchta RD. Eukaryotic DNA primase. Trends Biochem Sci. 2000 Nov; 25(11):572-6. PMID: 11084371.
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    63. Steet RA, Melancon P, Kuchta RD. 3'-Azidothymidine potently inhibits the biosynthesis of highly branched N-linked oligosaccharides and poly-N-acetyllactosamine chains in cells. J Biol Chem. 2000 Sep 01; 275(35):26812-20. PMID: 10842182.
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    64. Richardson FC, Kuchta RD, Mazurkiewicz A, Richardson KA. Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase. Biochem Pharmacol. 2000 May 01; 59(9):1045-52. PMID: 10704933.
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    65. Michl J, Gladysz JA, Kuchta RD. Over four hundred million characters served: 99 volumes, 2567 articles, 85623 pages, and more than 85 million words. Chem Rev. 2000 Jan 12; 100(1):1-6. PMID: 11749228.
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    66. Arezi B, Kirk BW, Copeland WC, Kuchta RD. Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit. Biochemistry. 1999 Sep 28; 38(39):12899-907. PMID: 10504261.
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    67. Zerbe LK, Goodman MF, Efrati E, Kuchta RD. Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase alpha during the synthesis of new DNA strands. Biochemistry. 1999 Sep 28; 38(39):12908-14. PMID: 10504262.
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    68. Kirk BW, Kuchta RD. Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection. Biochemistry. 1999 Aug 03; 38(31):10126-34. PMID: 10433721.
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    69. Kirk BW, Kuchta RD. Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology. Biochemistry. 1999 Jun 15; 38(24):7727-36. PMID: 10387012.
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    70. Steet R, Alizadeh M, Melan?on P, Kuchta RD. 3'-Azidothymidine significantly alters glycosphingolipid synthesis in melanoma cells and decreases the shedding of gangliosides. Glycoconj J. 1999 Mar; 16(3):237-45. PMID: 10596899.
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    71. Kirk BW, Harrington C, Perrino FW, Kuchta RD. Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells. Biochemistry. 1997 Jun 03; 36(22):6725-31. PMID: 9184153.
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    72. Traynor AJ, Hall ET, Walker G, Miller WH, Melan?on P, Kuchta RD. Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates. J Med Chem. 1996 Jul 19; 39(15):2894-9. PMID: 8709123.
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    73. Kuchta RD. Isotopic assays of viral polymerases and related proteins. Methods Enzymol. 1996; 275:241-57. PMID: 9026642.
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    74. Thompson HC, Sheaff RJ, Kuchta RD. Interactions of calf thymus DNA polymerase alpha with primer/templates. Nucleic Acids Res. 1995 Oct 25; 23(20):4109-15. PMID: 7479073.
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    75. Yan JP, Ilsley DD, Frohlick C, Steet R, Hall ET, Kuchta RD, Melan?on P. 3'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations. J Biol Chem. 1995 Sep 29; 270(39):22836-41. PMID: 7559416.
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    76. Catalano CE, Kuchta RD. Inactivation of DNA polymerase alpha-primase by acrolein: loss of activity depends on the DNA substrate. Biochem Biophys Res Commun. 1995 Sep 25; 214(3):971-7. PMID: 7575571.
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    77. Thompson HC, Kuchta RD. Arabinofuranosyl nucleotides are not chain-terminators during initiation of new strands of DNA by DNA polymerase alpha-primase. Biochemistry. 1995 Sep 05; 34(35):11198-203. PMID: 7545435.
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    78. Ilsley DD, Lee SH, Miller WH, Kuchta RD. Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action. Biochemistry. 1995 Feb 28; 34(8):2504-10. PMID: 7873530.
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    79. Sheaff RJ, Kuchta RD. Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase alpha. J Biol Chem. 1994 Jul 29; 269(30):19225-31. PMID: 8034683.
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    80. Hall ET, Yan JP, Melan?on P, Kuchta RD. 3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity. J Biol Chem. 1994 May 20; 269(20):14355-8. PMID: 8182037.
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    81. Sheaff RJ, Kuchta RD, Ilsley D. Calf thymus DNA polymerase alpha-primase: "communication" and primer-template movement between the two active sites. Biochemistry. 1994 Mar 01; 33(8):2247-54. PMID: 8117681.
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    82. Cheng CH, Kuchta RD. DNA polymerase epsilon: aphidicolin inhibition and the relationship between polymerase and exonuclease activity. Biochemistry. 1993 Aug 24; 32(33):8568-74. PMID: 8395209.
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    83. Sheaff RJ, Kuchta RD. Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination. Biochemistry. 1993 Mar 30; 32(12):3027-37. PMID: 7681326.
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    84. Kuchta RD, Ilsley D, Kravig KD, Schubert S, Harris B. Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds. Biochemistry. 1992 May 19; 31(19):4720-8. PMID: 1581321.
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    85. Sheaff R, Ilsley D, Kuchta R. Mechanism of DNA polymerase alpha inhibition by aphidicolin. Biochemistry. 1991 Sep 03; 30(35):8590-7. PMID: 1909569.
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    86. Eger BT, Kuchta RD, Carroll SS, Benkovic PA, Dahlberg ME, Joyce CM, Benkovic SJ. Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). Biochemistry. 1991 Feb 05; 30(5):1441-8. PMID: 1991125.
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    87. Kuchta RD, Willhelm L. Inhibition of DNA primase by 9-beta-D-arabinofuranosyladenosine triphosphate. Biochemistry. 1991 Jan 22; 30(3):797-803. PMID: 1703021.
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    88. Kuchta RD, Reid B, Chang LM. DNA primase. Processivity and the primase to polymerase alpha activity switch. J Biol Chem. 1990 Sep 25; 265(27):16158-65. PMID: 2398049.
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    89. Kuchta RD, Cowart M, Allen D, Benkovic SJ. Kinetic and structural investigations of the replicative fidelity of the Klenow fragment. Biochem Soc Trans. 1988 Dec; 16(6):947-9. PMID: 3224760.
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    90. Kuchta RD, Benkovic P, Benkovic SJ. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. Biochemistry. 1988 Sep 06; 27(18):6716-25. PMID: 3058205.
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    91. Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow). Biochemistry. 1987 Dec 15; 26(25):8410-7. PMID: 3327522.
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    92. Kuchta RD, Hanson GR, Holmquist B, Abeles RH. Fe-S centers in lactyl-CoA dehydratase. Biochemistry. 1986 Nov 18; 25(23):7301-7. PMID: 3026450.
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