 Polycomb Repressive Complex 2
"Polycomb Repressive Complex 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE COMPLEX 1 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063151
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| MeSH Number(s) |
D05.500.781.750 D08.811.913.555.500.800.400.500 D12.776.660.235.600.200 D12.776.664.235.800.200 D12.776.930.780.890.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 2".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 2".
This graph shows the total number of publications written about "Polycomb Repressive Complex 2" by people in this website by year, and whether "Polycomb Repressive Complex 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2013 | 6 | 0 | 6 | | 2014 | 4 | 0 | 4 | | 2015 | 5 | 2 | 7 | | 2016 | 1 | 2 | 3 | | 2017 | 2 | 1 | 3 | | 2018 | 5 | 2 | 7 | | 2019 | 3 | 0 | 3 | | 2020 | 3 | 1 | 4 | | 2021 | 3 | 0 | 3 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 1 | 3 | | 2024 | 2 | 0 | 2 | | 2025 | 2 | 0 | 2 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Polycomb Repressive Complex 2" by people in Profiles.
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Ingersoll S, Trouth A, Angel JC, Luo X, Espinoza A, Wen J, Zhu C, Tucker J, Astatike K, Phiel CJ, Sabaawy H, Kutateladze TG, Wu TP, Yao T, Lu C, Ramachandran S, Ren X. Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes. Mol Cell. 2026 Mar 19; 86(6):1015-1031.e16.
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Rosas R, Baracaldo-Lancheros LF, Dykhuizen EC, Musselman CA. Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition. J Biol Chem. 2026 Apr; 302(4):111344.
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Porazzi P, Nason S, Yang Z, Carturan A, Ghilardi G, Guruprasad P, Patel RP, Tan M, Padmanabhan AA, Lemoine J, Fardella E, Zhang Y, Pajarillo R, Chen L, Ugwuanyi O, Markowitz K, Delman D, Angelos MG, Shestova O, Isshiki Y, Blanchard T, Béguelin W, Melnick AM, Linette GP, Beatty GL, Carreno BM, Cohen IJ, Paruzzo L, Schuster SJ, Ruella M. EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models. Cancer Cell. 2025 Mar 10; 43(3):537-551.e7.
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Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E. Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat Struct Mol Biol. 2025 Feb; 32(2):393-404.
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Cech TR, Davidovich C, Jenner RG. PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner. Mol Cell. 2024 Oct 03; 84(19):3593-3595.
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Veronezi GMB, Ramachandran S. Nucleation and spreading maintain Polycomb domains every cell cycle. Cell Rep. 2024 04 23; 43(4):114090.
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Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337.
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Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220528120.
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Kwok HS, Freedy AM, Siegenfeld AP, Morriss JW, Waterbury AL, Kissler SM, Liau BB. Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma. Nat Chem Biol. 2023 09; 19(9):1105-1115.
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Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119.
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