 Ligases
"Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
| Descriptor ID |
D008025
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| MeSH Number(s) |
D08.811.464
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| Concept/Terms |
Ligases- Ligases
- Synthetases
- Synthetase
|
Below are MeSH descriptors whose meaning is more general than "Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ligases".
This graph shows the total number of publications written about "Ligases" by people in this website by year, and whether "Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 2 | 0 | 2 | | 2004 | 3 | 0 | 3 | | 2006 | 2 | 1 | 3 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligases" by people in Profiles.
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Brown K, Chew PY, Ingersoll S, Espinosa JR, Aguirre A, Espinoza A, Wen J, Astatike K, Kutateladze TG, Collepardo-Guevara R, Ren X. Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation. Cell Rep. 2023 10 31; 42(10):113136.
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Fitzsimmons LF, Liu L, Kant S, Kim JS, Till JK, Jones-Carson J, Porwollik S, McClelland M, Vazquez-Torres A. SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. mBio. 2020 02 25; 11(1).
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Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 01 17; 15(1):112-131.
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Plaks JG, Kaar JL. Lipoic Acid Ligase-Promoted Bioorthogonal Protein Modification and Immobilization. Methods Mol Biol. 2019; 2012:279-297.
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Herrera A, Vu BG, Stach CS, Merriman JA, Horswill AR, Salgado-Pab?n W, Schlievert PM. Staphylococcus aureus ?-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis. Biochemistry. 2016 05 03; 55(17):2510-7.
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Plaks JG, Falatach R, Kastantin M, Berberich JA, Kaar JL. Multisite clickable modification of proteins using lipoic acid ligase. Bioconjug Chem. 2015 Jun 17; 26(6):1104-12.
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Polley SR, Kuzmanov A, Kuang J, Karpel J, La?etic V, Karina EI, Veo BL, Fay DS. Implicating SCF complexes in organogenesis in Caenorhabditis elegans. Genetics. 2014 Jan; 196(1):211-23.
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Churchill ME, Sibhatu HM, Uhlson CL. Defining the structure and function of acyl-homoserine lactone autoinducers. Methods Mol Biol. 2011; 692:159-71.
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Churchill ME, Chen L. Structural basis of acyl-homoserine lactone-dependent signaling. Chem Rev. 2011 Jan 12; 111(1):68-85.
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Singh A, Karimpour-Fard A, Gill RT. Increased mutation frequency in redox-impaired Escherichia coli due to RelA- and RpoS-mediated repression of DNA repair. Appl Environ Microbiol. 2010 Aug; 76(16):5463-70.
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