 Inhibitor of Apoptosis Proteins
"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
| Descriptor ID |
D051034
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| MeSH Number(s) |
D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
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| Concept/Terms |
Inhibitor of Apoptosis Proteins- Inhibitor of Apoptosis Proteins
- Apoptosis Proteins Inhibitor
- Inhibitor-Of-Apoptosis Protein
- Inhibitor Of Apoptosis Protein
- Baculoviral Inhibitor Of Apoptosis Repeat Proteins
- IAP Repeat Containing Proteins
- IAP Protein (Apoptosis)
Baculoviral IAP Repeat-Containing 2 Protein- Baculoviral IAP Repeat-Containing 2 Protein
- Baculoviral IAP Repeat Containing 2 Protein
- Cellular Inhibitor of Apoptosis 1 Protein
- IAP2 Protein
- c-IAP1 Protein
- cIAP1 Protein
- Inhibitor of Apoptosis 2 Protein
- BIRC2 Protein
- Baculoviral IAP Repeat Containing Protein 2
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Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".
Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".
This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1997 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 5 | 5 | | 2003 | 0 | 3 | 3 | | 2005 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2011 | 1 | 1 | 2 | | 2013 | 1 | 3 | 4 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2021 | 1 | 0 | 1 | | 2023 | 1 | 1 | 2 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.
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Thorne AJ, Gao A, Necker-Brown A, Bansal A, Kalyanaraman K, Chandramohan P, Sasse SK, Gerber AN, Mostafa MM, Newton R. Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid. Mol Pharmacol. 2025 Oct; 107(10):100073.
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Tencer AH, Yu Y, Causse SZ, Campbell GR, Klein BJ, Xuan H, Cartier J, Miles MA, Gaurav N, Zadoroznyj A, Holt TA, Wen H, Hawkins CJ, Spector SA, Dubrez L, Shi X, Kutateladze TG. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat Struct Mol Biol. 2023 09; 30(9):1265-1274.
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Ventre KS, Roehle K, Bello E, Bhuiyan AM, Biary T, Crowley SJ, Bruck PT, Heckler M, Lenehan PJ, Ali LR, Stump CT, Lippert V, Clancy-Thompson E, Conce Alberto WD, Hoffman MT, Qiang L, Pelletier M, Akin JJ, Dougan M, Dougan SK. cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity. J Immunol. 2023 04 01; 210(7):991-1003.
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Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 05 19; 13(594).
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Al-Amin M, Min H, Shim YH, Kawasaki I. Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans. Sci Rep. 2016 09 21; 6:33884.
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Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol. 2016 07; 14(7):e1002507.
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Jain S, Keys D, Martin S, Edelstein CL, Jani A. Protection From Apoptotic Cell Death During Cold Storage Followed by Rewarming in 13-Lined Ground Squirrel Tubular Cells: The Role of Prosurvival Factors X-Linked Inhibitor of Apoptosis and PhosphoAkt. Transplantation. 2016 Mar; 100(3):538-45.
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Jain S, Keys D, Ljubanovic D, Edelstein CL, Jani A. Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. Transplantation. 2015 Nov; 99(11):2311-6.
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Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA. A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. Mol Cancer Ther. 2015 Nov; 14(11):2569-75.
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Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal. 2015 Aug 11; 8(389):ra80.
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