 Proteolysis
"Proteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational.
| Descriptor ID |
D059748
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| MeSH Number(s) |
G02.111.720 G03.812
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| Concept/Terms |
Proteolysis- Proteolysis
- Proteolyses
- Protein Degradation
- Degradation, Protein
- Degradations, Protein
- Protein Degradations
Protein Digestion- Protein Digestion
- Digestion, Protein
- Digestions, Protein
- Protein Digestions
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Below are MeSH descriptors whose meaning is more general than "Proteolysis".
Below are MeSH descriptors whose meaning is more specific than "Proteolysis".
This graph shows the total number of publications written about "Proteolysis" by people in this website by year, and whether "Proteolysis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 2 | 3 | | 2012 | 4 | 14 | 18 | | 2013 | 2 | 11 | 13 | | 2014 | 1 | 7 | 8 | | 2015 | 1 | 10 | 11 | | 2016 | 1 | 8 | 9 | | 2017 | 2 | 12 | 14 | | 2018 | 2 | 8 | 10 | | 2019 | 2 | 8 | 10 | | 2020 | 2 | 5 | 7 | | 2021 | 0 | 4 | 4 | | 2022 | 0 | 4 | 4 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 4 | 5 |
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Below are the most recent publications written about "Proteolysis" by people in Profiles.
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Das E, Le L, Sokolova V, Orth JD, Park S. Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome. Nat Commun. 2025 Apr 09; 16(1):3358.
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Currie J, Ng DCM, Pandi B, Black A, Manda V, Durham C, Pavelka J, Lam MPY, Lau E. Improved Method to Determine Protein Turnover Rates with Heavy Water Labeling by Mass Isotopomer Ratio Selection. J Proteome Res. 2025 Apr 04; 24(4):1992-2005.
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Schaunaman N, Cervantes D, Ferrington DA, Chu HW. Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness. Front Immunol. 2025; 16:1501898.
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Haddad G, Blaine J. miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum. Cells. 2025 03 01; 14(5).
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Sladky VC, Strong MA, Tapias-Gomez D, Jewett CE, Drown CG, Scott PM, Holland AJ. Rapid and sustained degradation of the essential centrosome protein CEP192 in live mice using the AID2 system. Sci Adv. 2025 Feb 28; 11(9):eadq2339.
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Bricelj A, Dora Ng YL, Gobec M, Kuchta R, Hu W, Javornik ?, Ro?ic M, G?tschow M, Zheng G, Kr?nke J, Steinebach C, Sosic I. Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry. 2024 Aug 12; 30(45):e202400430.
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Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 10 21; 11(10):3318-3329.
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Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, S?dhof TC, Malenka R, Wernig M, ?zkan E, Perrais D, Shen K. Endocytosis in the axon initial segment maintains neuronal polarity. Nature. 2022 09; 609(7925):128-135.
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Hammond DE, Simpson DM, Franco C, Wright Muelas M, Waters J, Ludwig RW, Prescott MC, Hurst JL, Beynon RJ, Lau E. Harmonizing Labeling and Analytical Strategies to Obtain Protein Turnover Rates in Intact Adult Animals. Mol Cell Proteomics. 2022 07; 21(7):100252.
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Shepard JD, Freitas BT, Rodriguez SE, Scholte FEM, Baker K, Hutchison MR, Longo JE, Miller HC, O'Boyle BM, Tandon A, Zhao P, Grimsey NJ, Wells L, Bergeron ?, Pegan SD. The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein. Front Immunol. 2021; 12:794664.
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