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Sharon Pine

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01CA239093     (PINE, SHARON R.)May 15, 2020 - Jan 31, 2026
    NIH
    Discovery and therapeutic targeting of biological determinants of lung cancer health disparities
    Role: Principal Investigator
    R01CA190578     (PINE, SHARON R.)Sep 19, 2014 - Aug 31, 2021
    NIH
    Sox9 signaling in lung adenocarcinoma
    Role: Principal Investigator
    K22CA140719     (PINE, SHARON R.)May 1, 2011 - Apr 30, 2015
    NIH
    Asymmetric Cell Division and Notch Signaling in Lung Cancer Stem Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pine SR. Editorial. Carcinogenesis. 2023 Dec 15; 44(10-11):717. PMID: 38190626.
      View in: PubMed
    2. Hoang DT, Dinstag G, Hermida LC, Ben-Zvi DS, Elis E, Caley K, Sammut SJ, Sinha S, Sinha N, Dampier CH, Stossel C, Patil T, Rajan A, Lassoued W, Strauss J, Bailey S, Allen C, Redman J, Beker T, Jiang P, Golan T, Wilkinson S, Sowalsky AG, Pine SR, Caldas C, Gulley JL, Aldape K, Aharonov R, Stone EA, Ruppin E. Prediction of cancer treatment response from histopathology images through imputed transcriptomics. Res Sq. 2023 Sep 15. PMID: 37790315.
      View in: PubMed
    3. Zhong H, Lu W, Tang Y, Wiel C, Wei Y, Cao J, Riedlinger G, Papagiannakopoulos T, Guo JY, Bergo MO, Kang Y, Ganesan S, Sabaawy HE, Pine SR. SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity. Oncogene. 2023 Jun; 42(27):2183-2194. PMID: 37258742.
      View in: PubMed
    4. Bhatt V, Lan T, Wang W, Kong J, Lopes EC, Wang J, Khayati K, Raju A, Rangel M, Lopez E, Hu ZS, Luo X, Su X, Malhotra J, Hu W, Pine SR, White E, Guo JY. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. Cell Death Dis. 2023 01 26; 14(1):61. PMID: 36702816.
      View in: PubMed
    5. Kwon M, Rubio G, Wang H, Riedlinger G, Adem A, Zhong H, Slegowski D, Post-Zwicker L, Chidananda A, Schrump DS, Pine SR, Libutti SK. Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis. Cancer Res Commun. 2022 10; 2(10):1197-1213. PMID: 36860703.
      View in: PubMed
    6. Castellano GM, Zeeshan S, Garbuzenko OB, Sabaawy HE, Malhotra J, Minko T, Pine SR. Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma. Mol Cancer Ther. 2022 09 06; 21(9):1381-1392. PMID: 35732569.
      View in: PubMed
    7. Chambers AM, Lupo KB, Wang J, Cao J, Utturkar S, Lanman N, Bernal-Crespo V, Jalal S, Pine SR, Torregrosa-Allen S, Elzey BD, Matosevic S. Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors. Elife. 2022 07 11; 11. PMID: 35815945.
      View in: PubMed
    8. Malhotra J, Ryan B, Patel M, Chan N, Guo Y, Aisner J, Jabbour SK, Pine S. Clinical outcomes and immune phenotypes associated with STK11 co-occurring mutations in non-small cell lung cancer. J Thorac Dis. 2022 Jun; 14(6):1772-1783. PMID: 35813711.
      View in: PubMed
    9. Malhotra J, Paddock LE, Lin Y, Pine SR, Habib MH, Stroup A, Manne S. Racial disparities in follow-up care of early-stage lung cancer survivors. J Cancer Surviv. 2023 10; 17(5):1259-1265. PMID: 35318568.
      View in: PubMed
    10. Sabaawy HE, Ryan BM, Khiabanian H, Pine SR. JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance. Carcinogenesis. 2021 12 31; 42(12):1411-1419. PMID: 34415330.
      View in: PubMed
    11. Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res. 2021 11 01; 81(21):5523-5539. PMID: 34417201.
      View in: PubMed
    12. Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021 04 15; 12(1):2259. PMID: 33859191.
      View in: PubMed
    13. Arauz RF, Byun JS, Tandon M, Sinha S, Kuhn S, Taylor S, Zingone A, Mitchell KA, Pine SR, Gardner K, Perez-Stable EJ, Napoles AM, Ryan BM. Whole-Exome Profiling of NSCLC Among African Americans. J Thorac Oncol. 2020 12; 15(12):1880-1892. PMID: 32931935.
      View in: PubMed
    14. Castellano GM, Pine SR. Liquid biopsies in non-small cell lung cancer management: what can we learn from methylation status and mutant allele frequencies? Transl Lung Cancer Res. 2020 Aug; 9(4):951-955. PMID: 32953473.
      View in: PubMed
    15. Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo WS, Bech PR, Clarke S, Abbara A, Tuck AB, Hess DA, Pine SR, Zong WX, Wondisford FE, Su X, Babwah AV, Bhattacharya M. G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer. Cell Death Dis. 2020 02 07; 11(2):106. PMID: 32034133.
      View in: PubMed
    16. Mitchell KA, Nichols N, Tang W, Walling J, Stevenson H, Pineda M, Stefanescu R, Edelman DC, Girvin AT, Zingone A, Sinha S, Bowman E, Rossi EL, Arauz RF, Zhu YJ, Lack J, Weingartner E, Waterfall JJ, Pine SR, Simmons J, Meltzer P, Ryan BM. Author Correction: Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans. Nat Commun. 2020 Jan 30; 11(1):700. PMID: 32001692.
      View in: PubMed
    17. Mitchell KA, Nichols N, Tang W, Walling J, Stevenson H, Pineda M, Stefanescu R, Edelman DC, Girvin AT, Zingone A, Sinha S, Bowman E, Rossi EL, Arauz RF, Jack Zhu Y, Lack J, Weingartner E, Waterfall JJ, Pine SR, Simmons J, Meltzer P, Ryan BM. Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans. Nat Commun. 2019 12 16; 10(1):5735. PMID: 31844068.
      View in: PubMed
    18. Malhotra J, Jabbour SK, Pine S. Impact of surveillance frequency on survival in non-small cell lung cancer (NSCLC) survivors. Transl Lung Cancer Res. 2019 Dec; 8(Suppl 4):S347-S350. PMID: 32038912.
      View in: PubMed
    19. Garbuzenko OB, Kuzmov A, Taratula O, Pine SR, Minko T. Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy. Theranostics. 2019; 9(26):8362-8376. PMID: 31754402.
      View in: PubMed
    20. Epsi NJ, Panja S, Pine SR, Mitrofanova A. pathCHEMO, a generalizable computational framework uncovers molecular pathways of chemoresistance in lung adenocarcinoma. Commun Biol. 2019; 2:334. PMID: 31508508.
      View in: PubMed
    21. Mitchell KA, Shah E, Bowman ED, Zingone A, Nichols N, Pine SR, Kittles RA, Ryan BM. Relationship between West African ancestry with lung cancer risk and survival in African Americans. Cancer Causes Control. 2019 Nov; 30(11):1259-1268. PMID: 31468279.
      View in: PubMed
    22. Castellano GM, Aisner J, Burley SK, Vallat B, Yu HA, Pine SR, Ganesan S. A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib. J Thorac Oncol. 2019 11; 14(11):1982-1988. PMID: 31254668.
      View in: PubMed
    23. Meaney CL, Mitchell KA, Zingone A, Brown D, Bowman E, Yu Y, Wenzlaff AS, Neslund-Dudas C, Pine SR, Cao L, Schwartz AG, Ryan BM. Circulating Inflammation Proteins Associated With Lung Cancer in African Americans. J Thorac Oncol. 2019 07; 14(7):1192-1203. PMID: 30953795.
      View in: PubMed
    24. Pine SR, Sabaawy HE. Editorial: Harnessing the Power of Patient Derived Models of Cancer. Front Oncol. 2018; 8:349. PMID: 30237982.
      View in: PubMed
    25. Pine SR, Ryan BM. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018 Sep; 7(Suppl 3):S265-S269. PMID: 30393619.
      View in: PubMed
    26. Pine SR. Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target? Clin Cancer Res. 2018 12 15; 24(24):6136-6141. PMID: 30104200.
      View in: PubMed
    27. Patrizii M, Bartucci M, Pine SR, Sabaawy HE. Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy. Front Oncol. 2018; 8:23. PMID: 29484285.
      View in: PubMed
    28. Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol Cancer Ther. 2017 Dec; 16(12):2759-2769. PMID: 28978720.
      View in: PubMed
    29. Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma. Clin Cancer Res. 2017 Sep 15; 23(18):5631-5638. PMID: 28539463.
      View in: PubMed
    30. Morgan KM, Riedlinger GM, Rosenfeld J, Ganesan S, Pine SR. Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer and Their Potential Utility in Personalized Medicine. Front Oncol. 2017; 7:2. PMID: 28154808.
      View in: PubMed
    31. Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14; 44(18):8855-8869. PMID: 27566146.
      View in: PubMed
    32. Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC. Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans. Cancer Epidemiol Biomarkers Prev. 2016 Mar; 25(3):488-97. PMID: 26711330.
      View in: PubMed
    33. Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC. Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. Cancer Res. 2015 Feb 01; 75(3):566-75. PMID: 25480945.
      View in: PubMed
    34. Ryan BM, Pine SR, Chaturvedi AK, Caporaso N, Harris CC. A combined prognostic serum interleukin-8 and interleukin-6 classifier for stage 1 lung cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Thorac Oncol. 2014 Oct; 9(10):1494-503. PMID: 25170636.
      View in: PubMed
    35. Pine SR, Liu W. Asymmetric cell division and template DNA co-segregation in cancer stem cells. Front Oncol. 2014; 4:226. PMID: 25191642.
      View in: PubMed
    36. Liu W, Morgan KM, Pine SR. Activation of the Notch1 Stem Cell Signaling Pathway during Routine Cell Line Subculture. Front Oncol. 2014; 4:211. PMID: 25147757.
      View in: PubMed
    37. Capaccione KM, Hong X, Morgan KM, Liu W, Bishop JM, Liu L, Markert E, Deen M, Minerowicz C, Bertino JR, Allen T, Pine SR. Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget. 2014 Jun 15; 5(11):3636-50. PMID: 25004243.
      View in: PubMed
    38. Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest. 2013 Dec; 123(12):5247-57. PMID: 24231352.
      View in: PubMed
    39. Liu W, Jeganathan G, Amiri S, Morgan KM, Ryan BM, Pine SR. Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines. Mol Cancer. 2013 Nov 15; 12(1):139. PMID: 24238140.
      View in: PubMed
    40. Capaccione KM, Pine SR. The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis. 2013 Jul; 34(7):1420-30. PMID: 23585460.
      View in: PubMed
    41. Patel SA, Ramkissoon SH, Bryan M, Pliner LF, Dontu G, Patel PS, Amiri S, Pine SR, Rameshwar P. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci Rep. 2012; 2:906. PMID: 23205268.
      View in: PubMed
    42. Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC. MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. Int J Cancer. 2012 Dec 01; 131(11):2710-6. PMID: 22487911.
      View in: PubMed
    43. Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE, Harris CC. Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst. 2011 Jul 20; 103(14):1112-22. PMID: 21685357.
      View in: PubMed
    44. Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM. Admixture mapping of lung cancer in 1812 African-Americans. Carcinogenesis. 2011 Mar; 32(3):312-7. PMID: 21115650.
      View in: PubMed
    45. Chaturvedi AK, Caporaso NE, Katki HA, Wong HL, Chatterjee N, Pine SR, Chanock SJ, Goedert JJ, Engels EA. C-reactive protein and risk of lung cancer. J Clin Oncol. 2010 Jun 01; 28(16):2719-26. PMID: 20421535.
      View in: PubMed
    46. Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2195-200. PMID: 20080668.
      View in: PubMed
    47. Olivo-Marston SE, Yang P, Mechanic LE, Bowman ED, Pine SR, Loffredo CA, Alberg AJ, Caporaso N, Shields PG, Chanock S, Wu Y, Jiang R, Cunningham J, Jen J, Harris CC. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Dec; 18(12):3375-83. PMID: 19959685.
      View in: PubMed
    48. Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol. 2009 Sep; 11(9):1135-42. PMID: 19701195.
      View in: PubMed
    49. Martin RC, Barker DF, Doll MA, Pine SR, Mechanic L, Bowman ED, Harris CC, Hein DW. Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population. DNA Cell Biol. 2008 Jun; 27(6):321-3. PMID: 18466086.
      View in: PubMed
    50. Pine SR, Marshall B, Varticovski L. Lung cancer stem cells. Dis Markers. 2008; 24(4-5):257-66. PMID: 18525120.
      View in: PubMed
    51. Pine SR, Mechanic LE, Ambs S, Bowman ED, Chanock SJ, Loffredo C, Shields PG, Harris CC. Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J Natl Cancer Inst. 2007 Sep 19; 99(18):1401-9. PMID: 17848669.
      View in: PubMed
    52. Pine SR, Guo Q, Yin C, Jayabose S, Druschel CM, Sandoval C. Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. Blood. 2007 Sep 15; 110(6):2128-31. PMID: 17576817.
      View in: PubMed
    53. Sabaawy HE, Sandoval C, Guo Q, Yin C, Kulangara A, Lee J, Wormser G, Jayabose S, Pine SR. Lymphoproliferative clonal origin of AIDS-related non-Hodgkin's lymphoma. Leuk Lymphoma. 2007 Apr; 48(4):812-5. PMID: 17454643.
      View in: PubMed
    54. Sandoval C, Pine SR. Down syndrome and GATA1-related transient leukemia. J Pediatr. 2007 Mar; 150(3):e34. PMID: 17307526.
      View in: PubMed
    55. Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG, Harris CC. MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1559-61. PMID: 16896050.
      View in: PubMed
    56. Pine SR, Guo Q, Yin C, Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C. GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome. Leuk Res. 2005 Nov; 29(11):1353-6. PMID: 15916804.
      View in: PubMed
    57. Pine SR, Yin C, Matloub YH, Sabaawy HE, Sandoval C, Levendoglu-Tugal O, Ozkaynak MF, Jayabose S. Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. J Mol Diagn. 2005 Feb; 7(1):127-32. PMID: 15681484.
      View in: PubMed
    58. Sandoval C, Pine SR, Guo Q, Sastry S, Stewart J, Kronn D, Jayabose S. Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature. Pediatr Blood Cancer. 2005 Jan; 44(1):85-91. PMID: 15390279.
      View in: PubMed
    59. Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S. Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Polymerase chain reaction. J Pediatr Hematol Oncol. 2003 Feb; 25(2):103-8. PMID: 12571459.
      View in: PubMed
    60. Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leuk Res. 2003 Feb; 27(2):155-64. PMID: 12526921.
      View in: PubMed
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