 DAX-1 Orphan Nuclear Receptor
"DAX-1 Orphan Nuclear Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.
| Descriptor ID |
D057137
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| MeSH Number(s) |
D12.776.826.209.059 D12.776.930.780.625.186
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| Concept/Terms |
DAX-1 Orphan Nuclear Receptor- DAX-1 Orphan Nuclear Receptor
- DAX 1 Orphan Nuclear Receptor
- DSS-AHC Critical Region on the X Chromosome, Gene 1 Protein
- DSS AHC Critical Region on the X Chromosome, Gene 1 Protein
- Nuclear Receptor NR0B1
- Nuclear Receptor DAX-1
- Nuclear Receptor DAX 1
- Nuclear Receptor Subfamily 0, Group B, Member 1
- NR0B1 Protein
- Nuclear Receptor 0B1
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Below are MeSH descriptors whose meaning is more general than "DAX-1 Orphan Nuclear Receptor".
Below are MeSH descriptors whose meaning is more specific than "DAX-1 Orphan Nuclear Receptor".
This graph shows the total number of publications written about "DAX-1 Orphan Nuclear Receptor" by people in this website by year, and whether "DAX-1 Orphan Nuclear Receptor" was a major or minor topic of these publications.
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Below are the most recent publications written about "DAX-1 Orphan Nuclear Receptor" by people in Profiles.
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Ahn SW, Gang GT, Tadi S, Nedumaran B, Kim YD, Park JH, Kweon GR, Koo SH, Lee K, Ahn RS, Yim YH, Lee CH, Harris RA, Choi HS. Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells. J Biol Chem. 2012 Dec 07; 287(50):41875-87.
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Nedumaran B, Kim GS, Hong S, Yoon YS, Kim YH, Lee CH, Lee YC, Koo SH, Choi HS. Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem. 2010 Mar 19; 285(12):9221-32.
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Nedumaran B, Hong S, Xie YB, Kim YH, Seo WY, Lee MW, Lee CH, Koo SH, Choi HS. DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression. J Biol Chem. 2009 Oct 02; 284(40):27511-23.
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Kim GS, Lee GY, Nedumaran B, Park YY, Kim KT, Park SC, Lee YC, Kim JB, Choi HS. The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARgamma. Biochem Biophys Res Commun. 2008 May 30; 370(2):264-8.
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