 Frailty
"Frailty" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A state of increased vulnerability to stressors, following declines in function and reserves across multiple physiologic systems, characterized by MUSCLE WEAKNESS; FATIGUE; slowed motor performance; low physical activity; and unintentional weight loss.
| Descriptor ID |
D000073496
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| MeSH Number(s) |
C23.550.359
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Frailty".
Below are MeSH descriptors whose meaning is more specific than "Frailty".
This graph shows the total number of publications written about "Frailty" by people in this website by year, and whether "Frailty" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 | | 2017 | 2 | 2 | 4 | | 2018 | 11 | 1 | 12 | | 2019 | 13 | 3 | 16 | | 2020 | 10 | 3 | 13 | | 2021 | 10 | 0 | 10 | | 2022 | 18 | 1 | 19 | | 2023 | 20 | 0 | 20 | | 2024 | 13 | 7 | 20 | | 2025 | 7 | 1 | 8 |
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Below are the most recent publications written about "Frailty" by people in Profiles.
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Foote IF, Flint JP, Fürtjes AE, Lawrence JM, Mullin DS, Fisk JD, Karakach TK, Rutenberg A, Martin NG, Lupton MK, Llewellyn DJ, Ranson JM, Cox SR, Luciano M, Rockwood K, Grotzinger AD. Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling. Nat Genet. 2025 Aug; 57(8):1848-1859.
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Biehler-Gomez L, Marklein KE, Yaussy SL, Crews DE, DeWitte SN, Cattaneo C. Sex Differences in Frailty in Milan Over the Last 2000?Years: A Hazards-Based and Cumulative Phenotype Approach. Am J Biol Anthropol. 2025 Aug; 187(4):e70111.
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Kulik GL, Mollner DC, Barbera L, Walker J, Gorvetzian S, Matlock D, Erlandson KM. Application of Pragmatic Criteria to Assessments of Frailty and Physical Function Among People With HIV. Clin Infect Dis. 2025 Jul 18; 80(6):1229-1234.
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Phillips EK, Huang Y, Regan E, Make B, Strand M, Yohannes AM, Hanania NA, Bon J, Hoth KF, Crapo JD, Silverman EK, DeMeo DL. Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort. Aging (Albany NY). 2025 Jul 03; 17(7):1590-1623.
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Nidadavolu LS, Sosnowski DW, Sivakumar N, Merino Gomez A, Wu Y, Laskow T, Bopp T, Milcik N, Le A, Zhang C, Khare P, Zammit A, Grodstein F, Walston JD, Bennett DA, Mathias RA, Phillip JM, Maher BS, Oh ES, Abadir PM. Cardiovascular-Derived Circulating Cell-Free DNA Fragments Are Associated With Frailty and Increased Cardiovascular Events in Older Adults. J Gerontol A Biol Sci Med Sci. 2025 Jun 10; 80(7).
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Peters BA, Xue X, Hanna DB, Wang Y, Wang Z, Sharma A, Floris-Moore M, Konkle-Parker D, Alcaide ML, Sheth AN, Topper EF, Weber KM, Tien PC, Merenstein D, Vásquez E, Chen Y, Mimiaga MJ, Stosor V, Brown TT, Erlandson KM, Dillon SM, Elsayed NS, Usyk M, Sollecito CC, Kaplan RC, Burk RD, Qi Q. Healthy Aging and the Gut Microbiome in People With and Without HIV. J Infect Dis. 2025 Apr 15; 231(4):981-992.
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Witham MD, McDonald C, Wilson N, Rennie KJ, Bardgett M, Bradley P, Clegg AP, Connolly S, Hancock H, Hiu S, Nicholson K, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, von Zglinicki T, Sayer AA. Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial. Lancet Healthy Longev. 2025 Mar; 6(3):100695.
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Wanigatunga AA, Dong Y, Jin M, Leroux A, Cui E, Zhou X, Zhao A, Schrack JA, Bandeen-Roche K, Walston JD, Xue QL, Lindquist MA, Crainiceanu CM. Moderate-to-Vigorous Physical Activity at any Dose Reduces All-Cause Dementia Risk Regardless of Frailty Status. J Am Med Dir Assoc. 2025 Mar; 26(3):105456.
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Baim-Lance A, Cooley S, Yoo-Jeong M, Ances B, Duque G, Ellis RJ, Flexner C, Pence BW, Plankey M, Mullins JD, Sun J, Thames AD, Margolick JB, Moore DJ, Erlandson KM. Current Challenges, Solutions, and Novel Directions in Research and Clinical Care: Proceedings From the 14th Annual International Workshop on HIV and Aging. J Gerontol A Biol Sci Med Sci. 2024 Dec 11; 80(1).
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Iriarte E, Smyth HL, Schmiege S, Tassiopoulos K, Jankowski CM, Erlandson KM. Predictors of frailty trajectories among people with HIV. AIDS. 2025 Mar 15; 39(4):373-380.
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