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Aaron Whiteley

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Conte AN, Ruchel ME, Ridgeway SM, Kibby EM, Nagy TA, Whiteley AT. DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25. PLoS Biol. 2025 May 30; 23(5):e3003203. PMID: 40446071.
      View in: PubMed
    2. Sullivan AE, Nabhani A, Schinkel K, Dinh DM, Duncan ML, Ednacot EMQ, Hoffman CRK, Izrailevsky DS, Kibby EM, Nagy TA, Nguyen CM, Tak U, Burroughs AM, Aravind L, Whiteley AT, Morehouse BR. A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins. bioRxiv. 2025 Mar 30. PMID: 40196609.
      View in: PubMed
    3. Conte AN, Ruchel ME, Ridgeway SM, Kibby EM, Nagy TA, Whiteley AT. Phage detection by a bacterial NLR-related protein is mediated by DnaJ. bioRxiv. 2024 Dec 19. PMID: 38895412.
      View in: PubMed
    4. Kibby EM, Robbins LK, Deep A, Min NK, Whalen LA, Nagy TA, Freeborn L, Corbett KD, Whiteley AT. A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection. bioRxiv. 2024 Dec 17. PMID: 39763729.
      View in: PubMed
    5. Bullen NP, Whiteley AT. Phages gain the upper hand in the metabolic arms race for NAD. Mol Cell. 2024 Dec 05; 84(23):4480-4482. PMID: 39642854.
      View in: PubMed
    6. Chambers LR, Ye Q, Cai J, Gong M, Ledvina HE, Zhou H, Whiteley AT, Suhandynata RT, Corbett KD. A eukaryotic-like ubiquitination system in bacterial antiviral defence. Nature. 2024 Jul; 631(8022):843-849. PMID: 39020180.
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    7. Ledvina HE, Whiteley AT. Author Correction: Conservation and similarity of bacterial and eukaryotic innate immunity. Nat Rev Microbiol. 2024 Jul; 22(7):451. PMID: 38532106.
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    8. Ledvina HE, Whiteley AT. Conservation and similarity of bacterial and eukaryotic innate immunity. Nat Rev Microbiol. 2024 Jul; 22(7):420-434. PMID: 38418927.
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    9. Chambers LR, Ye Q, Cai J, Gong M, Ledvina HE, Zhou H, Whiteley AT, Suhandynata RT, Corbett KD. Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems. bioRxiv. 2023 Sep 26. PMID: 37808811.
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    10. Tak U, Walth P, Whiteley AT. Bacterial cGAS-like enzymes produce 2',3'-cGAMP to activate an ion channel that restricts phage replication. bioRxiv. 2023 Jul 24. PMID: 37546940.
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    11. Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT. Bacterial NLR-related proteins protect against phage. Cell. 2023 05 25; 186(11):2410-2424.e18. PMID: 37160116.
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    12. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. Author Correction: An E1-E2 fusion protein primes antiviral immune signalling in bacteria. Nature. 2023 Mar; 615(7954):E25. PMID: 36914867.
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    13. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. An E1-E2 fusion protein primes antiviral immune signalling in bacteria. Nature. 2023 04; 616(7956):319-325. PMID: 36755092.
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    14. Govande AA, Duncan-Lowey B, Eaglesham JB, Whiteley AT, Kranzusch PJ. Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep. 2021 06 01; 35(9):109206. PMID: 34077735.
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    15. Kibby EM, Whiteley AT. The Linguistics of Bacterial Conflict Systems Reveal Ancient Origins of Eukaryotic Innate Immunity. J Bacteriol. 2020 11 19; 202(24). PMID: 32958633.
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    16. Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. PMID: 33087577.
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    17. Peterson BN, Young MKM, Luo S, Wang J, Whiteley AT, Woodward JJ, Tong L, Wang JD, Portnoy DA. (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. mBio. 2020 08 25; 11(4). PMID: 32843560.
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    18. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 07 09; 182(1):38-49.e17. PMID: 32544385.
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    19. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. PMID: 31932164.
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    20. Zhou W, Whiteley AT, Kranzusch PJ. Analysis of human cGAS activity and structure. Methods Enzymol. 2019; 625:13-40. PMID: 31455523.
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    21. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199. PMID: 30787435.
      View in: PubMed
    22. Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11. PMID: 30007416.
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    23. Mitchell G, Cheng MI, Chen C, Nguyen BN, Whiteley AT, Kianian S, Cox JS, Green DR, McDonald KL, Portnoy DA. Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E210-E217. PMID: 29279409.
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    24. Portman JL, Dubensky SB, Peterson BN, Whiteley AT, Portnoy DA. Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. mBio. 2017 10 17; 8(5). PMID: 29042499.
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    25. Whiteley AT, Ruhland BR, Edrozo MB, Reniere ML. A Redox-Responsive Transcription Factor Is Critical for Pathogenesis and Aerobic Growth of Listeria monocytogenes. Infect Immun. 2017 05; 85(5). PMID: 28193635.
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    26. Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA. c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation. Mol Microbiol. 2017 04; 104(2):212-233. PMID: 28097715.
      View in: PubMed
    27. Reniere ML, Whiteley AT, Portnoy DA. An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression. PLoS Pathog. 2016 07; 12(7):e1005741. PMID: 27414028.
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    28. Whiteley AT, Pollock AJ, Portnoy DA. The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected]. Cell Host Microbe. 2015 Jun 10; 17(6):788-98. PMID: 26028365.
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    29. Kellenberger CA, Chen C, Whiteley AT, Portnoy DA, Hammond MC. RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP. J Am Chem Soc. 2015 May 27; 137(20):6432-5. PMID: 25965978.
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    30. Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA. Glutathione activates virulence gene expression of an intracellular pathogen. Nature. 2015 Jan 08; 517(7533):170-3. PMID: 25567281.
      View in: PubMed
    31. Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. mBio. 2013 May 28; 4(3):e00282-13. PMID: 23716572.
      View in: PubMed
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