 Chemical and Drug Induced Liver Injury
"Chemical and Drug Induced Liver Injury" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Descriptor ID |
D056486
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| MeSH Number(s) |
C06.552.195 C25.100.562 C25.723.260
|
| Concept/Terms |
Chemically-Induced Liver Toxicity- Chemically-Induced Liver Toxicity
- Chemically Induced Liver Toxicity
- Chemically-Induced Liver Toxicities
- Liver Toxicities, Chemically-Induced
- Liver Toxicity, Chemically-Induced
- Toxicities, Chemically-Induced Liver
- Toxicity, Chemically-Induced Liver
Drug-Induced Acute Liver Injury- Drug-Induced Acute Liver Injury
- Drug Induced Acute Liver Injury
- Liver Injury, Drug-Induced, Acute
- Acute Liver Injury, Drug-Induced
- Acute Liver Injury, Drug Induced
Hepatitis, Toxic- Hepatitis, Toxic
- Toxic Hepatitis
- Hepatitides, Toxic
- Toxic Hepatitides
Drug-Induced Liver Disease- Drug-Induced Liver Disease
- Disease, Drug-Induced Liver
- Diseases, Drug-Induced Liver
- Drug Induced Liver Disease
- Drug-Induced Liver Diseases
- Liver Disease, Drug-Induced
- Liver Diseases, Drug-Induced
- Drug-Induced Liver Injury
- Drug Induced Liver Injury
- Drug-Induced Liver Injuries
- Injuries, Drug-Induced Liver
- Injury, Drug-Induced Liver
- Liver Injuries, Drug-Induced
- Liver Injury, Drug-Induced
- Liver Injury, Drug Induced
Hepatitis, Drug-Induced- Hepatitis, Drug-Induced
- Drug-Induced Hepatitides
- Drug-Induced Hepatitis
- Hepatitides, Drug-Induced
- Hepatitis, Drug Induced
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Below are MeSH descriptors whose meaning is more general than "Chemical and Drug Induced Liver Injury".
Below are MeSH descriptors whose meaning is more specific than "Chemical and Drug Induced Liver Injury".
This graph shows the total number of publications written about "Chemical and Drug Induced Liver Injury" by people in this website by year, and whether "Chemical and Drug Induced Liver Injury" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 2 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 1 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 1 | 2 | | 2010 | 5 | 0 | 5 | | 2011 | 3 | 2 | 5 | | 2012 | 4 | 1 | 5 | | 2013 | 2 | 1 | 3 | | 2014 | 5 | 0 | 5 | | 2016 | 2 | 2 | 4 | | 2017 | 1 | 0 | 1 | | 2018 | 4 | 1 | 5 | | 2019 | 3 | 0 | 3 | | 2020 | 3 | 1 | 4 | | 2021 | 9 | 0 | 9 | | 2022 | 6 | 0 | 6 | | 2023 | 4 | 2 | 6 | | 2024 | 3 | 1 | 4 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chemical and Drug Induced Liver Injury" by people in Profiles.
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Wei Z, Boateng NKK, Schmitt LR, Cline H, Fernandes Fonseca MT, Newberry A, Taylor A, Adelmeijer J, Poole LG, Stravitz RT, Lee WM, Lisman T, Hansen KC, Luyendyk JP. Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver. Blood. 2025 May 22; 145(21):2507-2517.
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Rutt LN, Orlicky DJ, McCullough RL. Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury. Cell Biol Toxicol. 2024 12 21; 41(1):5.
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Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson DC, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Arch Toxicol. 2024 10; 98(10):3241-3257.
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Ramachandran A, Akakpo JY, Curry SC, Rumack BH, Jaeschke H. Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure. Biochem Pharmacol. 2024 10; 228:116056.
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Bateman DN, Dart RC, Dear JW, Prescott LF, Rumack BH. Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver. Clin Toxicol (Phila). 2023 Dec; 61(12):1020-1031.
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Akakpo JY, Ramachandran A, Rumack BH, Wallace DP, Jaeschke H. Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine. Toxicology. 2023 12; 500:153692.
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Kandel SE, Gracey EG, Lampe JN. Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach. Chem Res Toxicol. 2023 Oct 16; 36(10):1631-1642.
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Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP. Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma. Clin Cancer Res. 2023 08 15; 29(16):2988-3003.
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Monte AA, Vest A, Reisz JA, Berninzoni D, Hart C, Dylla L, D'Alessandro A, Heard KJ, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. J Med Toxicol. 2023 07; 19(3):255-261.
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Boussetta-Charfi O, D'Andon CF, Nguyen H, Rumack BH, Launay M. Failure of Risk Assessment After Paracetamol Overdose-A Short Communication. Ther Drug Monit. 2023 04 01; 45(2):273-276.
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