 Up-Regulation
"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
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| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
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| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
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Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 6 | 7 | | 1999 | 1 | 4 | 5 | | 2000 | 0 | 4 | 4 | | 2001 | 2 | 9 | 11 | | 2002 | 4 | 21 | 25 | | 2003 | 1 | 16 | 17 | | 2004 | 3 | 22 | 25 | | 2005 | 2 | 27 | 29 | | 2006 | 5 | 28 | 33 | | 2007 | 4 | 29 | 33 | | 2008 | 4 | 17 | 21 | | 2009 | 2 | 26 | 28 | | 2010 | 2 | 23 | 25 | | 2011 | 8 | 27 | 35 | | 2012 | 9 | 31 | 40 | | 2013 | 3 | 28 | 31 | | 2014 | 2 | 23 | 25 | | 2015 | 5 | 23 | 28 | | 2016 | 2 | 26 | 28 | | 2017 | 2 | 20 | 22 | | 2018 | 5 | 24 | 29 | | 2019 | 2 | 27 | 29 | | 2020 | 4 | 18 | 22 | | 2021 | 5 | 7 | 12 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 3 | 2 | 5 | | 2025 | 0 | 6 | 6 | | 2026 | 1 | 4 | 5 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Laux L, Sullivan J, Perry MS, Brunklaus A, Desurkar A, Schreiber JM, Roberts CM, Knupp KG, Wheless JW, Wirrell EC, Ventola P, Wang F, Lynch J, Parkerson KA, Ticho B, Cross JH. Zorevunersen in Children and Adolescents with Dravet Syndrome. N Engl J Med. 2026 Mar 05; 394(10):969-982.
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Baird MA, Jewett CE, Malide DA, Kratz L, Cartagena-Rivera AX, Fischer RS, Waterman CM. Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion. Proc Natl Acad Sci U S A. 2026 Feb 24; 123(8):e2513031123.
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Hoyt-Miggelbrink AM, Waibl Polania J, Wachsmuth L, Lorrey S, Mohan A, Hardigan A, Blandford E, Lerner E, Wilkinson D, Hotchkiss KM, Cook S, Hemmers S, Patel A, Ayasoufi K, Fecci P. Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity. Clin Cancer Res. 2026 Feb 17; 32(4):782-800.
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Natarajan SK, Lum J, Skeans JH, Nenwani M, Eyunni S, Mota M, Bayliss JM, Deogharkar A, Hamanishi ET, Pun M, Sweha SR, Hoffman S, Young E, Zhang Q, Mehta R, Animasahun O, Narayanan P, Sunil S, Parolia A, Sajjakulnukit P, Panwalkar P, Doherty R, Clausen M, Dang D, Hawes D, Yang F, Santi M, Judkins AR, Wilson Y, Vigil T, Franson A, Mortensen RM, Ozawa T, Griesinger A, Holland EC, Foreman NK, Michealraj KA, Agnihotri S, Taylor M, Gilbertson RJ, Koschmann C, Chinnaiyan AM, Lyssiotis CA, Nagrath D, Venneti S. ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression. Nature. 2026 04; 652(8111):1004-1015.
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Owaki A, Kaseda S, Tanigawa S, Miike K, Sannomiya Y, Tsuhako H, Sato R, Mizumoto K, Horizono J, Kumabe R, Tokuyasu M, Fujiwara Y, Takeo T, Araki K, Davenport B, Lennon R, Shuto T, Nishinakamura R, Suico MA, Kai H. Protective role of early Tnfsf15 upregulation in limiting glomerular injury and proteinuria in experimental Alport Syndrome. J Pharmacol Sci. 2026 Mar; 160(3):158-166.
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Gutierrez VA, Beede-James KF, Martin LE, Zumpano KT, Kay KE, Medler KF, Torregrossa AM. Functional bitter taste signaling and stimulus intensity influence diet-induced salivary protein upregulation. Appetite. 2026 Apr 01; 219:108418.
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Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.
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Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T. Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2026 Jan 01; 330(1):H124-H136.
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Roth R, Häckh M, Schnick T, Rommel C, Koentges C, Bugger H, Domisch C, Bristow MR, Ambardekar AV, McKinsey TA, Gilsbach R, Hein L, Preissl S. Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors. Epigenetics. 2025 Dec; 20(1):2506625.
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Dylla L, Reisz JA, Poisson SN, Herson PS, Sansing LH, Monte AA. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection: Kynurenine and post-stroke infection. J Stroke Cerebrovasc Dis. 2025 May; 34(5):108268.
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