Nucleic Acid Hybridization
"Nucleic Acid Hybridization" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Descriptor ID |
D009693
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MeSH Number(s) |
E05.393.661 G02.111.611
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Concept/Terms |
Nucleic Acid Hybridization- Nucleic Acid Hybridization
- Acid Hybridization, Nucleic
- Acid Hybridizations, Nucleic
- Hybridization, Nucleic Acid
- Hybridizations, Nucleic Acid
- Nucleic Acid Hybridizations
Genomic Hybridization- Genomic Hybridization
- Genomic Hybridizations
- Hybridization, Genomic
- Hybridizations, Genomic
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Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Hybridization".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Hybridization".
This graph shows the total number of publications written about "Nucleic Acid Hybridization" by people in this website by year, and whether "Nucleic Acid Hybridization" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 2 | 2 | 1996 | 0 | 1 | 1 | 1997 | 0 | 2 | 2 | 1999 | 0 | 1 | 1 | 2000 | 1 | 1 | 2 | 2001 | 1 | 2 | 3 | 2002 | 0 | 2 | 2 | 2003 | 1 | 3 | 4 | 2004 | 0 | 6 | 6 | 2005 | 0 | 3 | 3 | 2006 | 0 | 4 | 4 | 2007 | 0 | 6 | 6 | 2008 | 2 | 0 | 2 | 2009 | 1 | 2 | 3 | 2010 | 2 | 2 | 4 | 2011 | 0 | 3 | 3 | 2012 | 0 | 2 | 2 | 2013 | 1 | 0 | 1 | 2014 | 1 | 1 | 2 | 2015 | 0 | 4 | 4 | 2017 | 0 | 1 | 1 | 2018 | 0 | 2 | 2 | 2019 | 1 | 2 | 3 | 2020 | 1 | 2 | 3 | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nucleic Acid Hybridization" by people in Profiles.
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Firneno TJ, Semenov G, Dopman EB, Taylor SA, Larson EL, Gompert Z. Quantitative Analyses of Coupling in Hybrid Zones. Cold Spring Harb Perspect Biol. 2023 12 01; 15(12).
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Sung HL, Nesbitt DJ. Single-molecule kinetic studies of DNA hybridization under extreme pressures. Phys Chem Chem Phys. 2020 Nov 07; 22(41):23491-23501.
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Culver HR, Sinha J, Prieto TR, Calo CJ, Fairbanks BD, Bowman CN. Click Nucleic Acid-DNA Binding Behavior: Dependence on Length, Sequence, and Ionic Strength. Biomacromolecules. 2020 10 12; 21(10):4205-4211.
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Traeger JC, Schwartz DK. Interplay of electrostatic repulsion and surface grafting density on surface-mediated DNA hybridization. J Colloid Interface Sci. 2020 Apr 15; 566:369-374.
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Sung HL, Nesbitt DJ. DNA Hairpin Hybridization under Extreme Pressures: A Single-Molecule FRET Study. J Phys Chem B. 2020 01 09; 124(1):110-120.
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Betin V, Penaranda C, Bandyopadhyay N, Yang R, Abitua A, Bhattacharyya RP, Fan A, Avraham R, Livny J, Shoresh N, Hung DT. Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis. Sci Rep. 2019 12 17; 9(1):19244.
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Traeger JC, Lamberty Z, Schwartz DK. Influence of Oligonucleotide Grafting Density on Surface-Mediated DNA Transport and Hybridization. ACS Nano. 2019 07 23; 13(7):7850-7859.
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Maciaszek A, Jastrzebska K, Guga P. Homopurine RP-stereodefined phosphorothioate analogs of DNA with hampered Watson-Crick base pairings form Hoogsteen paired parallel duplexes with (2'-OMe)-RNAs. Org Biomol Chem. 2019 05 08; 17(18):4611-4620.
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Han X, Domaille DW, Fairbanks BD, He L, Culver HR, Zhang X, Cha JN, Bowman CN. New Generation of Clickable Nucleic Acids: Synthesis and Active Hybridization with DNA. Biomacromolecules. 2018 10 08; 19(10):4139-4146.
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Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2018 01 25; 46(2):e7.
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