 Protein Kinase C
"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725
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| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 5 | 5 | 10 | | 1993 | 4 | 3 | 7 | | 1994 | 5 | 7 | 12 | | 1995 | 1 | 3 | 4 | | 1996 | 6 | 5 | 11 | | 1997 | 9 | 4 | 13 | | 1998 | 9 | 3 | 12 | | 1999 | 5 | 2 | 7 | | 2000 | 9 | 3 | 12 | | 2001 | 5 | 2 | 7 | | 2002 | 10 | 3 | 13 | | 2003 | 6 | 1 | 7 | | 2004 | 4 | 5 | 9 | | 2005 | 5 | 3 | 8 | | 2006 | 4 | 3 | 7 | | 2007 | 2 | 3 | 5 | | 2008 | 6 | 5 | 11 | | 2009 | 2 | 2 | 4 | | 2010 | 5 | 2 | 7 | | 2011 | 4 | 2 | 6 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 2 | 3 | | 2015 | 3 | 0 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 2 | 2 | | 2018 | 2 | 1 | 3 | | 2020 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Nandi P, Jang CE, Biggar K, Halari CD, Jansson T, Gupta MB. Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells. Biomolecules. 2021 09 18; 11(9).
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Taylor JP, Armitage LH, Aldridge DL, Cash MN, Wallet MA. Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA. Biol Open. 2020 12 21; 9(12).
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Atwood DJ, Brown CN, Holditch SJ, Pokhrel D, Thorburn A, Hopp K, Edelstein CL. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 11; 75:109760.
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Li BX, Zhang H, Liu Y, Li Y, Zheng JJ, Li WX, Feng K, Sun M, Dai SX. Novel pathways of HIV latency reactivation revealed by integrated analysis of transcriptome and target profile of bryostatin. Sci Rep. 2020 02 26; 10(1):3511.
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Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI. Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation. Clin Exp Nephrol. 2019 Jul; 23(7):898-907.
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Levi NJ, Wilson CW, Redweik GAJ, Gray NW, Grzybowski CW, Lenkey JA, Moseman AW, Bertsch AD, Dao N, Walsh HE. Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. Mol Cell Endocrinol. 2018 12 15; 478:97-105.
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Koli S, Prakash A, Choudhury S, Mandil R, Garg SK. Calcium Channels, Rho-Kinase, Protein Kinase-C, and Phospholipase-C Pathways Mediate Mercury Chloride-Induced Myometrial Contractions in Rats. Biol Trace Elem Res. 2019 Feb; 187(2):418-424.
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Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. PLoS One. 2018; 13(5):e0196678.
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Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vadász I. TGF-ß inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L807-L824.
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Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G. Downregulation of PKC?/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion. Cell Signal. 2017 10; 38:49-59.
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