 Protein Kinase C
"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725
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| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1984 | 0 | 1 | 1 | | 1985 | 0 | 1 | 1 | | 1986 | 3 | 3 | 6 | | 1987 | 4 | 4 | 8 | | 1988 | 2 | 1 | 3 | | 1989 | 2 | 1 | 3 | | 1990 | 5 | 3 | 8 | | 1991 | 2 | 3 | 5 | | 1992 | 7 | 7 | 14 | | 1993 | 8 | 4 | 12 | | 1994 | 7 | 9 | 16 | | 1995 | 3 | 6 | 9 | | 1996 | 11 | 6 | 17 | | 1997 | 11 | 5 | 16 | | 1998 | 9 | 6 | 15 | | 1999 | 8 | 4 | 12 | | 2000 | 10 | 5 | 15 | | 2001 | 6 | 2 | 8 | | 2002 | 16 | 4 | 20 | | 2003 | 8 | 5 | 13 | | 2004 | 9 | 5 | 14 | | 2005 | 8 | 4 | 12 | | 2006 | 8 | 6 | 14 | | 2007 | 3 | 6 | 9 | | 2008 | 7 | 6 | 13 | | 2009 | 5 | 4 | 9 | | 2010 | 5 | 1 | 6 | | 2011 | 4 | 2 | 6 | | 2012 | 2 | 3 | 5 | | 2013 | 3 | 2 | 5 | | 2014 | 0 | 4 | 4 | | 2015 | 5 | 0 | 5 | | 2016 | 2 | 0 | 2 | | 2017 | 2 | 2 | 4 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. PLoS One. 2018; 13(5):e0196678.
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Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 11; 57(11):2690-2700.
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Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vadász I. TGF-ß inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L807-L824.
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Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G. Downregulation of PKC?/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion. Cell Signal. 2017 10; 38:49-59.
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Edens LJ, Dilsaver MR, Levy DL. PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells. Mol Biol Cell. 2017 May 15; 28(10):1389-1399.
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Li F, Yao Q, Ao L, Cleveland JC, Dong N, Fullerton DA, Meng X. Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9. J Mol Med (Berl). 2017 Jul; 95(7):739-751.
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Sharma A, Nakade UP, Choudhury S, Garg SK. Functional involvement of protein kinase C, Rho-kinase and TRPC3 decreases while PLC increases with advancement of pregnancy in mediating oxytocin-induced myometrial contractions in water buffaloes (Bubalus bubalis). Theriogenology. 2017 Apr 01; 92:176-189.
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Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017 01; 101(1):261-273.
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Malkani N, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. Mol Cell Endocrinol. 2016 Apr 15; 425:48-60.
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Hypolite JA, Malykhina AP. Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology. BMC Urol. 2015 Nov 04; 15:110.
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