 Protein Kinase C
"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725
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| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 5 | 6 | 11 | | 1995 | 1 | 3 | 4 | | 1996 | 11 | 6 | 17 | | 1997 | 11 | 2 | 13 | | 1998 | 6 | 4 | 10 | | 1999 | 4 | 3 | 7 | | 2000 | 9 | 3 | 12 | | 2001 | 5 | 1 | 6 | | 2002 | 7 | 4 | 11 | | 2003 | 4 | 1 | 5 | | 2004 | 6 | 3 | 9 | | 2005 | 7 | 3 | 10 | | 2006 | 7 | 4 | 11 | | 2007 | 2 | 3 | 5 | | 2008 | 7 | 3 | 10 | | 2009 | 5 | 5 | 10 | | 2010 | 6 | 3 | 9 | | 2011 | 5 | 3 | 8 | | 2012 | 2 | 2 | 4 | | 2013 | 3 | 1 | 4 | | 2014 | 1 | 3 | 4 | | 2015 | 5 | 0 | 5 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 3 | 4 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Black JD, Affandi T, Black AR, Reyland ME. PKCa and PKCd: Friends and Rivals. J Biol Chem. 2022 08; 298(8):102194.
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Nandi P, Jang CE, Biggar K, Halari CD, Jansson T, Gupta MB. Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells. Biomolecules. 2021 09 18; 11(9).
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Singh RK, Kumar S, Tomar MS, Verma PK, Kumar A, Kumar S, Kumar N, Singh JP, Acharya A. Putative role of natural products as Protein Kinase C modulator in different disease conditions. Daru. 2021 Dec; 29(2):397-414.
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Taylor JP, Armitage LH, Aldridge DL, Cash MN, Wallet MA. Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA. Biol Open. 2020 12 21; 9(12).
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Atwood DJ, Brown CN, Holditch SJ, Pokhrel D, Thorburn A, Hopp K, Edelstein CL. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 11; 75:109760.
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Li BX, Zhang H, Liu Y, Li Y, Zheng JJ, Li WX, Feng K, Sun M, Dai SX. Novel pathways of HIV latency reactivation revealed by integrated analysis of transcriptome and target profile of bryostatin. Sci Rep. 2020 02 26; 10(1):3511.
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Naranjo CA, Jivan AD, Vo MN, de Sa Campos KH, Deyarmin JS, Hekman RM, Uribe C, Hang A, Her K, Fong MM, Choi JJ, Chou C, Rabara TR, Myers G, Moua P, Risser DD, Vierra CA, Franz AH, Lin-Cereghino J, Lin-Cereghino GP. Role of BGS13 in the Secretory Mechanism of Pichia pastoris. Appl Environ Microbiol. 2019 12 15; 85(24).
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George TJ, Franke AJ, Chakravarthy AB, Das P, Dasari A, El-Rayes BF, Hong TS, Kinsella TJ, Landry JC, Lee JJ, Monjazeb AM, Jacobs SA, Raben D, Rahma OE, Williams TM, Wu C, Coleman CN, Vikram B, Ahmed MM. National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer. Cancer. 2019 08 15; 125(16):2732-2746.
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Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI. Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation. Clin Exp Nephrol. 2019 Jul; 23(7):898-907.
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Levi NJ, Wilson CW, Redweik GAJ, Gray NW, Grzybowski CW, Lenkey JA, Moseman AW, Bertsch AD, Dao N, Walsh HE. Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. Mol Cell Endocrinol. 2018 12 15; 478:97-105.
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