 Protein Kinase C-theta
"Protein Kinase C-theta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
| Descriptor ID |
D000074121
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725.075
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| Concept/Terms |
Protein Kinase C-theta- Protein Kinase C-theta
- Protein Kinase C, theta
- PRKCQ
- Protein Kinase C theta
- PKC-theta
- PKC theta
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-theta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-theta".
This graph shows the total number of publications written about "Protein Kinase C-theta" by people in this website by year, and whether "Protein Kinase C-theta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C-theta" by people in Profiles.
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Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 2010 Nov 10; 170(4):1065-79.
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Nagy B, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP. Impaired activation of platelets lacking protein kinase C-theta isoform. Blood. 2009 Mar 12; 113(11):2557-67.
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Cipriani B, Knowles H, Chen L, Battistini L, Brosnan CF. Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. J Immunol. 2002 Nov 15; 169(10):5761-70.
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