 Protein Kinase C-delta
"Protein Kinase C-delta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.
| Descriptor ID |
D051745
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725.400
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| Concept/Terms |
Protein Kinase C-delta- Protein Kinase C-delta
- Kinase C-delta, Protein
- Protein Kinase C delta
- PKC-delta Serine-Threonine Kinase
- PKC delta Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-delta
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-delta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-delta".
This graph shows the total number of publications written about "Protein Kinase C-delta" by people in this website by year, and whether "Protein Kinase C-delta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 3 | 0 | 3 | | 2008 | 4 | 1 | 5 | | 2009 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 3 | 0 | 3 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 0 | 2 | 2 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-delta" by people in Profiles.
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Affandi T, Ohm AM, Speidel JT, Caino MC, Boulton DP, Reyland ME. PKCd Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response. Mol Cancer Res. 2025 Sep 04; 23(9):779-791.
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Collins J, Piscopio RA, Reyland ME, Johansen CG, Benninger RKP, Farnsworth NL. Cleavage of protein kinase c d by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets. J Biol Chem. 2024 Sep; 300(9):107611.
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Ohm AM, Affandi T, Reisz JA, Caino MC, D'Alessandro A, Reyland ME. Metabolic reprogramming contributes to radioprotection by protein kinase Cd. J Biol Chem. 2023 10; 299(10):105186.
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Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S. Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-a-induced inflammatory activation of synovial fibroblasts. Cell Mol Immunol. 2022 10; 19(10):1185-1195.
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Black JD, Affandi T, Black AR, Reyland ME. PKCa and PKCd: Friends and Rivals. J Biol Chem. 2022 08; 298(8):102194.
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Speidel JT, Affandi T, Jones DNM, Ferrara SE, Reyland ME. Functional proteomic analysis reveals roles for PKCd in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy. Adv Biol Regul. 2020 12; 78:100757.
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Ohm AM, Affandi T, Reyland ME. EGF receptor and PKCd kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. J Biol Chem. 2019 03 22; 294(12):4488-4497.
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Wie SM, Wellberg E, Karam SD, Reyland ME. Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-d. Mol Cancer Ther. 2017 09; 16(9):1989-1998.
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Ohm AM, Tan AC, Heasley LE, Reyland ME. Co-dependency of PKCd and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. Oncogene. 2017 07 27; 36(30):4370-4378.
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Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of a7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2017 05 01; 312(5):L748-L759.
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