 Microphthalmia-Associated Transcription Factor
"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
| Descriptor ID |
D051739
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| MeSH Number(s) |
D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
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| Concept/Terms |
Microphthalmia-Associated Transcription Factor- Microphthalmia-Associated Transcription Factor
- Microphthalmia Associated Transcription Factor
- Transcription Factor, Microphthalmia-Associated
- MITF Transcription Factor
- Transcription Factor Microphthalmia
- Microphthalmia, Transcription Factor
- MITF Protein
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Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".
This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 3 | 0 | 3 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.
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Li Y, Gao J, Kamran M, Harmacek L, Danhorn T, Leach SM, O'Connor BP, Hagman JR, Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nat Commun. 2021 01 21; 12(1):494.
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Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA. FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death Differ. 2018 06; 25(6):1040-1049.
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Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184.
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Kundu A, Khouri MG, Aryana S, Firestone GL. 1-Benzyl-indole-3-carbinol is a highly potent new small molecule inhibitor of Wnt/?-catenin signaling in melanoma cells that coordinately inhibits cell proliferation and disrupts expression of microphthalmia-associated transcription factor isoform-M. Carcinogenesis. 2017 12 07; 38(12):1207-1217.
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Seberg HE, Van Otterloo E, Cornell RA. Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma. Pigment Cell Melanoma Res. 2017 09; 30(5):454-466.
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Seberg HE, Van Otterloo E, Loftus SK, Liu H, Bonde G, Sompallae R, Gildea DE, Santana JF, Manak JR, Pavan WJ, Williams T, Cornell RA. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017 03; 13(3):e1006636.
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Huang H, Li Y, Liu B. Transcriptional regulation of mast cell and basophil lineage commitment. Semin Immunopathol. 2016 09; 38(5):539-48.
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Laurette P, Strub T, Koludrovic D, Keime C, Le Gras S, Seberg H, Van Otterloo E, Imrichova H, Siddaway R, Aerts S, Cornell RA, Mengus G, Davidson I. Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells. Elife. 2015 Mar 24; 4.
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Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, Chabon J, Graham B, Ohmori K, Li Y, Huang H. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity. 2013 Jul 25; 39(1):97-110.
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Van Otterloo E, Li W, Bonde G, Day KM, Hsu MY, Cornell RA. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet. 2010 Sep 16; 6(9):e1001122.
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