 Complement C3b Inactivator Proteins
"Complement C3b Inactivator Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous proteins that inhibit or inactivate COMPLEMENT C3B. They include COMPLEMENT FACTOR H and COMPLEMENT FACTOR I (C3b/C4b inactivator). They cleave or promote the cleavage of C3b into inactive fragments, and thus are important in the down-regulation of COMPLEMENT ACTIVATION and its cytolytic sequence.
| Descriptor ID |
D003180
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| MeSH Number(s) |
D12.776.124.486.274.920.325
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| Concept/Terms |
Complement C3b Inactivator Proteins- Complement C3b Inactivator Proteins
- C3b Inhibitors
- Inhibitors, C3b
- Complement 3b Inactivators
- Inactivators, Complement 3b
- Complement C3b Inactivators
- Inactivators, Complement C3b
- Complement C3b Inhibitor Proteins
- Conglutinogen Activating Factors
- Factors, Conglutinogen Activating
- C3b Inactivators
- Inactivators, C3b
- Complement 3b Inhibitors
- Inhibitors, Complement 3b
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Below are MeSH descriptors whose meaning is more general than "Complement C3b Inactivator Proteins".
Below are MeSH descriptors whose meaning is more specific than "Complement C3b Inactivator Proteins".
This graph shows the total number of publications written about "Complement C3b Inactivator Proteins" by people in this website by year, and whether "Complement C3b Inactivator Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C3b Inactivator Proteins" by people in Profiles.
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Irmscher S, Zipfel SLH, Halder LD, Ivanov L, Gonzalez-Delgado A, Waldeyer C, Seiffert M, Brunner FJ, von der Heide M, L?schmann I, Wulf S, Czamara D, Papac-Milicevic N, Strau? O, Lorkowski S, Reichenspurner H, Holers MV, Banda NK, Zeller T, Binder EB, Binder CJ, Wiech T, Zipfel PF, Skerka C. Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease. Sci Rep. 2021 11 18; 11(1):22511.
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Vaught AJ, Braunstein EM, Jasem J, Yuan X, Makhlin I, Eloundou S, Baines AC, Merrill SA, Chaturvedi S, Blakemore K, Sperati CJ, Brodsky RA. Germline mutations in the alternative pathway of complement predispose to HELLP syndrome. JCI Insight. 2018 03 22; 3(6).
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Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 01 01; 200(1):316-326.
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Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016; 11(11):e0166200.
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Holers VM. Human C3 glomerulopathy provides unique insights into complement factor H-related protein function. J Clin Invest. 2013 Jun; 123(6):2357-60.
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Seya T, Holers VM, Atkinson JP. Purification and functional analysis of the polymorphic variants of the C3b/C4b receptor (CR1) and comparison with H, C4b-binding protein (C4bp), and decay accelerating factor (DAF). J Immunol. 1985 Oct; 135(4):2661-7.
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