 Complement C3-C5 Convertases
"Complement C3-C5 Convertases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.
| Descriptor ID |
D050577
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| MeSH Number(s) |
D12.776.124.486.274.045.387
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| Concept/Terms |
Complement C3-C5 Convertases- Complement C3-C5 Convertases
- C3-C5 Convertases, Complement
- Complement C3 C5 Convertases
- Convertases, Complement C3-C5
- C3-C5 Convertase
- C3 C5 Convertase
- Convertase, C3-C5
Complement C3 Convertases- Complement C3 Convertases
- C3 Convertases, Complement
- Convertases, Complement C3
- Complement 3 Convertase
- Convertase, Complement 3
- C3 Convertase
- Convertase, C3
- C3 Activator
- Activator, C3
- C 3 Convertase
- Convertase, C 3
Complement C5 Convertases- Complement C5 Convertases
- C5 Convertases, Complement
- Convertases, Complement C5
- C5 Convertase
- C5 Cleaving Enzyme
- Complement 5 Convertase
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Below are MeSH descriptors whose meaning is more general than "Complement C3-C5 Convertases".
Below are MeSH descriptors whose meaning is more specific than "Complement C3-C5 Convertases".
This graph shows the total number of publications written about "Complement C3-C5 Convertases" by people in this website by year, and whether "Complement C3-C5 Convertases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C3-C5 Convertases" by people in Profiles.
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Gifford G, Vu VP, Banda NK, Holers VM, Wang G, Groman EV, Backos D, Scheinman R, Moghimi SM, Simberg D. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55. J Control Release. 2019 05 28; 302:181-189.
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Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016; 11(11):e0166200.
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Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013 May; 123(5):2218-30.
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Fridkis-Hareli M, Storek M, Mazsaroff I, Risitano AM, Lundberg AS, Horvath CJ, Holers VM. Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Blood. 2011 Oct 27; 118(17):4705-13.
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Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH. Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion. J Immunol. 2011 Jun 01; 186(11):6445-53.
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Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 2010 May; 255(2):517-26.
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Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y. Role of complement component C5 in cerebral ischemia/reperfusion injury. Brain Res. 2006 Jul 19; 1100(1):142-51.
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Salerno CT, Kulick DM, Yeh CG, Guzman-Paz M, Higgins PJ, Benson BA, Park SJ, Shumway SJ, Bolman RM, Dalmasso AP. A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar; 9(2):125-34.
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Kim YU, Kinoshita T, Molina H, Hourcade D, Seya T, Wagner LM, Holers VM. Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein. J Exp Med. 1995 Jan 01; 181(1):151-9.
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Giclas PC, King TE, Baker SL, Russo J, Henson PM. Complement activity in normal rabbit bronchoalveolar fluid. Description of an inhibitor of C3 activation. Am Rev Respir Dis. 1987 Feb; 135(2):403-11.
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