 Thrombin
"Thrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
| Descriptor ID |
D013917
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| MeSH Number(s) |
D08.811.277.656.300.760.855 D08.811.277.656.959.350.855 D12.776.124.125.890 D23.119.960
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thrombin".
Below are MeSH descriptors whose meaning is more specific than "Thrombin".
This graph shows the total number of publications written about "Thrombin" by people in this website by year, and whether "Thrombin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1998 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 1 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 2 | 3 | | 2010 | 2 | 2 | 4 | | 2011 | 1 | 3 | 4 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 1 | 2 | | 2014 | 4 | 2 | 6 | | 2015 | 2 | 1 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 3 | 0 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 4 | 1 | 5 |
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Below are the most recent publications written about "Thrombin" by people in Profiles.
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Link KG, Stobb MT, Monroe DM, Fogelson AL, Neeves KB, Sindi SS, Leiderman K. Computationally Driven Discovery in Coagulation. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):79-86.
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Sparkenbaugh EM, Kasztan M, Henderson MW, Ellsworth P, Davis PR, Wilson KJ, Reeves B, Key NS, Strickland S, McCrae K, Pollock DM, Pawlinski R. High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease. J Thromb Haemost. 2020 09; 18(9):2329-2340.
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Miszta A, Kopec AK, Pant A, Holle LA, Byrnes JR, Lawrence DA, Hansen KC, Flick MJ, Luyendyk JP, de Laat B, Wolberg AS. A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice. Blood. 2020 05 07; 135(19):1704-1717.
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Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2020 04; 40(4):901-913.
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Beyer JT, Lind SE, Fisher S, Trujillo TC, Wempe MF, Kiser TH. Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients. J Thromb Thrombolysis. 2020 Feb; 49(2):259-267.
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Link KG, Stobb MT, Sorrells MG, Bortot M, Ruegg K, Manco-Johnson MJ, Di Paola JA, Sindi SS, Fogelson AL, Leiderman K, Neeves KB. A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A. J Thromb Haemost. 2020 02; 18(2):306-317.
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Coleman JR, Moore EE, Samuels JM, Ryon JJ, Nelson JT, Olson A, Caus S, Bartley MG, Vigneshwar NG, Cohen MJ, Banerjee A, Silliman CC, Butenas S. Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury. Surgery. 2019 12; 166(6):1122-1127.
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Huebner BR, Moore EE, Moore HB, Stettler GR, Nunns GR, Lawson P, Sauaia A, Kelher M, Banerjee A, Silliman CC. Thrombin Provokes Degranulation of Platelet a-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1). Shock. 2018 12; 50(6):671-676.
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Suzuki S, Lis A, Schmitz C, Penner R, Fleig A. The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins. Cell Mol Life Sci. 2018 08; 75(16):3069-3078.
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McFarland CP, Lind SE. Thrombin Generation Biomarkers Decline With Parenteral Anticoagulation-An Overlooked Means of Anticoagulation Monitoring? Clin Appl Thromb Hemost. 2018 Jul; 24(5):708-717.
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