 Factor XII
"Factor XII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
| Descriptor ID |
D005174
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| MeSH Number(s) |
D12.776.124.125.450 D23.119.450
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| Concept/Terms |
Factor XII- Factor XII
- Factor Twelve
- Hageman Factor
- Factor 12
- Coagulation Factor XII
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Below are MeSH descriptors whose meaning is more general than "Factor XII".
Below are MeSH descriptors whose meaning is more specific than "Factor XII".
This graph shows the total number of publications written about "Factor XII" by people in this website by year, and whether "Factor XII" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Factor XII" by people in Profiles.
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Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, Debette S, Longstreth WT, Seshadri S, Reiner AP, Tracy RP. Coagulation factor?XII genetic variation, ex?vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study. J Thromb Haemost. 2015 Oct; 13(10):1867-77.
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Oliver JA, Monroe DM, Roberts HR, Hoffman M. Thrombin activates factor XI on activated platelets in the absence of factor XII. Arterioscler Thromb Vasc Biol. 1999 Jan; 19(1):170-7.
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Wiggins RC, Giclas PC, Henson PM. Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit. J Exp Med. 1981 Jun 01; 153(6):1391-404.
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Saba HI, Roberts HR, Herion JC. The anticoagulant activity of lysosomal cationic proteins from polymorphonuclear leukocytes. J Clin Invest. 1967 Apr; 46(4):580-9.
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