Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Michael J. Mitchell

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-EM MED Clinical
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-EM MED Clinical


    Collapse Research 
    Collapse research activities and funding
    R01HD115877     (MITCHELL, MICHAEL J)Aug 12, 2024 - Jul 31, 2029
    NIH
    mRNA lipid nanoparticles for pre-eclampsia
    Role: Principal Investigator
    DP2TR002776     (MITCHELL, MICHAEL J)Sep 20, 2018 - May 31, 2023
    NIH
    A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironment
    Role: Principal Investigator
    F32CA200351     (MITCHELL, MICHAEL J)Aug 13, 2015 - Aug 12, 2018
    NIH
    Polymeric Nanoparticles for siRNA Delivery to Bone Marrow Endothelium to Disrupt Tumor Cell Adhesion and Bone Metastasis Formation In Vivo
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Han X, Xu Y, Ricciardi AS, Xu J, Xiang Y, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Reker D, Weissman D, Mitchell MJ. Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Proc Natl Acad Sci U S A. 2026 Jun 02; 123(22):e2528144123. PMID: 42190011.
      View in: PubMed
    2. Shuler CF, Safford HC, Thatte AS, Ang M, Mitchell MJ. Examining the effect of lipid nanoparticle elasticity on endocytosis and mRNA delivery to cancer cells. Med X. 2026; 4(1):11. PMID: 42078581.
      View in: PubMed
    3. Kim D, Moon SJ, Han EL, Feng E, Murray AM, Wang J, Liu W, Kong G, June CH, Mitchell MJ. HITE: HIV Inspired Lipid Nanoparticle Platform for CAR T Cell Engineering. Nano Lett. 2026 May 06; 26(17):5668-5679. PMID: 42012130.
      View in: PubMed
    4. Geisler HC, Safford HC, Thatte AS, Padilla MS, Battistini E, Yamagata HM, Ullman VM, Chan A, Nachod BE, Agrawal A, Watkins MB, Hopkins JB, Tsourkas A, Gupta K, Mitchell MJ. Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses. bioRxiv. 2026 Apr 08. PMID: 41959436.
      View in: PubMed
    5. Yamagata HM, Padilla MS, Hamilton AG, Swingle KL, Thatte AS, Ricciardi AS, Agrawal A, Fitzgerald E, Poirier AJ, Geisler HC, Joseph RA, Chalom OZ, Du S, Li JJ, Kim D, Whitaker RC, Figueroa-Espada CG, Han EL, Murray AM, Alameh MG, Weissman D, Mitchell MJ. Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity. J Am Chem Soc. 2026 Apr 08; 148(13):14137-14150. PMID: 41873855.
      View in: PubMed
    6. Torborg SR, Kim JY, Singhal A, Grbovic-Huezo O, Holm M, Wu K, Han X, Ho YJ, Haglund C, Mitchell MJ, Lowe SW, Dow LE, Pitter KL, Sanchez-Rivera FJ, Levchenko A, Tammela T. Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Dev Cell. 2026 May 13; 61(5):1012-1027.e8. PMID: 41875882.
      View in: PubMed
    7. Shi Q, Gong N, Wang J, Palanki R, Zheng Q, Alameh MG, Dwivedi G, Davis B, Melamed J, Luo Z, Xu J, Figueroa-Espada CG, Xue L, Zeng Y, Han X, Kim D, Chen Q, Yamagata H, Geisler HC, El-Mayta R, Yoon IC, Weissman D, Mitchell MJ. Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy. Nat Nanotechnol. 2026 Mar; 21(3):430-442. PMID: 41851499.
      View in: PubMed
    8. Kim D, Gong N, Alameh MG, Han EL, Wang H, Wang J, Feng E, Yoon IC, Murray AM, Shi Q, Moon SJ, Mrksich K, Weissman D, Mitchell MJ. Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination. Nat Mater. 2026 Mar 17. PMID: 41844984.
      View in: PubMed
    9. Thatte AS, Mitchell MJ. To modify or not to modify: Rethinking mRNA design for CAR T cell engineering. Mol Ther Nucleic Acids. 2026 Jun 16; 37(2):102872. PMID: 41858836.
      View in: PubMed
    10. Swingle KL, Mitchell MJ. Preparation of placenta-tropic mRNA lipid nanoparticles for pregnancy disorders. Nat Protoc. 2026 Mar 10. PMID: 41807717.
      View in: PubMed
    11. Geisler HC, Battistini E, Thatte AS, Padilla MS, Mitchell MJ. Preparation of targeted lipid nanoparticles for precision nucleic acid delivery. Nat Protoc. 2026 Mar 09. PMID: 41803280.
      View in: PubMed
    12. Zare I, Jafari M, Zahed Nasab S, Ramezani Farani M, Rahi A, Ghaee A, Shourangiz-Haghighi A, Bakhshian Nik A, Zhang M, Kang H, Dabiri S, Malekpour Afshar R, Patel SK, Mitchell MJ, Schirhagl R, Hassani Najafabadi A. Stimuli-responsive nanodiamonds for precision pharmacokinetics, pharmacodynamics, and drug delivery applications. Adv Drug Deliv Rev. 2026 05; 232:115822. PMID: 41713655.
      View in: PubMed
    13. Kim JG, Xu J, Lee D, Song J, Lee S, Hong MH, Zhu J, Zhu A, Patwari K, Shim EH, Shin JE, Park OH, Rho J, Ko KC, Lee EG, Kang OY, Won EJ, Kim BH, Jang JP, Jang JH, Kim DJ, Hwang JH, Mitchell MJ, Cha-Molstad H. Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines. ACS Nano. 2026 Mar 03; 20(8):7022-7045. PMID: 41691524.
      View in: PubMed
    14. Al Dala Ali M, Longepied G, Lévy N, Metzler-Guillemain C, Mitchell MJ. Nucleoporin NUP210L and BAF-paralogue BAF-L redundantly ensure nuclear integrity and manchette microtubule organisation in mouse spermatids. Hum Mol Genet. 2026 Feb 10; 35(3). PMID: 41459802.
      View in: PubMed
    15. Palanki R, Fitzgerald E, Poirier AJ, Mitchell MJ. Editing the skin in place: In vivo genome correction of rare skin disease. Cell Stem Cell. 2026 Feb 05; 33(2):170-172. PMID: 41650933.
      View in: PubMed
    16. Martins C, Mitchell MJ, Peer D, Perrie Y, Siegwart DJ, Alonso MJ, Aparicio-Blanco J. The RNA delivery dilemma-lipid versus polymer nanoparticle platforms. Drug Deliv Transl Res. 2026 Jan 30. PMID: 41615621.
      View in: PubMed
    17. Hamilton AG, Thatte AS, Xu J, Luo Z, Safford HC, Swingle KL, Muscat-Rivera J, Kegel M, Han X, Joseph RA, Murray AM, Geisler HC, Whitaker RC, Xue L, Spektor R, Melamed JR, Weissman D, Mitchell MJ. High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering. Adv Mater. 2026 Mar; 38(13):e14370. PMID: 41603124.
      View in: PubMed
    18. Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Joseph RA, Yamagata HM, Ricciardi AS, Mrksich K, Issadore D, Gupta K, Mitchell MJ. Author Correction: Elucidating lipid nanoparticle properties and structure through biophysical analyses. Nat Biotechnol. 2026 Jan 22. PMID: 41571920.
      View in: PubMed
    19. Han X, Shi Q, Mitchell MJ. Lipid nanoparticles for cell and gene therapy. Mol Ther Adv. 2026 Mar 12; 34(1):201671. PMID: 42137275.
      View in: PubMed
    20. Han EL, Kim D, Murray AM, Mrksich K, Hamilton AG, Tang S, Yoo S, Zhu AT, Tong ER, Palanki R, Hall ML, Bedingfield SK, Mitchell MJ. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS Nano. 2026 Feb 03; 20(4):3807-3820. PMID: 41555650.
      View in: PubMed
    21. Ang MJY, Metzloff AE, Thatte AS, Mitchell MJ. Lipid nanoparticles for engineering next generation CAR T cell immunotherapy. Nanoscale Horiz. 2026 Jan 05; 11(1):22-36. PMID: 41114533.
      View in: PubMed
    22. Nachod BE, Thatte AS, Palanki R, Mitchell MJ. Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies. Angew Chem Int Ed Engl. 2026 Feb 02; 65(6):e24097. PMID: 41451511.
      View in: PubMed
    23. Hanna AR, Shepherd SJ, Datto GA, El-Mayta R, Anderson T, Navarro IB, Ricciardi AS, Padilla MS, Srikumar N, Zhang S, Yamagata HM, Meng NY, Buser JR, Alameh MG, Mitchell MJ, Issadore DA. Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries. ACS Nano. 2026 Jan 13; 20(1):772-789. PMID: 41453807.
      View in: PubMed
    24. Luo Z, Mitchell MJ. Dual switches ignite tumour-specific mRNA therapeutics. Nat Nanotechnol. 2025 Dec; 20(12):1725-1726. PMID: 41225184.
      View in: PubMed
    25. Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2215. PMID: 40745065.
      View in: PubMed
    26. O'Brien EM, Tylek T, Geisler HC, Mukalel AJ, Whitaker RC, Sung S, Binder-Markey BI, Weissman D, Mitchell MJ, Spiller KL. Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries. Biomaterials. 2026 May; 328:123869. PMID: 41317703.
      View in: PubMed
    27. Safford HC, Palanki R, Ang M, Mitchell MJ. Emerging Nucleic Acid Cargos for Next-Generation RNA Vaccines and Therapeutics. Bioconjug Chem. 2025 11 19; 36(11):2317-2323. PMID: 41186979.
      View in: PubMed
    28. Wang J, Huang X, Shi Q, Swingle KL, Hamilton AG, Gong N, Mitchell MJ. Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2409564122. PMID: 41183182.
      View in: PubMed
    29. Henrich IC, Billingsley MM, Jain K, Mondal S, Quick LN, Young R, Nguyen N, Oliveira AM, Blobel GA, Mitchell MJ, Chou MM. Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma. Mol Cancer Ther. 2025 Nov 03; 24(11):1802-1814. PMID: 40556502.
      View in: PubMed
    30. Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Joseph RA, Yamagata HM, Ricciardi AS, Mrksich K, Issadore D, Gupta K, Mitchell MJ. Elucidating lipid nanoparticle properties and structure through biophysical analyses. Nat Biotechnol. 2025 Oct 23. PMID: 41131152.
      View in: PubMed
    31. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Author Correction: Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Oct 07; 16(1):8890. PMID: 41057390.
      View in: PubMed
    32. Padilla MS, Li JJ, Zhang Q, Patwari K, Shi S, Yamagata HM, Joseph RA, Hymms BN, Teerdhala SV, Alameh MG, Weissman D, Le AD, Mitchell MJ. Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy. bioRxiv. 2025 Oct 06. PMID: 41256582.
      View in: PubMed
    33. Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Joseph RA, Yamagata HM, Ricciardi AS, Mrksich K, Issadore D, Gupta K, Mitchell MJ. Elucidating lipid nanoparticle properties and structure through biophysical analyses. bioRxiv. 2025 Oct 06. PMID: 39763759.
      View in: PubMed
    34. Han EL, Safford HC, Mitchell MJ. Designer lipids for delivering mRNA to the brain. Nat Mater. 2025 Oct; 24(10):1518-1519. PMID: 40128627.
      View in: PubMed
    35. Yoo S, Han EL, Murray AM, Kim D, Bang EK, Mitchell MJ. High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH). Nano Lett. 2025 10 08; 25(40):14695-14703. PMID: 40997783.
      View in: PubMed
    36. Joseph RA, Haley RM, Padilla MS, Ricciardi AS, Yamagata HM, Mitchell MJ. Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair. Nano Lett. 2025 10 01; 25(39):14348-14355. PMID: 40961329.
      View in: PubMed
    37. Swingle KL, Hamilton AG, Han X, Liao KC, Safford HC, Thatte AS, Geisler HC, Xu J, Saw TY, Wan Y, Mitchell MJ. Circular RNA lipid nanoparticle vaccine against SARS-CoV-2. Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2505718122. PMID: 40953267.
      View in: PubMed
    38. Murray AM, Swingle KL, Mitchell MJ. Engineering Nanoparticles for Gynecologic Cancer Therapy. ACS Nano. 2025 Sep 02; 19(34):30758-30785. PMID: 40829053.
      View in: PubMed
    39. Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2181-2195. PMID: 40681859.
      View in: PubMed
    40. Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo. Proc Natl Acad Sci U S A. 2025 Jul 22; 122(29):e2409266122. PMID: 40668829.
      View in: PubMed
    41. Vadovics M, Zhao W, Daley EF, Lam K, Daly O, Rashid K, Lee HR, Schreiner P, Lundgreen KA, Gaudette BT, Shuvaev VV, Arguiri E, Muramatsu H, Sárközy A, Mdluli T, Xu J, Han X, De Luna N, Castaño D, Bettini E, Ábrahám E, Lipinszki Z, Carlucci G, Bansode AH, Nguyen K, Le TM, Luu T, Muzykantov VR, Bates P, Allman D, Mitchell MJ, Locci M, Radu CG, Heyes J, Pardi N. Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications. Nat Nanotechnol. 2025 Sep; 20(9):1312-1322. PMID: 40550975.
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    42. Karlath FA, Rehan MA, Geigor A, Mitchell MJ, Arnaout S, Greenough TC, Ellison RT. Retrospective Analysis of the Clinical Significance of Positive Blood Cultures in the Emergency Department: A Single-Center Study. Open Forum Infect Dis. 2025 Jul; 12(7):ofaf352. PMID: 40612932.
      View in: PubMed
    43. Hanna AR, Shepherd SJ, Datto GA, Navarro IB, Ricciardi AS, Padilla MS, Srikumar N, Zhang S, Yamagata HM, Meng NY, Buser JR, Mitchell MJ, Issadore DA. Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries. bioRxiv. 2025 May 29. PMID: 40501993.
      View in: PubMed
    44. Wu F, Li N, Xiao Y, Palanki R, Yamagata H, Mitchell MJ, Han X. Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components. Small Methods. 2026 Jan; 10(2):e2401632. PMID: 40434188.
      View in: PubMed
    45. Shin JE, Won EJ, Xu J, Lee JC, Bang JK, Mitchell MJ, Cha-Molstad H. Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery. ACS Appl Mater Interfaces. 2025 May 14; 17(19):28012-28024. PMID: 40325908.
      View in: PubMed
    46. Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ. Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. ACS Nano. 2025 04 15; 19(14):13790-13804. PMID: 40183470.
      View in: PubMed
    47. Tang S, Han EL, Mitchell MJ. Peptide-functionalized nanoparticles for brain-targeted therapeutics. Drug Deliv Transl Res. 2026 Mar; 16(3):741-760. PMID: 40164912.
      View in: PubMed
    48. Jester M, Haley RM, Billingsley MM, Figueroa-Espada C, Joseph RA, Han X, Mitchell MJ. Ionizable lipid nanoparticles with functionalized PEG-lipids increase retention in the tumor microenvironment. Mol Ther Methods Clin Dev. 2025 Jun 12; 33(2):101457. PMID: 40321415.
      View in: PubMed
    49. Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ. Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Nano Lett. 2025 03 26; 25(12):4800-4808. PMID: 40084657.
      View in: PubMed
    50. Han X, Xu Y, Ricciardi A, Xu J, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Weissman D, Mitchell MJ. Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. bioRxiv. 2025 Mar 01. PMID: 40060499.
      View in: PubMed
    51. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature. 2025 Feb; 638(8051):E33. PMID: 39900626.
      View in: PubMed
    52. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Jan 24; 16(1):996. PMID: 39856035.
      View in: PubMed
    53. Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ. Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. J Am Chem Soc. 2025 Jan 15; 147(2):1542-1552. PMID: 39742515.
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    54. Arnaout S, Stock S, Clifford JM, Greenough TC, Wedig A, Mitchell MJ, Ellison RT. Prospective Trial of a Passive Diversion Device to Reduce Blood Culture Contamination. Open Forum Infect Dis. 2025 Jan; 12(1):ofae751. PMID: 39834750.
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    55. Hwang YH, Shepherd SJ, Kim D, Mukalel AJ, Mitchell MJ, Issadore DA, Lee D. Robust, Scalable Microfluidic Manufacturing of RNA-Lipid Nanoparticles Using Immobilized Antifouling Lubricant Coating. ACS Nano. 2025 01 14; 19(1):1090-1102. PMID: 39700475.
      View in: PubMed
    56. Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810. PMID: 39688915.
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    57. Yoon IC, Xue L, Chen Q, Liu J, Xu J, Siddiqui Z, Kim D, Chen B, Shi Q, Laura Han E, Cherry Ruiz M, Vining KH, Mitchell MJ. Piperazine-Derived Bisphosphonate-Based Ionizable Lipid Nanoparticles Enhance mRNA Delivery to the Bone Microenvironment. Angew Chem Int Ed Engl. 2025 Jan 15; 64(3):e202415389. PMID: 39379320.
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    58. Sanati M, Figueroa-Espada CG, Han EL, Mitchell MJ, Yavari SA. Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers. ACS Nano. 2024 12 24; 18(51):34425-34463. PMID: 39666006.
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    59. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature. 2025 01; 637(8045):412-421. PMID: 39663452.
      View in: PubMed
    60. Han X, Alameh MG, Xu Y, Palanki R, El-Mayta R, Dwivedi G, Swingle KL, Xu J, Gong N, Xue L, Shi Q, Yoon IC, Warzecha CC, Wilson JM, Weissman D, Mitchell MJ. Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nat Biomed Eng. 2024 Nov; 8(11):1412-1424. PMID: 39578640.
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    61. Mossburg KJ, Shepherd SJ, Barragan D, O NH, Berkow EK, Maidment PSN, Rosario Berrios DN, Hsu JC, Siedlik MJ, Yadavali S, Mitchell MJ, Issadore D, Cormode DP. Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip. Eur J Nucl Med Mol Imaging. 2025 Feb; 52(3):1177-1188. PMID: 39528844.
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    62. Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat Nanotechnol. 2025 Jan; 20(1):132-143. PMID: 39354147.
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    63. Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ. Lipid nanoparticle-mediated RNA delivery for immune cell modulation. Eur J Immunol. 2024 Dec; 54(12):e2451008. PMID: 39279550.
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    64. Mrksich K, Padilla MS, Mitchell MJ. Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome. Adv Drug Deliv Rev. 2024 11; 214:115446. PMID: 39293650.
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    65. Gong N, Zhong W, Alameh MG, Han X, Xue L, El-Mayta R, Zhao G, Vaughan AE, Qin Z, Xu F, Hamilton AG, Kim D, Xu J, Kim J, Teng X, Li J, Liang XJ, Weissman D, Guo W, Mitchell MJ. Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nat Mater. 2024 Dec; 23(12):1736-1747. PMID: 39223270.
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    66. Palanki R, Yamagata H, Mitchell MJ. OLAH connects fatty acid metabolism to the severity of respiratory viral disease. Cell. 2024 Aug 22; 187(17):4549-4551. PMID: 39178832.
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    67. Swingle KL, Hamilton AG, Mitchell MJ. Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Placenta. 2025 Jun 13; 166:132-138. PMID: 39181830.
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    68. Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab Chip. 2024 08 06; 24(16):3790-3801. PMID: 39037068.
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    69. Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2400783121. PMID: 39078677.
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    70. Thatte AS, Weaver JD, Pearson R, Mitchell MJ. Drug delivery technologies for autoimmunity therapies. Adv Drug Deliv Rev. 2024 09; 212:115412. PMID: 39074562.
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    71. Chan A, Haley RM, Najar MA, Gonzalez-Martinez D, Bugaj LJ, Burslem GM, Mitchell MJ, Tsourkas A. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nat Commun. 2024 Jul 10; 15(1):5808. PMID: 38987546.
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    72. Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nat Chem. 2024 Oct; 16(10):1687-1697. PMID: 38982196.
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    73. Gong N, Alameh MG, El-Mayta R, Xue L, Weissman D, Mitchell MJ. Enhancing in situ cancer vaccines using delivery technologies. Nat Rev Drug Discov. 2024 08; 23(8):607-625. PMID: 38951662.
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    74. Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ. High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. ACS Nano. 2024 06 25; 18(25):16151-16165. PMID: 38861479.
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    151. Swingle KL, Hamilton AG, Mitchell MJ. Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines. Trends Mol Med. 2021 06; 27(6):616-617. PMID: 33836968.
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    152. Choueiri TK, Atkins MB, Bakouny Z, Carlo MI, Drake CG, Jonasch E, Kapur P, Lewis B, Linehan WM, Mitchell MJ, Pal SK, Pels K, Poteat S, Rathmell WK, Rini BI, Signoretti S, Tannir N, Uzzo R, Wood CG, Hammers HJ. Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research. J Natl Cancer Inst. 2021 03 01; 113(3):234-243. PMID: 32359162.
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    153. Aronson MR, Medina SH, Mitchell MJ. Peptide functionalized liposomes for receptor targeted cancer therapy. APL Bioeng. 2021 Mar; 5(1):011501. PMID: 33532673.
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    154. Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ. Ionizable lipid nanoparticles for in utero mRNA delivery. Sci Adv. 2021 01; 7(3). PMID: 33523869.
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    155. Gong N, Sheppard NC, Billingsley MM, June CH, Mitchell MJ. Nanomaterials for T-cell cancer immunotherapy. Nat Nanotechnol. 2021 01; 16(1):25-36. PMID: 33437036.
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    156. Zhang R, El-Mayta R, Murdoch TJ, Warzecha CC, Billingsley MM, Shepherd SJ, Gong N, Wang L, Wilson JM, Lee D, Mitchell MJ. Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. Biomater Sci. 2021 Feb 21; 9(4):1449-1463. PMID: 33404020.
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    157. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021 02; 20(2):101-124. PMID: 33277608.
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    158. Palanki R, Peranteau WH, Mitchell MJ. Delivery technologies for in utero gene therapy. Adv Drug Deliv Rev. 2021 02; 169:51-62. PMID: 33181188.
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    159. Gong N, Zhang Y, Teng X, Wang Y, Huo S, Qing G, Ni Q, Li X, Wang J, Ye X, Zhang T, Chen S, Wang Y, Yu J, Wang PC, Gan Y, Zhang J, Mitchell MJ, Li J, Liang XJ. Proton-driven transformable nanovaccine for cancer immunotherapy. Nat Nanotechnol. 2020 12; 15(12):1053-1064. PMID: 33106640.
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    160. Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 11; 4(11):1076-1089. PMID: 33020600.
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    161. Figueroa-Espada CG, Hofbauer S, Mitchell MJ, Riley RS. Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy. Adv Drug Deliv Rev. 2020; 160:244-261. PMID: 32956719.
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    162. Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Deliv Transl Res. 2020 06; 10(3):661-677. PMID: 32077052.
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    163. Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Nano Lett. 2020 03 11; 20(3):1578-1589. PMID: 31951421.
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    164. Yeom J, Guimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A. Chiral Supraparticles for Controllable Nanomedicine. Adv Mater. 2020 Jan; 32(1):e1903878. PMID: 31686433.
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    165. Guimaraes PPG, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ. Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. J Control Release. 2019 12 28; 316:404-417. PMID: 31678653.
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    166. Moore GW, Van Cott EM, Cutler JA, Mitchell MJ, Adcock DM. Recommendations for clinical laboratory testing of activated protein C resistance; communication from the SSC of the ISTH. J Thromb Haemost. 2019 09; 17(9):1555-1561. PMID: 31317658.
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    167. Mukalel AJ, Riley RS, Zhang R, Mitchell MJ. Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy. Cancer Lett. 2019 08 28; 458:102-112. PMID: 31100411.
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    168. Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019 03; 18(3):175-196. PMID: 30622344.
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    169. Bisso PW, Gaglione S, Guimarães PPG, Mitchell MJ, Langer R. Nanomaterial Interactions with Human Neutrophils. ACS Biomater Sci Eng. 2018 Dec 10; 4(12):4255-4265. PMID: 31497639.
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    170. Mitchell MJ, Jain RK, Langer R. Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2018 11; 18(11):720. PMID: 30337715.
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    171. Zhang R, Billingsley MM, Mitchell MJ. Biomaterials for vaccine-based cancer immunotherapy. J Control Release. 2018 12 28; 292:256-276. PMID: 30312721.
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    172. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J Control Release. 2018 11 28; 290:75-87. PMID: 30290244.
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    173. Auguste Y, Delague V, Desvignes JP, Longepied G, Gnisci A, Besnier P, Levy N, Beroud C, Megarbane A, Metzler-Guillemain C, Mitchell MJ. Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251 Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in Men. Am J Hum Genet. 2018 09 06; 103(3):413-420. PMID: 30122541.
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    174. Paci M, Elkhatib R, Longepied G, Bourgeois P, Ray PF, Levy N, Mitchell MJ, Metzler-Guillemain C. The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review. Basic Clin Androl. 2018; 28:7. PMID: 29946470.
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    175. Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in Biomaterials for Drug Delivery. Adv Mater. 2018 May 07; e1705328. PMID: 29736981.
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    176. Guimarães PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano. 2018 02 27; 12(2):912-931. PMID: 29378114.
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    177. Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2017 11; 17(11):659-675. PMID: 29026204.
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    178. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. . 2017 10 11; 17(10):6235-6240. PMID: 28819978.
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    179. Elkhatib RA, Paci M, Longepied G, Saias-Magnan J, Courbière B, Guichaoua MR, Lévy N, Metzler-Guillemain C, Mitchell MJ. Homozygous deletion of SUN5 in three men with decapitated spermatozoa. Hum Mol Genet. 2017 08 15; 26(16):3167-3171. PMID: 28541472.
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    180. Paci M, Elkhatib R, Longepied G, Hennebicq S, Bessonat J, Courbière B, Bourgeois P, Levy N, Mitchell MJ, Metzler-Guillemain C. Abnormal retention of nuclear lamina and disorganization of chromatin-related proteins in spermatozoa from DPY19L2-deleted globozoospermic patients. Reprod Biomed Online. 2017 Nov; 35(5):562-570. PMID: 28882431.
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    181. Kherraf ZE, Christou-Kent M, Karaouzene T, Amiri-Yekta A, Martinez G, Vargas AS, Lambert E, Borel C, Dorphin B, Aknin-Seifer I, Mitchell MJ, Metzler-Guillemain C, Escoffier J, Nef S, Grepillat M, Thierry-Mieg N, Satre V, Bailly M, Boitrelle F, Pernet-Gallay K, Hennebicq S, Fauré J, Bottari SP, Coutton C, Ray PF, Arnoult C. SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes. EMBO Mol Med. 2017 08; 9(8):1132-1149. PMID: 28554943.
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    182. Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V, Bourgeois P, Levy N, Branger N, Mitchell MJ, Metzler-Guillemain C. LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction. 2017 10; 154(4):387-401. PMID: 28684548.
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    183. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 03 20; 8:14179. PMID: 28317839.
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    184. Ray PF, Toure A, Metzler-Guillemain C, Mitchell MJ, Arnoult C, Coutton C. Genetic abnormalities leading to qualitative defects of sperm morphology or function. Clin Genet. 2017 02; 91(2):217-232. PMID: 27779748.
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    185. Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 03 08; 17(3):1326-1335. PMID: 28273716.
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    186. Mitchell MJ, Metzler-Guillemain C, Toure A, Coutton C, Arnoult C, Ray PF. Single gene defects leading to sperm quantitative anomalies. Clin Genet. 2017 02; 91(2):208-216. PMID: 27779755.
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    187. Bradshaw H, Mitchell MJ, Edwards CJ, Stolz U, Naser O, Peck A, Patanwala AE. Medication Palatability Affects Physician Prescribing Preferences for Common Pediatric Conditions. Acad Emerg Med. 2016 11; 23(11):1243-1247. PMID: 27264915.
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    188. Yamauchi Y, Riel JM, Ruthig VA, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29; 351(6272):514-6. PMID: 26823431.
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    189. Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development. PLoS One. 2016; 11(1):e0145398. PMID: 26765744.
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    190. Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. J Control Release. 2016 Feb 10; 223:215-223. PMID: 26732555.
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    191. Decarpentrie F, Ojarikre OA, Mitchell MJ, Burgoyne PS. Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. Chromosoma. 2016 Jun; 125(2):177-88. PMID: 26596988.
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    192. Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR. Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 2015 Dec 01; 309(11):C736-46. PMID: 26447202.
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    193. Okoli S, Madan B, Mwirigi A, Moore G, Drew A, Mitchell MJ, Cutler JA. A diagnostic dilemma: variant Bernard-Soulier syndrome, a difficult clinical and genetic diagnosis. Haemophilia. 2015 Nov; 21(6):e510-3. PMID: 26226975.
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    194. Wheeler RB, Cutler JA, Alamelu J, Mitchell MJ. The first report of a multi-exon duplication in the F9 gene causative of severe haemophilia B. Haemophilia. 2015 Sep; 21(5):e433-5. PMID: 26389844.
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    195. Mitchell MJ, Castellanos CA, King MR. Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials. 2015 Jul; 56:179-86. PMID: 25934290.
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    196. Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. J Biomed Mater Res A. 2015 Oct; 103(10):3407-18. PMID: 25761664.
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    197. Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophys J. 2015 Feb 03; 108(3):471-8. PMID: 25650915.
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    198. Elkhatib R, Longepied G, Paci M, Achard V, Grillo JM, Levy N, Mitchell MJ, Metzler-Guillemain C. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015 Mar; 21(3):225-36. PMID: 25477337.
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    199. Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opin Drug Deliv. 2015 Mar; 12(3):375-92. PMID: 25270379.
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    200. Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division. PLoS Genet. 2014 Jun; 10(6):e1004444. PMID: 24967676.
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    201. Bajpai S, Mitchell MJ, King MR, Reinhart-King CA. A microfluidic device to select for cells based on chemotactic phenotype. Technology (Singap World Sci). 2014 Jun; 2(2):101-105. PMID: 24999488.
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    202. Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophys J. 2014 May 20; 106(10):2243-53. PMID: 24853753.
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    203. Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther. 2014 Jun; 14(6):641-4. PMID: 24791860.
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    204. Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):930-5. PMID: 24395803.
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    205. Mitchell MJ, King MR. Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells. . 2014 Jan 15; 306(2):C89-97. PMID: 24133067.
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    206. Cao TM, Mitchell MJ, Liesveld J, King MR. Stem cell enrichment with selectin receptors: mimicking the pH environment of trauma. Sensors (Basel). 2013 Sep 17; 13(9):12516-26. PMID: 24048341.
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    207. Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol. 2013; 3:44. PMID: 23467856.
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    208. Mitchell MJ, King MR. Fluid Shear Stress Sensitizes Cancer Cells to Receptor-Mediated Apoptosis via Trimeric Death Receptors. New J Phys. 2013 Jan 18; 15:015008. PMID: 25110459.
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    209. Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophys J. 2012 Apr 18; 102(8):1804-14. PMID: 22768936.
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    210. Streichemberger E, Perrin J, Saias-Magnan J, Karsenty G, Malzac P, Grillo JM, Mitchell MJ, Metzler-Guillemain C. Case report of apoptosis in testis of four AZFc-deleted patients: increased DNA fragmentation during meiosis, but decreased apoptotic markers in post-meiotic germ cells. Hum Reprod. 2012 Jul; 27(7):1939-45. PMID: 22508792.
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    211. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Hum Mol Genet. 2012 Jun 15; 21(12):2631-45. PMID: 22407129.
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    212. Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. J Control Release. 2012 Jun 28; 160(3):609-17. PMID: 22421423.
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    213. Mitchell MJ, Castellanos CA, King MR. Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes. J Nanomater. 2012; 2012. PMID: 25152752.
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    214. Schlaberg R, Mitchell MJ, Taggart EW, She RC. Verification of performance specifications for a US Food and Drug Administration-approved molecular microbiology test: Clostridium difficile cytotoxin B using the Becton, Dickinson and Company GeneOhm Cdiff assay. Arch Pathol Lab Med. 2012 Jan; 136(1):20-5. PMID: 22208483.
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    215. Kichine E, Rozé V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, Lévy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod. 2012 Feb; 27(2):615-24. PMID: 22158087.
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    216. Hayden RT, Yan X, Wick MT, Rodriguez AB, Xiong X, Ginocchio CC, Mitchell MJ, Caliendo AM. Factors contributing to variability of quantitative viral PCR results in proficiency testing samples: a multivariate analysis. J Clin Microbiol. 2012 Feb; 50(2):337-45. PMID: 22116152.
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    217. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93. PMID: 21530259.
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    218. Cutler JA, Patel R, Rangarajan S, Tait RC, Mitchell MJ. Molecular characterization of 11 novel mutations in patients with heterozygous and homozygous FV deficiency. Haemophilia. 2010 Nov; 16(6):937-42. PMID: 20546033.
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    219. Hayden RT, Wick MT, Rodriguez AB, Caliendo AM, Mitchell MJ, Ginocchio CC. A survey-based assessment of United States clinical laboratory response to the 2009 H1N1 influenza outbreak. Arch Pathol Lab Med. 2010 Nov; 134(11):1671-8. PMID: 21043821.
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    220. Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Arch Pathol Lab Med. 2010 Oct; 134(10):1490-503. PMID: 20923306.
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    221. Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010 Oct; 25(10):2655-63. PMID: 20716563.
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    222. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, Yahaya AA, Chiaroni J, Mitchell MJ. Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean. Eur J Hum Genet. 2011 Jan; 19(1):89-94. PMID: 20700146.
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    223. Chiaroni J, King RJ, Myres NM, Henn BM, Ducourneau A, Mitchell MJ, Boetsch G, Sheikha I, Lin AA, Nik-Ahd M, Ahmad J, Lattanzi F, Herrera RJ, Ibrahim ME, Brody A, Semino O, Kivisild T, Underhill PA. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 2010 Mar; 18(3):348-53. PMID: 19826455.
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    224. Mitchell MJ, Stubbs BA, Eisenberg MS. Socioeconomic status is associated with provision of bystander cardiopulmonary resuscitation. Prehosp Emerg Care. 2009 Oct-Dec; 13(4):478-86. PMID: 19731160.
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    225. Metzler-Guillemain C, Depetris D, Luciani JJ, Mignon-Ravix C, Mitchell MJ, Mattei MG. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008; 16(5):761-82. PMID: 18592385.
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    226. Kichine E, Msaidie S, Bokilo AD, Ducourneau A, Navarro A, Levy N, Terriou P, Collignon P, Boetsch G, Chiaroni J, Mitchell MJ. Low-frequency protamine 1 gene transversions c.102G->T and c.-107G->C do not correlate with male infertility. J Med Genet. 2008 Apr; 45(4):255-6. PMID: 18381856.
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    227. Mitchell MJ, Montgomery M, Reiter CG, Culp WC. Pericardial tamponade following CT-guided lung biopsy. Cardiovasc Intervent Radiol. 2008 Jul; 31 Suppl 2:S227-30. PMID: 17962996.
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    228. Dai L, Cutler JA, Savidge GF, Mitchell MJ. Characterization of a causative mutation of hemophilia A identified in the promoter region of the factor VIII gene (F8). J Thromb Haemost. 2008 Jan; 6(1):193-5. PMID: 17944985.
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    229. Mitchell MJ, Dai L, Clarke JB, Bolton-Maggs PH, Savidge GF, Alhaq A. Characterisation of five factor XI mutations. Thromb Haemost. 2007 Jun; 97(6):884-9. PMID: 17549289.
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    230. Karcanias AC, Ichimura K, Mitchell MJ, Sargent CA, Affara NA. Analysis of sex chromosome abnormalities using X and Y chromosome DNA tiling path arrays. J Med Genet. 2007 Jul; 44(7):429-36. PMID: 17327287.
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    231. Bolton-Maggs PH, Hay CR, Shanks D, Mitchell MJ, McVey JH. The importance of tissue factor source in the management of Factor VII deficiency. Thromb Haemost. 2007 Jan; 97(1):151-2. PMID: 17200783.
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    232. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9. PMID: 16580996.
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    233. Perrin J, Metzler-Guillemain C, Karsenty G, Grillo JM, Mitchell MJ, Guichaoua MR. Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. Fertil Steril. 2006 Feb; 85(2):494.e5-8. PMID: 16595237.
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    234. Giachini C, Guarducci E, Longepied G, Degl'Innocenti S, Becherini L, Forti G, Mitchell MJ, Krausz C. The gr/gr deletion(s): a new genetic test in male infertility? J Med Genet. 2005 Jun; 42(6):497-502. PMID: 15937085.
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    235. Cutler JA, Patel R, Mitchell MJ, Savidge GF. The significance of published polymorphisms in 14 cases of mild factor VII deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):91-5. PMID: 15741795.
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    236. Machev N, Saut N, Longepied G, Terriou P, Navarro A, Levy N, Guichaoua M, Metzler-Guillemain C, Collignon P, Frances AM, Belougne J, Clemente E, Chiaroni J, Chevillard C, Durand C, Ducourneau A, Pech N, McElreavey K, Mattei MG, Mitchell MJ. Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility. J Med Genet. 2004 Nov; 41(11):814-25. PMID: 15520406.
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    237. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency. . 2004 Aug 15; 129A(1):13-5. PMID: 15266608.
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    238. Cutler JA, Mitchell MJ, Savidge GF. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients. J Thromb Haemost. 2004 Jun; 2(6):1021. PMID: 15140150.
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    239. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56. PMID: 15241014.
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    240. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. The identification and classification of 41 novel mutations in the factor VIII gene (F8C). Hum Mutat. 2002 Mar; 19(3):274-8. PMID: 11857744.
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    241. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4. PMID: 11750690.
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    242. Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Bishop C, Eicher EM, Mitchell MJ, Burgoyne PS. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001 Sep; 29(1):49-53. PMID: 11528390.
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    243. Lingenfelter PA, Delbridge ML, Thomas S, Hoekstra HE, Mitchell MJ, Graves JA, Disteche CM. Expression and conservation of processed copies of the RBMX gene. Mamm Genome. 2001 Jul; 12(7):538-45. PMID: 11420617.
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    244. Cutler JA, Mitchell MJ, Greenslade K, Smith MP, Savidge GF. A rapid and cost-effective method for analysis of three common genetic risk factors for thrombosis. Blood Coagul Fibrinolysis. 2001 Jan; 12(1):33-6. PMID: 11229824.
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    245. Affara NA, Mitchell MJ. The role of human and mouse Y chromosome genes in male infertility. J Endocrinol Invest. 2000 Nov; 23(10):630-45. PMID: 11097427.
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    246. Saut N, Terriou P, Navarro A, Lévy N, Mitchell MJ. The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility. Mol Hum Reprod. 2000 Sep; 6(9):789-93. PMID: 10956550.
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    247. Scott D, Addey C, Ellis P, James E, Mitchell MJ, Saut N, Jurcevic S, Simpson E. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens. Immunity. 2000 Jun; 12(6):711-20. PMID: 10894170.
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    248. Denton ER, Mitchell MJ, Nash RR, Bingham M. Use of the site percutaneous breast biopsy device. Breast. 2000 Apr; 9(2):107-9. PMID: 14731709.
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    249. Lévy N, Navarro A, Bishop CE, Mitchell MJ. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Mamm Genome. 2000 Feb; 11(2):164-8. PMID: 10656933.
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    250. Mitchell MJ. Spermatogenesis and the mouse Y chromosome: specialisation out of decay. Results Probl Cell Differ. 2000; 28:233-70. PMID: 10626301.
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    251. Bishop CE, Mitchell MJ. Mouse Y chromosome. Mamm Genome. 1999 Oct; 10(10):962. PMID: 10501963.
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    252. Mazeyrat S, Saut N, Mattei MG, Mitchell MJ. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nat Genet. 1999 Jul; 22(3):224-6. PMID: 10391207.
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    253. Smith MP, Spence KJ, Waters EL, Beresford-Webb R, Mitchell MJ, Cuttler J, Alhaq A, Brown SA, Savidge GF. Immune tolerance therapy for haemophilia A patients with acquired factor VIII alloantibodies: comprehensive analysis of experience at a single institution. Thromb Haemost. 1999 Jan; 81(1):35-8. PMID: 9974371.
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    254. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct; 7(11):1725-37. PMID: 9736774.
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    255. Mazeyrat S, Saut N, Sargent CA, Grimmond S, Longepied G, Ehrmann IE, Ellis PS, Greenfield A, Affara NA, Mitchell MJ. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum Mol Genet. 1998 Oct; 7(11):1713-24. PMID: 9736773.
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    256. Mitchell MJ, Wilcox SA, Watson JM, Lerner JL, Woods DR, Scheffler J, Hearn JP, Bishop CE, Graves JA. The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Hum Mol Genet. 1998 Mar; 7(3):429-34. PMID: 9467000.
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    257. Mazeyrat S, Mitchell MJ. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Hum Mol Genet. 1998 Mar; 7(3):557-62. PMID: 9467017.
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    258. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome VII. Mouse chromosome Y. Mamm Genome. 1998; 8 Spec No:S378-81. PMID: 9662638.
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    259. Levy N, de Boer P, Mattei J, Mitchell MJ. Molecular analysis of an isoYq chromosome in a sterile male mouse. Mamm Genome. 1996 Aug; 7(8):608-9. PMID: 8678984.
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    260. Laval SH, Blair HJ, Mitchell MJ, Boyd Y. Smcx lies distal to DXHX674 and DXHX679 on the mouse X chromosome. Mamm Genome. 1996 Jul; 7(7):552. PMID: 8672147.
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    261. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome V. Mouse Y chromosome. Mamm Genome. 1996; 6 Spec No:S331-3. PMID: 8800777.
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    262. Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E, Mitchell MJ. Identification of a mouse male-specific transplantation antigen, H-Y. Nature. 1995 Aug 24; 376(6542):695-8. PMID: 7544442.
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    263. King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics. 1994 Nov 01; 24(1):159-68. PMID: 7896271.
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    264. Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE. A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun; 3(6):873-8. PMID: 7524912.
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    265. Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL, Bishop CE. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Hum Mol Genet. 1994 Jun; 3(6):879-84. PMID: 7951230.
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    266. McLaren A, Simpson E, Bishop CE, Mitchell MJ, Darling SM. Recombination between the X and Y chromosomes and the Sxr region of the mouse. Genet Res. 1992 Dec; 60(3):175-84. PMID: 1286802.
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    267. Mitchell MJ, Woods DR, Wilcox SA, Graves JA, Bishop CE. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Nature. 1992 Oct 08; 359(6395):528-31. PMID: 1406968.
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    268. Mitchell MJ, Bishop CE. A structural analysis of the Sxr region of the mouse Y chromosome. Genomics. 1992 Jan; 12(1):26-34. PMID: 1733861.
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    269. Zwelling LA, Mitchell MJ, Satitpunwaycha P, Mayes J, Altschuler E, Hinds M, Baguley BC. Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development. Cancer Res. 1992 Jan 01; 52(1):209-17. PMID: 1309224.
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    270. Mitchell MJ, Woods DR, Tucker PK, Opp JS, Bishop CE. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Nature. 1991 Dec 12; 354(6353):483-6. PMID: 1684224.
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    271. Tiersch TR, Mitchell MJ, Wachtel SS. Studies on the phylogenetic conservation of the SRY gene. Hum Genet. 1991 Sep; 87(5):571-3. PMID: 1916759.
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    272. Mitchell MJ, Laughon BE, Lin S. Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro. Infect Immun. 1987 Jul; 55(7):1610-5. PMID: 3596804.
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    273. Kalaria RN, Mitchell MJ, Harik SI. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proc Natl Acad Sci U S A. 1987 May; 84(10):3521-5. PMID: 3495000.
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    274. Ridler MA, Lax R, Mitchell MJ, Shapiro A, Saldaña-Garcia P. An adult male with XYYY sex chromosomes. Clin Genet. 1973; 4(1):69-77. PMID: 4691557.
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