 Sex Hormone-Binding Globulin
"Sex Hormone-Binding Globulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
| Descriptor ID |
D012738
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| MeSH Number(s) |
D12.776.124.790.223.800 D12.776.157.762 D12.776.377.715.182.800
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| Concept/Terms |
Sex Hormone-Binding Globulin- Sex Hormone-Binding Globulin
- Globulin, Sex Hormone-Binding
- Hormone-Binding Globulin, Sex
- Sex Hormone Binding Globulin
- Testosterone-Estradiol Binding Globulin
- Binding Globulin, Testosterone-Estradiol
- Globulin, Testosterone-Estradiol Binding
- Testosterone Estradiol Binding Globulin
- Sex Steroid-Binding Protein
- Sex Steroid Binding Protein
- Steroid-Binding Protein, Sex
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Below are MeSH descriptors whose meaning is more general than "Sex Hormone-Binding Globulin".
Below are MeSH descriptors whose meaning is more specific than "Sex Hormone-Binding Globulin".
This graph shows the total number of publications written about "Sex Hormone-Binding Globulin" by people in this website by year, and whether "Sex Hormone-Binding Globulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 3 | 5 | | 2012 | 1 | 3 | 4 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 2 | 2 | | 2019 | 1 | 2 | 3 | | 2020 | 3 | 1 | 4 | | 2022 | 1 | 0 | 1 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sex Hormone-Binding Globulin" by people in Profiles.
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Mitro SD, Waetjen LE, Lee C, Wise LA, Zaritsky E, Harlow SD, El Khoudary SR, Santoro N, Solomon DH, Thurston RC, Hedderson MM. Diabetes and Uterine Fibroid Diagnosis in Midlife: Study of Women's Health Across the Nation (SWAN). J Clin Endocrinol Metab. 2025 May 19; 110(6):e1934-e1942.
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Dias JP, Piggott DA, Sun J, Wehbeh L, Garza J, Abraham A, Astemborski J, Moseley KF, Basaria S, Varadhan R, Brown TT. SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV. J Clin Endocrinol Metab. 2022 06 16; 107(7):e2971-e2981.
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Dhindsa S, Ghanim H, Jenkins T, Inge TH, Harmon CM, Ghoshal A, Wu Z, McPhaul MJ, Saad F, Dandona P. High prevalence of subnormal testosterone in obese adolescent males: reversal with bariatric surgery. Eur J Endocrinol. 2022 Feb 01; 186(3):319-327.
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Aroda VR, Christophi CA, Edelstein SL, Perreault L, Kim C, Golden SH, Horton E, Mather KJ. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program. BMJ Open Diabetes Res Care. 2020 12; 8(2).
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Mueller NT, Liu T, Mitchel EB, Yates KP, Suzuki A, Behling C, Lavine JE. Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease. J Clin Endocrinol Metab. 2020 11 01; 105(11).
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Petrick JL, Florio AA, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Van Den Eeden SK, Stanczyk FZ, Simon TG, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Purdue MP, Palmer JR, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Guillemette C, Graubard BI, Giovannucci E, Gaziano JM, Gapster SM, Freedman ND, Engel LS, Chong DQ, Chen Y, Chan AT, Caron P, Buring JE, Bradwin G, Beane Freeman LE, Campbell PT, McGlynn KA. Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Postmenopausal Women. Hepatology. 2020 08; 72(2):535-547.
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Cort?s YI, Barinas-Mitchell E, Suder Egnot N, Bhasin S, Jasuja R, Santoro N, Thurston RC. Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women. J Clin Endocrinol Metab. 2020 04 01; 105(4).
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Nokoff N, Thurston J, Hilkin A, Pyle L, Zeitler PS, Nadeau KJ, Santoro N, Kelsey MM. Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty. J Clin Endocrinol Metab. 2019 10 01; 104(10):4390-4397.
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Grossmann M, Wierman ME, Angus P, Handelsman DJ. Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease. Endocr Rev. 2019 04 01; 40(2):417-446.
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Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E707-E718.
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