 Sex Hormone-Binding Globulin
"Sex Hormone-Binding Globulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
| Descriptor ID |
D012738
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| MeSH Number(s) |
D12.776.124.790.223.800 D12.776.157.762 D12.776.377.715.182.800
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| Concept/Terms |
Sex Hormone-Binding Globulin- Sex Hormone-Binding Globulin
- Globulin, Sex Hormone-Binding
- Hormone-Binding Globulin, Sex
- Sex Hormone Binding Globulin
- Testosterone-Estradiol Binding Globulin
- Binding Globulin, Testosterone-Estradiol
- Globulin, Testosterone-Estradiol Binding
- Testosterone Estradiol Binding Globulin
- Sex Steroid-Binding Protein
- Sex Steroid Binding Protein
- Steroid-Binding Protein, Sex
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Below are MeSH descriptors whose meaning is more general than "Sex Hormone-Binding Globulin".
Below are MeSH descriptors whose meaning is more specific than "Sex Hormone-Binding Globulin".
This graph shows the total number of publications written about "Sex Hormone-Binding Globulin" by people in this website by year, and whether "Sex Hormone-Binding Globulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 3 | 5 | | 2012 | 1 | 3 | 4 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 2 | 2 | | 2019 | 2 | 3 | 5 | | 2020 | 3 | 1 | 4 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 1 | 2 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Sex Hormone-Binding Globulin" by people in Profiles.
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Grahnemo L, Marriott RJ, Murray K, Tyack LT, Nethander M, Matsumoto AM, Orwoll ES, Vanderschueren D, Yeap BB, Ohlsson C. Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men. J Clin Endocrinol Metab. 2025 Jun 17; 110(7):1964-1973.
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Mitro SD, Waetjen LE, Lee C, Wise LA, Zaritsky E, Harlow SD, El Khoudary SR, Santoro N, Solomon DH, Thurston RC, Hedderson MM. Diabetes and Uterine Fibroid Diagnosis in Midlife: Study of Women's Health Across the Nation (SWAN). J Clin Endocrinol Metab. 2025 May 19; 110(6):e1934-e1942.
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Narinx N, Marriott RJ, Murray K, Adams RJ, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Hankey GJ, Hannemann A, Wilkening R, Martin SA, Matsumoto AM, Ohlsson C, O'Neill TW, Orwoll ES, Shores MM, Steveling A, Travison TG, Wittert GA, Wu FCW, Antonio L, Vanderschueren D, Yeap BB. Sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses. Eur J Endocrinol. 2024 Oct 29; 191(5):523-534.
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Yeap BB, Marriott RJ, Dwivedi G, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses. Ann Intern Med. 2024 06; 177(6):768-781.
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Marriott RJ, Murray K, Adams RJ, Antonio L, Ballantyne CM, Bauer DC, Bhasin S, Biggs ML, Cawthon PM, Couper DJ, Dobs AS, Flicker L, Handelsman DJ, Hankey GJ, Hannemann A, Haring R, Hsu B, Karlsson M, Martin SA, Matsumoto AM, Mellström D, Ohlsson C, O'Neill TW, Orwoll ES, Quartagno M, Shores MM, Steveling A, Tivesten Å, Travison TG, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB. Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses. Ann Intern Med. 2023 09; 176(9):1221-1234.
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Dias JP, Piggott DA, Sun J, Wehbeh L, Garza J, Abraham A, Astemborski J, Moseley KF, Basaria S, Varadhan R, Brown TT. SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV. J Clin Endocrinol Metab. 2022 06 16; 107(7):e2971-e2981.
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Dhindsa S, Ghanim H, Jenkins T, Inge TH, Harmon CM, Ghoshal A, Wu Z, McPhaul MJ, Saad F, Dandona P. High prevalence of subnormal testosterone in obese adolescent males: reversal with bariatric surgery. Eur J Endocrinol. 2022 Feb 01; 186(3):319-327.
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Yeap BB, Marriott RJ, Antonio L, Chan YX, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Hankey GJ, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men. J Clin Endocrinol Metab. 2021 01 23; 106(2):e625-e637.
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Aroda VR, Christophi CA, Edelstein SL, Perreault L, Kim C, Golden SH, Horton E, Mather KJ. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program. BMJ Open Diabetes Res Care. 2020 12; 8(2).
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Mueller NT, Liu T, Mitchel EB, Yates KP, Suzuki A, Behling C, Lavine JE. Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease. J Clin Endocrinol Metab. 2020 11 01; 105(11).
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