 beta 2-Microglobulin
"beta 2-Microglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
| Descriptor ID |
D001613
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| MeSH Number(s) |
D12.776.124.790.223.100 D12.776.377.715.182.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "beta 2-Microglobulin".
Below are MeSH descriptors whose meaning is more specific than "beta 2-Microglobulin".
This graph shows the total number of publications written about "beta 2-Microglobulin" by people in this website by year, and whether "beta 2-Microglobulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1994 | 3 | 1 | 4 | | 1995 | 1 | 1 | 2 | | 1996 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 1 | 3 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2018 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "beta 2-Microglobulin" by people in Profiles.
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Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 10; 27(10):1241-1256.
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Ribeiro ?L, Ara?jo FP, Martins JP, Louren?o AA, Huang J, Pereira FV, Andrade LAF, Paim AAO, da Fonseca FG, Barbosa-Stancioli EF, Martins-Filho OA, Peruhype-Magalh?es V, Tsuji M, Coelho-Dos-Reis JG. A chimeric HLA-A2:?2M:Ig fusion protein for the study of virus-specific CD8+ T-cells. J Immunol Methods. 2021 05; 492:112997.
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Jotwani V, Garimella PS, Katz R, Malhotra R, Bates J, Cheung AK, Chonchol M, Drawz PE, Freedman BI, Haley WE, Killeen AA, Punzi H, Sarnak MJ, Segal MS, Shlipak MG, Ix JH. Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants. Am J Nephrol. 2020; 51(10):797-805.
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Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 04; 41(2):213-226.
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Bjornstad P, Singh SK, Snell-Bergeon JK, Lovshin JA, Lytvyn Y, Lovblom LE, Rewers MJ, Boulet G, Lai V, Tse J, Cham L, Orszag A, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI. The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes. Diabetes Obes Metab. 2019 03; 21(3):575-583.
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Zhang WR, Craven TE, Malhotra R, Cheung AK, Chonchol M, Drawz P, Sarnak MJ, Parikh CR, Shlipak MG, Ix JH. Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study. Ann Intern Med. 2018 11 06; 169(9):610-618.
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Haworth KB, Arnold MA, Pierson CR, Leddon JL, Kurmashev DK, Swain HM, Hutzen BJ, Roberts RD, Cripe TP. Characterization of MHC Class I and ?-2-Microglobulin Expression in Pediatric Solid Malignancies to Guide Selection of Immune-Based Therapeutic Trials. Pediatr Blood Cancer. 2016 Apr; 63(4):618-26.
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Navaneethan SD, Fealy CE, Scelsi AC, Arrigain S, Malin SK, Kirwan JP. A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease. Am J Nephrol. 2015; 42(4):274-81.
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Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ. Innate PLZF+CD4+ a? T cells develop and expand in the absence of Itk. J Immunol. 2014 Jul 15; 193(2):673-87.
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Oboho I, Abraham AG, Benning L, Anastos K, Sharma A, Young M, Burian P, Gandhi M, Cohen M, Szczech L. Tenofovir use and urinary biomarkers among HIV-infected women in the Women's Interagency HIV Study (WIHS). J Acquir Immune Defic Syndr. 2013 Apr 01; 62(4):388-95.
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