 Exodeoxyribonucleases
"Exodeoxyribonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products.
| Descriptor ID |
D005090
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| MeSH Number(s) |
D08.811.277.352.335.375 D08.811.277.352.365.290
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Exodeoxyribonucleases".
Below are MeSH descriptors whose meaning is more specific than "Exodeoxyribonucleases".
This graph shows the total number of publications written about "Exodeoxyribonucleases" by people in this website by year, and whether "Exodeoxyribonucleases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 3 | 0 | 3 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Exodeoxyribonucleases" by people in Profiles.
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Amico G, Hemphill WO, Severino M, Moratti C, Pascarella R, Bertamino M, Napoli F, Volpi S, Rosamilia F, Signa S, Perrino F, Zedde M, Ceccherini I. Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core. Genes (Basel). 2022 06 30; 13(7).
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Hemphill WO, Simpson SR, Liu M, Salsbury FR, Hollis T, Grayson JM, Perrino FW. TREX1 as a Novel Immunotherapeutic Target. Front Immunol. 2021; 12:660184.
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Simpson SR, Hemphill WO, Hudson T, Perrino FW. TREX1 - Apex predator of cytosolic DNA metabolism. DNA Repair (Amst). 2020 10; 94:102894.
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Rawal CC, Zardoni L, Di Terlizzi M, Galati E, Brambati A, Lazzaro F, Liberi G, Pellicioli A. Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity. Cell Rep. 2020 05 05; 31(5):107603.
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Simpson SR, Rego SL, Harvey SE, Liu M, Hemphill WO, Venkatadri R, Sharma R, Grayson JM, Perrino FW. T Cells Produce IFN-a in the TREX1 D18N Model of Lupus-like Autoimmunity. J Immunol. 2020 01 15; 204(2):348-359.
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Hemphill WO, Perrino FW. Measuring TREX1 and TREX2 exonuclease activities. Methods Enzymol. 2019; 625:109-133.
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Adang LA, Frank DB, Gilani A, Takanohashi A, Ulrick N, Collins A, Cross Z, Galambos C, Helman G, Kanaan U, Keller S, Simon D, Sherbini O, Hanna BD, Vanderver AL. Aicardi goutières syndrome is associated with pulmonary hypertension. Mol Genet Metab. 2018 12; 125(4):351-358.
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Kumar S, Morrison JH, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018 08 15; 92(16).
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Brambati A, Zardoni L, Achar YJ, Piccini D, Galanti L, Colosio A, Foiani M, Liberi G. Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription. Nucleic Acids Res. 2018 02 16; 46(3):1227-1239.
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Dickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. 2017 05 30; 56(21):2651-2662.
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